Identification of key gene modules and pathways of human glioma through coexpression network
In this study, we extracted data sets from GEO (Gene Expression Omnibus) data set by using “glioma” as the keyword. Then, a coexpression module was constructed with the help of WGCNA (Weighted Gene Coexpression Network Analysis) software. Besides, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on the genes in these modules. As a result, the critical modules and target genes were identified. Eight coexpression modules were constructed using the 4,000 genes with a high expression value of the total 141 glioma samples. The result of the analysis of the inte...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Tianming Shi, Jianchun Chen, Jing Li, Bing ‐Yin Yang, Qiao‐Lin Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The effect of high ‐fat diet and inhibition of ceramide production on insulin action in liver
Hepatic insulin resistance induced by high ‐fat diet resulted from an increase in synthesis rate of ceramide and diacylglycerol (DAG). Myriocin treatment improved insulin sensitivity, which was accompanied by a decrease in the synthesis rate and content of ceramide and DAG. Liver, as one of the most important organs involved in lipids and glucose metabolism, is perceived as a key tissue for pharmacotherapy of insulin resistance (IRes) and type 2 diabetes. Ceramides (Cer) are biologically active lipids, which accumulation is associated with the induction of muscle IRes. We sought to determine the role of intrahepatic bioa...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Piotr Zabielski, Jaros ław Daniluk, Hady Razak Hady, Adam R. Markowski, Monika Imierska, Jan Górski, Agnieszka U. Blachnio‐Zabielska Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Protective effects of ex ‐527 on cerebral ischemia–reperfusion injury through necroptosis signaling pathway attenuation
This study provides a new approach to the possible neuroprotective potential of ex‐527 orchestrated by necroptosis pathway inhibition to alleviate ischemia–reperfusion brain injury. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Sara Nikseresht, Fariba Khodagholi, Abolhassan Ahmadiani Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma
Our results demonstrated that LCD inhibited the kinase activity of JAK2, soft agar colony formation, and the proliferation of HN22 and HSC4 cells. LCD also induced mitochondrial apoptotic events such as altered mitochondrial membrane potential and reactive oxygen species production and, LCD increased expression of apoptosis ‐associated proteins in oral squamous cell carcinoma cells. These results indicate that the anticancer effect of LCD is due to the direct targeting of JAK2 kinase. Licochalcone (LC) families have been reported to have a wide range of biological function such as antioxidant, antibacterial, antiviral, a...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Ji ‐Hye Seo, Hyun Woo Choi, Ha‐Na Oh, Mee‐Hyun Lee, Eunae Kim, Goo Yoon, Seung‐Sik Cho, Seon‐Min Park, Young Sik Cho, Jung‐Il Chae, Jung‐Hyun Shim Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells
In conclusion, ECH exerted its antitumor activity via decreasing TREM2 expression and PI3K/AKT signaling. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Ying Ye, Yanan Song, Juhua Zhuang, Guoyu Wang, Jing Ni, Wei Xia Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

CircHIPK3 promotes proliferation and invasion in nasopharyngeal carcinoma by abrogating miR ‐4288‐induced ELF3 inhibition
In conclusion, our findings demonstrated that circHIPK3 facilitated NPC progression through protecting ELF3 from miR‐4288‐mediated silencing, which suggested that the circHIPK3‐miR‐4288‐ELF3 regulatory loop might be a potential target for NPC prev ention. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Zhaoyang Ke, Fei Xie, Chaopan Zheng, Daishi Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Brain ‐derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cells
We are the first to show stimulatory effects of brain ‐derived neurotrophic factor (BDNF) on proliferation and progesterone (P4) synthesis by bovine granulosa cells (GCs); and that the AKT signaling pathway participates in both proliferation and P4 synthesis induced by BDNF, while the ERK1/2 signaling pathway only participates in cellular proliferation. CCNA1: cyclin A1; CCND1: cyclin D1; CCNE2: cyclin E2; CDK1: cyclin ‐dependent kinase 1; STAR: steroidogenic acute regulatory protein; MAPK: mitogen‐activated protein kinases; PI3K: phosphoinositide 3‐kinase AbstractBrain ‐derived neurotrophic factor (BDNF) is invo...
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Shuxiong Chen, Fengge Wang, Zhuo Liu, Yun Zhao, Yanwen Jiang, Lu Chen, Chunjin Li, Xu Zhou Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Inhibitory effect of MSH6 gene silencing in combination with cisplatin on cell proliferation of human osteosarcoma cell line MG63
In conclusion, our preliminary results indicated that the combination ofMSH6 gene silencing coupled with DDP may have a better effect on the inhibition of OS cell proliferation and promote apoptosis, potentially providing targets for the OS treatment. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Hu ‐Cheng Liu, Jin Zeng, Bin Zhang, Xu‐Qiang Liu, Min Dai Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Downregulation of long noncoding RNA LOC101928134 inhibits the synovial hyperplasia and cartilage destruction of osteoarthritis rats through the activation of the Janus kinase/signal transducers and activators of transcription signaling pathway by upregulating IFNA1
This study aims to explore the role of long noncoding RNA (lncRNA) LOC101928134 in the synovial hyperplasia and cartilage destruction, more specifically, in the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway in an OA rat model. Microarray ‐based gene expression analysis was conducted to screen out the lncRNA differentially expressed in OA and predict the target gene of the lncRNA with the involvement of the signaling pathway through Kyoto encyclopedia of genes and genomes (KEGG) analysis. A model of OA was established and treated w ith the small interfering RNA LOC101928134/i...
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Da ‐Wei Yang, Xin Zhang, Gui‐Bin Qian, Ming‐Jiu Jiang, Peng Wang, Kun‐Zheng Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

New insights into the roles and regulation of SphK2 as a therapeutic target in cancer chemoresistance
Development of multidrug resistance (MDR) is still a big obstacle against successful and complete cancer treatment. Sphingosine kinase 2 targeting could provide a novel approach and a potentially more effective treatment strategy for MDR in cancer. AbstractChemoresistance is a complicated process developed by most cancers and accounts for the majority of relapse and metastasis in cancer. The main mechanisms of chemoresistance phenotype include increased expression and/or activated drug efflux pumps, altered DNA repair, altered metabolism of therapeutics as well as impaired apoptotic signaling pathways. Aberrant sphingolipi...
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Leili Hasanifard, Roghayeh Sheervalilou, Maryam Majidinia, Bahman Yousefi Tags: REVIEW ARTICLE Source Type: research

Inflammatory molecules produced by meniscus and synovium in early and end ‐stage osteoarthritis: a coculture study
Inflammatory mediators, metalloproteinases, and metalloproteinases inhibitors are produced by meniscus and synovium from early and end ‐stage osteoarthritic patients. Production of inflammatory molecules by synovium and meniscus can trigger inflammatory signals in early osteoarthritis (OA) patients, and induce extracellular matrix loss in the progressive and final stages of OA pathology. The interaction between synovium and menis cus is suggested in early and late osteoarthritic patients and it may provide a basis for identifying the mechanisms contributing to the development of OA associated with meniscal tear. Abstract...
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Marta Favero, Elisa Belluzzi, Giovanni Trisolino, Mary B Goldring, Steven R Goldring, Augusto Cigolotti, Assunta Pozzuoli, Pietro Ruggieri, Roberta Ramonda, Brunella Grigolo, Leonardo Punzi, Eleonora Olivotto Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

PINK1/Parkin ‐mediated mitophagy promotes apelin‐13‐induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions
In this study, we aimed to investigate the role of mitophagy in apelin‐13‐induced VSMC proliferation and atherosclerotic lesions in apolipoprotein E knockout (ApoE‐/‐) mice. Apelin‐13 enh ances human aortic VSMC proliferation and proliferative regulator proliferating cell nuclear antigen expression in dose and time‐dependent manner, while is abolished by APJ antagonist F13A. We observe the engulfment of damage mitochondria by autophagosomes (mitophagy) of human aortic VSMC in apeli n‐13 stimulation. Mechanistically, apelin‐13 increases p‐AMPKα and promotes mitophagic activity such as the LC3I to LC3...
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Lu He, Qionglin Zhou, Zheng Huang, Jin Xu, Hong Zhou, Deguan Lv, Liqun Lu, Shifang Huang, Mingzhu Tang, Jiuchang Zhong, Jianxiong Chen, Xulin Luo, Lanfang Li, Linxi Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction
In this study, we examine the inhibition of annexin A3 (ANXA3) on AMI through the phosphatidylinositide 3 ‐kinase/protein kinase B (PI3K/Akt) signaling pathway. We selected rats to build an AMI model which was then assigned into different groups. The hemodynamic parameters after transfection were detected by using enzyme‐linked immunosorbent assay. The effect of silencing of ANXA3 on inflammatory re action and the PI3K/Akt signaling pathway was assessed. Rats transfected with ANXA3‐short hairpin RNA had alleviated hemodynamics, inflammatory reaction, decreased infarct size, α‐smooth muscle actin, Collagen I, ...
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Hua Meng, Yan Zhang, Song ‐Tao An, Yan Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Glutamate triggers intracellular Ca2+ oscillations and nitric oxide release by inducing NAADP ‐ and InsP3‐dependent Ca2+ release in mouse brain endothelial cells
Glutamate induces intracellular Ca2+ oscillations in mouse brain microvascular endothelial cells. Glutamate ‐induced intracellular Ca2+ oscillations lead to robust, although delayed, nitric oxide release. Brain microvascular endothelial cells could play a crucial role in neurovascular coupling during synaptic activity. The neurotransmitter glutamate increases cerebral blood flow  by activating postsynaptic neurons and presynaptic glial cells within the neurovascular unit. Glutamate does so by causing an increase in intracellular Ca2+ concentration ([Ca2+]i) in the target cells, which activates the Ca2+/Calmodulin ...
Source: Journal of Cellular Physiology - November 19, 2018 Category: Cytology Authors: Estella Zuccolo, Dlzar A. Kheder, Dmitry Lim, Angelica Perna, Francesca Di Nezza, Laura Botta, Giorgia Scarpellino, Sharon Negri, Simona Martinotti, Teresa Soda, Greta Forcaia, Laura Riboni, Elia Ranzato, Giulio Sancini, Luigi Ambrosone, Eg Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Prostacyclin: A major prostaglandin in the regulation of adipose tissue development
Prostacyclin is a major prostaglandin of the arachidonate cyclooxygenase (COX) pathway. It mediates its action through a prostacyclin receptor (IP), triggers the terminal differentiation of adipocytes, and can work in both autocrine and paracrine manners. It can also induce the transformation of white adipose tissues to form thermogenic brite (brown ‐like) adipose tissues, indicating its potential to treat obesity. Prostaglandins (PGs) belong to the group lipid mediators and can act as local hormones. They contain 20 carbon atoms, including a 5 ‐carbon ring, and are biosynthesized from membrane phospholipid derived ara...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Mohammad Sharifur Rahman Tags: REVIEW ARTICLE Source Type: research

Agomelatine modulates calcium signaling through protein kinase C and phospholipase C ‐mediated mechanisms in rat sensory neurons
The obtained results of agomelatine ‐induced [Ca2+]i signals indicates that peripheral mechanisms are involved in analgesic effects of agomelatine. Agomelatine seems to possess antinociceptive properties which may be of clinical value AbstractAgomelatine, a novel antidepressant exerting its effects through melatonergic and serotonergic systems, implicated to be effective against pain including neuropathic pain but without any knowledge of mechanism of action. To explore the possible role of agomelatine on nociceptive transmission at the peripheral level, the effects of agomelatine on intracellular calcium ([Ca2+]i) signa...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Ihsan Serhatlioglu, Batuhan Bilgin, Emine Kacar, Sibel Ozcan, Sinan Canpolat, Ahmet Ayar, Haluk Kelestimur, Mete Ozcan Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

MicroRNA ‐99a‐5p suppresses breast cancer progression and cell‐cycle pathway through downregulating CDC25A
In this study, we aimed to explore the association between miR ‐99a‐5p andCDC25A in breast cancer and the regulatory mechanisms of miR ‐99a‐5p on breast cancer. The expressions of messenger RNA and microRNAs in breast cancer tissues and adjacent tissues were analyzed by the Cancer Genome Atlas microarray analysis. Quantitative real‐time polymerase chain reaction was conducted to find out the expression levels of miR‐99a‐ 5p andCDC25A. The expression levels of proteins (CDC25A, ki67, cyclin D1, p21, BAX, BCL ‐2, BCL‐XL, MMP2, and MMP9) were determined by Western blot analysis. The relationship between...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Hongzhen Qin, Wenfei Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A study of quiet eye's phenomenon in the shooting section of “laser run” of modern pentathlon
The study is the first evaluating visual behavior in the “Laser Run” section of modern pentathlon in elite athletes. The results provide insightful information about different cognitive and perceptual processes involved in Modern Pentathlon's athletes' performances at both elite and non‐elite level. AbstractThe aim of the study was to evaluate the effects of the Quiet eye (QE) phenomenon on performances during the shooting section of “Laser Run” of Modern Pentathlon, in two samples of athletes (novices and experts). The “Laser Run” consists of running and shooting activities. The study...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Andrea Chirico, Dario Fegatelli, Federica Galli, Luca Mallia, Fabio Alivernini, Susanna Cordone, Francesco Giancamilli, Stefano Pecci, Gian Marco Tosi, Antonio Giordano, Fabio Lucidi, Mina Massaro Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR ‐488‐3p in Hirschsprung's disease
In conclusion, this is the first report revealing that cir‐CCDC66 modulates DCX expression through sponging miR‐488‐3p and thus participates in the onset of HSCR. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Zechao Wen, Qiyang Shen, Hua Zhang, Yang Su, Zhongxian Zhu, Guanglin Chen, Lei Peng, Hongxing Li, Chunxia Du, Hua Xie, Xiaoqun Xu, Weibing Tang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Organ ‐on‐chip models: Implications in drug discovery and clinical applications
In this study, we review the recent advances in in vitro modeling including three‐dimensi onal (3D) organoids, 3D microfabrication, and 3D bioprinting for various organs including the heart, kidney, lung, gastrointestinal tract (intestine–gut–stomach), liver, placenta, adipose, retina, bone, and brain as well as multiorgan models. The availability of organ‐on‐chip models provides a wealth of opportunities to understand the pathogenesis of human diseases and provide a potentially better model to screen a drug, as these models utilize a dynamic 3D environment similar to the human body. Although there are li...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Rahul Mittal, Frank W. Woo, Carlo S. Castro, Madeline A. Cohen, Joana Karanxha, Jeenu Mittal, Tanya Chhibber, Vasanti M. Jhaveri Tags: REVIEW ARTICLE Source Type: research

MiRNA ‐548c‐5p downregulates inflammatory response in preeclampsia via targeting PTPRO
In this study, we first elucidate the role of miR‐548c‐5p and its underlying molecular mechanism in preeclampsia. Compared with healthy controls, miR‐548c‐5p was obviously downregulated in serum exosomes and placental mononuclear cells in patients with preeclampsia. Nonetheless, PTPRO was significantly upregulated and negatively associated with miR‐548c‐5p in placental mononuclear cells in patients with preeclampsia. PTPRO was a target of miR‐548c‐5p. PTPRO was downregulated in the miR‐548c‐5p‐overexpressed macropha ges. In addition, miR‐548c‐5p could inhibit the proliferation and activation of LP...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Zengfang Wang, Pingping Wang, Zengyan Wang, Zhihao Qin, Xia Xiu, Donghua Xu, Xiaozhen Zhang, Yingliang Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The lncRNA SCARNA2 mediates colorectal cancer chemoresistance through a conserved microRNA ‐342‐3p target sequence
AbstractLong noncoding RNAs (lncRNAs) have been implicated in numerous physiological and pathological processes, including cancer development and progression. However, the role and molecular mechanism of lncRNAs in resistance to chemotherapy of colorectal cancer (CRC) remain enigmatic. Here, we found that lncRNA small Cajal body ‐specific RNA 2 (SCARNA2) is expressed higher in CRC tissues than in adjacent normal tissues, and a robust expression of SCARNA2 is correlated with a bad prognosis of CRC patients after surgery. SCARNA2 overexpression significantly promoted chemoresistance in CRC cells, and downregulation of SCAR...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Peng ‐Fei Zhang, Jing Wu, Yin Wu, Wei Huang, Min Liu, Zhao‐Ru Dong, Bai‐Ying Xu, Yong Jin, Fei Wang, Xue‐Mei Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Potential of bacterial culture media in biofabrication of metal nanoparticles and the therapeutic potential of the as ‐synthesized nanoparticles in conjunction with artemisinin against MDA‐MB‐231 breast cancer cells
The present research endeavor explores the potential of bacterial culture media  (CM) in the biofabrication of metal nanoparticles (NPs) and, thereafter, ascertains their therapeutic potential against MDA‐MB‐231 breast cancer cells together with artemisinin. AbstractIn the recent past, various groups have proposed diverse biocompatible methods for the synthesis of metal nanoparticles (NPs). Besides culture biomass, culture supernatants (CS) are increasingly being explored for the synthesis of NPs; however, with the ever ‐increasing exploration of various CS in the biofabrication of NPs, it is equally important t...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Badrealam Farheen Khan, Hamidullah, Sonam Dwivedi, Riyuraj Konwar, Swaleha Zubair, Mohammad Owais Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Sodium –glucose cotransporter inhibitors and oxidative stress: An update
In this report we have reviewed the recent evidence of the impact that SGLT2 inhibition may have on improved oxidative stress by either amelioration of free radical generation or potentiation of cellular anti‐oxidative capacity, and its importance in preven tion of cardiovascular and diabetes complications. AbstractSodium –glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control. Recent data suggest that SGLT2 inhibitors have antioxi...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Habib Yaribeygi, Stephen L. Atkin, Alexandra E. Butler, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Benzo(a)pyrene inhibits endometrial cell apoptosis in early pregnant mice via the WNT5A pathway
In this study, we focused on the effect of BaP on endometrial cell apoptosis and the role of WNT signaling during this process. Pregnant mice were gavaged with corn o il (control group) or 0.2 mg·kg−1·day−1 BaP (treatment group) from Days 1 to 6 of pregnancy. BaP impaired endometrial function by decreasing the expression of HOXA10 and BMP2, two markers of receptivity and decidualization. WNT5A and β‐catenin were activated in the BaP group. BaP affected the expression of apoptosis‐related proteins and inhibited the apoptosis of endometrial stromal cells. In vitro, human endometrial ...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Ting Yi, Min Liu, Xueyan Li, Xueqing Liu, Yubin Ding, Junlin He, Hanting Xu, Rufei Gao, Xinyi Mu, Yanqing Geng, Yingxiong Wang, Xuemei Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Pathophysiological changes in experimental polycystic ovary syndrome in female albino rats: Using either hemin or L ‐arginine
In conclusion, either hemin or L‐arginine had protective effects against PCOS with better pa thophysiological changes with hemin. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Merhan M. Ragy, Heba A. Abdel ‐Hamid, Nisreen D.M. Toni Tags: REVIEW ARTICLE Source Type: research

Ethyl acetate and n ‐butanol fraction of Cissus quadrangularis promotes the mineralization potential of murine pre‐osteoblast cell line MC3T3‐E1 (sub‐clone 4)
The present study reports the osteoblast differentiation and mineralization potential of ethyl acetate (CQ ‐EA) and butanol (CQ‐B) extracts ofCissus quadrangularis (CQ) on mouse pre ‐osteoblast cell line MC3T3‐E1 (sub‐clone 4) with an objective to isolate an antiosteoporotic compound. We have concluded in this part of the study that the CQ‐EA treatment resulted in early differentiation and mineralization as compared with the CQ‐B treatment. These findings suggest that low concentrations of CQ‐EA and CQ‐B have proliferative and osteogenic properties. CQ‐EA, however, is more potent osteogenic than CQ‐B....
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Rabail Hassan Toor, Raazia Tasadduq, Achyut Adhikari, Muhammad Iqbal Chaudhary, Jane B. Lian, Janet L. Stein, Gary S. Stein, Abdul Rauf Shakoori Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Retraction: “Identification of Novel Biomarkers for Pancreatic Cancer Using Integrated Transcriptomics With Functional Pathways Analysis” by Zhang, X., Tong, P., Chen, J., Pei, Z., Zhang, X., Chen, W., Xu, J., and Wang, J.
The above article from theJournal of Cellular Physiology, published online on 10 March 2016 in Wiley Online Library as Early View (http://onlinelibrary.wiley.com/enhanced/doi/10.1002/jcp.25353/), has been retracted by agreement between Gary Stein, the journal's Editor ‐in‐Chief, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation at the University of Texas, MD Anderson Cancer Center, which confirmed that the article was submitted and approved for publication by Dr. Jin Wang without acknowledgement of NIH funding received or t he consent and authorship of Dr. Ann Killary and Dr. Subrata...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Tags: Retraction Source Type: research

Chronic myeloid leukemia with complex karyotypes: Prognosis and therapeutic approaches
ConclusionCML classification using different features such as Ph and ACAs can play a decisive role in the evaluation of treatment responses in patients, for example, CML patients with Ph negative and monosomy 7 develop MDS or CML patient –Y and extra copy of Ph have a good response to tyrosine kinase inhibitors, therefore, classifications according to Ph and ACAs play an important role in choosing better treatment protocols and therapeutic strategies. Karyotype analysis in CML patients with complex karyotype shows unrandom pattern so ACAs can be great clue in medical guidelines. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 14, 2018 Category: Cytology Authors: Ali Amin Asnafi, Zeinab Deris Zayeri, Saeid Shahrabi, Kazem Zibara, Tina Vosughi Tags: REVIEW ARTICLE Source Type: research

DANCR contributed to hepatocellular carcinoma malignancy via sponging miR ‐216a‐5p and modulating KLF12
In conclusion, our study indicated that DANCR might provide a new perspective for HCC treatment. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 14, 2018 Category: Cytology Authors: Jianchu Wang, Jian Pu, Ying Zhang, Tianwei Yao, Zongjiang Luo, Wenchuan Li, Guidan Xu, Juan Liu, Wujun Wei, Yibin Deng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

TGF β mediates collagen production in human CRSsNP nasal mucosa‐derived fibroblasts through Smad2/3‐dependent pathway and CTGF induction and secretion
Transforming growth factor β1 (TGF‐β1) mediates collagen expression–production through a canonical Smad2/3‐dependent pathway and connective tissue growth factor (CTGF) induction and secretion in human nasal fibroblasts. Moreover, TGF‐β1, CTGF, and collagen are highly expressed in human chronic rhinosinusitis withou t nasal polyp (CRSsNP) nasal mucosa specimens, suggesting their roles in tissue remodeling during CRSsNP progression. AbstractChronic rhinosinusitis without nasal polyp (CRSsNP) is characterized by tissue remodeling and fibrosis. Transforming growth factor ‐β (TGF‐β) is c...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Jiunn ‐Min Shieh, Yih‐Jeng Tsai, Jessie Chao‐Yun Chi, Wen‐Bin Wu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Pre ‐eclampsia onset and SPARC: A possible involvement in placenta development
In conclusion, SPARC can play a pivot al role in PE and PE–IUGR onset and it should be considered as a key molecule for future investigations in such pathologies. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Giovanni Tossetta, Sonia Fantone, Stefano R. Giannubilo, Elena Marinelli Busilacchi, Andrea Ciavattini, Mario Castellucci, Nicoletta Di Simone, Monica Mattioli ‐Belmonte, Daniela Marzioni Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction
Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR ‐induced insulin sensitivity and improved insulin resistance. AbstractLifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is di...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Habib Yaribeygi, Stephen L. Atkin, Majid Ramezani, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population
AbstractGenome ‐wide association studies (GWASs) showed that three single nucleotide polymorphisms (SNPs; rs10968576, rs1412239, and rs824248) in the leucine‐rich repeat and Ig domain containing 2 (LINGO2) were associated with obesity or type 2 diabetes (T2D). We aimed to determine the influence of the LINGO2 variants on the gestational diabetes mellitus (GDM) risk. Thus, we performed a case–control study including 964 GDM cases and 1,021 controls to test the associations between the three LINGO2 variants (rs10968576, rs1412239, and rs824248) and susceptibility to GDM. Logistic regression analyses show ed no sign...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Tong Su, Qingxia Ren, Yingying Lu, Wen Tai, Yuan Zhu, Zhengying Li, Juan Wen, Lingmin Hu, Le Zhang, Jiehua Ma Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO ‐1 pathway
In conclusion, our study showed that LL202 exerts an anti‐inflammatory effect by enhancing the antioxidant capacity of the Nrf2/HO‐1 pathway to macrophages. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Yuan Gao, Dongsheng Bai, Yue Zhao, Qin Zhu, Yihui Zhou, Zhiyu Li, Na Lu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Pulsed electromagnetic fields regulate osteocyte apoptosis, RANKL/OPG expression, and its control of osteoclastogenesis depending on the presence of primary cilia
This study enriches our basic knowledge for further understanding the biological behaviors of osteocytes, and is also helpful for providing a more comprehensive mechanistic understanding of the effect of electromagnetic stimulation on bone and relevant skeletal diseases (e.g., bone fractu re and osteoporosis). AbstractGrowing evidence has shown that pulsed electromagnetic fields (PEMF) can modulate bone metabolism in vivo and regulate the activities of osteoblasts and osteoclasts in vitro. Osteocytes, accounting for 95% of bone cells, act as the major mechanosensors in bone for transducing external mechanical signals and p...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Pan Wang, Chi Tang, Junjie Wu, Yuefan Yang, Zedong Yan, Xiyu Liu, Xi Shao, Mingming Zhai, Jie Gao, Shengru Liang, Erping Luo, Da Jing Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Key microRNAs in the biology of breast cancer; emerging evidence in the last decade
A large number of microRNAs (miRNAs) have been demonstrated to be implicated in breast cancer (BC) biology such as cell proliferation, migration, invasion, and metastasis by various molecular pathways and targeting that result in up ‐ or downregulation of particular involved genes. AbstractmicroRNAs (miRNAs) are a family of small noncoding RNAs that play a pivotal role in the regulation of main biological and physiological processes, including cell cycle regulation, proliferation, differentiation, apoptosis, stem cell maintenance, and organ development. Dysregulation of these tiny molecules has been related to different ...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Monireh Khordadmehr, Roya Shahbazi, Hamed Ezzati, Farinaz Jigari ‐Asl, Sanam Sadreddini, Behzad Baradaran Tags: REVIEW ARTICLE Source Type: research

Identification and characterization of circular RNAs involved in mechanical force ‐induced periodontal ligament stem cells
Circular RNAs (circRNAs) are a large class of animal RNAs with regulatory potency. Mechanical force (MF) can induce the expression changes of circRNAs in periodontal ligament stem cells (PDLSCs) which may modulate the orthodontic tooth movement process and the alveolar bone remodeling. CircRNAs may serve as miRNAs sponges by regulating one or several miRNA/miRNAs to affect the osteogenic differentiation in MF ‐induced PDLSCs AbstractCircular RNAs (circRNAs) play critical roles in signal transduction during cell proliferation, differentiation, and apoptosis in a posttranscriptional manner. Recently, circRNAs have been pro...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Hong Wang, Cheng Feng, Ye Jin, Wanye Tan, Fulan Wei Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Let ‐7g‐5p regulates mouse mammary cells differentiation and function by targeting PRKCA
In this study, to unravel the role of let‐7g‐5p, we found PRKCA (PKC‐alpha, PKC‐α) might serve as potential targets of let ‐7g‐5p by bioinformatics. Then let‐7g‐5p was knocked down by an antisense oligonucleotide in mouse primary mammary epithelial cells. As predicted,PRKCA gene expression and mammary epithelial cells growth were increased by anti ‐let‐7g‐5p regulation in vitro. By using reporter constructs, it showed that the let‐7g‐5p could direct binding with 3′‐the untranslated regions (3′‐UTR) of PRKCA mRNA. Furthermore, ectopic overexpression of let‐7g‐5p in vivo re...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Lei Tian, Ye Li, Chunmei Wang, Qingzhang Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

miR ‐150 might inhibit cell proliferation and promote cell apoptosis by targeting LMO4 in Burkitt lymphoma
This study aimed at investigating the effect of microRNA ‐150 (miR‐150) on cell proliferation of Burkitt lymphoma and its molecular mechanism. Gene expression analysis was applied to identify target genes of miR‐150 in Burkitt lymphoma cell line ST486 based on the dataset from the Gene Expression Omnibus (GEO) datasets GSE86432. miRNA mimics, inhibi tor and small interfering RNA (siRNA) were fluorescently labeled by Cy3, whereas plasmid vector was labeled by EGFP. Cells were viewed by fluorescence microscope and transfection efficiency was evaluated through fluorescent cell percentage. Quantitative real‐time polym...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Dandan Zhang, Yanshuan Wei, Jun Zhou, Guannan Wang, Lin Xiao, Jingjing Xu, Na Wei, Wencai Li, Mingzhi Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

miR ‐483 inhibits bovine myoblast cell proliferation and differentiation via IGF1/PI3K/AKT signal pathway
MicroRNA ‐483 (miR‐483) inhibits bovine myoblast cell proliferation and differentiation by targeting insulin‐like growth factor 1 (IGF1) and downregulated the expression of key proteins in the PI3K/AKT signaling pathway. These results will provide an insight target in breeding strategies appealing to c attle industry. AbstractMicroRNAs (miRNAs) have been established to regulate skeletal muscle development in mammals. However, few studies have been conducted on the regulation of proliferation and differentiation of bovine myoblast cells by miRNAs. The aim of our study was to explore the function of miR ‐483 in cell ...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Chengchuang Song, Zhaoxin Yang, Dong Dong, Jiawei Xu, Jian Wang, Hui Li, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Yun Ma, Hong Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Potentiation of paclitaxel effect by resveratrol in human breast cancer cells by counteracting the 17 β‐estradiol/estrogen receptor α/neuroglobin pathway
Res treatment does not reduce cancer cell viability by itself Res interferes with estradiol/estrogen receptor α‐induced NGB upregulation in breast cancer cells This new Res‐based mechanism potentiate cancer cell susceptibility to chemotherapeutic agent AbstractNeuroglobin (NGB), an antiapoptotic protein upregulated by 17 β‐estradiol (E2), is part of E2/estrogen receptor α (ERα) pathway pointed to preserve cancer cell survival in presence of microenvironmental stressors including chemotherapeutic drugs. Here, the possibility that resveratrol (Res), an anticancer plant polyphenol, could increase ...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Manuela Cipolletti, Emiliano Montalesi, Maria Teresa Nuzzo, Marco Fiocchetti, Paolo Ascenzi, Maria Marino Tags: RAPID COMMUNICATION Source Type: research

Serenoa repens and N ‐acetyl glucosamine/milk proteins complex differentially affect the paracrine communication between endothelial and follicle dermal papilla cells
1)Paracrine communication between endothelial and follicle dermal papilla cells. 2)Characterization of the role of natural compounds on in vutro cocultures systems. 3)mechanistic background for the potential use of natural compounds as promoters of HF vascularization. AbstractCurrent treatments for hair follicle (HF) disruption are based on 5 ‐α reductase inhibitors and prostaglandin modulators. Botanicals and nutraceutical compounds interfere with hair loss or stimulate its partial regrowth. Here, we used in vitro cocultures to investigate the activity ofSerenoa repens (SR) andN‐acetyl glucosamine +&thins...
Source: Journal of Cellular Physiology - November 12, 2018 Category: Cytology Authors: Eleonora Bassino, Franco Gasparri, Luca Munaron Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Medical Cannabis: A plurimillennial history of an evergreen
We report through the centuries evidence of its use in numerous pathologic conditions especially for its anti ‐inflammatory, antiseptic, and anticonvulsing properties that support the requirement to direct our present research efforts into the definitive understanding of its efficacy. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: S. Pisanti, M. Bifulco Tags: REVIEW ARTICLE Source Type: research

Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells
We reported previously that the δ2 isoform of Ca2+/calmodulin ‐dependent protein kinase II (CaM kinase IIδ2) was involved in GnRH‐induced ERK activation in cultured GnRH neurons (GT1–7 cells). Recently, we found that GnRH treatment of GT1–7 cells activated proline‐rich tyrosine kinase 2 (Pyk2), and Pyk2 was involved in ERK activation. In the current study, we examined the possibility that CaM kinase IIδ2 might activate Pyk2. Knockdown of CaM kinase IIδ2 and KN93, an inhibitor of CaM kinases, inhibited the GnRH‐induced activation of Pyk2. In the case of cultured gonadotroph cells ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Shiho Okitsu ‐Sakurayama, Sayomi Higa‐Nakamine, Hidetsugu Torihara, Hana Takahashi, Shigeki Higashiyama, Hideyuki Yamamoto Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Impaired DNA double ‐strand breaks repair by kinesin family member 4A inhibition renders human H1299 non‐small‐cell lung cancer cells sensitive to cisplatin
Cisplatin treatment stimulates the expression of kinesin family member 4A (KIF4A) protein in human non ‐small‐cell lung cancer (NSCLC) cells. KIF4A knockdown suppresses the formation of BRCA2 and Rad51 foci and limits the further increase in poly(ADP‐ribose) polymerase 1 activity, thereby enhancing cisplatin‐induced cell cycle arrest in S and G2/M phases and cytotoxicity in human NSCLC cells. KIF4A functions as a novel modulator of cisplatin sensitivity in human NSCLC cells via multiple mechanisms. AbstractPatients with non ‐small‐cell lung cancer (NSCLC) are routinely treated with the platinum‐based chemothe...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Qing Wan, Yong Shen, Huzi Zhao, Bei Wang, Lei Zhao, Yongchen Zhang, Xiaodong Bu, Meiling Wan, Chuanlu Shen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Prognostic value of a gene signature in clear cell renal cell carcinoma
The 3 ‐mRNA classifier proved be a useful tool for prognostic evaluation and could facilitate personalized management of ccRCC patients. AbstractRenal cancer is a  common urogenital system malignance. Novel biomarkers could provide more and more critical information on tumor features and patients’ prognosis. Here, we performed an integrated analysis on the discovery set and established a three‐gene signature to predict the prognosis for clear cell renal cell carcinoma (ccRCC). By constructing a LASSO Cox regression model, a 3‐messenger RNA (3‐mRNA) signature was identified. Based on the 3‐mRNA sig...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Liang Chen, Yongwen Luo, Gang Wang, Kaiyu Qian, Guofeng Qian, Chin ‐Lee Wu, Han C. Dan, Xinghuan Wang, Yu Xiao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Osteoblast autophagy in glucocorticoid ‐induced osteoporosis
Although the pathogenesis of glucocorticoid ‐induced osteoporosis (GIO) has been studied for decades, over the past ten years the autophagy machinery has been implicated as a novel mechanism. Autophagy in osteoblasts, osteocytes, and osteoclasts plays a critical role in the maintenance of bone homeostasis. Herein, we specifically discuss ho w osteoblast autophagy responds to glucocorticoids and its role in the development of GIO. AbstractAdministration of glucocorticoids is an effective strategy for treating many inflammatory and autoimmune diseases. However, glucocorticoid treatment can have adverse effects on bone, lea...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Lufei Wang, Bradlee L. Heckmann, Xianrui Yang, Hu Long Tags: MINI ‐REVIEW Source Type: research

Inhibition of PI3K/Akt/NF ‐κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies
Inhibition of PI3K/Akt/NF ‐κB signaling with leonurine for ameliorating the progression of osteoarthritis: in vitro and in vivo studies AbstractOsteoarthritis (OA) is characterized as the degeneration and destruction of articular cartilage. In recent decades, leonurine (LN), the main active component in medical and edible dual purpose plant Herba Leonuri, has been shown associated with potent anti ‐inflammatory effects in several diseases. In the current study, we examined the protective effects of LN in the inhibition of OA development as well as its underlying mechanism both in vitro and in vivo experiments. In...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Zhi ‐Chao Hu, Lan‐Fang Gong, Xiao‐Bin Li, Xin Fu, Jiang‐Wei Xuan, Zhen‐Hua Feng, Wen‐Fei Ni Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Fusion with mesenchymal stem cells differentially affects tumorigenic and metastatic abilities of lung cancer cells
This study will contribute to explaning the origin of lung cancer stem cells and to elucidate the role of cell fusion in cancer metastasis. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Li ‐Na Zhang, Chen‐Fei Kong, Dan Zhao, Xian‐Ling Cong, Shen‐Sen Wang, Ling Ma, Ying‐Hui Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research