MicroRNA ‐141 binds to the nerve growth factor receptor associated protein 1 gene and restores the erectile function of diabetic rats through down‐regulating the nerve growth factor/neurotrophin receptor p75 (NGF/p75NTR) signaling
ConclusionsNGF/p75NTR signaling actively participates in the pathogenesis of DMED. miR ‐141 binds toNGFRAP1 and restores the erectile function of diabetic rats via downregulation of NGF/p75NTR signaling. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Yan Wen, Guohui Liu, Linpei Jia, Wei Ji, Hai Li Tags: RESEARCH ARTICLE Source Type: research

Long noncoding RNA uc.4 inhibits cell differentiation in heart development by altering DNA methylation
In this study, methylated DNA immunoprecipi tation was performed to identify the different expression levels of methylation regions. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were also performed to identify the possible biological process and pathway that uc.4 may join, associated with Rap1 signaling pathway, g onadotropin‐releasing hormone signaling pathway, and Calcium signaling pathway. We found that the distribution of differentially methylated regions peaks was mainly located in intergenic and intron regions. Altogether, our result showed that differentially methylated genes are signi...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Qijun Zhang, Mengwen Feng, Hao Zhang, Jia Xu, Li Zhang, Xuejun Wang, Zijie Cheng, Lingmei Qian Tags: RESEARCH ARTICLE Source Type: research

Phosphoinositide ‐specific phospholipase C in normal human liver and in alcohol abuse
We describe PLCs ’ expression panels in normal liver and alcohol abuse. We suggest that the regulation of PLC expression might be due to posttranscriptional events and that alcohol affects the epigenetic control of PLC expression belonging to phosphoinositide signaling. We observed alternate expression of PLCB1 an d PLCH1 genes in liver. AbstractThe phosphoinositide (PI) signal transduction pathway participates in liver metabolism. Abnormal activity or expression of PI ‐specific phospholipase C (PLC) enzymes has been described in different liver diseases. We resume the role of the PI metabolism in liver and PLC abnorma...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Paolo Fais, Martina Leopizzi, Valeria Di Maio, Lucia Longo, Carlo Della Rocca, Franco Tagliaro, Federica Bortolotti, Vincenza Rita Lo Vasco Tags: RESEARCH ARTICLE Source Type: research

A novel messenger RNA and long noncoding RNA signature associated with the progression of nonmuscle invasive bladder cancer
ConclusionAltogether, our study preliminarily indicated that KIT and LAMC3 might play a crucial role in the development of NMIBC cancer via a complex mRNA ‐lncRNA‐miRNA regulatory network. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Yu ‐hui He, Yi‐sen Deng, Pan‐xin Peng, Ning Wang, Jian‐feng Wang, Zhen‐shan Ding, Xing Chen, Xiao‐feng Zhou Tags: RESEARCH ARTICLE Source Type: research

microRNA ‐383 regulates cell viability and apoptosis by mediating Wnt/β‐catenin signaling pathway in non–small cell lung cancer
AbstractThe aim of this study was to investigate the roles of microRNA ‐383 (miRNA‐383) in progression of non–small cell lung cancer (NSCLC) and the potential mechanism. The expressions of miR‐383 and Wnt1 protein were detected in lung cancer tissues and cells by quantitative real‐time polymerase chain reaction (qRT‐PCR) and Western blot analysis. After the transfection of miR‐383 mimics, si‐Wnt1 or miR‐383+Wnt1, the viability and apoptosis of NSCLC cells were detected by cell counting kit‐8 and terminal deoxynucleotidyl transferase–mediated dUTP nick‐end labeling, respectively. The interaction betw...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Biao Gu, Jipeng Wang, Yaqi Song, Qi Wang, Qingquan Wu Tags: RESEARCH ARTICLE Source Type: research

Gene therapy by lentivirus ‐mediated RNA interference targeting extracellular‐regulated kinase alleviates neuropathic pain in vivo
ConclusionLentivirus ‐mediated RNA interference (RNAi) silencing targeting ERK might reverse CCD‐induced neuropathic pain in rats through transient receptor potential vanilloid 4. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Lei Jia, Yang Zhang, Yu ‐Juan Qu, Juan Huai, Hui Wei, Shou‐Wei Yue Tags: RESEARCH ARTICLE Source Type: research

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor ‐κB and nuclear factor of activated T‐cell signaling pathways
In this study, we found that CEP inhibited receptor activator of nuclear factor‐κB (NF‐κB) ligand (RANKL)‐induced osteoclast formation and bone‐resorbing activities using osteoclastogenesis and bone resorption assay. By polymerase chain reaction, we also found that CEP inhibited the expression of osteoclast‐differentiation marker genes includingCtsk,Calcr,Atp6v0d2,Mmp9 andNfatc1. Mechanistic analyses including Western blot and luciferase reporter assay revealed that CEP inhibited RANKL ‐induced activation of NF‐κB and nuclear factor of activated T‐cell, which are essential for the formation of osteoclast...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Xixi Lin, Fangming Song, Lin Zhou, Ziyi Wang, Chengming Wei, Jiake Xu, Jinmin Zhao, Qian Liu Tags: RESEARCH ARTICLE Source Type: research

NOTCH1 regulates the proliferation and migration of bladder cancer cells by cooperating with long non ‐coding RNA HCG18 and microRNA‐34c‐5p
This study focused on the mechanism by which NOTCH1 affects the biological behaviors of BCa cells. According to the experimental results of quantitative real ‐time polymerase chain reaction, NOTCH1 was dysregulated in BCa tissues and cell lines. The prognostic value of NOTCH1 for the patients with BCa was determined using the Kaplan‐Meier method. Mechanism investigations revealed that NOTCH1 is a target of miR‐34c‐5p in BCa. Furthermore, microarr ay analysis was used to find the dysregulated long noncoding RNAs (lncRNA), which can bind with miR‐34c‐5p. Mechanism experiments further demonstrated the rationality...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Zhihui Xu, Banggao Huang, Qi Zhang, Xiang He, Haibin Wei, Dahong Zhang Tags: RESEARCH ARTICLE Source Type: research

TRF4, the novel TBP ‐related protein of Drosophila melanogaster, is concentrated at the endoplasmic reticulum and copurifies with proteins participating in the processes associated with endoplasmic reticulum
The novel TBP ‐related protein‐coding gene, trf4, specific for Drosophila species, is described. TRF4 has lost nuclear localization signal sequence, has cytoplasmic localization and is concentrated at the endoplasmic reticulum (ER). TRF4 copurifies with the proteins participating in the ER‐associated proces ses. AbstractUnderstanding the functions of TBP ‐related factors is essential for studying chromatin assembly and transcription regulation in higher eukaryotes. The novel TBP‐related protein‐coding gene,trf4, was described inDrosophila melanogaster.trf4 is found only inDrosophila and has likely originated in...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Maria M. Kurshakova, Elena N. Nabirochkina, Sofia G. Georgieva, Daria V. Kopytova Tags: RESEARCH ARTICLE Source Type: research

MKL1/miR34a/FOXP3 axis regulates cell proliferation in gastric cancer
Overexpression of megakaryoblastic leukemia 1 (MKL1) promoted proliferation of MGC80 ‐3 cells, MKL1 inhibited the expression of forkhead box protein 3 (FOXP3) via miR‐34a. AbstractMegakaryoblastic leukemia 1 (MKL1) was closely related to the pathogenesis of various human malignant cancers. MiR34a was reported to be closely related to cancer cell proliferation. Forkhead box protein 3 (FOXP3) was a transcription factor that played a different role in different cancer types. CDK6 was involved in cell cycle progression and was upregulated in several types of cancers. The present study investigated the effects of MKL1/miR34...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Jia ‐Peng Li, Xing‐Hua Liao, Yuan Xiang, Ao Yao, Li‐Juan Fan, Hui Li, Zi‐Jian Zhang, Feng Huang, Zhou‐Tong Dai, Tong‐Cun Zhang Tags: RESEARCH ARTICLE Source Type: research

The role of tumor suppressor of resveratrol and prednisolone by downregulation of YKL ‐40 expression in CCRF‐CEM cell line
ConclusionIn this study, we first evaluated YKL ‐40 expression and resveratrol and prednisolone effect on YKL‐40 in ALL. This finding supports the idea of targeting YKL‐40 as a new drug treatment of ALL and extends the use of resveratrol in antileukemia research. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Milad Zadi Heydarabad, Sina Baharaghdam, Ako Azimi, Hammed Mohammadi, Jamal Eivazi Ziaei, Behruz Yazdanpanah, Mohsen Sharif Zak, Mohammad Esfini Farahani, Aghdas Dohrabpour, Nasim Partash, Mehdi Talebi Tags: RESEARCH ARTICLE Source Type: research

Programmed cell death protein 4 deficiency suppresses foam cell formation by activating autophagy in advanced glycation end ‐product low‐density lipoprotein–induced macrophages
ConclusionOur data revealed that PDCD4 deficiency can facilitate autophagy and benefit for AGE ‐LDL–induced foam cell formation. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Shan Li, Guangdong Gao, Fuyun Wu, Dan Liu, Hongyan Zhao, Jing Ke, Ying Liu, Fei Li, Jian Li, Zongyun Chen, Zhiming Tang, Lei Bai, Jinxuan Zhang, Wei Zheng, Xin Chen Tags: RESEARCH ARTICLE Source Type: research

Oxidative stress in cervical cancer pathogenesis and resistance to therapy
In this study, we reviewed studies that have addressed the cross‐talk between oxidative stress and CC pathogenesis and resistance to therapy. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Safieh Ebrahimi, Arash Soltani, Seyed Isaac Hashemy Tags: PROSPECTS Source Type: research

Knockdown GREM1 suppresses cell growth, angiogenesis, and epithelial ‐mesenchymal transition in colon cancer
AbstractGremlin 1 (GREM1), as a bone morphogenetic protein (BMP) antagonist and vascular endothelial growth factor receptor ‐2 (VEGFR2) novel agonist, has been confirmed as overexpressed in colorectal cancer (CRC) tissues but its role in carcinogenesis remains unclear. Here we reported that the GREM1 expression in mesenchymal‐like colon cancer cells (SW620 and SW480) was significantly higher than that of epithelial‐ like colon cancer cells (Caco‐2, HTC116, and HT29) and normal colon cell. Simultaneously, we analyzed two series of CRC transcriptomes from Gene Expression Omnibus (GEO) databases and found the great ma...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Yan Liu, Yongchao Li, Ruizhe Hou, Zhenbo Shu Tags: RESEARCH ARTICLE Source Type: research

Investigating the role of CRIPTO ‐1 (TDGF‐1) in glioblastoma multiforme U87 cell line
In this study, we sought to delineate the role of Cripto‐1 in facilitating pathogenesis, stemness, proliferation, invasion, migration, and angiogenesis in GBM. Taken together our results support a role for Cripto‐1 in the initiation, development, progression and maintenance of GBM pathogenesis. AbstractCripto ‐1 has been implicated in a number of human cancers. Although there is high potential for a role of Cripto‐1 in glioblastoma multiforme (GBM) pathogenesis and progression, few studies have tried to define its role in GBM. These studies were limited in that Cripto‐1 expression was not studied i n detail in re...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Faisal Alowaidi, Saeed M Hashimi, Maria Nguyen, Mallika Meshram, Naif Alqurashi, Brenton L Cavanagh, Bernadette Bellette, Saso Ivanovski, Adrian Meedenyia, Stephen A Wood Tags: RESEARCH ARTICLE Source Type: research