LncRNA CASC2 inhibits proliferation and migration of adenocarcinoma cells via miR ‐4735‐3p and mTOR
Cancer susceptibility candidate 2 and miR ‐4735‐3p pair regulate proliferation and migration of adenocarcinoma cells via the mammalian target of rapamycin (mTOR)‐associated signaling. This further confirmed the critical role of this signaling molecule in the development of lung adenocarcinoma and thus justified the efforts in developi ng new drugs targeting the mTOR‐associated signaling network. AbstractLung adenocarcinoma is a major form of non –small‐cell lung cancer that frequently strikes nonsmokers. The disease is often diagnosed at a late stage and the 5‐year survival rate is very low. Although previous...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Meng Luo, Demiao Kong, Dengke Pei, Xing Jin, Di Liu Tags: RESEARCH ARTICLE Source Type: research

Effect of autophagy on the resveratrol ‐induced apoptosis of ovarian cancer SKOV3 cells
ConclusionRes can induce autophagy to inhibit apoptosis in tumor SKOV3 cells, and inhibition of Res+3 ‐MA could not only enhance the effects of chemotherapy but also prevent normal cells from tumorigenesis. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: HongYan Wang, Yan Peng, Jing Wang, AnXin Gu, Qi Li, DongWei Mao, LiYuan Guo Tags: RESEARCH ARTICLE Source Type: research

Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia ‐reperfusion injury
In conclusion, our study demonstrates that RNF182 silencing can prevent ventricular remodeling in rats after MIRI by activating the mTOR signaling pathway. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Jing ‐Hua Wang, Zhi‐Feng Wei, Yan‐Li Gao, Cong‐Cong Liu, Jing‐Hui Sun Tags: RESEARCH ARTICLE Source Type: research

Sestrin2 regulates monocyte activation through AMPK ‐mTOR nexus under high‐glucose and dyslipidemic conditions
Sestrin2 expression levels were decreased upon high ‐glucose and oxidized LDL (OxLDL) treatments in monocytes with the alterations in adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR) phosphorylation and activation. Further, we have observed that sestrin2 regulates monocyte activation, adhesion, and foam cell formatio n upon high‐glucose or OxLDL treatments through the AMPK–mTOR‐signaling pathway. Thus we conclude that sestrin2 could play a major role in the development of atherogenesis. AbstractThe vicious cycle between hyperinsulinemia and insulin resistance results in the progressi...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Saravanakumar Sundararajan, Isaivani Jayachandran, Muthuswamy Balasubramanyam, Viswanathan Mohan, Balachandar Venkatesan, Nagaraj Manickam Tags: RESEARCH ARTICLE Source Type: research

Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand –mediated triple negative breast cancer cell death
Aryl hydrocarbon receptor ligand 5F 203 induces the expression of putative tumor suppressor cytoglobin (CYGB) and promotes anticancer activity and apoptosis in vivo and in vitro. CYGB promotes 5F 203 –mediated cell death, caspase‐3/‐7 activation, proapoptotic gene expression, lysosomal membrane permeabilization (LMP), and cathepsin B release in triple negative breast cancer (TNBC) cells. These findings suggest that AhR ligands such as 5F 203 upregulate CYGB to confer TNBC cell death. AbstractNearly 40 000 women die annually from breast cancer in the United States. Clinically available targeted breast cancer therapy i...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Leah K. Rowland, Petreena S. Campbell, Nicole Mavingire, Jonathan V. Wooten, Lancelot McLean, Dain Zylstra, Gabriell Thorne, Devin Daly, Kristopher Boyle, Sonya Whang, Juli Unternaehrer, Eileen J. Brantley Tags: RESEARCH ARTICLE Source Type: research

Long noncoding RNA STXBP5 ‐AS1 inhibits cell proliferation, migration, and invasion via preventing the PI3K/AKT against STXBP5 expression in non–small‐cell lung carcinoma
In our study, the functional role and mechanism of syntaxin ‐binding protein 5‐antisense RNA 1 (STXBP5‐AS1) in non–small‐cell lung carcinoma (NSCLC) have been explored in our study. Our results showed that STXBP5‐AS1 could inhibit cell proliferation, migration, and invasion abilities in NSCLC by preventing the phosphatidylinositol 3 kinase/protei n kinase B signaling pathway against STXBP5 expression. AbstractLong noncoding RNAs participate in carcinogenesis and tumor progression in non –small‐cell lung carcinoma (NSCLC), but the mechanisms underlying NSCLC tumorigenesis remain to be fully elucidated. Here...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Jingyu Huang, Nianlin Xie, Hu Huang, Jie Yao, Weidong Hu Tags: RESEARCH ARTICLE Source Type: research

IL ‐28β gene polymorphism determines virological response to PEGylated interferon therapy in hepatitis C virus genotype 4 Egyptian patients
Conclusionwe conclude that IL28B polymorphism is highly associated with SVR to therapy in the Egyptian population infected with HCV genotype 4 and patients who carry CC genotype have a higher chance of SVR. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Nashwa El ‐Khazragy, Naglaa El Sayed, Ahmed M. Salem, Nahla S. Hassan, Amal Tohamy Abdelmoeaz, Amany M. Maher, Azza El‐Sayed Mansy Tags: RESEARCH ARTICLE Source Type: research

Wnt and BMP signaling pathways co ‐operatively induce the differentiation of multiple myeloma mesenchymal stem cells into osteoblasts by upregulating EMX2
This study aims to test the involvement of Wnt, bone morphogenetic proteins (BMP) pathways, and empty spiracles homeobox 2 (EMX2) in osteoblast differentiation and MM development. Initially, differentially expressed genes in bone marrow mesenchymal stem cells (MSCs) from MM patients and healthy donors were identified using microarray ‐based gene expression profiling. The functional role of Wnt and BMP in MM was determined. Next, we focused on the co‐operative effects of Wnt and BMP on calcium deposition, alkaline phosphatase (ALP) activity, the number of mineralized nodules, and osteocalcin (OCN) content in MSCs. The e...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Xiao ‐Fang Wei, Qiao‐Lin Chen, Yuan Fu, Qi‐Ke Zhang Tags: RESEARCH ARTICLE Source Type: research

IGFBP7 regulates sepsis ‐induced acute kidney injury through ERK1/2 signaling
IGFBP7 levels were increased in the urine of AKI patients and in LPS ‐induced HK‐2 cells. IGFBP7 silencing inhibited LPS‐induced apoptosis and cell cycle arrest in HK‐2 cells and cecal ligation and puncture (CLP)‐induced AKI in mice. ERK1/2 signaling is associated with the IGFBP7‐mediated injury in HK‐2 cells. AbstractIGFBP7 as an early biomarker has been used to identify patients at risk of developing acute kidney injury (AKI). Nevertheless, its role in AKI remains obscure. The aim of our study is to determine the role and mechanism of IGFBP7 in lipopolysaccharide (LPS) ‐induced HK‐2 cells in vitro and o...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Xiaolin Wang, Teng Ma, Xiaojian Wan, Yan Meng, Zhenzhen Zhao, Jinjun Bian, Rui Bao, Xiaoming Deng, Tao Yang Tags: RESEARCH ARTICLE Source Type: research

Knockdown of long noncoding RNA GAS5 attenuates H2O2 ‐induced damage in retinal ganglion cells through upregulating miR‐124: Potential role in traumatic brain injury
ConclusionKnocking down lncRNA GAS5 alleviated H2O2‐induced injury in PRGCs via upregulation of miR‐124, which might dependent on activation of JAK/STAT3 signaling pathway and inhibition of JNK signaling pathway. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Xinglu Miao, Anran Liang Tags: RESEARCH ARTICLE Source Type: research

ACT001 can prevent and reverse tamoxifen resistance in human breast cancer cell lines by inhibiting NF ‐κB activation
Tamoxifen simultaneously promotes apoptosis and activates the nuclear factor ‐κB (NF‐κB)–mediated antiapoptotic pathway, as a stress response, and that NF‐κB signaling and antiapoptotic gene expression are associated with tamoxifen resistance. AbstractEndocrine therapy is one of the main treatments for estrogen receptor –positive breast cancers. Tamoxifen is the most commonly used drug for endocrine therapy. However, primary or acquired tamoxifen resistance occurs in a large proportion of breast cancer patients, leading to therapeutic failure. We found that the combination of tamoxifen and ACT001, a nuclear fa...
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Xiao ‐Han Jin, Yong‐Sheng Jia, Ye‐Hui Shi, Qiu‐Ying Li, Shi‐Qi Bao, Wen‐Ping Lu, Zhong‐Sheng Tong Tags: RESEARCH ARTICLE Source Type: research

Key pathway and gene alterations in the gastric mucosa associated with obesity and obesity ‐related diabetes
ConclusionsObesity and obesity ‐related diabetes are associated with important gene expression and pathway alterations in the stomach. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 18, 2018 Category: Biochemistry Authors: Xin Wen, Chunhua Qian, Yi Zhang, Ruijin Wu, Liesheng Lu, Cuiling Zhu, Xiaoyun Cheng, Rai Cui, Hui You, Fangyun Mei, Jingyang Gao, Feng Li, Le Bu, Shen Qu Tags: RESEARCH ARTICLE Source Type: research

Study on immortal conditions of chicken embryonic stem cells
This study not only optimized the isolation and culture of chicken embryonic stem cells (ESCs) but also investigated the immortalization of chicken ESCs by transfecting chicken ESCs with pEGFP ‐hTERT and culturing transfected cells in conditioned medium with exogenous factors and 10 μmol/L vitamin C. The results showed that cells can passage to tenth generations. Following indirect immunofluorescence and quantitative real‐time polymerase chain reaction detection indicated that the cells still have pluripotency. The method of efficient separation of chicken ESCs and the immobilized system was established, which provi...
Source: Journal of Cellular Biochemistry - November 16, 2018 Category: Biochemistry Authors: Changhua Sun, Yingjie Wang, Kai Jin, Jiuzhou Song, Qisheng Zuo, Yani Zhang, Guohong Chen, Bichun Li Tags: RESEARCH ARTICLE Source Type: research

Traditional Chinese medicine as targeted treatment for epithelial ‐mesenchymal transition‐induced cancer progression
This review summarize the crucial signaling pathways associated with the epithelial ‐mesenchymal transition (EMT) process in cancer patients and discuss the interconnections between EMT and other molecular factors (such as cancer stem cells [CSCs], vasculogenic mimicry [VM] and the tumor‐related immune microenvironment). The authors attempt to identify common regulators that mi ght be potential therapeutic targets to thereby optimize tumor treatment. In addition, the article also outlines recent research on traditional Chinese medicine (TCM) approaches that target EMT which will be helpful on the further study of TCM o...
Source: Journal of Cellular Biochemistry - November 15, 2018 Category: Biochemistry Authors: Jianrong Liu, Fei Ke, Haibo Cheng, Jinrong Zhou Tags: VIEW POINTS Source Type: research

Knockdown of TMPRSS3 inhibits cell proliferation, migration/invasion and induces apoptosis of glioma cells
Knockdown of transmembrane protease serine 3 (TMPRSS3) exhibited the antiglioma effect, which is associated with the inactivation of the Notch signaling pathway. These findings suggested that TMPRSS3 might be used as a therapeutic target for glioma treatment. AbstractTransmembrane protease serine 3 (TMPRSS3) is a member of type II transmembrane serine proteases (TTSP) family, which play important roles in the development and progression of various cancers. However, the role of TMPRSS3 in glioma remains unclear. In the present study, we evaluated the expression patterns of TMPRSS3 in clinical tumor samples and glioma cell l...
Source: Journal of Cellular Biochemistry - November 15, 2018 Category: Biochemistry Authors: Jun ‐Feng Huo, Xiao‐Bing Chen Tags: RESEARCH ARTICLE Source Type: research