UXT antisense RNA 1 sever as a novel prognostic long non-coding RNA in early stage pancreatic ductal adenocarcinoma patients after receiving pancreaticoduodenectomy
Conclusion: Our current study has identified UXT-AS1 as a novel biomarker for the prognosis of early stage PDAC. We also clarified its biological functional mechanisms and identified two targeted drugs of UXT-AS1 in PDAC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xiwen Liao, Rui Huang, Xiangkun Wang, Ketuan Huang, Chengkun Yang, Xin Zhou, Chuangye Han, Hao Su, Xinping Ye, Kang Liu, Guangzhi Zhu, Tao Peng Tags: Research Paper Source Type: research
Exosomal miR-10b-5p mediates cell communication of gastric cancer cells and fibroblasts and facilitates cell proliferation
Tumor microenvironment interacts with gastric cancer (GC) cells and affects tumor development. The communication between GC cells and fibroblasts has not been clearly studied and understood. MiR-10b-5p was found highly expressed in tissue and serum samples of patients with advanced stages (stage III+IV) than that in early stage patients (stage I+II). The expression determination of serum exosomal microRNA was also shown with high expression of miR-10b-5p in GC patients with advanced stages. Dual-luciferase activity assays indicated that miR-10b-5p targeted PTEN in GC cells and KLF11 in fibroblasts. The silence of miR-10b-5...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ting Yan, Xiaping Wang, Guohua Wei, Hai Li, Leiyu Hao, Yan Liu, Xinqian Yu, Wei Zhu, Ping Liu, Yichao Zhu, Xin Zhou Tags: Research Paper Source Type: research
Comprehensive investigation of the clinical significance of long non-coding RNA HOXA-AS2 in acute myeloid leukemia using genome-wide RNA sequencing dataset
Conclusion: Our findings suggest that HOXA-AS2 is up-regulated in the bone marrow in patients with AML, and may serve as a novel prognostic biomarker for AML. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Rui Huang, Xiwen Liao, Xiangkun Wang, Qiaochuan Li Tags: Research Paper Source Type: research
Telomere shortening in head and neck cancer: association between DNA demethylation and survival
A growing body of evidence indicates that telomere dysfunction is a biological marker of progression in several types of cancer. However, the association between head and neck squamous cell carcinoma (HNSCC) and telomere length (TL) remains unknown. We measured the absolute TL levels in a well-characterised dataset of 211 tumoral vs normal tissues obtained from the same patients by quantitative polymerase chain reaction assay. Normalised TL levels were significantly lower in tumour samples than in normal tissue (P < 0.001) and there was a positive correlation between tumour tissue and normal mucosal tissue (R2 = 0.176,...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Satoshi Yamada, Kiyoshi Misawa, Masato Mima, Atsushi Imai, Daiki Mochizuki, Taiki Yamada, Daichi Shinmura, Junya Kita, Ryuji Ishikawa, Yuki Yamaguchi, Yuki Misawa, Hideya Kawasaki, Hiroyuki Mineta Tags: Research Paper Source Type: research
Genome-wide Expression Analysis Identifies the Association between SEC14L2 and Castration-resistant Prostate Cancer Survival
Conclusions: Low expression of SEC14L2 was significantly associated with CRPC, and correlated with PCa aggressiveness and poorer prognosis. SEC14L2 might be a potential biomarker or drug target for CRPC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Shiyun Liu, Da Huang, Jingyi Huang, Jiaqi Yan, Tianhe Chen, Ning Zhang, Guangliang Jiang, Yi Gao, Danfeng Xu, Rong Na Tags: Research Paper Source Type: research
Updated applications of Ultrasound in Uterine Cervical Cancer
Cervical cancer is a common gynecologic malignancy worldwide. It is the fourth for both incidence and mortality. For cervical cancer, imaging and pathology assessments are incorporated in the revised 2018 Federation of Gynecology and Obstetrics (FIGO) staging system. Uses of imaging techniques for the pre-treatment work-up of cervical cancer have been increasing. Among imaging techniques for the evaluation of cervical cancer, ultrasound is cheaper, faster and widely available than other imaging techniques such as computed tomography (CT) or magnetic resonance imaging (MRI). Advanced technique in ultrasound, such as three-d...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yi-Hsuan Hsiao, Shun-Fa Yang, Ya-Hui Chen, Tze-Ho Chen, Horng-Der Tsai, Ming-Chih Chou, Pang-Hsin Chou Tags: Review Source Type: research
Management of early-stage breast cancer patients during the coronavirus disease 2019 (COVID-19) pandemic: The experience in China from a surgical standpoint
Breast cancer is the most common malignant tumor in women globally. Currently, due to limited data, there are no international guidelines for addressing the management of a large group of patients during infectious disease pandemics. Coronavirus disease 2019 (COVID-19), declared as a pandemic by the World Health Organization (WHO), has rapidly spread globally. The COVID-19 pandemic changed our daily routines and forced us to rethink the management of breast cancer patients. Clinicians need to take into account multiple factors such as the timing and delivery of cancer care, epidemic prevention and control, and the allocati...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Wan Wang, Baoliang Guo, Chunguo Cui, Tong Sun, Shengnan Liu Tags: Review Source Type: research
Proteomic profiling reveals a signature for optimizing prognostic prediction in Colon Cancer
In conclusion, we developed a proteomic signature which can improve prognostic accuracy of patients with colon cancer and optimize the therapeutic and follow-up strategies. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zezhi Shan, Dakui Luo, Qi Liu, Sanjun Cai, Renjie Wang, Yanlei Ma, Xinxiang Li Tags: Research Paper Source Type: research
CDK1 serves as a novel therapeutic target for endometrioid endometrial cancer
Conclusion: CDK1 was involved in the pathogenesis of endometrioid endometrial cancer and provided a novel therapeutic target for endometrioid endometrial cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xue Ying, Xuan Che, Jianzhang Wang, Gen Zou, Qin Yu, Xinmei Zhang Tags: Research Paper Source Type: research
The genetic effect and molecular function of the SOCS5 in the prognosis of esophageal squamous cell carcinoma
Expression of cytokines and growth factors have been shown to be highly correlated with the prognosis of esophageal squamous cell carcinoma (ESCC), a deadly disease with poor prognosis. The suppressor of cytokine signaling (SOCS) family of proteins are key factors in regulating cytokines and growth factors. Yet the role of the SOCS proteins in ESCC is hardly investigated. We currently investigated the prognostic role of SOCS5 in ESCC. We analyzed the prognostic effects of 16 single nucleotide polymorphisms (SNPs) within the SOCS genes in 632 ESCC patients. We repeatedly observed that the 3 SNPs in SOCS5, SOCS5:rs3814039, S...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Pei-Wen Yang, Ya-Han Chang, Li-Fan Wong, Ching-Ching Lin, Pei-Ming Huang, Min-Shu Hsieh, Jang-Ming Lee Tags: Research Paper Source Type: research
Identification of Prognosis-related Hub RNA Binding Proteins Function through Regulating Metabolic Processes in Tongue Cancer
RNA binding proteins (RBPs) are dysregulated and associated with the occurrence and development in various malignant tumors. However, the role of RBPs in tongue cancer are largely unclear. Here, by integrating the differential gene expression analysis and the Weighted Gene Co-expression Network Analysis (WGCNA) of TCGA-retrieved RNA-seq data, we identified a total of 171 differential co-expression RBPs. Then, in a protein-protein interaction (PPI) network containing 134 nodes (RBPs) and 315 network edges (RBP-RBP interacting networks), the top 30 hub RBPs were identified using the CytoHubba plugin of Cytoscape. Furthermore...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Tao Shen, Meiting Wang, Xiangting Wang Tags: Research Paper Source Type: research
MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma
In conclusion, these findings suggested that monocyte acted as a protective factor and MMP9/IGFBP1 played a vital role in tumor immune, which might become potential novel biomarkers and therapeutic targets for immunotherapy in ccRCC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Tianbo Xu, Su Gao, Jingchong Liu, Yu Huang, Ke Chen, Xiaoping Zhang Tags: Research Paper Source Type: research
MicroRNA-32-5p inhibits epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting SMAD family 3
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated death worldwide. MicroRNA (miRNA)-32-5p is as an important cancer-associated miRNA in different types cancer. To date, the role of miR-32-5p in the migration and invasion of NSCLC remains unknown. In the present study, a Transwell assay was performed to investigate the role of miR-32-5p in lung adenocarcinoma. miR-32-5p expression level was determined via reverse transcription-quantitative PCR in 24 pairs of NSCLC and adjacent normal tissues. SMAD family member 3 (SMAD3) was considered as a novel target gene by luciferase reporter assay and wester...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jin-Xing Zhang, Wei Yang, Jun-Zheng Wu, Chun Zhou, Sheng Liu, Hai-Bin Shi, Wei-Zhong Zhou Tags: Research Paper Source Type: research
Long non-coding RNA RP11-379k17.4 derived microRNA-200c-3p modulates human endometrial cancer by targeting Noxa
Conclusion: LncRNAs possess microRNA response elements (MREs) and give scope to significant roles in the post-transcriptional mechanism in EC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Weijuan Xin, Xiaodong Gao, Peng Zhao, Taiyong Wang, Xue Ding, Qianyu Wu, Keqin Hua Tags: Research Paper Source Type: research
Prognostic efficacy of the combination of the pretreatment systemic Immune-Inflammation Index and Epstein-Barr virus DNA status in locally advanced Nasopharyngeal Carcinoma Patients
Conclusions: The pretreatment SII and EBV DNA levels are promising factors for predicting survival in locally advanced NPC patients. The combination of them, which was superior to either score alone, was a complement to the conventional TNM staging system. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ying Xiong, Liang-Liang Shi, Li-Sheng Zhu, Qian Ding, Li Ba, Gang Peng Tags: Research Paper Source Type: research
