Impacts of AURKA Genetic Polymorphism on Urothelial Cell Carcinoma Development
Urothelial cell carcinoma (UCC) is the most common primary malignancy of the urinary system and the second-most common type of renal cell carcinoma. Aurora kinase A (AURKA), a serine/threonine kinase, has a critical role in centrosome duplication, spindle assembly checkpoint, and cytokinesis. Here, we determined the correlation between UCC susceptibility and AURKA polymorphisms. We used real-time polymerase chain reaction to compare the genotype distributions and allelic frequencies of four single-nucleotide polymorphisms (SNPs) of AURKA, namely rs1047972, rs2273535, rs2064863, and rs6024836, between 431 UCC cases and 862 ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chia-Hung Huang, Chih-Jung Chen, Pei-Ni Chen, Shian-Shiang Wang, Ying-Erh Chou, Sheng-Chun Hung, Shun-Fa Yang Tags: Research Paper Source Type: research
The Down-Regulation of SUZ12 Accelerates the Migration and Invasion of Liver Cancer Cells via Activating ERK1/2 Pathway
The suppressor of zest 12 (SUZ12), an essential subunit of the transcription polycomb repressive complex 2 (PRC2), has been found to be involved in HBV X-induced oncogenic transformation in hepatocellular carcinoma (HCC). However, the specific function of SUZ12 has not yet been determined in the pathogenesis of migration and invasion of HBV-associated HCC. Here, our results showed that SUZ12 was significantly down-regulated in HBV-related HCC tissues compared with adjacent non-tumor tissues by immunohistochemical and Western blot assays. The 5-years survival rate was worse in patients with low expression level of SUZ12. SU...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Cailin Xue, Kunyuan Wang, Xiaofeng Jiang, Chengxin Gu, Ganxiang Yu, Yun Zhong, Shiming Liu, Yuqiang Nie, Yongjian Zhou, Hui Yang Tags: Research Paper Source Type: research
Down-regulation of miR-338-3p and Up-regulation of MACC1 Indicated Poor Prognosis of Epithelial Ovarian Cancer Patients
Objective To detect the expression of microRNA-338-3p (miR-338-3p) and MET transcriptional regulator MACC1 (MACC1) gene in different ovarian tissues, to analyze their relationships, their correlations to the clinicopathologic characteristics of epithelial ovarian cancer and their significant to the progression of ovarian cancer.Methods The expression of miR-338-3p and MACC1 gene in 20 specimens of normal ovarian tissues, 20 specimens of benign epithelial ovarian tumor and 65 specimens of epithelial ovarian cancer was detected by real-time PCR method. Their interrelationships and their correlations to the clinicopathologic ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ruitao Zhang, Huirong Shi, Fang Ren, Zheying Liu, Pengcheng Ji, Weiwei Zhang, Wenwen Wang Tags: Research Paper Source Type: research
High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Michal Tich ý , Lucia Knopfov á , Ji ř í Jarkovsk ý , Petr Vl č ek, Jana Katolick á , Ivan Č apov, Mark é ta Hermanov á , Jan Š marda, Petr Bene š Tags: Short Research Communication Source Type: research
The Identification of Potential Biomarkers and Biological Pathways in Prostate Cancer
Conclusions: Our analysis revealed that the changes of cell cycle and p53 signaling pathway are two major signatures of PCa. CENPA, KIF20A and CDCA8 might promote the tumorigenesis and progression of PCa, especially in BCR and metastasis, which could be novel therapeutic targets and biomarkers for diagnosis, prognosis of PCa. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhengshuai Song, Yu Huang, Ye Zhao, Hailong Ruan, Hongmei Yang, Qi Cao, Di Liu, Xiaoping Zhang, Ke Chen Tags: Research Paper Source Type: research
Nimotuzumab Plus Paclitaxel and Cisplatin as a 1st-Line Treatment for Esophageal Cancer: Long Term Follow-up of a Phase II Study
In conclusion, TPN is effective as a first-line treatment for patients with unresectable and metastatic ESCC. In addition, TPN treatment with sequential radiation might improve survival in patients with limited or oligo lymph node metastases. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaodong Zhang, Jun Jia, Ming Lu, Xicheng Wang, Jifang Gong, Jie Li, Jian Li, Yan Li, Xiaotian Zhang, Zhihao Lu, Jun Zhou, Jing Yu, Zhiwei Sun, Ying Yang, Chuanling Liu, Yanjie Xiao, Lin Shen Tags: Research Paper Source Type: research
Genetic Polymorphisms of DNA Repair Pathways in Sporadic Colorectal Carcinogenesis
DNA repair systems play a critical role in maintaining the integrity and stability of the genome, which mainly include base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR) and double-strand break repair (DSBR). The polymorphisms in different DNA repair genes that are mainly represented by single-nucleotide polymorphisms (SNPs) can potentially modulate the individual DNA repair capacity and therefore exert an impact on individual genetic susceptibility to cancer. Sporadic colorectal cancer arises from the colorectum without known contribution from germline causes or significant family history ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jingwei Liu, Bowen Zheng, Ying Li, Yuan Yuan, Chengzhong Xing Tags: Review Source Type: research
High Expression of Human AugminComplex Submit 3 Indicates Poor Prognosis and Associates with Tumor Progression in Hepatocellular Carcinoma
This study aims to elucidate the clinical significance and the role of Haus3 in tumor progression of hepatocellular carcinoma (HCC). We analyzed the expression of Haus3 in 50 HCC patients from The Cancer Genome Atlas and 137 HCC patients in our hospital. Compared with adjacent normal tissue, Haus3 expression assessed by immunohistochemical staining was dramatically increased in tumor tissues. A high level of Haus3 expression was significantly correlated with large tumor size (p=0.025) and tumor multiplicity (p=0.004). Univariate and multivariate survival analysis showed thatexpression of Haus3 was an independent prognostic...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xuanyu Zhang, Runzhou Zhuang, Qianwei Ye, Jianyong Zhuo, Kangchen Chen, Di Lu, Xuyong Wei, Haiyang Xie, Xiao Xu, Shusen Zheng Tags: Research Paper Source Type: research
Does Lymphadenectomy with at Least 15 Perigastric Lymph Nodes Retrieval Promise an Improved Survival for Gastric Cancer: A Retrospective Cohort Study in Southern China
This study aims to investigate survival significance from various numbers of perigastric (N1) LNs retrieval and to determine an optimal number harvested in such region.Study design: From April 1994 to March 2012, 1003 resectable GC patients with at least 15 LNs examined were included. Patients with at least 15 N1 nodes retrieval were assigned into study group, with the rest into control group. The 5-year overall survival (OS) rate was compared between two groups, and an optimal number of examined N1 nodes was detected by a survival joinpoint analysis.Results: 635 (63.3%) patients in study group had median 22 (range, 15-75)...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jinning Ye, Yufeng Ren, Weigang Dai, Jianhui Chen, Shirong Cai, Min Tan, Yulong He, Yujie Yuan Tags: Research Paper Source Type: research
Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma
In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ketuan Huang, Xiwen Liao, Chuangye Han, Xiangkun Wang, Tingdong Yu, Chengkun Yang, Xiaoguang Liu, Long Yu, Zhiwei Chen, Wei Qin, Guangzhi Zhu, Hao Su, Zhengqian Liu, Xianmin Zeng, Xin Zhou, Sicong Lu, Jianlv Huang, Yu Liang, Zhengtao Liu, Jianlong Deng, X Tags: Research Paper Source Type: research
Dual-Inhibition of mTOR and Bcl-2 Enhances the Anti-tumor Effect of Everolimus against Renal Cell Carcinoma In Vitro and In Vivo
This study thus proposes the everolimus-ABT-737 combination as a novel therapeutic strategy for the treatment of RCC to overcome the current clinical problem of everolimus resistance. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ayse Hande Nayman, Halime Siginc, Ebru Zemheri, Faruk Yencilek, Asif Yildirim, Dilek Telci Tags: Research Paper Source Type: research
Significance of Amphiregulin (AREG) for the Outcome of Low and High Grade Astrocytoma Patients
Background: Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor which levels was shown to have a tight coherence with various types of cancer. AREG was also designated to be a promising marker for several types of cancer however precious little data about AREG role in the most frequent and generally lethal human brain tumours - astrocytomas reported up to date. The aim of the study was to investigate how AREG changes at epigenetic and expression levels reflect on astrocytoma malignancy and patient outcome.Methods: In total 205 low and high grade astrocytoma samples (15 pilocytic astrocytomas, ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Giedrius Steponaitis, Arunas Kazlauskas, Daina Skiriute, Paulina Vaitkiene, Kestutis Skauminas, Arimantas Tamasauskas Tags: Research Paper Source Type: research
The Diagnostic and Prognostic Value of Digital Rectal Examination in Gastric Cancer Patients with Peritoneal Metastasis
This study aimed to explore the diagnostic and prognostic value of digital rectal examination (DRE) in GC.Methods: 247 GC patients with PM confirmed by operation were included. The diagnostic yield of DRE compared with computed tomography (CT) was calculated. In another group of 1330 cases receiving radical gastrectomy, 38 cases with DRE (+) postoperatively were analyzed to identify risk factors. A nomogram was constructed to predict postoperative DRE (+).Results: The specificity, positive predictive value and positive likelihood ratio of DRE in diagnosis of PM was 99.8%, 91.2% and 58.4, higher than CT (97.6%, 64.9% and 10...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jing Guo, Yongming Chen, Zhimin Liu, Yuanxiang Guan, Wei Wang, Xiaowei Sun, Wei Li, Dazhi Xu Tags: Research Paper Source Type: research
Current Treatment for Low-Risk Prostate Cancer in China: A National Network Survey
Objective: To analyze the current treatment for low-risk prostate cancer (LRPC) in China.Methods: A national questionnaire survey titled “A survey of current treatment of LRPC” was designed and released nationally through the network from July 16 to August 3, 2017.Results: A total of 1,116 valid questionnaires were recovered. The percentages of preferred treatment by active surveillance (AS) or radical prostatectomy (RP) were 29.21% and 45.61%, respectively. A correspondence analysis showed that the physician in charge was more inclined to choose AS than RP. Respondents from different institution types, hospita...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yongbao Wei, Longfei Liu, Xin Li, Wei Song, Dewen Zhong, Xiande Cao, Daozhang Yuan, Shaoxiong Ming, Peng Zhang, Yanlin Wen, Jiu Jing Group Tags: Research Paper Source Type: research
Prognostic and Clinicopathological Significance of lncRNA MVIH in Cancer Patients
Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in malignant tumors.Materials and methods: PubMed, PMC, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Database were carefully searched for articles published as of Jan. 1, 2018. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (95% CIs) were c...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yi Zhang, Shibu Lin, Xianjin Yang, Xu Zhang Tags: Research Paper Source Type: research
Nodal Promotes the Migration and Invasion of Bladder Cancer Cells via Regulation of Snail
Urinary bladder cancer is one of commonly diagnosed malignancies worldwide, especially in males. Understanding the mechanisms of advanced metastasis in bladder cell is important for therapy and drug development. Nodal, an important embryonic morphogen, has been reported to modulate tumorigenesis. We found that the expression of Nodal was upregulated in bladder cancer cells and tissues as compared to their corresponding controls. Knockdown of Nodal can suppress the migration, invasion, and epithelial-to-mesenchymal transition (EMT) of bladder cancer cells. Nodal can positively regulate the expression of Snail, one powerful ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wenwei Chen, Tao Jiang, Houping Mao, Rui Gao, Xingjian Gao, Yanfeng He, Hua Zhang, Qin Chen Tags: Research Paper Source Type: research
A 10-year Population-based Study of the Differences between NECs and Carcinomas of the Esophagus in Terms of Clinicopathology and Survival
Purpose: The prevalence of esophageal NECs is rising, but to date, no studies have compared its clinicopathological characteristics to those of esophageal ACs and SCCs from the same period.Patients and methods: A 10-year population-based retrospective cohort study was conducted with the Surveillance, Epidemiology, and End Results Program database. Statistical analyses were performed using Intercooled Stata 12.0 software.Results: A total of 17,196 eligible patients with esophageal tumors, including 246 NECs, 6,102 SCCs and 10,848 ACs, were analyzed. ACs showed an obviously higher prevalence than the other two tumor types, a...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wen Cai, Weiting Ge, Ying Yuan, Kefeng Ding, Yinuo Tan, Dehao Wu, Hanguang Hu Tags: Research Paper Source Type: research
Prognostic Value of XIAP Level in Patients with Various Cancers: A Systematic Review and Meta-Analysis
Conclusion: Our results suggested that elevated XIAP level seemed to represent an unfavorable prognostic factor for clinical outcomes in cancer patients. However, there were limited studies describing the association between XIAP expression and clinical prognosis in each different type of tumors. Therefore, concrete roles of XIAP in various cancers need to be further explored. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xian Gao, Lei Zhang, Yong Wei, Yiqi Yang, Jun Li, Hao Wu, Yongmei Yin Tags: Research Paper Source Type: research
Genetic Association between Interleukin-4 Receptor Polymorphisms and Cancer Susceptibility: A Meta-Analysis Based on 53 Case-Control Studies
Polymorphisms in interleukin-4 receptor (IL-4R) gene have been reported susceptible to a variety of cancer types, nevertheless, data from these publications remained inconsistent and controversial. We further performed a comprehensive meta-analysis to present a precise estimation of its relationship. Extensive retrieve was performed in PubMed, Google Scholar and Web of Science up to May 25, 2018. Odds ratios (ORs) and 95% confidence intervals (CIs) were conducted to evaluate the overall strength of the associations in five genetic models, as well as in subgroup analyses, stratified by ethnicity, cancer type or source of co...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yong Qi, Taofei Zeng, Song Fan, Li Zhang, Chaozhao Liang Tags: Research Paper Source Type: research
A Panel of 12-lncRNA Signature Predicts Survival of Pancreatic Adenocarcinoma
Conclusions: Our study demonstrated a lncRNA signature including 12 lncRNAs with the potential to be served as an independent prognostic biomarker of PCa. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Huo Zhang, Mingxia Zhu, Yiping Du, Hui Zhang, Qing Zhang, Qingxie Liu, Zebo Huang, Lan Zhang, Hai Li, Lei Xu, Xin Zhou, Wei Zhu, Yongqian Shu, Ping Liu Tags: Research Paper Source Type: research
Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers
Background: The biological role of microRNAs (miRNAs) in field cancerization is unknown. To investigate the involvement of miRNAs in gastric field cancerization, we evaluated the expression profile of ten miRNAs and their diagnostic value.Methods: We used three groups of FFPE gastric samples: non-cancer (NC), cancer adjacent (ADJ) and gastric cancer (GC). The expression profiles of hsa-miR-10a, -miR-21, -miR-29c, -miR-135b, -miR-148a, -miR-150, -miR-204, -miR-215, -miR-483 and -miR-664a were investigated using qRT-PCR. The results obtained by qRT-PCR were validated in Small RNA-Seq data from the TCGA database. The search f...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Adenilson Le ã o Pereira, Leandro Magalh ã es, Fabiano Cordeiro Moreira, La í s Reis-das-Merc ê s, Amanda Ferreira Vidal, Andr é Maur í cio Ribeiro-dos-Santos, Samia Demachki, Ana Karyssa Mendes Anaissi, Rommel Mario Rodr í guez Burbano, Paulo Alb Tags: Research Paper Source Type: research
The Carcinogenic Role of the Notch Signaling Pathway in the Development of Hepatocellular Carcinoma
The Notch signaling pathway, known to be a highly conserved signaling pathway in embryonic development and adult tissue homeostasis, participates in cell fate decisions that include cellular differentiation, cell survival and cell death. However, other studies have shown that aberrant in Notch signaling is pro-tumorigenic, particularly in hepatocellular carcinoma (HCC). HCC is one of the most common malignant tumors in the world and has a high mortality rate. Growing evidence supports that Notch signaling plays a critical role in the development of HCC by regulating the tumor microenvironment, tumorigenesis, progression, a...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qinfeng Huang, Junhong Li, Jinghui Zheng, Ailing Wei Tags: Review Source Type: research
Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma
Conclusions: These findings suggest that MSI-1 overexpression is associated with the prognosis of OC patients, and knockdown of MSI-1 can suppress malignant properties and reverse paclitaxel-resistance in OC cells. MSI-1 maybe act as a potential prognostic indicator and a therapeutic target in OC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Huaizeng Chen, Jia Liu, Hanzhi Wang, Qi Cheng, Caiyun Zhou, Xiaojing Chen, Feng Ye Tags: Research Paper Source Type: research
Association between Primary Tumor Location and Prognostic Survival in Synchronous Colorectal Liver Metastases after Surgical Treatment: A Retrospective Analysis of SEER Data
The prognostic and predictive role of primary tumor location (PTL) in localized and metastatic colorectal cancer (CRC) is a hotspot issue in recent years. However, its prognostic role is still unclear in synchronous colorectal liver metastases (sCRLM), especially in those receiving surgical treatment of primary tumor and liver metastases. Here, a retrospective survival analysis was performed using the Surveillance, Epidemiology, and End Results Program (SEER) database between 2010 and 2014, on patients who were pathologically confirmed sCRLM, and received surgical treatment of both primary tumor and liver metastases. After...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zheng Wang, Xiangyu Wang, Ze Zhang, Xuan Wang, Mo Chen, Lu Lu, Wenwei Zhu, Jubo Zhang, Huliang Jia, Jinhong Chen Tags: Research Paper Source Type: research
c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer
Conclusions: In conclusion, the overexpression of both c-Myb and COX-2 would be of prognostic screening value in patients with CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ruting Xie, Yongzhi Yang, Huizhen Zhang, Hu Liu, Jing Guo, Huanlong Qin, Yanlei Ma, Ajay Goel, Xinxiang Li, Qing Wei Tags: Research Paper Source Type: research
The Impact of Primary Tumor Sidedness on the Effect of Regorafenib in Refractory Metastatic Colorectal Cancer
Recently, the sidedness of the primary tumor (right versus left) has been investigated for its ability to prognosticate and predict outcomes. We evaluated the effect of regorafenib based on KRAS mutation status and the sidedness of the primary tumor in patients with metastatic colorectal cancer (mCRC). We analyzed 135 patients with refractory metastatic colorectal cancer (mCRC) being treated with regorafenib at Samsung Medical Center, between January 2014 and January 2018. Primary tumors originating in the splenic flexure, descending colon, sigmoid colon, rectum, or proximal third of the transverse colon were defined as le...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sang Eun Yoon, Su Jin Lee, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park, Seung Tae Kim Tags: Research Paper Source Type: research
Estrogen Enhances Endometrial Cancer Cells Proliferation by Upregulation of Prohibitin
Estrogen plays an essential role in type I endometrial cancer cell proliferation. Despite great progresses in the etiology has been obtained in the past, however, the molecular mechanisms remain to be fully clarified. Prohibitin has been demonstrated involvement in multiple cancers' development. If it also contributes to estrogen-driven endometrial cancer proliferation is not clear. IHC assay result display that prohibitin overexpressed in endometrial cancer tissue and associated with the poor prognosis; Western blot assay detect that upregulated prohibitin expression with dose- and time-dependent manners. The cellular gro...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bin Yang, Ruiying Chen, Xiaoyan Liang, Jiayan Shi, Xiaomei Wu, Zhenbo Zhang, Xiong Chen Tags: Research Paper Source Type: research
The Prospective Value of Dopamine Receptors on Bio-Behavior of Tumor
Dopamine receptors are belong to the family of G protein-coupled receptor. There are five types of dopamine receptor (DR), including DRD1, DRD2, DRD3, DRD4, and DRD5, which are divided into two major groups: the D1-like receptors (DRD1 and DRD5), and the D2-like receptors (DRD2, DRD3, and DRD4). Dopamine receptors are involved in all of the physiological functions of dopamine, including the autonomic movement, emotion, hormonal regulation, dopamine-induced immune effects, and tumor behavior, and so on. Increasing evidence shows that dopamine receptors are associated with the regulation of tumor behavior, such as tumor cell...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xu Wang, Zhi-Bin Wang, Chao Luo, Xiao-Yuan Mao, Xi Li, Ji-Ye Yin, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu Tags: Review Source Type: research
Deleted in Breast Cancer 1 as a Novel Prognostic Biomarker for Digestive System Cancers: A Meta-Analysis
Deleted in Breast Cancer 1 (DBC1/CCAR2) is a regulatory protein involved in cell survival and cancer progression. Herein, we focused on summarizing the overall prognostic value of DBC1 for digestive system cancers. Therefore, we conducted a meta-analysis based on 9 studies with 2391 patients to generated combined hazard ratios (HR) or odds ratio (OR) with its 95% confidence intervals (CI) for overall survival (OS) and clinicopathological features. Positive DBC1 expression was significantly associated with poor OS of digestive system cancers (pooled HR=1.650, 95% CI=1.087-2.504, P
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jingting Liu, Chunyan Meng, Changcan Li, Kaifeng Tang, Hongchao Tang, Jianhua Liao Tags: Research Paper Source Type: research
A Comparative Study of Genetic Profiles of Key Oncogenesis-Related Genes between Primary Lesions and Matched Lymph Nodes Metastasis in Lung Cancer
Conclusion: Since the heterogeneity of genetic profiling exists between primary lesion and LN metastasis lesion, multi-region lesion mutation profiling is required to fully understand the progression of NSCLC, and develop an appropriate therapeutic guide. Mutations in genes involved in cell proliferation, invasion and migration may be the genetic mechanism of metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yuqiao Chen, Beibei Mao, Xiong Peng, Yuan Zhou, Kun Xia, Hao Guo, Hong Jiang, Guo Wang, Wei Zhuang Tags: Research Paper Source Type: research
Salivary Microbial Dysbiosis is Associated with Systemic Inflammatory Markers and Predicted Oral Metabolites in Non-Small Cell Lung Cancer Patients
In this study, we presented the characteristics of the salivary microbiota in patients from NSCLC and healthy controls by sequencing of the 16S rRNA microbial genes. Our result revealed distinct salivary microbiota composition in patients from NSCLC compared to the healthy controls. As principal co-ordinates analysis (PCoA) showed, saliva samples clearly differed between the two groups, considering the weighted (p = 0.001, R2 = 0.17), and unweighted (p = 0.001, R2 = 0.25) UniFrac distance. Phylum Firmicutes (31.69% vs 24.25%, p
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Weiquan Zhang, Junwen Luo, Xiaopeng Dong, Shukang Zhao, Yingtao Hao, Chuanliang Peng, Hubo Shi, Yong Zhou, Lei Shan, Qifeng Sun, Yuyang Li, Xiaogang Zhao Tags: Research Paper Source Type: research
The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis
Available studies demonstrate that receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) is expressed in different tumor tissues, and functions in cell proliferation, cell adhesion and migration, epithelial-to-mesenchymal transition, cancer stem cells and treatment resistance by interacting with or binding to several molecules. These included pleiotrophin (PTN), midkine, interleukin-34, β-catenin, VEGF, NF-κB, HIF-2, PSD-95, MAGI-3, contactin and ErbB4. PTPRZ1 was involved in survival signaling and could predict the prognosis of several tumors. This review discusses: the current knowledge about PTPRZ1, its ex...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhenkun Xia, Dengjie Ouyang, Qianying Li, Moyun Li, Qiongyan Zou, Lun Li, Wenjun Yi, Enxiang Zhou Tags: Review Source Type: research
Multiple Myeloma: What Do We Do About Immunodeficiency?
Multiple myeloma (MM) is an incurable hematological malignancy. Immunodeficiency results in the incapability of immunity to eradicate both tumor cells and pathogens. Immunotherapies along with antibiotics and other anti-infectious agents are applied as substitutes for immunity in MM. Immunotherapies including monoclonal antibodies, immune checkpoints inhibitors, affinity- enhanced T cells, chimeric antigen receptor T cells and dendritic cell vaccines are revolutionizing MM treatment. By suppressing the pro-inflammatory milieu and pathogens, prophylactic and therapeutic antibiotics represent anti-tumor and anti-infection pr...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Linrong Li, Liang Wang Tags: Review Source Type: research
Comparison of the Prognostic Value of Systemic Inflammation Response Markers in Small Cell Lung Cancer Patients
Increasing evidences support that systemic inflammation-based prognostic scores, modified Glasgow Prognostic Score (mGPS), C-reactive Protein/Albumin (CRP/ALB), Albumin/Globulin (AGR), Prognostic Nutritional Index (PNI) and Advanced Lung cancer Inflammation index (ALI), are key determinants of patients' outcome in solid tumors. However, in small cell lung cancer (SCLC), there have been no direct comparisons of them. Thus, the aim of this study was to compare the prognostic value of these markers in SCLC, and select a most appropriative one. The patients with confirmed SCLC were screened between 2006 and 2011, and inflammat...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ting Zhou, Yuanyang Zhao, Shen Zhao, Yunpeng Yang, Yan Huang, Xue Hou, Hongyun Zhao, Li Zhang Tags: Research Paper Source Type: research
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway
In conclusion, peptide V3 could inhibit the growth of human HCC by inhibiting the Ras/Raf/MEK/ERK signaling pathway. Novel peptides and modification strategies could be designed and applied for the treatment of different types of cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Dongdong Wu, Mengling Li, Yingran Gao, Wenke Tian, Jianmei Li, Qianqian Zhang, Zhengguo Liu, Mengli Zheng, Hongju Wang, Jun Wang, Tieshan Teng, Lei Zhang, Xinying Ji, Zhongwen Xie, Ailing Ji, Yanzhang Li Tags: Research Paper Source Type: research
Prognostic Value of MTV, SUVmax and the T/N Ratio of PET/CT in Patients with Glioma: A Systematic Review and Meta-Analysis
Background: In the past decade, positron emission tomography/computed tomography (PET/CT) has become an important imaging tool for clinical assessment of tumor patients. Our meta-analysis aimed to compare the predictive value of PET/CT parameters regard to overall survival (OS) and progression-free survival (PFS) outcomes in glioma.Methods: Relevant articles were systematically searched in PMC, PubMed, EMBASE and WEB of science. Studies involving the prognostic roles of PET/CT parameters with OS and PFS in glioma patients were evaluated. The impact of metabolic tumor volume (MTV), maximal standard uptake value (SUVmax), an...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qing Zhang, Xian Gao, Guohua Wei, Cheng Qiu, Hongyi Qu, Xin Zhou Tags: Research Paper Source Type: research
Prognostic Value of Ferritin-to-Hemoglobin Ratio in Patients with Advanced Non-Small-Cell Lung Cancer
This study investigated the ability of the ferritin-to-hemoglobin ratio to predict survival in patients with advanced non-small-cell lung cancer (NSCLC).Methods: The medical records of patients with pathologically confirmed advanced NSCLC were retrospectively reviewed. The ferritin level, hemoglobin level, and ferritin-to-hemoglobin ratio at the initiation of treatment were investigated. After descriptive analysis of the ferritin-to-hemoglobin ratio, the optimal diagnostic cutoff value for survival was determined using receiver operating characteristic analysis. After dichotomizing patients according to the optimal cutoff ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sookyung Lee, Hyeonjin Jeon, Bumsang Shim Tags: Research Paper Source Type: research
P16 Methylation Leads to Paclitaxel Resistance of Advanced Non-Small Cell Lung Cancer
This study aimed to investigate whether P16 methylation could be used to predict paclitaxel chemosensitivity of NSCLC. Advanced NSCLC (N=45) were obtained from patients who were enrolled in a phase-III randomized paclitaxel-based clinical trial. Genomic DNA samples were extracted from the biopsies prior to chemotherapy. P16 methylation was detected using MethyLight. The association between P16 methylation and the sensitivity of paclitaxel in cell lines was determined by in vitro assay using a P16-specific DNA demethylase (P16-TET) and methyltransferase (P16-Dnmt). The total response rate of the low-dose paclitaxel-based ch...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhaojun Liu, Hongmei Lin, Ying Gan, Chenghua Cui, Baozhen Zhang, Liankun Gu, Jing Zhou, Guangying Zhu, Dajun Deng Tags: Research Paper Source Type: research
Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells
Conclusions: Metformin has antineoplastic effects in bile duct cancer, and hyperglycemic environment interrupts the effect of metformin. In addition, AMPK and IGF-1R play a key role in the proliferation of bile duct cancer cells. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jin Lee, Eun Mi Hong, Jung Han Kim, Jang Han Jung, Se Woo Park, Dong Hee Koh, Min Ho Choi, Hyun Joo Jang, Sea Hyub Kae Tags: Research Paper Source Type: research
Circulating Lymphocytes, PD-L1 Expression on Tumor-infiltrating Lymphocytes, and Survival of Colorectal Cancer Patients with Different Mismatch Repair Gene Status
In this study, we examined the association of systemic inflammatory markers, PD-1/PD-L1 pathway expression, microsatellite instability (MSI) status, and clinicopathological characteristics of CRC with patient survival between MMR-deficient (dMMR) group (N=168) and MMR-proficient (pMMR) group (N=169). We found a large proportion of dMMR CRC patients displayed increased level of systemic inflammatory markers such as C-reactive protein, Neutrophil/Lymphocyte Ratio (NLR), Glasgow Prognostic Score (GPS), and low expression of PD-L1 in tumor stroma. Several systemic inflammatory markers were associated with AJCC stage only in dM...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Pengfei Kong, Jing Wang, Ze Song, Shousheng Liu, Wenzhuo He, Chang Jiang, Qiankun Xie, Lin Yang, Xiaojun Xia, Liangping Xia Tags: Research Paper Source Type: research
Downregulation of DACT-2 by Promoter Methylation and its Clinicopathological Significance in Prostate Cancer
Conclusions: Our study provides evidence that DACT-2 may be a useful biomarker for distinguishing prostate tumor tissues from non-cancerous samples and a potential target for epigenetic silencing in primary prostate Cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shibao Li, Lingyu Yin, Kai Huang, Yao zhao, Haoliang Zhang, Chenchen Cai, Yinhai Xu, Lingyan Huang, Xiaozhou Wang, Ting Lan, Hongchun Li, Ping Ma Tags: Research Paper Source Type: research
Molecular Mechanisms and Countermeasures of Immunotherapy Resistance in Malignant Tumor
Tumor immunotherapy inhibits the proliferation and invasion of tumor cells by inducing or enhancing anti-tumor immune responses in active or passive ways. It is the fourth therapeutic method with efficiency and safety in addition to surgery, radiotherapy and chemotherapy. At present, anti-tumor immune related clinical trials have made promising achievements in prolonging progression free survival and overall survival, therefore, FDA approved a variety of immune checkpoint blockers (ICBs) such as nivolumab, pembrolizumab, ipilimumab. However, primary or acquired resistance results in massive perplexity to oncologist and pat...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaoyue Jiang, Li Li, Yingrui Li, Qin Li Tags: Review Source Type: research
Five P53 SNPs Involved in Low Rectal Cancer Risk and Prognosis in a Chinese Population
Although the impact and potential mechanisms of p53 polymorphisms on human malignancies have been intensively studied, analyses for association between p53 polymorphisms and colorectal cancer (CRC) risk were still limited to some common variants. Moreover, the majority of previous studies did not classify the specimens of CRC based on tumor location. This case-control study aimed to evaluate the association of five p53 polymorphisms (rs1042522, rs12947788, rs1625895, rs2909430 and rs12951053) with the risk of low rectal cancer (LRC) and investigate the prognostic significance. A total of 347 cases and 353 controls from a C...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guangzhe Zhang, Qian Xu, Jingwei Liu, Zhi Lv, Youzhu Lu, Huaiwei Yang, Liping Sun, Chengzhong Xing, Yuan Yuan Tags: Research Paper Source Type: research
Bacteria in Cancer Therapeutics: A Framework for Effective Therapeutic Bacterial Screening and Identification
By 2030, the global incidence of cancer is expected to increase by approximately 50%. However, most conventional therapies still lack cancer selectivity, which can have severe unintended side effects on healthy body tissue. Despite being an unconventional and contentious therapy, the last two decades have seen a significant renaissance of bacterium-mediated cancer therapy (BMCT). Although promising, most present-day therapeutic bacterial candidates have not shown satisfactory efficacy, effectiveness, or safety. Furthermore, therapeutic bacterial candidates are available to only a few of the approximately 200 existing cance...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Eta E. Ashu, Jianping Xu, Ze-Chun Yuan Tags: Review Source Type: research
Identification of Optimal Baseline Blood Pressure Predicting Postoperative Digestive Tract Cancer-Specific Mortality in the FIESTA Cohort Involving 6865 Patients
Background and Objectives: Emerging evidence indicates that hypertension is a potential risk and prognostic factor for cancer at many sites. Currently, no data are available on optimal blood pressure target in patients with resectable digestive tract cancer. Here, we did an exploratory analysis in 6865 patients from the FIESTA cohort to identify optimal blood pressure at baseline that can better predict digestive tract cancer-specific mortality risk postoperatively.Methods and Results: Patients were enrolled between January 2000 and December 2010, with follow-up ending in December 2015. All patients received no preoperativ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Dan Hu, Rongqing Jia, Xinran Zhang, Xiandong Lin, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Feng Peng, Wenquan Niu Tags: Research Paper Source Type: research
CUEDC2 Contributes to Cisplatin-Based Chemotherapy Resistance in Ovarian Serious Carcinoma by Regulating p38 MAPK Signaling
Chemoresistance remains an obstacle to the successful treatment of ovarian carcinoma. CUE domain-containing 2 (CUEDC2) plays critical roles in tumor genesis and overexpresses in many solid cancers, including ovarian serous carcinoma. In previous study, we found that overexpression of CUEDC2 might be a promising biomarker to evaluate the progression and to predict likely relapse of serous ovarian carcinoma. In present study, we found that higher expression of CUEDC2 was associated with higher resistance to cisplatin. The overall survival (OS) and disease-free survival time (DFS) of patients with cisplatin resistant was shor...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Aichun Wang, Jinhang Li, Tao Zhou, Tao Li, Hong Cai, Huaiyin Shi, Aijun Liu Tags: Research Paper Source Type: research
LMO1 Super-Enhancer rs2168101 G > T Polymorphism Reduces Wilms Tumor Risk
Wilms tumor is one of the most prevalent pediatric malignancies in childhood cancer worldwide. A genome-wide association study recognized that LIM domain only 1 (LMO1) increases the risk of oncogenic potential. An association has been found that LMO1 gene polymorphisms are associated with the susceptibility to Wilms tumor. One hundred forty-five children with Wilms tumor and 531 cancer-free children were included in this hospital-based case-control study. Five potentially functional polymorphisms in the LMO1 gene (rs2168101 G>T, rs1042359 A>G, rs11041838 G>C, rs2071458 C>A and rs3750952 G>C) were genotyped b...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guoyuan Li, Wei Jia, Zijun Yin, Jinhong Zhu, Guochang Liu, Huimin Xia, Jing He, Wen Fu Tags: Research Paper Source Type: research
Challenges of Providing Concordant Interpretation of Somatic Variants in Non-Small Cell Lung Cancer: A Multicenter Study
Conclusions: Owing to numerous reasons, the interpretation of variants differed greatly, which might in turn lead to the inappropriate clinical care of patients with NSCLC. By analyzing the limitations of different databases used by laboratories, we integrated various types of databases with different levels of evidence to form a comprehensive and detailed variant interpretation pipeline, aiming to standardize the variant classification and provide accurate and sufficient therapeutic drug recommendation to clinicians for minimal-inappropriate therapeutic options. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Peng Gao, Rui Zhang, Ziyang Li, Jiansheng Ding, Jiehong Xie, Jinming Li Tags: Research Paper Source Type: research
Dysregulated Expression of Circular RNAs Serve as Prognostic and Clinicopathological Markers in Cancer
Conclusion: Our study indicates that circRNAs may serve as important biomarkers for clinicopathologic features and prognosis in human cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xin Huang, Zhicai Zhang, Xiangcheng Qing, Weiyue Zhang, Binlong Zhong, Xiangyu Deng, Shangyu Wang, Cheng Cheng, Hongzhi Hu, Zengwu Shao Tags: Research Paper Source Type: research
Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression
In conclusion, our study indicated that Pokemon through stimulation of STRN4 expression promotes prostate tumor progression via a Pokemon /STRN4 axis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fuquan Jiang, Qingfan Zheng, Liping Chang, Xu Li, Xinsheng Wang, Xinquan Gu Tags: Research Paper Source Type: research