Expression of DEK in pancreatic cancer and its correlation with clinicopathological features and prognosis
Background: The oncogene DEK, which was originally identified as part of the protein product of the DEK-CAN fusion oncogene, has been shown to promote tumorigenesis in a variety of cancer cell types. However, little is known about the expression and role of DEK in pancreatic ductal adenocarcinoma (PDAC), which is one of the most refractory malignant tumors worldwide and has poor prognosis. Our study aimed to understand the role of DEK in the development and progression of pancreatic adenocarcinoma.Materials and methods: We used western blotting and immunohistochemistry to examine the expression of DEK in pancreatic adenoca...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ting Zhao, Bijun Qiu, Senhao Zhou, Guoping Ding, Liping Cao, Zhengrong Wu Tags: Research Paper Source Type: research

Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma
Alterations in cellular metabolism are one of the characteristics in cancer. They are not only the result of tumor progression but also the cause of cancer initiation. Pyruvate dehydrogenase kinase 4 (PDK4) is a key metabolic enzyme, which regulates cell metabolism by inhibiting pyruvate dehydrogenase (PDH). However, the function and regulating mechanism of PDK4 in HCC remain unclear. Here, we found that the expression of PDK4 was significantly decreased in HCC tissues, and its downregulation could predict poor prognosis of HCC patients. Silencing PDK4 significantly facilitated proliferation and migration of HCC cells. Kno...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chen Yang, Siying Wang, Haoyu Ruan, Botai Li, Zhuoan Cheng, Jia He, Qiaozhu Zuo, Chengtao Yu, Hui Wang, Yuanyuan Lv, Dishui Gu, Guangzhi Jin, Ming Yao, Wenxin Qin, Haojie Jin Tags: Research Paper Source Type: research

5'-Methylthioadenosine and Cancer: old molecules, new understanding
While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a century ago, altered metabolism has recently returned as a focus of cancer research. 5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside found in numerous species. While MTA was first isolated several decades ago, a lack of sensitive and specific analytical methodologies designed for its direct quantification has hampered the study of its physiological and pathophysiological features. Many studies indicate that MTA suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yaofeng Li, Yubo Wang, Ping Wu Tags: Review Source Type: research

PD-1 and PD-L1 Expression Predicts Radiosensitivity and Clinical Outcomes in Head and Neck Cancer and is Associated with HPV Infection
Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection impacts intrinsic radiosensitivity of head and neck cancers (HNCs). Herein, this study aims to determine PD-1/PD-L1 expression differences in tumors with different HPV statuses and their prognostic value in patients with different radiosensitivity gene signatures to define the characteristics of patients who will benefit from radiotherapy combined with anti-PD-1/PD-L1 therapy.Material and methods: According to the identified gene signature related to radiosensi...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xintong Lyu, Miao Zhang, Guang Li, Yuanjun Jiang, Qiao Qiao Tags: Research Paper Source Type: research

CHFR Promoter Hypermethylation Is Associated with Gastric Cancer and Plays a Protective Role in Gastric Cancer Process
Background: Chromosomally unstable tumors account for 50% of gastric cancer. CHFR plays a role in controlling chromosomal instability and its inactivation will eventually lead to tumorigenesis. In addition to genetic deletion, DNA methylation could silence the expression of many cancer-related genes including CHFR. Its methylation was found to be associated with the initiation and progression of gastric cancer.Methods: We performed a meta-analysis involving methylation analyses of CHFR promoter in gastric cancer. Nineteen studies with 1,249 tumor tissues and 745 normal tissues had been included in current study.Results: We...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Dongjun Dai, Bingluo Zhou, Wenxia Xu, Hongchuan Jin, Xian Wang Tags: Review Source Type: research

The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis in Hepatocellular Carcinoma
Conclusions: Elevated TROAP expression predicted a poor prognosis, and TROAP may serve as a potential biomarker for application in oncotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hao Hu, Liang Xu, Yan Chen, Shao-Ju Luo, Ying-zi Wu, Shi-Hua Xu, Meng-Ting Liu, Fen Lin, Yan Mei, Qin Yang, Yuan-yuan Qiang, You-wu Lin, Yuan-jiang Deng, Tong Lin, Yong-qiang Sha, Bi-Jun Huang, Shi-Jun Zhang Tags: Research Paper Source Type: research

Efficacy and safety of gemcitabine plus anti-angiogenesis therapy for advanced pancreatic cancer: a systematic review and meta-analysis of clinical randomized phase III trials
Conclusions: Although gemcitabine plus anti-angiogenesis therapy might prolong the progression-free survival in locally advanced or metastatic pancreatic cancer, these successful results did not translate into a significant improvement in the overall survival or change in the clinical guidelines. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mengting Tong, Jing Wang, Hongliang Zhang, Haibo Xing, Yanling Wang, Yong Fang, Hongming Pan, Da Li Tags: Review Source Type: research

Overexpression of TAF1L Promotes Cell Proliferation, Migration and Invasion in Esophageal Squamous Cell Carcinoma
Currently, it reported that TAF1L gene mutation is found in a number of carcinomas, but its pathophysiological function has not been well studied. We focused on investigating expressive levels of TAF1L gene and protein in esophageal squamous cell carcinoma (ESCC) with two tissue microarrays, forty fresh paired ESCC and paracancer samples using immunohistochemistry, real-time PCR or Western blot in this study. Furthermore, we executed TAF1L silence with siRNA in ESCC cell lines to evaluate effects of TAF1L expression on cell proliferation, migration and invasion of ESCC via CCK-8, wound healing and transwell chamber assays....
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shan Zhong, Hongfei Yan, Zhengshan Chen, Yanpeng Li, Yanqin Shen, Yongyu Wang, Lan Li, Sitong Sheng, Yun Wang Tags: Research Paper Source Type: research

Aberrant Activation Of Hedgehog Signalling Promotes Cell Migration And Invasion Via Matrix Metalloproteinase-7 In Ovarian Cancer Cells
Conclusion: Aberrant activation of the Hh-Gli-MMP-7 signalling axis is essential for acceleration of the progression and metastasis of human ovarian cancer, implicating its use as a novel therapeutic target of ovarian cancer. In addition, MMP-7 can potentially serve as a prognostic marker of ovarian cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hong Zhang, Yiting Wang, Tingtao Chen, Yan Zhang, Rong Xu, Wanwan Wang, Minzhang Cheng, Qi Chen Tags: Research Paper Source Type: research

Tumor-associated inflammatory microenvironment in non-small cell lung cancer: correlation with FGFR1 and TLR4 expression via PI3K/Akt pathway
The tumor-associated inflammatory microenvironment plays a pivotal role in human non-small cell lung cancer (NSCLC) development. FGFR1 and TLR4 involve in the regulation of inflammatory microenvironment of NSCLC.However, the relationship between the FGFR1 and TLR4 signaling and the mechanisms that involved in tumor-associated microenvironment are still unclear. We investigated the expression of FGFR1 and TLR4 in cancerous tissues and noncancerous lung tissues from 60 primary NSCLC patients using immunohistochemical staining. Three cell lines (A549, PC-9 and SK-MES-1) were used for in vitro studies. We demonstrated that the...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ruhui Zhang, Yongquan Dong, Mingjiao Sun, Yina Wang, Changqing Cai, Yun Zeng, Yueguang Wu, Qiong Zhao Tags: Research Paper Source Type: research

LncRNA SNHG16 Functions as an Oncogene by Sponging MiR-135a and Promotes JAK2/STAT3 Signal Pathway in Gastric Cancer
lncRNA can serve as a miRNA sponge and block the function of miRNA. High expression of lncRNA SNHG16 (small nucleolar RNAhostgene16) was discovered in gastric cancer (GC) and many other tumors. However, the mechanism of SNHG16 in GC is still unclear. In this research, we detected the expression level of SNHG16 in GC tissues and cell lines by qRT-PCR and FISH assay. RIP and Dual Luciferase Reporter Assay revealed that miR-135a is a target of SNHG16. SNHG16 gene knockdown experiment indicated that the expression level of SNHG16 can influence GC cells proliferation, colony formation, invasion ability and apoptosis in a miR-13...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xinguo Wang, Jie Kan, Jun Han, Wenyan Zhang, Liyan Bai, Hao Wu Tags: Research Paper Source Type: research

The Role of Polymorphisms in Genes of PI3K/Akt Signaling Pathway on Prostate
Background and Objective: Increasing evidence suggested that polymorphisms in genes of PI3K/Akt pathway were closely related to prostate cancer (PCa) risk. Nevertheless, these results are controversial and inconclusive. Here, we conducted a comprehensive updated meta-analysis and systematic review to precisely illustrate the association between polymorphisms in genes of PI3K/Akt signaling pathway and PCa risk.Materials and Methods: The gene set of PI3K/Akt pathway was referenced from the Kyoto Encyclopedia of Genes and Genomes (KEGG) website. Relevant studies were identified by the systematically researching on PubMed, Web...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wei Xu, Zhihao Ni, Meng Zhang, Jinbo Chen, Li Zhang, Song Wu, Chaozhao Liang Tags: Research Paper Source Type: research

Eosinophil peroxidase over-expression predicts the clinical outcome of patients with primary lung adenocarcinoma
Eosinophil peroxidase (EPO), a heme protein abundantly expressed in eosinophils, involves in the catalysis of cytotoxic oxidants associated with the pathogenesis of cancer, asthma, and allergic inflammatory disorders. To date, its roles in the pathogenesis of lung cancer are still not known. We determined the expression of EPO in the lung adenocarcinoma tissues and the normal adjacent lung tissues using Real-time PCR and Western blotting analysis, respectively. Also, EPO protein expression in 90 lung adenocarcinoma (AD) samples were confirmed with immunohistochemistry (IHC) using tissue microarrays. Meanwhile, we investiga...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Liang Ye, Hongying Wang, Huijuan Li, Hongbing Liu, Tangfeng Lv, Yong Song, Fang Zhang Tags: Research Paper Source Type: research

MiR-192-5p reverses cisplatin resistance by targeting ERCC3 and ERCC4 in SGC7901/DDP cells
Cisplatin chemoresistance is a clinical obstacle in the treatment of gastric cancer (GC). Enhanced DNA repair capacity may lead to cisplatin resistance. However, the detailed molecular mechanism of GC cisplatin resistance specifically involving nucleotide excision repair (NER) is not clear. However, the mechanism through which the NER pathway contributes to cisplatin resistance in GC is still unclear. In light of the crucial role of microRNAs (miRNAs) in regulating protein expression and biological behavior, we aimed to analyze the expression and function of miR-192-5p in the NER pathway and its role in cisplatin resistanc...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaoque Xie, Nana Huang, Yiyin Zhang, Xiaoli Wei, Mengru Gao, Min Li, Jie Ning, Wei Liu, Qihong Zhao, Hua Wang, Kangsheng Gu Tags: Research Paper Source Type: research

Positive impact of the negative lymph node count on the survival rate of stage III colon cancer with pN1 and right-side disease
Background: We aimed to investigate the role of the negative lymph node count (NLN) as a predictor of prognosis in patients with stage III colon cancer.Methods: We conducted a retrospective study on patients who were diagnosed with stage III colon cancer at Sun Yat-sen University Cancer Center. According to the number of negative lymph nodes, all patients were divided into the low or high NLN group. Overall survival (OS) and disease-free survival (DFS) were assessed using the Kaplan-Meier method and log-rank test between the two groups. Univariate and multivariate Cox proportional hazards models were used to evaluate the r...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Quan, Mingshu Zhu, Shousheng Liu, Ping Chen, Wenzhuo He, Yuanyuan Huang, Yuming Rong, Huijuan Qiu, Bei Zhang, Liangping Xia Tags: Research Paper Source Type: research

AAV-Mig-6 Increase the Efficacy of TAE in VX2 Rabbit Model, Is Associated With JNK Mediated Autophagy
In this study, we found up-regulation the expression of Mig-6 enhances autophagy in HCC cells. This function of Mig-6 is related to the activation of the JNK pathway. Next AAV-9 encoding Mitogen inducible gene 6 (Mig-6) was delivered into VX2 liver transplant tumor of rabbits by using hepatic artery catheter. Wild-type AAV is not associated with any human or animal disease and has very low immunogenicity. There are over 100 different AAV serotypes that vary in the amino acid sequence of their capsid protein. We also describe a novel combination therapy coupling AAV-Mig-6 and TAE in a rabbit model resulted in a growth rate ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zixuan Li, Yulong Tian, Lianyue Qu, Jingsong Mao, Hongshan Zhong Tags: Research Paper Source Type: research

Effects of perioperative Eicosapentaenoic acid-enriched oral nutritional supplement on lean body mass after total gastrectomy for gastric cancer
Conclusions: The perioperative EPA-ON could not be recommended to prevent loss of LBM after total gastrectomy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Toru Aoyama, Takaki Yoshikawa, Satoshi Ida, Haruhiko Cho, Kentaro Sakamaki, Yuichi Ito, Kazumasa Fujitani, Nobuhiro Takiguchi, Yoshiyuki Kawashima, Kazuhiro Nishikawa, Takashi Oshima, Souya Nunobe, Naoki Hiki Tags: Research Paper Source Type: research

Annexin A2 Silencing Inhibits Proliferation and Epithelial-to-mesenchymal Transition through p53-Dependent Pathway in NSCLCs
In this study, we showed that Annexin A2 was evidently overexpressed in human NSCLCs cell lines and NSCLCs tissues. Clinicopathologic analysis showed that Annexin A2 expression was significantly correlated with clinical stage, and lymph node metastasis. Kaplan-Meier analysis revealed that patients with high Annexin A2 expression had poorer overall survival rates than those with low Annexin A2 expression. Moreover, we found that knockdown of Annexin A2 significantly suppressed cell proliferation and invasion of NSCLCs cells. Mechanistically, our studies showed that knockdown of Annexin A2 increased the expression of p53, wh...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Minhua Wu, Yanqin Sun, Feipeng Xu, Yanqing Liang, Hao Liu, Yanmei Yi Tags: Research Paper Source Type: research

Association between TNF- ɑ -308G/A polymorphism and esophageal cancer risk: An updated meta-analysis and trial sequential analysis
Conclusions: This meta-analysis study suggested no significant association between TNF-ɑ-308G/A polymorphism and the risk of esophageal cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fengming Yang, Ke Wei, Zhiqiang Qin, Chuchu Shao, Yongqian Shu, Hua Shen Tags: Research Paper Source Type: research

Neoadjuvant chemotherapy followed by minimally invasive esophagectomy versus primary surgery for management of esophageal carcinoma: a retrospective study
There is no consensus about the combined therapeutic strategy for esophageal squamous cell carcinoma in China. The quality control and standardization of surgery procedures were far from satisfactory in past neoadjuvant chemotherapy trials, which may underestimate the survival benefits. Therefore, we tried to evaluate the survival benefit of paclitaxel plus platinum followed by minimally invasive esophagectomy with total two-field lymphadenectomy patterns versus primary surgery. Between 06/2011 and 12/2014, there were 279 consecutive patients who underwent minimally invasive esophagectomy with total two-field lymphadenecto...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yan Zheng, Yin Li, Xianben Liu, Ruixiang Zhang, Zongfei Wang, Haibo Sun, Shilei Liu Tags: Research Paper Source Type: research

Efficacy and Toxicity of IMRT-Based Simultaneous Integrated Boost for the Definitive Management of Positive Lymph Nodes in Patients with Cervical Cancer
Conclusions: Our findings demonstrate that a dose of 62.5 Gy to positive LNs using the IMRT with SIB method can achieve excellent clinical outcomes with acceptable toxicity. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yun-Zhi Dang, Pei Li, Jian-Ping Li, Ying Zhang, Li-Na Zhao, Wei-Wei Li, Li-Chun Wei, Mei Shi Tags: Research Paper Source Type: research

Clinical validation of Ki67 by quantitative reverse transcription-polymerase chain reaction (RT-PCR) in HR+/HER2- early breast cancer
Conclusions: Ki67 assessed by RT-PCR assay was weakly correlated to Ki67 by IHC. Using 5.68 as cutoff point, Ki67 by RT-PCR had shown potential as a prognostic biomarker in HR+/HER2- early breast cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Weiqi Gao, Jiayi Wu, Xiaosong Chen, Lin Lin, Xiaochun Fei, Kunwei Shen, Ou Huang Tags: Research Paper Source Type: research

Current Status of Research on the Period Family of Clock Genes in the Occurrence and Development of Cancer
Several physiological activities of organisms are coordinated based on periodic variations of ~24 h, which is called a circadian rhythm. Circadian rhythms, driven by circadian clock genes, play an important role in the regulation of various complex life activities of organisms, in an orderly and coordinated manner. Period (Per)1/2/3 genes are important core clock genes and part of the Per gene family. Current research has demonstrated that the abnormal expression of Per genes and disruption of circadian rhythms can lead to the occurrence and development of cancer; however, the exact mechanism has not yet been elucidated. F...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fan Deng, Kai Yang Tags: Review Source Type: research

Risk Factors of Lymph Node Metastasis in Patients with Early Pure and Mixed Signet Ring Cell Gastric Carcinomas
Background: Early gastric carcinoma (EGC) with pure signet ring cell carcinoma (pSRCC) has been reported to have favourable prognosis and low risk of lymph node metastasis (LNM). However, risk factors of LNM and clinicopathological features for early gastric mixed signet ring cell carcinoma (mSRCC) remain poorly investigated. The aim of this study was to identify risk factors of LNM and compare clinicopathological characteristics and prognosis of early gastric pSRCC with mSRCC.Methods: This retrospective study was conducted at our center between 2005 and 2015 in 796 patients underwent radical gastrectomies combined with ly...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qingqing Hu, Raymond Dekusaah, Shouli Cao, Taohong Pang, Yi Wang, Bin Zhang, Ying Lv, Xiaoqi Zhang, Tingsheng Ling, Yuzheng Zhuge, Lei Wang, Xiaoping Zou, Weijie Zhang, Qin Huang, Guifang Xu Tags: Research Paper Source Type: research

The nucleosome binding protein 1 promotes the growth of gastric cancer cells
In conclusion, this study provides the first evidence that NSBP1 enhances the proliferation while inhibits the apoptosis of gastric cancer cells, and this is related to the regulation of the expression of apoptosis related proteins by NSBP1. These data suggest that NSBP1 plays oncogenic role in gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lantao Liu, Zhifang Lang, Pengyu Wang, Hongwei Wang, Yanli Cao, Xianghui Meng, Jing Hu, Yukuan Feng Tags: Research Paper Source Type: research

Relationship of common variants in Interleukin 33 gene with susceptibility and prognosis of osteosarcoma in Han Chinese population
In conclusion, our results suggested that IL-33 may play a key role in the etiology of OS, indicating IL-33 as a potential genetic risk factor of the development and prognosis of OS. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chao Kang, Jianwu Zhao, Yuanchun Wang, Chenguang Yang, Jie Chen, Liqiang Zhi Tags: Research Paper Source Type: research

Cloning and characterization of the putative AFAP1-AS1 promoter region
This study is the first to clone and characterize the AFAP1-AS1 promoter region. Our findings will help to better understand the underlying mechanism of high AFAP1-AS1 expression in tumorigenesis and to develop new strategies for therapeutic high expression of AFAP1-AS1 in NPC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fang Wei, Yi-Zhou Jing, Yi He, Yan-Yan Tang, Li-Ting Yang, Ying-Fen Wu, Le Tang, Lei Shi, Zhao-Jian Gong, Can Guo, Ming Zhou, Bo Xiang, Xiao-Ling Li, Yong Li, Gui-Yuan Li, Wei Xiong, Zhao-Yang Zeng, Fang Xiong Tags: Research Paper Source Type: research

PD-L1 expression patterns in tumour cells and their association with CD8+ tumour infiltrating lymphocytes in clear cell renal cell carcinoma
Conclusion: The intrinsic and extrinsic expression patterns are both detected in ccRCC. High positive rate of TC-PD-L1 correlated closely to the strong infiltration of CD8+ TILs. TC-PD-L1-positive ccRCC patients with abundant CD8+ TILs infiltration confer the high risk of death and disease relapse. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qian Zhu, Mu-Yan Cai, De-Sheng Weng, Jing-Jing Zhao, Qiu-Zhong Pan, Qi-Jing Wang, Yan Tang, Jia He, Min Li, Jian-Chuan Xia Tags: Research Paper Source Type: research

Combining Red Blood Cell Distribution Width (RDW-CV) and CEA Predict Poor Prognosis for Survival Outcomes in Colorectal Cancer
Background: Colorectal cancer is one of the common tumors that seriously threaten human health worldwide. Serum tumor markers, including CEA and CA19-9, have become the focus of research on colorectal cancer in recent years. As one of the classic blood test results, RDW is related to the pathological features, diagnosis and prognosis of various cancers in recent studies. We hope to search the correlation between RDW and the pathological features of colorectal cancer through the following studies, explore the potential relationship between RDW and the prognosis of colorectal cancer, and find a more effective prognostic eval...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yalun Li, Chengzhong Xing, Minjie Wei, Huizhe Wu, Xiaoyun Hu, Shanqiong Li, Guangwei Sun, Guangzhe Zhang, Bo Wu, Fangxiao Zhang, Zhuang Li Tags: Research Paper Source Type: research

External Radiation versus Internal Radiation for Patients with Advanced Unresectable HCC -A SEER Based Study
This study aimed to compare external radiation (beam radiation) and internal radiation as a single radiation therapy to advanced HCC patients (TNA stage III and IV according to the derived AJCC Stage, 6th edition) stratified by other risk factors, based on the data collected from the Surveillance, Epidemiology and End Results (SEER) national database. In this cohort study, we mainly clarified the following three points: 1. Choices of radiation therapy for advanced HCC patients vary in demographic and clinical factors. Among these, TNM classification is the key factor. 2. Internal radiation provides a better prognosis in bo...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xuan Wang, Mo Chen, Ran Wei, Zheng Wang Tags: Research Paper Source Type: research

Prognostic Factors and Recurrence Patterns in T4 Gastric Cancer Patients after Curative Resection
Background: To investigate prognostic factors and recurrence patterns in T4 gastric cancer (GC) patients after curative resection.Methods: Between January 2004 and December 2014, 249 patients with T4 gastric cancer undergoing curative resection were recruited. Patient characteristics, survival, prognostic factors and recurrence patterns were analyzed.Results: Our results showed that the median survival time (MST) for T4 gastric cancer after curative resection was 55.47 months, with 59.47 months for T4a (tumor perforating serosa) and 25.90 months for T4b (tumor invasion of the adjacent structure). Multivariate analysis indi...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bao-Yan Zhu, Shu-Qiang Yuan, Run-Cong Nie, Shu-Man Li, Li-Rong Yang, Jin-Ling Duan, Ying-Bo Chen, Xiao-Shi Zhang Tags: Research Paper Source Type: research

Transarterial Chemoembolization (TACE) Combined with Sorafenib versus TACE Alone for Unresectable Hepatocellular Carcinoma: A Propensity Score Matching Study
Objective: To compare the outcomes of transarterial chemoembolization (TACE) combined with sorafenib versus TACE alone for treating patients with unresectable hepatocellular carcinoma (HCC).Methods: This retrospective analysis included all patients receiving either TACE plus sorafenib therapy or TACE alone for unresectable HCC between February 2008 and August 2015 at the First Affiliated Hospital of Soochow University, China. Propensity score matching (PSM) was carried out to reduce bias due to confounding variables. The primary outcome was overall survival (OS), calculated from the date of the first TACE treatment until t...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Baosheng Ren, Wansheng Wang, Jian Shen, Wanci Li, Caifang Ni, Xiaoli Zhu Tags: Research Paper Source Type: research

Lyn Kinase Promotes the Proliferation of Malignant Melanoma Cells through Inhibition of Apoptosis and Autophagy via the PI3K/Akt Signaling Pathway
In this study, we discovered that Lyn kinase expression was up-regulated in melanoma tissues and cells. The function of Lyn was determined by knocking down its expression with a lentivirus containing Lyn shRNA and upregulating its expression with pcDNA3.1-Lyn in the melanoma cell lines M14 and A375. The results showed that Lyn knockdown could significantly inhibit the proliferation, migration and invasiveness through its inhibition of apoptosis and autophagy via the PI3K/Akt pathway in melanoma cell lines. This was further confirmed by treatment with PI3K inhibitor BEZ235. Up-regulation of Lyn promoted the expression of p-...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qianqian Zhang, Xianguang Meng, Guojing Qin, Xiaotong Xue, Ningning Dang Tags: Research Paper Source Type: research

Survival benefit of adjuvant chemotherapy for patients with poorly differentiated stage IIA colon cancer
Conclusion: ACT decreased the recurrence rate and distant metastasis rate thus improving prognosis for poorly differentiated or undifferentiated stage IIA colon cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Liu, Dakui Luo, Hongyin An, Sheng Zhang, Sanjun Cai, Qingguo Li, Xinxiang Li Tags: Research Paper Source Type: research

Palliative beam radiotherapy offered real-world survival benefit to metastatic rectal cancer: A large US population-based and propensity score-matched study
The objective of this study was to evaluate the survival benefit of RT in mRC.Methods: A retrospective population-based cohort study was performed using the Surveillance, Epidemiology, and End Results Program (SEER) database. Patient baseline demographic characteristics between the RT and no-RT groups were compared using Pearson chi-square tests. The outcome of interest was cause-specific survival (CSS). Propensity score (PS) matching and Cox proportional hazards regression analyses were performed to evaluate the prognostic power of variables on CSS.Results: A total of 8851 patients with mRC were identified in the SEER dat...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Liu, Zezhi Shan, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li Tags: Research Paper Source Type: research

Cryoablation versus Partial Nephrectomy for Clinical Stage T1 Renal Masses: A Systematic Review and Meta-Analysis
Introduction: Cryoablation has been considered as the most efficacious ablative alternative to partial nephrectomy (PN) for selected patients. Our objective is to assess the existing evidence relating to the safety and efficacy of cryoablation compared with PN for clinical T1 renal masses.Materials and Methods: A comprehensive search of PMC, EMBASE, and the Cochrane Library was conducted to identify studies containing comparison of cryoablation and PN. By utilizing those included studies, a systematic review and cumulative meta-analyses were performed to assess the safety and efficacy between cryoablation and PN for T1 ren...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wen Deng, Luyao Chen, Yibing Wang, Xiaoqiang Liu, Gongxian Wang, Weipeng Liu, Cheng Zhang, Xiaochen Zhou, Yu Li, Bin Fu Tags: Review Source Type: research

Overexpression of FZD1 is Associated with a Good Prognosis and Resistance of Sunitinib in Clear Cell Renal Cell Carcinoma
In conclusion, our results suggested that expression status of FZD1 had a diagnostic value and prognostic value in ccRCC patients, it also may serve as a potential drug target to relieve sunitinib resistance in renal cancer patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qiang Peng, Lu Wang, Danfeng Zhao, Yulin Lv, Hongzhi Wang, Guang Chen, Jiaqi Wang, Wanhai Xu Tags: Research Paper Source Type: research

Diagnostic and prognostic value of microRNAs for cancers- strategies and approaches to improve the clinical utility
(Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Rama Jayaraj, Chellan Kumarasamy, Shanthi Sabarimurugan, Siddhartha Baxi Tags: Letter Source Type: research

Prognosis of EGFR-mutant advanced lung adenocarcinoma patients with different intrathoracic metastatic patterns
Conclusion: The prognosis of EGFR-mutant lung adenocarcinoma patients diagnosed only with intrathoracic metastasis was different, indicating that M1a staging should be refined. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fang Hu, Bo Zhang, Changhui Li, Jianlin Xu, Huimin Wang, Ping Gu, Xiaoxuan Zheng, Wei Nie, Yinchen Shen, Hai Zhang, Ping Hu, Xueyan Zhang Tags: Research Paper Source Type: research

Development and Validation of Nomograms Predictive of Axillary Nodal Status to Guide Surgical Decision-Making in Early-Stage Breast Cancer
Conclusion: The nomograms could predict the extent of ALN metastasis and facilitate decision-making preoperatively. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jiao Li, Weimei Ma, Xinhua Jiang, Chunyan Cui, Hongli Wang, Jiewen Chen, Runcong Nie, Yaopan Wu, Li Li Tags: Research Paper Source Type: research

Antitumor activity of histone deacetylase inhibitor chidamide alone or in combination with epidermal growth factor receptor tyrosine kinase inhibitor icotinib in NSCLC
The study was performed to investigate the antitumor efficacy of histone deacetylase inhibitor (HDACi) chidamide alone or with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) icotinib in non-small cell lung cancer (NSCLC). The cell viability, cell cycle, apoptosis, protein expression, and the molecular mechanisms were explored among ten NSCLC cell lines with chidamide and icotinib alone or in combination, and further validated in xenograft models of nude mice. Chidamide significantly reduced the viability of A549, HCC827, HCC827IR (icotinib resistant) cells, increased the sensitivity of icotinib syner...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ningning Zhang, Caixia Liang, Wenya Song, Dan Tao, Jiarui Yao, Shuai Wang, Li Ma, Yuankai Shi, Xiaohong Han Tags: Research Paper Source Type: research

Lower Expression of Gelsolin in Colon Cancer and Its Diagnostic Value in Colon Cancer Patients
In conclusion, our results suggest that the secreted GSN restrains the invasion and migration of colon cancer cells. Meanwhile, the serum GSN may be a new biomarker for the diagnosis of colon cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhuoyu Chen, Kaifei Li, Xiaofeng Yin, Haixia Li, Yao Li, Qiong Zhang, Haifang Wang, Yurong Qiu Tags: Research Paper Source Type: research

O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area
Conclusion: O blood type was associated with an unfavorable DMFS in female patients with nasopharyngeal carcinoma in epidemic area, which might contribute to unfavorable OS and DSS in female patients, even contribute to a lower DMFS in the whole patients. It might be beneficial to predict metastasis so as to guide the treatment in female patients with nasopharyngeal carcinoma in epidemic area. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guan-Nan Wang, Shu Zhou, Chen Chen, Hui Chang, Yalan Tao, Shan Liu, Xiao-Hui Wang, Wen-Wen Zhang, Yang Liu, Song-Ran Liu, Shi-Rong Ding, Xin Yang, Zheng-Qian Ye, Yi-Feng Gao, Yun-Fei Xia Tags: Research Paper Source Type: research

Survival Benefit of Preoperative Versus Postoperative Radiotherapy in Metastatic Rectal Cancer Treated With Definitive Surgical Resection of Primary Tumor: A Population Based, Propensity Score-Matched Study
Preoperative chemoradiation followed by surgery has been recommended as a standard treatment for patients with stage II/III rectal cancer. However, the optimal sequencing of radiotherapy for metastatic rectal cancer remains unclear. Between 2004 and 2014, patients diagnosed with metastatic rectal cancer who underwent the resection of primary site and received radiotherapy were retrospectively selected using the Surveillance, Epidemiology, and End Results (SEER) database. The propensity score matching analyses were used to lessen the effects of confounding factors including age, sex, race, marital status, serum carcinoembry...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Dakui Luo, Qi Liu, Ji Zhu, Yanlei Ma, Sanjun Cai, Qingguo Li, Xinxiang Li Tags: Research Paper Source Type: research

High expression of Oct4 and Nanog predict poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection
Oct4 and Nanog are reported to promote tumor progression in several cancers, but the effect on intrahepatic cholangiocarcinoma (ICC) is unknown. The aim of our present study was to explore the prognostic role of Oct4 and Nanog on patients with ICC. Immunohistochemistry was used to detect the expression of Oct4 and Nanog in a random cohort of 116 ICC patients, and validated in another independent cohort of 103 patients. Prognostic nomograms were formulated for OS and RFS prediction of ICC patients. Our results showed Oct4 and Nanog highly expressed in ICC tumor tissues and were identified as independent prognostic factors f...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Mei-xia Zhang, Wei Gan, Chu-yu Jing, Su-su Zheng, Yong Yi, Juan Zhang, Xin Xu, Jia-jia Lin, Bo-heng Zhang, Shuang-jian Qiu Tags: Research Paper Source Type: research

Gender disparity in the survival of patients with primary myelodysplastic syndrome
Several prognostic scoring systems have been developed to assess prognosis in myelodysplastic syndrome (MDS). However, currently there are no systems that list gender as a prognostic factor. We queried a National Cancer Institute database to investigate the prognostic influence of gender on the survival of patients with MDS. We first identified 34,681 qualified patients diagnosed with MDS from 2001-2014 in the Surveillance, Epidemiology, and End Results (SEER) database, and then analyzed the characteristics of these patients using chi-squared tests. The Kaplan-Meier method and the multivariate Cox regression model were use...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Fangfang Wang, Jun Ni, Lei Wu, Ying Wang, Bin He, Duonan Yu Tags: Research Paper Source Type: research

Knockdown of long non-coding RNA SNHG5 inhibits malignant cellular phenotypes of glioma via Wnt/CTNNB1 signaling pathway
Conclusion: SNHG5 gene was high-expressed in glioma, knockdown of SNHG5 inhibits malignant cellular phenotypes of glioma via Wnt/CTNNB1 signaling pathway. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xuanhao Hu, Yang Hong, Chao Shang Tags: Research Paper Source Type: research

Increased circulating GrMyeloid-derived suppressor cells correlated with tumor burden and survival in locally advanced cervical cancer patient
Conclusion: Our study demonstrates that the increased frequency of circulating GrMDSCs is associated with tumor burden and recurrence in early and locally advanced cervical cancer patients, that the GrMDSCs may be potential biomarkers for disease progression cervical cancers. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yun Liang, Bingjian L ü , Peng Zhao, Weiguo L ü Tags: Research Paper Source Type: research

Prognostic impact of family history of cancer in Southern Chinese patients with esophageal squamous cell cancer
In this study, we investigated the prognoses of patients with ESCC with a family history.Methods: A total of 479 ESCC patients were retrospectively enrolled from a Southern Chinese institution. A positive family history was defined as having malignant cancer among parents and siblings. Kaplan-Meier plots and Cox proportional hazards regressions were applied for overall survival (OS) and progression-free survival (PFS).Results: Among 479 patients, 119 (24.8%) and 68 (14.2%) reported a first-degree family history of cancer and digestive tract cancer, respectively. Compared with patients without a family history of cancer, th...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhen Su, Guo-Rong Zou, Yan-Ping Mao, Pu-Yun OuYang, Xiao-Long Cao, Fang-Yun Xie, Qun Li Tags: Research Paper Source Type: research

Nanotechnology in metastatic cancer treatment: Current Achievements and Future Research Trends
The systemic spread of malignant cells from a primary site, a process termed metastasis represents a global challenge in cancer treatment. There is a real need to develop novel therapy strategies and nanomedicine may have remarkable and valuable contribution through specific and selective delivery of chemotherapeutic agents, through its intrinsic cytotoxic activity or through imaging applications, appealing also in the context of cancer personalized therapy. This review is focused on the applications of nanoparticles in the treatment of metastatic cancer, particularly on the possible effect on cell stabilization, growth in...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Diana Gonciar, Teodora Mocan, Cristian Tudor Matea, Claudiu Zdrehus, Ofelia Mosteanu, Lucian Mocan, Teodora Pop Tags: Review Source Type: research