Development and validation of a robust multigene signature as an aid to predict early relapse in stage I-III clear cell and papillary renal cell cancer
Background and objectives: Multi-gene signature can be used as prognostic indicator in many types of cancer, but the association with early-relapse in patients with stage I-III clear cell and papillary renal cell cancer (RCC) is unknown. We aim to establish a mRNAs signature for improving prediction of early-relapse in patients with stage I-III clear cell and papillary RCC.Methods: The data of 610 patients with stage I-III RCC from The Cancer Genome Atlas (TCGA) and 270 patients from Fudan University Shanghai Cancer Center (FUSCC) were extracted. Propensity score matching analysis, linear models for microarray data VOOM me...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Da-Long Cao, Wei-Xing Dai, Yong-Qiang Huang, Lei-Jun Yu, Jun-Long Wu, Guo-Hai Shi, Hai-Liang Zhang, Yao Zhu, Bo Dai, Ding-Wei Ye Tags: Research Paper Source Type: research

Late results of a randomized trial on the role of mild hypofractionated radiotherapy for the treatment of localized prostate cancer
Conclusion: No difference in the toxicity profile could be identified between hypofractionation and conventional fractionation. Our schedule of 2,25Gy/fr seems safe and tolerable by the patients with acceptable rates of acute and late toxicity. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Petros Alexidis, Sotirios Karatzoglou, Dimitris Dragoumis, Konstantinos Drevelegas, Ioannis Tzitzikas, Konstantinos Hatzimouratidis, Ioannis Chrisogonidis, Aris Ioannidis, Iason Nikolaos Katsios, Paul Zarogoulidis, Konstantinos Sapalidis, Charilaos Koulou Tags: Research Paper Source Type: research

Target Therapy With Vaccinia Virus Harboring IL-24 For Human Breast Cancer
Conclusions: Our findings provided documentation that VG9-IL-24 was targeted in vitro and exhibited enhanced antitumor effects, and it may be an innovative therapy for breast cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lili Deng, Jun Fan, Yuedi Ding, Xue Yang, Biao Huang, Zhigang Hu Tags: Research Paper Source Type: research

Phosphoribosyl pyrophosphate synthetases 2 knockdown inhibits prostate cancer progression by suppressing cell cycle and inducing cell apoptosis
Phosphoribosyl pyrophosphate synthetases 2 (PRPS2) protein function as nucleotide synthesis enzyme that plays vital roles in cancer biology. However, the expression profile and function of PRPS2 in prostate cancer (PCa) remain to be identified. Here we investigated the expression of PRPS2 protein in human PCa and paired normal tissues by immunohistochemistry, meanwhile the regulatory effects on cell proliferation, apoptosis and growth of xenograft tumors in nude mice were evaluated in PCa cells with PRPS2 depletion. Moreover, the signaling pathways were also explored by western blot analysis and quantitative polymerase cha...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hui Qiao, Xiao Tan, Dao-jun Lv, Rong-wei Xing, Fang-peng Shu, Chuan-fan Zhong, Chun Li, Ya-guang Zou, Xiang-ming Mao Tags: Research Paper Source Type: research

The somatic mutation landscape of Chinese Colorectal Cancer
In this study, we have performed whole exome-sequencing analysis of 63 CRC cases. We found that Chinese CRC were hypermutated, which were enriched in ECM-receptor interaction, antigen processing and presentation, and focal adhesion. Analysis with clinical characteristics indicated that the deficiency of CRC driver gene, FCGBP and NBPF1 conferred CRC development and was showed worse survival rates, which could be the novel regulators and, diagnostic and prognostic biomarkers for Chinese CRC. Taken together, the application of whole exome-sequencing unveiled previously unsuspected somatic mutation landscape in Chinese CRCs, ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Rong Ma, Changwen Jing, Yuan Zhang, Haixia Cao, Siwen Liu, Zhuo Wang, Dan Chen, Junying Zhang, Yang Wu, Jianzhong Wu, Jifeng Feng Tags: Research Paper Source Type: research

Risk of non-melanoma skin cancer in patients with psoriasis: An updated evidence from systematic review with meta-analysis
Background Psoriasis is a chronic inflammatory skin disorder which may result in an increased cancer risk due to defects of immune surveillance. The relationship between psoriasis and risk of non-melanoma skin cancer (NMSC) has not yet been fully determined. The aim of this study was to update the evidence on the association between psoriasis and risk of NMSC.Methods We conducted an extensive literature search of publications in Pubmed, EMBASE, and Cochrane Library without restrictions on language from inception through August 2019 using predefined keywords. Eligible observational studies were selected if they assessed the...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiujuan Wang, Qiang Liu, Lingling Wu, Zhenhua Nie, Zubing Mei Tags: Research Paper Source Type: research

Thirty-year trends in clinicopathologic characteristics and prognosis after gastrectomy for gastric cancer: A single institution in Northern China
Background: We integrated changes in the trends in clinicopathologic characteristics and postoperative prognosis in patients with gastric cancer Northern China over a 30-year period.Methods: A retrospective analysis of patients undergoing gastric cancer resection and complete follow-up information from January 1981 to December 2010 in the first affiliated Hospital of China Medical University was carried out. We divided the patients into three consecutive periods.Results: A total of 3,520 patients were included in this study. The proportion of lower tumors increased (from 58.8 to 66.9%), while that of upper tumors decreased...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yu-en Tan, Peng-liang Wang, Song-cheng Yin, Chao Zhang, Wen-bin Hou, Hui-mian Xu Tags: Research Paper Source Type: research

Prognostic value of the serum apolipoprotein B to apolipoprotein A-I ratio in metastatic colorectal cancer patients
Background: The aim of our research was to assess the prognostic value of the apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) ratio (ApoB/ApoA-I) in metastatic colorectal cancer (mCRC) patients.Methods: We randomly assigned 838 patients into the training cohort (n=578) and the validation cohort (n=260). The cut-off value of the ApoB/ApoA-I in the training cohort identified by a receiver operating characteristic (ROC) curve was 0.69 and was further validated in the validation cohort. A propensity score matching (PSM) analysis was carried out to eliminate the imbalance in the baseline characteristics of the high and l...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Dong-Dong Yang, Zhan-Hong Chen, De-Shen Wang, Hong-En Yu, Jia-Huan Lu, Rui-Hua Xu, Zhao-Lei Zeng Tags: Research Paper Source Type: research

Systematic analyses of genetic variants in chromatin interaction regions identified four novel lung cancer susceptibility loci
In this study, we integrated the chromatin interaction information (Hi-C data) of lung cancer cell line and conducted a meta-analysis with two Asian GWASs (7,127 cases and 6,818 controls) to evaluate the association of potentially functional SNPs in chromatin interaction regions with lung cancer risk. We identified four novel lung cancer susceptibility loci located at 1q21.1 (rs17160062, P=4.00×10-6), 2p23.3 (rs670343, P=4.87×10-7), 2p15 (rs9309336, P=3.24×10-6) and 17q21.2 (rs9252, P=1.51×10-5) that were significantly associated with lung cancer risk after correction for multiple tests. Functional ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Pei Ji, Dongsheng Ding, Na Qin, Cheng Wang, Meng Zhu, Yuancheng Li, Juncheng Dai, Guangfu Jin, Zhibin Hu, Hongbing Shen, Liang Chen, Hongxia Ma Tags: Research Paper Source Type: research

Diagnostic accuracy of photodynamic diagnosis with 5-aminolevulinic acid, hexaminolevulinate and narrow band imaging for non-muscle invasive bladder cancer
Conclusions: NBI appears to outperform 5-ALA and HAL in terms of diagnostic accuracy. All three modalities present high FPR, hence indicating the ability to detect additional cases and lesions beyond WLC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Changhao Chen, Hao Huang, Yue Zhao, Hao Liu, Yuming Luo, Richard J. Sylvester, Jia ping Li, Thomas B. Lam, Tianxin Lin, Jian Huang Tags: Research Paper Source Type: research

Androgen Receptor (AR)-TLR4 Crosstalk Mediates Gender Disparities in Hepatocellular Carcinoma Incidence and Progression
Conclusions: DHT-AR-TLR4 signaling enhances the development of HCC cells and facilitates their migration and invasion, demonstrating a mechanism underlying gender disparity in HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Qiuju Han, Dan Yang, Chunlai Yin, Jian Zhang Tags: Research Paper Source Type: research

Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models
Conclusions: Notably, the results suggested that 18F-FLT PET/CT could reflect the tumor boundaries more accurately than 18F-FDG PET/CT, MRI and CT, which makes 18F-FLT PET-CT more advantageous for the clinical delineation of the target volume in NPC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhang-Qiang Xiang, Saber Imani, Yue Hu, Rui-Lin Ding, Hao-Wen Pang, Yue Chen, Shao-Zhi Fu, Fang Xie, Wen-Feng He, Qing-Lian Wen Tags: Research Paper Source Type: research

Dihydroartemisinin suppresses bladder cancer cell invasion and migration by regulating KDM3A and p21
Emerging evidences have shown that Dihydroartemisinin (DHA), used in malaria treatment, possess anti-cancer activity. However, the study of its potential functional roles and the anti-cancer mechanisms in bladder cancer is limited. We performed this study to elucidate the influence of DHA in the biological behavior of bladder cancer cells and tried to explore the molecular mechanism. The results of CCK-8 assay showed that DHA significantly inhibited bladder cancer cell 5637, UMUC3 and T24 proliferation and the inhibitory effect is dose- and time- dependent. Further mechanism study showed that DHA performed its function via...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Tao Wang, Rongtuan Luo, Wei Li, Houyu Yan, Shunqiang Xie, Wen Xiao, Yongfeng Wang, Bin Chen, Peide Bai, Jinchun Xing Tags: Research Paper Source Type: research

Nicotinic-nAChR signaling mediates drug resistance in lung cancer
Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking is the most common risk factor for lung carcinoma; other risks include genetic factors and exposure to radon gas, asbestos, secondhand smoke, and air pollution. Nicotine, the primary addictive constituent of cigarettes, contributes to cancer progression through activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand-gated ion channels. Activation of nicotine/nAChR signaling is associated with lung cancer risk and drug resistance. We focused on nAChR pathways activated by nicotine and its downstream signaling involved i...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wan-Li Cheng, Kuan-Yuan Chen, Kang-Yun Lee, Po-Hao Feng, Sheng-Ming Wu Tags: Review Source Type: research

Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation
Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 expression and DSC prognosis.Methods: We conducted a meta-analysis to estimate the association strength between MMP-14 expression and prognosis. GEPIA and Kaplan Meier plotters were used to assess overall survival (OS), disease-free survival (DFS)/progression-free survival (PFS) in DSC patients and the differe...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fujiao Duan, Zhen Peng, Jingjing Yin, Zhongyu Yang, Jia Shang Tags: Research Paper Source Type: research

Overexpression of PPT2 Represses the Clear Cell Renal Cell Carcinoma Progression by Reducing Epithelial-to-mesenchymal Transition
In conclusion, PPT2 is downregulated in ccRCC. Decreased PPT2 expression may be considered as a novel diagnostic marker and prognostic factor and serve as a therapeutic target for ccRCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: ChangFei Yuan, ZhiYong Xiong, Jian Shi, JingTao Peng, XianGui Meng, Cheng Wang, WenJun Hu, ZeYuan Ru, KaiRu Xie, HongMei Yang, Ke Chen, XiaoPing Zhang Tags: Research Paper Source Type: research

Modulating cancer stemness provides luminal a breast cancer cells with HER2 positive-like features
This study contributes in providing an efficient multiplexing CRISPR/dCas9 system that enriches our genetic modulation tool box, and suggests that HER2 positive cells are potential progenitors of luminal A cells and that these two breast cancer subtypes may share similar treatment strategies once rewired between the two states. Our results also implicate that triple negative breast cancer cells, though sharing similar cancer stemness with HER2 positive cells, represent a distinct type of disease and require unique treatment solutions. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yi Mei, Dongyan Cai, Xiaofeng Dai Tags: Research Paper Source Type: research

Up-regulation of peroxiredoxin-1 promotes cell proliferation and metastasis and inhibits apoptosis in cervical cancer
Conclusions: PRDX1 promoted cell proliferation, migration, and invasion and suppressed apoptosis of cervical cancer possibly via regulating the expression of related protein. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ermei Lu, Xiaoli Hu, Chunyu Pan, Jingjing Chen, Yichi Xu, Xueqiong Zhu Tags: Research Paper Source Type: research

Enhanced expression of FCER1G predicts positive prognosis in multiple myeloma
Conclusions: The expression level of FCER1G negatively correlated with myeloma progression, and high FCER1G expression may be applied as a favorable biomarker in MM patients. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lin Fu, Zhiheng Cheng, Fen Dong, Liang Quan, Longzhen Cui, Yan Liu, Tiansheng Zeng, Wenhui Huang, Jinghong Chen, Ying Pang, Xu Ye, Guangsheng Wu, Tingting Qian, Yang Chen, Chaozeng Si Tags: Research Paper Source Type: research

Down-regulation of tissue factor inhibits invasion and metastasis of non-small cell lung cancer
Conclusion: Both in vivo and in vitro, the invasion and migration of NSCLC cells are suppressed by TF knockdown. TF has the potential to become an effective biomarker for the prediction of prognosis of patients with stage I-IV NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Qing Xia, Xu Zhang, Qianqian Chen, Xiangyun Chen, Junliang Teng, Changhui Wang, Ming Li, Lihong Fan Tags: Research Paper Source Type: research

Weighted gene co-expression network analysis identifies CCNA2 as a treatment target of prostate cancer through inhibiting cell cycle
In this study, the transcriptome data of prostate cancer on TCGA was analyzed by weighted gene co-expression network, and the gene with a significant correlation with disease Gleason stage and tumor T stage was identified: CCNA2. CCNA2 was significantly associated with biochemical recurrence, disease-free survival and overall survival rate of prostate cancer. The ability of cancer cell proliferation, invasion and metastasis was decreased after down-regulated expression of CCNA2 in prostate cancer cell lines. Flow cytometry revealed that tumor cells were arrested in the S phase after down-regulated the expression of CCNA2. ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Rui Yang, Yang Du, Lei Wang, Zhiyuan Chen, Xiuheng Liu Tags: Research Paper Source Type: research

Prognostic value of downregulated 5-hydroxymethylcytosine expression in renal cell carcinoma: a 10 year follow-up retrospective study
This study aimed to define the clinical significance of 5hmC in RCC. We performed dot blot assays to measure the relative expression of 5hmC in RCC. We reviewed the clinical records of 310 RCC patients and performed immunohistochemical (IHC) staining of 5hmC. The overall survival (OS) and cancer specific survival (CSS) of all patients were recorded over a 10-year follow-up period. Effective prognostic nomograms which contained 5hmC were established to provide individualized OS and CSS in RCC. 5hmC expression level was significantly decreased in RCC tissues compared with those in the normal counterparts. Kaplan-Meier curves...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Song Chen, Qiang Zhou, Tongzu Liu, Weibing Zhang, Xian-Tao Zeng, Zhongqiang Guo Tags: Research Paper Source Type: research

Proposal of predictive model on survival in unresectable pancreatic cancer receiving systemic chemotherapy
Aims: To construct a predictive model for overall survival (OS) in unresectable pancreatic cancer (PaC) undergoing systemic chemotherapy and to confirm its accuracy in an independent cohort.Patients and methods: The training set (Ts) and the validation set (Vs) included 93 patients (median age=71 years) and 75 patients (median age=76 years). In the Ts, we examined variables linked to OS by uni- and multivariate analyses and constructed a predictive model for OS. Next, we evaluated the reproducibility of the proposed model in the Vs.Results: In the multivariate analysis for the Ts, PaC stage IV (P=0.0020) and carbohydrate a...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Noriko Ishii, Hiroki Nishikawa, Yoshinori Iwata, Hirayuki Enomoto, Hironori Tanaka, Nobuyuki Katakami, Takashi Nishimura, Hiroko Iijima, Shuhei Nishiguchi Tags: Research Paper Source Type: research

Preventable lifestyle and eating habits associated with gastric adenocarcinoma: A case-control study
Conclusions: Education level, sleep quality, smoking, the frequencies of use of several foods and seasonings, the preference for specific tastes, and various eating and living habits were associated with GaC. The findings offer important hints for further prospective investigations and for easy effective GaC-preventative strategy-making. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lei Huang, Lei Chen, Zhong-Xuan Gui, Shun Liu, Zhi-Jian Wei, A-Man Xu Tags: Research Paper Source Type: research

TRIM67 Promotes the Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Positively Regulating the Notch Pathway
Tripartite motif-containing 67 (TRIM67), an E3 ubiquitin ligase, belongs to the TRIM protein family. The relationship between TRIM67 and tumorigenesis is not fully clear. Here, we elucidated TRIM67 function in non-small cell lung cancer (NSCLC). TRIM67 immunostaining results were correlated with clinicopathological features. Moreover, the function of TRIM67 in cultured NSCLC cells was evaluated by MTT, colony formation, and Transwell assays. TRIM67 expression was associated with tumor size, lymph node metastasis, p-TNM stage, cancer cell differentiation, and poor prognosis. We altered TRIM67 expression in A549 and H1299 ce...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jun Jiang, Hongjiu Ren, Yitong Xu, Muli Wudu, Qiongzi Wang, Zongang Liu, Hongbo Su, Xizi Jiang, Yao Zhang, Bo Zhang, Xueshan Qiu Tags: Research Paper Source Type: research

Antitumor functions and mechanisms of nitidine chloride in human cancers
Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell proliferation, stimulate apoptosis, and induce cell cycle arrest, retard migration, invasion and metastasis. Moreover, NC is reported to sensitize cancer cells to chemotherapeutic drugs. In this review article, we describe the functions of NC in human cancers and discuss the molecular insight into NC-involved antitumor feature. This revi...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yue Cui, Linhui Wu, Ruoxue Cao, Hui Xu, Jun Xia, Z Peter Wang, Jia Ma Tags: Review Source Type: research

LMP1 Up-regulates Calreticulin to Induce Epithelial-mesenchymal Transition via TGF- β /Smad3/NRP1 Pathway in Nasopharyngeal Carcinoma Cells
Conclusion: LMP1 induced cell EMT via TGF-β/Smad3/NRP1 pathway, which promoted migration and invasion of NPC cells. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Dongmei Ye, Junhui Zhu, Qiang Zhao, Wei Ma, Yiyang Xiao, Gaosheng Xu, Zhiwei Zhang Tags: Research Paper Source Type: research

Nicotine Upregulates the Level of Mcl-1 through STAT3 in H1299 Cells
Conclusions: We have demonstrated that nicotine induces up-regulation of Mcl-1 through STAT3, which process may be independent on JAKs and not only dependent on the phosphorylation of Y705. Downregulation of Mcl-1 transcription by inhibiting STAT3 cascade may be a potential strategy for the treatment of this cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Maojun Zhou, Jinfeng Zhao, Qi Zhang, Xin Jin, Mingmei Liao, Lihua Zhang, Jiwei Wang, Manyi Yang Tags: Research Paper Source Type: research

M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling
The roles of M2 macrophages on promoting tumor progression and chemotherapy resistance have been well studied in many cancers, such as pancreatic cancer, kidney cancer and so on, but its linkage to HCC cells still remains unclear. Here we found that M2 macrophages could alter miR-149-5p to increase MMP9 expression in HCC cells and mechanism dissection revealed that miR-149-5p might directly target the 3'UTR of MMP9-mRNA to suppress its translation. The in vivo orthotopic xenografts mouse model with oemiR-149-5p also validated in vitro data. Together, these findings suggest that M2 macrophages may through altering the miR-1...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Guodong Liu, Lei Yin, Xiwu Ouyang, Ke Zeng, Yao Xiao, Yixiong Li Tags: Research Paper Source Type: research

Identification of a Sixteen-gene Prognostic Biomarker for Lung Adenocarcinoma Using a Machine Learning Method
Conclusion: Based on the RSF model and clinically-integrated RNA-Seq data, we identified sixteen key genes that formed the prognostic gene expression signature. These sixteen key genes could achieve a strong power for prognostic prediction of LUAD patients in cohort II (HR = 3.80, p = 1.63e-06, C-index = 0.656), and were further validated in the GSE72094 cohort (HR = 4.12, p = 1.34e-10, C-index = 0.672) and GSE11969 cohort (HR = 3.87, p = 6.81e-07, C-index = 0.670). The experimental results of three independent validation cohorts showed that compared with the traditional Cox model and the use of standalone RNA-Seq data, th...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Baoshan Ma, Yao Geng, Fanyu Meng, Ge Yan, Fengju Song Tags: Research Paper Source Type: research

p62 Suppressed VK3-induced Oxidative Damage Through Keap1/Nrf2 Pathway In Human Ovarian Cancer Cells
Imbalance of redox homeostasis may be responsible for the resistance of cancer to chemotherapy. Currently, increasing studies demonstrated that vitamin K3 (VK3), which promoted the production of ROS, had potential to be developed as an anti-tumor agent. We found SKOV3/DDP cells with high levels of p62 were insensitive to VK3 compared with SKOV3 cells. Furthermore, Nrf2 downstream antioxidant genes such as HO-1(heme oxygenase 1) and NQO1 (NAD (P) H: quinone oxidoreductase 1) were upregulated in SKOV3/DDP cells with VK3 treatment, which indicated VK3 activated Nrf2 signaling in SKOV3/DDP cells. Moreover, co-localization of p...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Mei-hui Xia, Xiao-yu Yan, Lei Zhou, Long Xu, Li-chao Zhang, Hao-wei Yi, Jing Su Tags: Research Paper Source Type: research

Creating nanocrystallized chemotherapy: the differences in pressurized aerosol chemotherapy (PAC) via intracavitary (IAG) and extracavitary aerosol generation (EAG) regarding particle generation, morphology and structure
Conclusions: Under optimal conditions, the formation of nanocrystals via aerosol creation device is possible. While a wide range of possible applications of nanocrystals is conceivable, surface coating with drug particles is especially interesting as it may serve as an alternative to conventional liquid intraperitoneal chemotherapy. Further studies are required to investigate nanocrystallization of chemotherapeutic solutions as well as its physical and pharmacological properties and side effects. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Tanja Khosrawipour, Justyna Schubert, Joanna Kulas, Pawel Migdal, Mohamed Arafkas, Jacek Bania, Veria Khosrawipour Tags: Research Paper Source Type: research

MicroRNA-183 in Cancer Progression
MicroRNA-183(miR-183) is abnormally expressed in many kinds of tumors. It participates in the initiation and development of tumors. There are many pathways regulate the expression of miR-183. The action mechanism of miR-183 in cancer is very extensive, and contradictory conclusions are often drawn. It was upregulated in 18 kinds of cancer, downregulated in 6 kinds of cancer. In addition, there are seven types of cancer, both upregulated and downregulated reports can be found. Evidence showed that miR-183 can not only directly play the role of oncogene or antioncogene, but also regulate the expression of other oncogene or a...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Dingren Cao, Min Di, Jingjie Liang, Shuang Shi, Qiang Tan, Zhengguang Wang Tags: Review Source Type: research

Serum miR-1290 and miR-1246 as Potential Diagnostic Biomarkers of Human Pancreatic Cancer
This study was performed to screen and identify serum microRNAs (miRNAs) as noninvasive biomarkers for PC diagnosis.Methods: Two upregulated miRNAs were selected by integrated analysis of three independent GEO datasets. Then, the expressions of two miRNAs in serum were determined by quantitative reverse-transcription PCR among 120 PC patients, 40 benign disease controls and 40 healthy controls. The correlation between serum miRNAs and clinical characteristics was analyzed. The diagnostic utility of miRNAs was compared to CA19-9 using receiver operating characteristic curve analysis.Results: We discovered miR-1290 and miR-1...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jia Wei, Lu Yang, Yi-ning Wu, Jian Xu Tags: Research Paper Source Type: research

Gustave Roussy Immune Score (GRIm-Score) is a prognostic marker in patients with resectable esophageal squamous cell carcinoma
Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients with esophageal squamous cell carcinoma (ESCC) undergoing surgical resection.Methods: A retrospective single institutional study including 372 ESCC patients undergoing surgical resection was performed. The GRIm-Score was simply calculated by lactate dehydrogenase (LDH), neutrophil lymphocyte ratio (NLR) and album...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ji-Feng Feng, Liang Wang, Xun Yang, Sheng Chen Tags: Research Paper Source Type: research

Outcomes after Treatment of Metaplastic Versus Other Breast Cancer Subtypes
Purpose: Metaplastic breast cancer (BC) is an uncommon yet aggressive histologic subtype of BC. We sought to identify factors associated with its diagnosis and compare the management and outcomes of metaplastic BC with those of other BCs and triple negative invasive ductal carcinoma in particular given how often it has a triple negative phenotype.Patients and Methods: We identified women diagnosed with invasive BC in 2010-2014 in the National Cancer Data Base, and used univariate analysis to compare baseline patient and tumor characteristics by BC subtype. Overall survival (OS) was estimated with the Kaplan-Meier method, a...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Amy C. Moreno, Yan Heather Lin, Isabelle Bedrosian, Yu Shen, Gildy V. Babiera, Simona F. Shaitelman Tags: Research Paper Source Type: research

High level of RNF187 contributes to the progression and drug resistance of osteosarcoma
Conclusions: Our results indicate that Elevated RNF187 expression is a new adverse outcomes marker for OS patients and may be used as a new therapeutic target of OS. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wen-Bing Wan, Kai Wu, Kun Peng, Zhi-Qiang Qiu, Zhi-Bin Duan, Xiang Chen, Ze-Min Xu, Ke Cheng, Jiang-Ming-Hao Zhao, Qing-Ming Shi Tags: Research Paper Source Type: research

The RNA-binding protein QKI suppresses tumorigenesis of clear cell renal cell carcinoma by regulating the expression of HIF-1 α
Conclusions: QKI may be useful as a novel, independent diagnostic and biological marker for ccRCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fei Shi, Di Wei, Zheng Zhu, Fei Yan, Fuli Wang, Keke Zhang, Xi'an Li, Yu Zheng, Jiarui Yuan, Zifan Lu, Jianlin Yuan Tags: Research Paper Source Type: research

Practice of the New Integrated Molecular Diagnostics in Gliomas: Experiences and New Findings in a Single Chinese Center
Conclusion: We detected the newly recommended markers in a large cohort of Chinese glioma patients. Our data demonstrated a relatively lower frequency of IDH mutations and a higher prevalence of triple-negative glioma in Chinese compared with American and European, indicating ethnic and geographical difference in some markers. In addition, the new molecular phenotype “IDH wildtype and 1p/19q codeletion” glioma deserved special focus. These findings suggest that further stratification of infiltrating gliomas is needed for different treatment strategy and precision medicine. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wan-Ming Hu, Fang Wang, Shao-Yan Xi, Xiao Zhang, Jun-Peng Lai, Hui-Yu Wu, Li-Ling Liu, Ke Sai, Jing Zeng Tags: Research Paper Source Type: research

Long non-coding RNA TCL6 enhances preferential toxicity of paclitaxel to renal cell carcinoma cells
Conclusions: TCL6 effectively sensitizes RCC to PTX mainly through downregulation of miR-221. Our results suggest that PTX combined with TCL6 might be a potentially more effective chemotherapeutic approach for renal cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhizhao Chen, Quan Zhuang, Ke Cheng, Yingzi Ming, Yujun Zhao, Qifa Ye, Sheng Zhang Tags: Research Paper Source Type: research

Identification of key genes and pathways associated with esophageal squamous cell carcinoma development based on weighted gene correlation network analysis
Discussion: Differentially expressed genes and key modules contributing to initiation and progression in ESCC were identified by WGCNA. These findings provide novel insights into the mechanisms underlying the initiation, prognosis and treatment of ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Mingrui Shao, Wenya Li, Shiyang Wang, Zhenghua Liu Tags: Research Paper Source Type: research

The Molecular Mechanism of Metabolic Remodeling in Lung Cancer
Metabolic remodeling is a key phenomenon in the occurrence and development of tumors. It not only offers materials and energy for the survival and proliferation of tumor cells, but also protects tumor cells so that they may survive, proliferate and transfer in the harsh microenvironment. This paper attempts to reveal the role of abnormal metabolism in the development of lung cancer by considering the processes of glycolysis and lipid metabolism, Identification of the molecules that are specifically used in the processes of glycolysis and lipid metabolism, and their underlying molecular mechanisms, is of great clinical and ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ligong Chang, Surong Fang, Wei Gu Tags: Review Source Type: research

Downregulation of EVI1 Expression Inhibits Cell Proliferation and Induces Apoptosis in Hilar Cholangiocarcinoma via the PTEN/AKT Signalling Pathway
Conclusion: Our data revealed that EVI1 played important roles in HCCA tumourigenesis and development. Our findings suggest that EVI1 may be a potentially useful therapeutic target in HCCA. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiao-ming Zhang, Zeng-li Liu, Bo Qiu, Yun-fei XU, Chang Pan, Zong-li Zhang Tags: Research Paper Source Type: research

The microRNA212 regulated PEA15 promotes ovarian cancer progression by inhibiting of apoptosis
In conclusion, our findings revealed PEA15 appears as a novel predictive biomarker, thus providing a valuable therapeutic target in OC treatment strategy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yonghong Luo, Chuanchuan Fang, Lan Jin, Huafeng Ding, Yuanyuan Lyu, Guantai Ni Tags: Research Paper Source Type: research

Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma
Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC patients. However, during EC patients follow-up, we found that some EC patients with down-regulation of PTEN, but up-regulation of ER or PR , and some EC patients with down-regulation of ER or PR, but up-regulation of PTEN also had a poor prognosis. Therefore, to reveal the prognosis of EC patients with different...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yanfang Liang, Bihua Lin, Ziyu Ye, Shasha Chen, Haibo Yu, Can Chen, Xin Zhang, Keyuan Zhou, Jincheng Zeng Tags: Research Paper Source Type: research

The miR-34 family and its clinical significance in ovarian cancer
The tumor suppressor miR-34 family is transcriptionally induced by p53. Clinical significance of the various miR-34 family members has not been studied in ovarian cancer. In 228 ovarian cancers and in 19 non-neoplastic fallopian tube samples we analysed miR-34 a/b/c expression in relation to clinicopathological characteristics and clinical outcome. We found significantly lower levels of miR-34 a/b/c in ovarian cancers as compared to control-tissues (P=0.002, P
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hannah Welponer, Irina Tsibulak, Verena Wieser, Christine Degasper, Giridhar Shivalingaiah, S ö ren Wenzel, Susanne Sprung, Christian Marth, Hubert Hackl, Heidelinde Fiegl, Alain G. Zeimet Tags: Research Paper Source Type: research

p16 promotes proliferation in cervical carcinoma cells through CDK6-HuR-IL1A axis
In conclusion, p16 promotes proliferation in cervical carcinoma cells through CDK6-HuR-IL1A axis. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Mingzhe Li, Jiong Yang, Kaiyu Liu, Jianming Yang, Xiangwen Zhan, Le Wang, Xiaomeng Shen, Jing Chen, Zebin Mao Tags: Research Paper Source Type: research

LncRNA00518 promotes cell proliferation through regulating miR-101 in bladder cancer
The purpose of our study is to elucidate the expression of lncRNA00518 (lnc00518) in the bladder cancer, and its potential mechanism in regulating the development of bladder cancer. The expression of lnc00518 in bladder cancer tissues and cells was examined by qRT-PCR. Correlation between lnc00518 expression with clinicopathologic characteristics and prognosis of bladder cancer patients was analyzed. In vitro effects of lnc00518 on the cellular behaviors of bladder cancer cells were explored. Moreover, in vivo effect of lnc00518 was evaluated by subcutaneous tumorigenesis in nude mice. The possible miRNA targets of lnc0051...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Kunpeng Wang, Long Ma, Jingyuan Tang, Qiu Yu, Yang Shen, Yunfei Wei, Chen Zhu, Zhonglei Deng, Wei Zhang Tags: Research Paper Source Type: research

Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications
Background: Cytochrome P-450 4A11 (CYP4A11) and peroxisome proliferator-activated receptor-α (PPARα) are expressed at high levels in renal proximal tubules, and upregulation of CYP4A11 protein levels is known to be influenced by PPAR agonists. The goal of this study was to evaluate the clinicopathological role of CYP4A11 expression in renal cell carcinoma (RCC).Methods: We performed immunohistochemical analysis of CYP4A11, CYP4A22 and PPARα and correlated the results with the clinicopathological features of RCC (n=139). Reverse transcription digital droplet polymerase chain reaction (RT-ddPCR) against CYP...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Sup Kim, Jin Man Kim, Hyo Jin Lee, Jae Sung Lim, In-Ock Seong, Kyung-Hee Kim Tags: Research Paper Source Type: research

LRG1 Suppresses Migration and Invasion of Esophageal Squamous Cell Carcinoma by Modulating Epithelial to Mesenchymal Transition
Conclusion/Significance: LRG1 suppresses ESCC cell migration and invasion via negative modulation of TGFβ signaling and EMT. Down-regulation of LRG1 in ESCC patients may favor tumor metastasis and disease progression. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ninggang Zhang, Yaqiong Ren, Yusheng Wang, Lei Zhao, Bin Wang, Nina Ma, Zhengxing Gao, Bangwei Cao Tags: Research Paper Source Type: research