Consumption of sugar-sweetened beverages and fruit juice and human cancer: a systematic review and dose-response meta-analysis of observational studies
Conclusions: Our findings suggest the consumption of sugary beverages may increase the risk and mortality of cancer, especially risk of breast cancer, hepatocellular carcinoma, colorectal cancer, and prostatic cancer, and mortality of breast cancer, though the evidence was limited. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yuting Li, Lilianagzi Guo, Kaiyin He, Changbing Huang, Shaohui Tang Tags: Research Paper Source Type: research
Changes of Body Mass Index and Body Shape in relation to risk of Gastric Cancer: A population-based case-control study
Conclusion: The association between body fatness and GC risk might differ by time point of measurement and Hp-infection status. Further, the influence of changes of body fatness might be different by baseline body fatness and Hp-infection status. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xiaolin Yin, Xiaorong Yang, Tongchao Zhang, Ziyu Yuan, Hui Chen, Li Jin, Xingdong Chen, Ming Lu, Weimin Ye Tags: Research Paper Source Type: research
Highly deregulated lncRNA LOC is associated with overall worse prognosis in Hepatocellular Carcinoma patients
Although numerous long non-coding RNAs (lncRNAs) were reported to be deregulated in Hepatocellular Carcinoma (HCC), experimentally characterized, and/or associated with patient's clinical characteristics, there is, thus far, minimal concerted research strategy to identify deregulated lncRNAs that modulate prognosis of HCC patients. Here, we present a novel strategy where we identify lncRNAs, which are not only de-regulated in HCC patients, but are also associated with pertinent clinical characteristics, potentially contributing to the prognosis of HCC patients. LOC101926913 (LOC) was further characterized because it is the...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Lee Jin Lim, Lay Hiang Ling, Yu Pei Neo, Alexander Y.F. Chung, Brian K.P. Goh, Pierce K.H. Chow, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Tony K.H. Lim, Samuel S. Chong, London L. P. J. Ooi, Caroline G. Lee Tags: Research Paper Source Type: research
Describing Treatment Patterns for Elderly Patients with Intrahepatic Cholangiocarcinoma and Predicting Prognosis by a Validated Model: A Population-Based Study
Conclusion: Active treatment should not be abandoned among all the elderly patients with ICC. The validated nomogram provided an effective and practical tool to accurately evaluate prognosis and to guide personalized treatment for elderly ICC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hanlong Zhu, Kun Ji, Wei Wu, Si Zhao, Jian Zhou, Chunmei Zhang, Ruiyi Tang, Lin Miao Tags: Research Paper Source Type: research
The natural compound n-butylidenephthalide kills high-grade serous ovarian cancer stem cells by activating intrinsic apoptosis signaling pathways
In conclusion, BP could kill ALDH+ CSCs of HGSOC in vitro and in vivo by inducing apoptosis. BP may provide a new therapeutic approach for HGSOC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yu-Hsun Chang, Kun-Chi Wu, Dah-Ching Ding Tags: Research Paper Source Type: research
Association Between Smoking And Cancers Among Women: Results From The FRiCaM Multisite Cohort Study
Conclusions: Our results thus demonstrate how smoke exposure increases the risk of several types of cancer. Considering the increasing prevalence of smoking among women, our results highlight the need to prioritize the development of anti-smoking campaigns targeted at women in order to contrast the evident gender inequality with respect to healthcare. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Angelo Giosu รจ Mezzoiuso, Anna Odone, Carlo Signorelli, Antonio Giampiero Russo Tags: Research Paper Source Type: research
CDC37L1 acts as a suppressor of migration and proliferation in gastric cancer by down-regulating CDK6
This study aimed to explore the expression and function of CDC37L1 in gastric cancer (GC). The immunohistochemical staining in a tissue microarray showed a weak expression of CDC37L1 in high grade GC tissues compared with low grade tissues. Consistently, data from online database analysis demonstrated that CDC37L1 level was decreased in stage 4 patients and low expression of CDC37L1 indicated a poor prognosis. Functional studies revealed that CDC37L1 could inhibit GC cell proliferation and migration in CCK8, EdU incorporation, colony formation and transwell assays. In the meantime, CDC37L1 also inhibited the tumorigenicity...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Li Li, Xinyi Tao, Yandong Li, Yong Gao, Qinchuan Li Tags: Research Paper Source Type: research
MiRNA-202-5p promotes Colorectal Carcinogenesis through suppression of PTEN
Colorectal cancer (CRC) is still one of the leading causes of cancer-associated death in the modern society. The biological function of miR-202-5p for CRC development remains controversial, largely due to the fact that miR-202-5p can be tumor-suppressive or oncogenic in different contexts. Obtained results indicated that aberrant expression of miR-202-5p was observed in majority of human CRC samples and miR-202-5p was transcriptionally up-regulated by c-Myc. In addition, miR-202-5p functions to promote the activation of PI3K/Akt signaling pathway by directly suppressing PTEN. Silencing or enforced expression of miR-202-5p ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jing Huang, Yaqin Zhang, Yuan Xu, Qi Xie, Shuang Wu, Yi Dong, Bing Chen, Yang Xia, Lili Guo, Qun Li, Hao Gu, Wanglai Hu Tags: Research Paper Source Type: research
Signature of gene aberrant alternative splicing events in pancreatic adenocarcinoma prognosis
Alternative splicing (AS), as an effective and universal mechanism of transcriptional regulation, is involved in the development and progression of cancer. Therefore, systematic analysis of alternative splicing in pancreatic adenocarcinoma (PAAD) is warranted. The corresponding clinical information of the RNA-Seq data and PAAD cohort was downloaded from the TCGA data portal. Then, a java application, SpliceSeq, was used to evaluate the RNA splicing pattern and calculate the splicing percentage index (PSI). Differentially expressed AS events (DEAS) were identified based on PSI values between PAAD cancer samples and normal s...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jun Yao, Yu-Chen Tang, Bin Yi, Jian Yang, Yun Chai, Ni Yin, Zi-Xiang Zhang, Yi-Jun Wei, De-Chun Li, Jian Zhou Tags: Research Paper Source Type: research
Adjuvant Radiotherapy of Involved Field versus Elective Lymph Node in Patients with Operable Esophageal Squamous Cell Cancer: A Single Institution Prospective Randomized Controlled Study
Conclusions: The results indicated that IFI tended to improve survival and reduce toxicities for patients with operative ESCC and did not increase locoregional failure compared to ENI. It is thus suggested that IFI for ESCC PORT is worthy of clinical recommendation and further study. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ruifeng Liu, Xueliang Zhang, Qiuning Zhang, Hongtao Luo, Shihong Wei, Tingting Liu, Shilong Sun, Zhiqiang Liu, Zheng Li, Jinhui Tian, Xiaohu Wang Tags: Research Paper Source Type: research
Serum metabolomics analysis for the progression of esophageal squamous cell carcinoma
CONCLUSIONS: These results demonstrated that serum metabolites are associated with the progression of ESCC. These metabolites are capable of potential biomarkers for the risk prediction and early detection of ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xia Li, Lihong Zhao, Mengke Wei, Jiali Lv, Yawen Sun, Xiaotao Shen, Deli Zhao, Fuzhong Xue, Tao Zhang, Jialin Wang Tags: Research Paper Source Type: research
Overexpression of ZNF460 predicts worse survival and promotes metastasis through JAK2/STAT3 signaling pathway in patient with colon cancer
In this study, we found that the expression of ZNF460 protein were markedly increased in clinical colon cancer tissues compared with para-cancer non-cancerous tissues by tissue immunohistochemistry (IHC) and western blot (WB). We also confirmed this result at the mRNA and protein levels of ZNF460 through bioinformatics analysis. In addition, high expression of ZNF460 was correlated with increased depth of invasion (P<0.05), increased lymph node metastasis (P<0.05), distant metastasis (P<0.05) and high blood serum CA19-9 level (P<0.05). High expression of ZNF460 predicted poor overall survival (OS) and recur...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Tengfei Hao, Jiannan Xu, Sufen Fang, Jianlong Jiang, Xinyuan Chen, Wenhui Wu, Liang Li, Mingzhe Li, Changhua Zhang, Yulong He Tags: Research Paper Source Type: research
Longnon-coding RNA BLACAT2 promotes gastric cancer progression via the miR-193b-5p/METTL3 pathway
Gastric cancer is one of the leading prevalent and malignant cancers worldwide, especially in east Asia. However, the in-depth molecular mechanism underlying gastric cancer progression remains uncertain. Recently, studies have identified that long non-coding RNA (lncRNA) could play critical roles in the tumorigenesis of multiple types of cancer. Studies on long non-coding RNA BLACAT2 have proven that it participates in bladder cancer and colorectal cancer regulation and was identified as highly expressed using the cBioPortal for Cancer Genomics in gastric cancer. However, the precise function of lncRNA-BLACAT2 in the carci...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Hao Hu, Qi Kong, Xiao-xu Huang, Hao-ran Zhang, Kai-feng Hu, Yan Jing, Yang-fan Jiang, Yue Peng, Long-chao Wu, Qi-sheng Fu, Li Xu, Ya-bin Xia Tags: Research Paper Source Type: research
Targeted Sequencing Analysis of Predominant Histological Subtypes in Resected Stage I Invasive Lung Adenocarcinoma
Conclusions: We revealed distinctive mutation landscape of the 5 major histological subtypes of LADC, evident by distinctive average mutation rate with SPA and LPA having the highest and lowest average mutation rate, respectively. SPA patients showed higher mutation rate of LRP1B and higher rates for PD-L1 positivity, indicating that SPA patients may have better response to immunotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yan Li, Yan Tan, Song Hu, Jun Xie, Zhantao Yan, Xian Zhang, Yun Zong, Han Han-Zhang, Qing Li, Chong Li Tags: Research Paper Source Type: research
Clinical diagnostic values of transfer RNA-derived fragment tRF-19-3L7L73JD and its effects on the growth of gastric cancer cells
Conclusion: The results suggest that tRF-19-3L7L73JD may be useful as a biomarker of gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yijing Shen, Yaoyao Xie, Xiuchong Yu, Shuangshuang Zhang, Qiuyan Wen, Guoliang Ye, Junming Guo Tags: Research Paper Source Type: research
