Resection versus Resection with Preoperative Transcatheter Arterial Chemoembolization for Resectable Hepatocellular Carcinoma Recurrence
The value of preoperative transcatheter arterial chemoembolization (TACE) for patients with recurrent hepatocellular carcinoma (rHCC) after liver resection is uncertain. We aimed to determine its effect on postoperative complication and survival. There were 33 patients who received preoperative TACE and repeated liver resection (TACE-LR) and 119 patients who received repeated liver resection (LR) alone for rHCC. Seventy-eight patients (TACE-LR, 28; LR, 50) were identified by propensity score matching (PSM) analysis for comparison of postoperative complication, disease-free survival (DFS) and overall survival (OS). Univaria...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qiang Tao, Wei He, Binkui Li, Yun Zheng, Ruhai Zou, Jingxian Shen, Wenwu Liu, Yuanping Zhang, Yunfei Yuan Tags: Research Paper Source Type: research

Polymorphisms in ERCC2 and ERCC5 and Risk of Prostate Cancer: A Meta-Analysis and Systematic Review
This study aimed to obtain the overall profile regarding the associations between ERCCs polymorphisms and PCa risk.Materials and Methods: We identified relevant studies by a systematic search of PubMed, Medline, Embase, Google Scholar databases, Web of Science and Wanfang databases up to April 8, 2018. Odds ratios (ORs) with 95% confidential intervals (95%CIs) were conducted to evaluate the associations. All the statistical analyses were conducted basing on STATA 12.0 software.Results: Finally, a total of 29 previous studies published in 17 publications were included for four polymorphisms in two DNA repair genes (ERCC2-rs...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yi Liu, Yonghui Hu, Meng Zhang, Runze Jiang, Chaozhao Liang Tags: Research Paper Source Type: research

Multiple Primary Malignant Tumors - A Clinical Analysis of 15,321 Patients with Malignancies at a Single Center in China
Conclusions: The early diagnosis of rare MPMTs should not be neglected in patients not only when treated for a primary malignancy but also during long-term follow-up. Effective treatment for MPMTs may yield promising curative effect and warrants further investigation. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chongya Zhai, Yulan Cai, Fang Lou, Zhen Liu, Jiansheng Xie, Xiaoyun Zhou, Zhanggui Wang, Yong Fang, Hongming Pan, Weidong Han Tags: Research Paper Source Type: research

Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China
Conclusions: This is one of the largest studies of HPV genotyping for women with CIN2/3 in China. The prevalence and distribution of HPV genotypes in these Chinese women differed from those in women from Western countries. Our results provide important information for developing specific HPV vaccines for Chinese women. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhilian Wang, Zaibo Li, Jing Li, Chen Wang, Wenhao Wang, Min Hao, Chengquan Zhao Tags: Research Paper Source Type: research

MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma
In conclusion, our study demonstrated that MT1G acts as a tumor suppressor gene in HCC development, but its clinical potential in HCC requires further evaluation. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ju-deng Zeng, Ning Zhang, Gui-jun Zhao, Li-xia Xu, Yang Yang, Xiao-yi Xu, Meng-ke Chen, Hui-yun Wang, Steven Xiao-feng Zheng, Xiao-xing Li Tags: Research Paper Source Type: research

Diagnostic accuracy of frozen section analysis of borderline ovarian tumors: a meta-analysis with emphasis on misdiagnosis factors
Objective: First, to evaluate the sensitivity and positive predictive value (PPV) of intra-operative frozen section (FS) diagnosis in borderline ovarian tumors (BOTs), and to explore the factors affecting the diagnostic accuracy. Second, to assess the clinical outcomes of misdiagnosed BOT patients.Methods: We performed a retrospective study of all patients diagnosed as BOT through FS or paraffin section (PS) at Qilu Hospital between January 2005 and December 2015. Clinical and pathologic data were extracted. Univariate analysis was performed using standard two-sided statistical tests. We also performed a meta-analysis to f...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhen Huang, Li Li, ChengCheng Li, Samuel Ngaujah, Shu Yao, Ran Chu, Lin Xie, XingSheng Yang, Xiangning Zhang, Peishu Liu, Jie Jiang, Youzhong Zhang, Baoxia Cui, Kun Song, Beihua Kong Tags: Research Paper Source Type: research

Phosphorylation of the Cytoskeletal Protein CAP1 Regulates Non-Small Cell Lung Cancer Survival and Proliferation by GSK3 β
Adenylate cyclase-associated protein 1 (CAP1) is an evolutionarily conserved protein that regulates actin dynamics. Our previous study indicates that CAP1 is overexpressed in NSCLC tissues and correlated with poor clinical outcomes. Further establishing the role and dissecting underlying mechanisms are imperative before targeting CAP1 can become a possibility for cancer treatment. Here we report our findings that knockdown of CAP1 inhibited cell proliferation and induced apoptosis in vitro and in vivo. Moreover, phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both the invasivene...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shuanshuan Xie, Yang Liu, Xuan Li, Min Tan, Changhui Wang, Jeffrey Field, Guo-Lei Zhou Tags: Research Paper Source Type: research

Upregulated Expression of Long Non-Coding RNA, LINC00460, Suppresses Proliferation of Colorectal Cancer.
Through bioinformatics analysis, a novel lncRNA, LINC00460, was implicated in the development of multiple cancers. However, the precise expression pattern, clinical significance and biological function of LINC00460 in colorectal cancer (CRC) remain unknown. Network databases were used to investigate the correlation between LINC00460 and CRC. In situ hybridization was performed to verify the precise expression pattern and clinical significance of LINC00460 in a CRC tissue microarray, which included 92 pairs of CRC and adjacent normal tissues. The effect of LINC00460 on proliferation was evaluated by MTT, colony formation as...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xin Wang, Fong-Ming Mo, Hao Bo, Lei Xiao, Guan-Yang Chen, Peng-Wei Zeng, Yan-Ning Huang, Zhuo Lei, Wei-Jie Yuan, Zi-Hua Chen Tags: Research Paper Source Type: research

Additional Cervical Lymph Node Biopsy is Not a Significant Prognostic Factor for Nasopharyngeal Carcinoma in the Intensity-Modulated Radiation Therapy Era: A Propensity Score-matched Analysis from an Epidemic Area
Conclusions: Pretreatment cervical lymph node biopsy is not associated with impaired survival in NPC, suggesting the resist of the biopsy and more aggressive treatment after the biopsy may be unnecessary. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xing-Li Yang, Yan Wang, Yong Bao, Shao-Bo Liang, Sha-Sha He, Dan-Ming Chen, Hai-Yang Chen, Li-Xia Lu, Yong Chen Tags: Research Paper Source Type: research

The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma
Epstein-Barr virus (EBV) is an oncogenic herpes virus that is closely associated with the initiation and development of nasopharyngeal carcinoma (NPC), lymphoma and other malignant tumors. EBV encodes 44 mature miRNAs that regulate viral and host cell gene expression and plays a variety of roles in biological functions and the development of cancer. In this review, we summarized the biological functions and molecular mechanisms of Epstein-Barr virus-encoded microRNAs (EBV miRNAs) in tumor immune evasion, proliferation, anti-apoptosis, invasion, metastasis and as a potential biomarker for NPC diagnosis and prognosis. The kn...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chunmei Fan, Yanyan Tang, Jinpeng Wang, Fang Xiong, Can Guo, Yumin Wang, Bo Xiang, Ming Zhou, Xiayu Li, Xu Wu, Yong Li, Xiaoling Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng Tags: Review Source Type: research

Relationship between the Methylation of Folic Acid Metabolism-Related Genes and the Incidence and Prognosis of Esophageal Cancer among Ethnic Kazakhs
Objective: To investigate the relationship between the hypermethylation of folic acid metabolism-related genes and the incidence and prognosis of esophageal cancer among ethnic Kazakhs in Xinjiang (China).Methods: According to the standard of esophageal cancer diagnosis, exclusion and epidemiological investigation of the experimental and control groups. Ion capture immunoassays were used to measure serum folic acid levels, while methylation-specific polymerase chain reaction was used to detect gene promoter methylation levels. Log-rank tests and Cox regression models were used to identify prognostic factors in the patient ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yin Dong, Xu Yi, Zhen Yujie, Zhang Huixia, Chen Yan Tags: Research Paper Source Type: research

Diagnostic and Prognostic Value of Circulating MicroRNAs for Esophageal Squamous Cell Carcinoma: a Systematic Review and Meta-analysis
Conclusions: Circulating microRNAs distinguish patients with ESCC from healthy controls with high sensitivity and specificity, compared to other invasive currently used screening methods. Simultaneously, there was prognostic value for the prognosis of ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Can Yao, Hai-Ning Liu, Hao Wu, Yan-Jie Chen, Yu Li, Ying Fang, Xi-Zhong Shen, Tao-Tao Liu Tags: Research Paper Source Type: research

Different Risk Profiles for the Postsurgical Prognosis of Gastric Cancer Patients with Different Blood Types: The FIESTA Study
Conclusions: Our findings indicated that the prognostic factors differed between postsurgical gastric cancer patients with “O+” and “O-” blood types. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Guohui Fan, Dan Hu, Feng Peng, Guodong Xu, Xiandong Lin, Binying Liang, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu Tags: Research Paper Source Type: research

Clinicopathological and prognostic significance of leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) in malignant tumors: A meta-analysis
Conclusions: LRIG1 expression was associated with a good prognosis in terms of overall survival (OS) and might act as a predictive factor for characteristics of cancer patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qianqian Zhang, Wenhua Shi, Qingting Wang, Yanting Zhu, Cui Zhai, Jian Wang, Xin Yan, Limin Chai, Manxiang Li Tags: Research Paper Source Type: research

Pemetrexed Monotherapy as Salvage Treatment in Patients with Metastatic Colorectal Cancer Refractory to Standard Chemotherapy: A Phase II Single-arm Prospective Trial
Conclusions: Pemetrexed monotherapy showed moderate disease control and acceptable toxicity profile as salvage therapy for refractory CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Sung Won Lim, Sujin Lee, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Seung Tae Kim Tags: Research Paper Source Type: research

Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction
Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the patients with PDAC. However, PDAC is also considered to owe its intractability to other critical factors such as cellular interaction between tumor cells and tumor microenvironment as well as architectural barriers, which increases in therapeutic resistance. Here, we report a specific cellular interaction bet...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ken Saito, Masakiyo Sakaguchi, Satoshi Maruyama, Hidekazu Iioka, Endy Widya Putranto, I Wayan Sumardika, Nahoko Tomonobu, Takashi Kawasaki, Keiichi Homma, Eisaku Kondo Tags: Research Paper Source Type: research

Clinicopathologic characteristics and survival outcome in patients with advanced lung adenocarcinoma and KRAS mutation
Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are one of the most common observed genetic events in lung adenocarcinoma. The present study aimed to characterize treatment patterns and to estimate survival for patients in China with advanced lung adenocarcinoma and KRAS mutation. We identified KRAS-mutant lung adenocarcinoma between February 2013 and June 2017 in Zhejiang Cancer Hospital. Patients' characteristics and treatment outcomes were analyzed. A total of 159 lung adenocarcinoma were included, and 26 (16.4%) patients harbored KRAS mutations. Compared to KRAS-wild patients, patients with KRAS-mutant tumo...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Shifeng Yang, Xinmin Yu, Yun Fan, Xun Shi, Ying Jin Tags: Research Paper Source Type: research

PD-L1 Expression Correlates With Tumor Infiltrating Lymphocytes And Response To Neoadjuvant Chemotherapy In Cervical Cancer
Programmed death-ligand 1 (PD-L1) has been reported to be expressed in many types of tumor cells, and bind to PD-1 on T lymphocytes to inhibit immune response. Immunologic checkpoint blockade with antibodies that target the PD1/PD-L1 pathway has demonstrated to have impressive antitumor effects on many malignancies. However, the significance of PD1/PD-L1 pathway in cervical cancer remains unclear. Here we studied PD-L1, PD-1, CD8 and HPV expression in cervical cancer and normal cervix by immunohistochemical staining. Our results showed that there was more frequently positive for PD-L1, PD-1 and CD8 in cervical cancer tissu...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ying Meng, Huyi Liang, Jianguo Hu, Shuaibin Liu, Xiaoming Hao, Micheal Sze Ka Wong, Xiaoyi Li, Lina Hu Tags: Research Paper Source Type: research

The preliminary application of liver imaging reporting and data system (LI-RADS) with contrast-enhanced ultrasound (CEUS) on small hepatic nodules ( ≤   2cm)
To evaluate the diagnostic accuracy of liver imaging reporting and data system (LI-RADS) with contrast-enhanced ultrasound (CEUS) for patients at risk for hepatocellular carcinoma with hepatic nodules (≤2cm). We retrospectively evaluated 56 CEUS exam records of hepatic nodules (≤2cm) performed between January 2015 and July 2016 at West China hospital. Each nodule was classified into a LI-RADS-CEUS category by two radiologists according to imaging features. The ultimate CEUS categories were then compared with pathological reports and their correlation was then calculated. Inter-observer agreement for LI-RADS between r...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wenwu Ling, Manni Wang, Xuelei Ma, Tingting Qiu, Jiawu Li, Qiang Lu, Yan Luo Tags: Research Paper Source Type: research

The inhibitory effects of COL1A2 on colorectal cancer cell proliferation, migration, and invasion
Conclusions: Our study identified COL1A2 as a novel tumor suppressor in CRC and provided a potential therapeutic approach to treat CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yifan Yu, Dongliang Liu, Zhenghao Liu, Shuqiang Li, Yang Ge, Wei Sun, Baolin Liu Tags: Research Paper Source Type: research

ESR1 PvuII (rs2234693 T > C) polymorphism and cancer susceptibility: Evidence from 80 studies
Emerging epidemiological researches have been performed to assess the association of ESR1 PvuII (rs2234693 T>C) polymorphism with the risk of cancer, yet with conflicting conclusions. Therefore, this updated meta-analysis was performed to make a more accurate evaluation of such relationship. We adopted EMBASE, PubMed, CNKI, and WANFANG database to search relevant literature before January 2018. Odds ratios (ORs) and 95% confidence intervals (CIs) were employed to estimate the relationship strengths. In final, 80 studies (69 publications) involving 26428 cases and 43381 controls were enrolled. Our results failed to provi...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiaoqi Liu, Jiawen Huang, Huiran Lin, Lingjuan Xiong, Yunzi Ma, Haiyan Lao Tags: Review Source Type: research

Molecular analysis of gastric cancer identifies genomic markers of drug sensitivity in Asian gastric cancer
Discussion: A novel group of chemo-sensitivity related genes provided new therapeutic strategies to overcome the development and evolution of resistance to cancer chemotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qin Yang, Chunchao Zhu, Yanli Zhang, Yangyang Wang, Yahui Wang, Lei Zhu, Xiaomei Yang, Jun Li, Huizhen Nie, Shuheng Jiang, Xiaoxin Zhang, Xiaoyan Cao, Qing Li, Xueli Zhang, Guangang Tian, Lipeng Hu, Lili Zhu, Gang Zhao, Zhigang Zhang Tags: Research Paper Source Type: research

A comprehensive look at the role of hyperlipidemia in promoting colorectal cancer liver metastasis
In this study, we provide a comprehensive overview of the role that hyperlipidemia played in CRC metastasis to help reduce the mortality associated with CRC metastasis from the standpoint of metabolic. We also review cancer metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yimin Shen, Caihua Wang, Yuezhong Ren, Jun Ye Tags: Review Source Type: research

Impact of menopausal status and HER-2/neu protein on efficacy of EGFR-TKI in EGFR mutant patients with non-small cell lung cancer
Clinical studies have confirmed epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) used in lung cancer patients with EGFR mutations can obtain a better result, but still part of the patients with poor efficacy. EGFR mutation is highly related to female, nonsmoking and adenocarcinoma. Thus, we hypothesize that estrogen and circulating HER-2/neu protein might influence the efficacy of EGFR-TKIs in EGFR mutant patients with non-small cell lung cancer. HER-2/neu expression level of 357 eligible patients in its peripheral serum was determined using ELISA. The median progression-free survival (PFS) in five...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zi-Jun Yin, Hai-Yan Tu, Ming Fu, Wen-Zhao Zhong, She-Juan An, Hong-Hong Yan, Hua-Jun Chen, Hui-Ran Lin, Yi-Long Wu Tags: Research Paper Source Type: research

Loss of UHRF2 Is Associated With Non-small Cell Lung Carcinoma Progression
Conclusion: Our findings indicate that UHRF2 is a tumor suppressor in NSCLC by influence TET2 expression and serve as a potential therapeutic target in NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chun Jin, Dian Xiong, Hao-Ran Li, Jia-Hao Jiang, Jian-Chao Qi, Jian-Yong Ding Tags: Research Paper Source Type: research

Identification of microRNA-124 in regulation of Hepatocellular carcinoma through BIRC3 and the NF- κ B pathway
In conclusion, our data proved that miR-124 inhibits the proliferation and migration of HCC at least partly through targeting BIRC3 and regulating NF-κB signaling pathway, and it may be a therapeutic target for HCC prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jia Cao, Jing Qiu, Xi Wang, ZhenHui Lu, Danni Wang, HuiMin Feng, XiaoHan Li, QiaoQiao Liu, HuaZheng Pan, XueBo Han, Jun Wei, ShiHai Liu, LiBin Wang Tags: Research Paper Source Type: research

Identification of Genes and Pathways Involved in Ovarian Epithelial Cancer by Bioinformatics Analysis
This study integrated two cohorts profile datasets to investigate the potential key candidate genes and pathways associated with OEC. Gene expression in two datasets (GSE9891 and GSE12172), including 327 OECs and 48 LMP tumors, were analyzed. 559 differentially expressed genes were found to overlap, 251 up-regulated and 308 down-regulated. Subsequently, analysis of gene ontology, signaling pathway enrichment and protein-protein interaction (PPI) network was performed. Gene ontology analysis clustered the up-regulated and down-regulated genes based on significant enrichment. 282 nodes/ differentially expressed genes (DEGs) ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yun Zhou, Olivia Layton, Li Hong Tags: Research Paper Source Type: research

Concurrent Chemoradiotherapy versus Intensity-modulated Radiotherapy Alone for Elderly Nasopharyngeal Carcinoma Patients with Pre-treatment Epstein-Barr Virus DNA: A Cohort Study in an Endemic Area with Long-term Follow-up
This study evaluated the efficacy of concurrent chemotherapy (CCRT) for NPC in elderly patients treated with intensity-modulated radiotherapy (IMRT).Methods: Patients were identified from a prospectively maintained database. A total of 198 consecutive cases of elderly patients with NPC receiving IMRT, including 103 patients treated with IMRT plus CCRT and 95 patients treated with IMRT alone, were analysed from January 2002 to December 2013. Multivariate analysis (MVA) using the Cox proportional hazards model and propensity score analysis (PSA) were performed for overall survival (OS) and disease-free survival (DFS). Finall...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qin Yang, Ting-Ting Zhao, Meng-Yun Qiang, Liang Hu, Xing Lv, Yan-Fang Ye, Liang-Ru Ke, Ya-Hui Yu, Wen-Ze Qiu, Guo-Ying Liu, Xin-Jun Huang, Wang-Zhong Li, Shu-Hui Lv, Yao Sun, Lu-Yao Zhang, Fei Pei, Xiang Guo, Yan-Qun Xiang, Chao-Nan Qian, Bi-Jun Huang, We Tags: Research Paper Source Type: research

NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines
This study shows that vandetanib might be one of useful treatment strategies for CRC patient with NCOA4-RET fusion. Therefore, inhibition of the RET kinase is a promising targeted therapy for cancer patients whose tumors harbor a RET rearrangement. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Sun Young Kim, Seiyoon Oh Oh, Kyung Kim, Jeeyun Lee, SoYoung Kang, Kyoung-Mee Kim, WooYong Lee, Seung Tae Kim, Dohyun Nam Nam Tags: Research Paper Source Type: research

The cost of hospital treatment of advanced stage lung cancer patients in a developing South East European country
Assessing the lung cancer treatment costs is necessary in order to estimate the budget impact of new interventions and therapeutic innovations. However, there are few studies regarding the use of resources and costs associated with treatment of lung cancer patients, not only in Serbia, but internationally. The aim of this paper was to assess the hospital costs of diagnosing and treating patients with stage IIIB and IV non-small cell lung cancer. Analysis of costs of care, services, medications and medical supplies, as well as of total hospital costs, was performed. Patients diagnosed with stage IIIB or IV NSCLC in the Inst...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jelena Perin, Bojan Zari ć , Jelica Eremi ć Đ o đ i ć , Zoran Poti ć , Marijela Poti ć , Vanesa Sekeru š , Stella Laskou, Charilaos Koulouris, Athanasios Katsaounis, Efstathios Pavlidis, Stylianos Mantalovas, Dimitrios Giannakidis, Nikolaos Michal Tags: Research Paper Source Type: research

Lung Cancer and Pulmonary Embolism: What Is the Relationship? A Review
Pulmonary embolism (PE) is gradually considered to be the third most common disease in the vascular disease category. Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer death among males worldwide. Although initially appearing as distinct entities, lung cancer is a great risk factor for the development of PE. Pulmonary embolism is common in lung cancer patients, with a pooled incidence of 3.7%, and unsuspected pulmonary embolism (UPE) is also non-negligible with a rough rate ranging from 29.4% to 63%. Many risk factors of PE have been detected and could be classified into three categories: ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yupeng Li, Yu Shang, Wenwen Wang, Shangwei Ning, Hong Chen Tags: Review Source Type: research

Risk Assessment and Hydrodissection Technique for Radiofrequency Ablation of Thyroid Benign Nodules
Conclusion: It is a very safe and effective way to carry out radiofrequency ablation after pre-treatment of thyroid nodules by hydrodissection technique according to risk assessment. It will provide clinicians with greater help in the ablation treatment of thyroid nodules, and improve the safety of the thyroid ablation. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Tang Xiaoyin, Li Ping, Cui Dan, Ding Min, Chi Jiachang, Wang Tao, Shi Yaoping, Wang Zhi, Zhai Bo Tags: Research Paper Source Type: research

NKX2-2 Suppresses Osteosarcoma Metastasis and Proliferation by Downregulating Multiple Target Genes
Osteosarcoma is the most common primary malignant bone tumor. However, our understanding of the molecular mechanism underlying its pathogenesis is incomplete. Studies have shown that aberrant expression of NK homeobox (NKX) genes may be involved in the oncogenesis of various cancers. Here, through migration screening assay, we found that a series of NKX genes inhibit the migration of osteosarcoma cells. Among these genes, NKX2-2 is a bona fide tumor suppressor for osteosarcoma. Overexpression of NKX2-2 decreases the migration, invasion, proliferation and colony formation of osteosarcoma cells in vitro and suppresses tumor ...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Huiming Chen, Wenqiang Liu, Li Zhong, Dan Liao, Ruhua Zhang, Tiebang Kang, Yuanzhong Wu Tags: Research Paper Source Type: research

Genetic polymorphisms may influence the vertical growth rate of melanoma
Conclusion: These findings suggest that genetic alteration in XPD contributes to melanoma progression and may be a potential diagnostic and molecular prognostic marker. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Mariusz Sikora, Lidia Rudnicka, Barbara Borkowska, Agnieszka Kardyna ł , Monika S ł owi ń ska, Adriana Rakowska, Olga Warszawik-Hendzel, Anna Wiergowska, Iwona Ł ugowska, Piotr Rutkowski, Tadeusz D ę bniak, Jan Lubi ń ski, Ma ł gorzata Olszewska Tags: Research Paper Source Type: research

Exosome-related tumor microenvironment
The tumor microenvironment (tumor cells are located in the internal and external environment) is vital for the occurrence, growth and metastasis of tumors. An increasing number of studies have shown that exosomes are closely related to the tumor microenvironment. The mechanisms involved, however, are unclear. The focus of this review is on the exosome-related tumor microenvironment and other relevant factors, such as hypoxia, inflammation and angiogenesis. Many studies have suggested that exosomes are important mediators of metastasis, angiogenesis, and immune modulation in the tumor microenvironment. Additionally, exosome...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Cheng Hu, Meijuan Chen, Rilei Jiang, Yuanyuan Guo, Mianhua Wu, Xu Zhang Tags: Review Source Type: research

Systemic neutrophil lymphocyte ratio and mismatch repair status in colorectal cancer patients: correlation and prognostic value
Conclusions: Our results suggest that dMMR CRC correlates with higher neutrophil count, NLR and CRP levels only in non-metastatic patients, and NLR has prognostic value only in pMMR CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wen-Zhuo He, Wan-Ming Hu, Peng-Fei Kong, Lin Yang, Yuan-Zhong Yang, Qian-Kun Xie, Chang Jiang, Chen-Xi Yin, Hui-Juan Qiu, Bei Zhang, Hui-Zhong Zhang, Liang-Ping Xia Tags: Research Paper Source Type: research

Clinical Value of Combining 18F-FDG PET/CT and Routine Serum Tumor Markers in The Early Detection of Recurrence Among Follow-up Patients Treated for Cervical Squamous Cell Carcinoma
Conclusion: 18F-FDG PET/CT is highly sensitive in the diagnosis of recurrent cervical cancer. When 18F-FDG PET/CT is associated with both SCC Ag and CEA elevation or only SCC Ag elevation, the accuracy is increased but not when associated with only CEA elevation. Positive 18F-FDG PET/CT associated with both tumor markers elevation can precisely predict recurrence. Moreover, normal levels of both tumor markers with a negative 18F-FDG PET/CT result may clinically reassure that a recurrence is absent. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Rajiv Rai Sookha, Wenhua Zhi, Yanxia Shen, Cordelle Lazare, Ling Wang, Yifan Meng, Canhui Cao, Junbo Hu, Peng Wu Tags: Research Paper Source Type: research

The relationship between miR-302b and EphA2 and their clinical significance in gastric cancer
This study plans to investigate their relationship and clinical significance in clinical samples.Materials and Methods: We explored the correlation of the expression of EphA2 and miR-302b, and their clinical significance in the training (n=226) cohort of GC patients, and then validated the results in the validation (n=128) cohort.Results: miR-302b was remarkably downregulated in GC tissues, while high EphA2 expression were detected, and they were inversely correlated both in mRNA and protein, (r=-0.4209, P
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Lanhua Tang, Huabin Hu, Yijing He, Howard L. Mcleod, Desheng Xiao, Pan Chen, Liangfang Shen, Shan Zeng, Xianli Yin, Jie Ge, Li Li, Jian Ma, Zihua Chen, Jin Huang Tags: Research Paper Source Type: research

Preoperative CEA levels are supplementary to CA19-9 levels in predicting prognosis in patients with resectable intrahepatic cholangiocarcinoma
Conclusions: With the cutoff value of 200U/ml, CA19-9 was a better preoperative biomarker for predicting survival for ICC patients after surgical resection. Combination of preoperative CA19-9 and CEA showed the strongest predictive power in survival analyses in these patients and should be recognized in daily clinical care. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chaobin He, Yu Zhang, Yunda Song, Jun Wang, Kaili Xing, Xiaojun Lin, Shengping Li Tags: Research Paper Source Type: research

Mesenchymal Stem Cell Derived Exosomes in Cancer Progression, Metastasis and Drug Delivery: A Comprehensive Review
With the development of cancer treatments, it has become a popular research focus that mesenchymal stem (or stromal) cells (MSCs) have the functional mechanisms that influence cancer progression. One of the underestimated mechanisms is secretion of highly specialized double-membrane structures called exosomes. Mesenchymal stem cells generate several exosomes that may act as paracrine mediators by exchanging genetic information. MSC-derived exosomes are microvesicles ranging from approximately 60-200 nm in size and detected in various body fluids. It has been demonstrated that MSC-derived exosomes are involved in tumor grow...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jingyi Zhou, Xiaohong Tan, Yiheng Tan, Qiuyu Li, Jianjun Ma, Gangyang Wang Tags: Review Source Type: research

Role of CXCR7 as a Common Predictor for Prognosis in Solid Tumors: a Meta-Analysis
Conclusions: Our meta-analysis revealed that high expression of CXCR7 predicted unfavorable prognosis and may serve as potential targets of cancer therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Qitai Zhao, Penghua Zhang, Guohui Qin, Feifei Ren, Yujia Zheng, Yamin Qiao, Ting Sun, Yi Zhang Tags: Research Paper Source Type: research

Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation
Covalent CDK7 inhibitor THZ1 is a newly discovered anti-tumor drug.THZ1 affects the function of transcription factor TFIIH by inhibiting CDK7, which in turn affects RNA polymerase II, and ultimately affects transcription initiation. Study found that THZ1 could inhibit proliferation and promote apoptosis of several tumor cell lines. However, there is no report of the potential side effect of THZ1 in normal tissues. In the course of cancer, the muscle consumption of cachexia needs to be supplemented by the differentiation of muscle cells. However, the effect of THZ1 on myogenic differentiation remains unclear. Our study in t...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xinqi Ma, Xielan Kuang, Qing Xia, Zixin Huang, Yuting Fan, Jie Ning, Jiajie Wen, Han Zhang, Jianhua Yan, Qingjiong Zhang, Huangxuan Shen, Chongde Long Tags: Research Paper Source Type: research

Overall survival and cancer-specific survival in patients with surgically resected pancreatic head adenocarcinoma: A competing risk nomogram analysis
The objective of this study was to estimate probabilities of overall survival (OS) and cancer-specific survival (CSS) in patients with pancreatic head adenocarcinoma after surgery. In addition, we attempted to build nomograms to predict prognosis of these patients.Methods: Patients diagnosed with surgically resected pancreatic head adenocarcinoma between 2004 and 2014 were selected for the study from the Surveillance, Epidemiology, and End Results (SEER) database. Nomograms were established for estimating 1-, 2- and 3-year OS and CSS based on Cox regression model and Fine and Grey's model. The performance of the nomogram w...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chaobin He, Yu Zhang, Zhiyuan Cai, Xiaojun Lin, Shengping Li Tags: Research Paper Source Type: research

Significantly higher pathologic complete response (pCR) after the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy for HER2-positive breast cancer: Evidence from a meta-analysis of randomized controlled trials
Objectives: To investigate the effect of the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer in terms of pCR and cardiotoxicity.Methods: We systematically searched Pubmed, Embase, Cochrane and SinoMed databases from inception until 1 July 2017 for relevant articles of randomized controlled studies. After identified all relevant studies that reported the concurrent use of trastuzumab and anthracycline-based NAC for HER2-positive locally advanced breast cancer, five eligible randomized studies were extracted relevant data and assessed for design and quality...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Yu-tuan Wu, Zhou Xu, Bilal Arshad, Jiu-song Wu, Ke Zhang, He Wu, Xin Li, Hao Li, Ying-cun Li, Zhong-liang Wang, Kai-nan Wu, Ling-quan Kong Tags: Research Paper Source Type: research

Alternative Splicing of SMAD4 and Its Function in HaCaT Cells in Response to UVB Irradiation
Alternative splicing is one of the most common mechanisms of human gene regulation and plays a crucial role in increasing the diversity of functional proteins. Many diseases are linked to alternative splicing, especially cancer. SMAD4 is a member of the SMAD family and plays a critical role in mediating of TGF-β signal transduction and gene regulatory events. Smad4 is a tumour suppressor and acts as a shuttling protein between nucleus and cytoplasm. The splicing variants of Smad4 have been found in many cancers. The present study performed nested PCR to detect alternative splicing of Smad4 in HaCaT cells lines in resp...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Irfan Ullah, Yi Liao, Rongxue Wan, Liling Tang, Jianguo Feng Tags: Research Paper Source Type: research

Study to evaluate the immunomodulatory effects of radiofrequency ablation compared to surgical resection for liver cancer
Conclusion: Studies have shown that decrease in the NLR, PLR and expression of CD4+CD39+ on T lymphocytes as the marker of better survival in hepatic cancer patients and our findings have confirmed that these changes can be induced following application of RF energy. Moreover, this could be the explanation of better survival observed in different studies using RFA or other RF-based devices in comparison to non-RF based liver resection techniques. However, further larger studies are needed to confirm these findings. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Ketevan Mazmishvili, Kumar Jayant, Nona Janikashvili, Nino Kikodze, Malkhaz Mizandari, Ia Pantsulaia, Natela Paksashvili, Mikael H Sodergren, Isabella Reccia, Madhava Pai, Nagy Habib, Tinatin Chikovani Tags: Research Paper Source Type: research

Inhibition of Transient Receptor Potential Vanilloid 6 channel, elevated in human ovarian cancers, reduces tumour growth in a xenograft model
Conclusion: TRPV6 mRNA and protein are elevated in biopsies of ovarian cancers compared to normal tissue. Inhibition of TRPV6 activity significantly reduces ovarian tumour growth providing evidence that TRPV6 is a feasible oncology target in ovarian cancers. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Hui Xue, Yuzhuo Wang, Tyson J. MacCormack, Tyler Lutes, Christopher Rice, Michelle Davey, Dominique Dugourd, T. Toney Ilenchuk, John M. Stewart Tags: Research Paper Source Type: research

Validation of Urine-based Gene Classifiers for Detecting Bladder Cancer in a Chinese Study
Conclusions: Our study proves that our non-invasive diagnostic BC tests can be reproduced in independent cohorts and in an external laboratory. All the four gene classifiers have shown equal or superior performance to the current gold standard in the present and previously reported validation studies. Consequently, they may be taken for consideration as molecular tests applicable to clinical practice in the management of BC.Patient summary: Our gene classifiers achieve sensitivities up to 90% in HR NMIBC and MIBC patients, while this achievement is comparatively lower in LR NMIBC ones. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Chengtao Han, Lourdes Mengual, Bin Kang, Juan Jos é Lozano, Xiaoqun Yang, Cuizhu Zhang, Antonio Alcaraz, Ji Liang, Dingwei Ye Tags: Research Paper Source Type: research

Distribution and Clinical Utility of the 21-gene Recurrence Score in Pure Mucinous Breast Cancer Patients: a case-control study
The 21-gene recurrence score (RS) is increasingly being used for patients with early stage, hormone receptor-positive, Her-2-negative breast cancer. However, these results are largely from populations with infiltrating ductal carcinoma (IDC). The clinical value of RS testing in mucinous carcinoma has not been well investigated. Pure mucinous breast cancer (PMBC) and paired pure IDC patients who underwent 21-gene RS were retrospectively reviewed and matched with tumor stage and molecular subtype. Clinic-pathological factors, treatment strategies, and RS distribution were compared between the PMBC and IDC patients. A total o...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Wei Wang, Xiaosong Chen, Lin Lin, Xiaochun Fei, David H. Garfield, Jin Hong, Weiqi Gao, Siji Zhu, Jiayi Wu, Ou Huang, Jianrong He, Yafen Li, Li Zhu, Weiguo Chen, Kunwei Shen Tags: Research Paper Source Type: research

Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma
In this study, we analyzed HBV integrations in patients with hepatitis B and HCC using HBV probe-based capturing and next-generation sequencing. The results revealed that the sizes of the HBV integrations ranged from 28 bp to 3215 bp, including the full-length HBV DNA sequence. The integration breakpoints were preferentially distributed in the viral enhancer, X protein, and core protein regions of the HBV genome. The number of HBV integrations followed an increasing trend from hepatitis to HCC, which was positively correlated with the HBV virus load in patients with hepatitis. The number of HBV integrations in the HBeAg po...
Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Liu Yang, Song Ye, Xinyi Zhao, Liyan Ji, Yinxin Zhang, Pingyu Zhou, Jun Sun, Yanfang Guan, Yingxin Han, Chao Ni, Xiaoge Hu, Weilong Liu, Haiyan Wang, Boping Zhou, Jian Huang Tags: Research Paper Source Type: research