The Power of Phytochemicals Combination in Cancer Chemoprevention
This study showed the compounds had a synergestic effect in inhibiting cell proliferation, reducing cellular migration and invasion, inducing both cell cycle arrest and apoptosis. Despite the vast number of basic science and preclinical cancer studies involving phytochemicals, the number of CAM clinical trials in cancer treatment still remains nascent. In this review, we summarize findings from preclinical and clinical studies, including our work involving use of phytochemicals, individually as well as in combination and further discuss the potential of these phytochemicals to pave way to integrate CAM in primary health ca...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Balsam Rizeq, Ishita Gupta, Josephine Ilesanmi, Mohammed AlSafran, MD Mizanur Rahman, Allal Ouhtit Tags: Review Source Type: research

Drug-eluting beads transarterial chemoembolization with CalliSpheres microspheres for treatment of unresectable intrahepatic cholangiocarcinoma
Conclusion: DEB-TACE with CSM is safe and well-tolerated for unresectable ICC patients, with a low complication rate and a relative benefit in terms of survival. Subsequent treatments including systemic/loco-regional treatments is an independent favorable prognostic factor, but cholangiectasis, extensive intrahepatic tumor burden and extrahepatic metastases are the three prognostic factors associated with poor survival. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Tan-Yang Zhou, Guan-Hui Zhou, Yue-Lin Zhang, Chun-Hui Nie, Tong-Yin Zhu, Hong-Liang Wang, Sheng-Qun Chen, Bao-Quan Wang, Zi-Niu Yu, Li-Ming Wu, Shu-Sen Zheng, Jun-Hui Sun Tags: Research Paper Source Type: research

Circulating let-7f-5p improve risk prediction of prostate cancer in patients with benign prostatic hyperplasia
Conclusions: Our study suggests that plasma let-7f-5p combining PSA could serve as potentially diagnostic biomarkers for PCa. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yuqiu Ge, Qiangdong Wang, Wei Shao, You Zhao, Qianqian Shi, Qinbo Yuan, Li Cui Tags: Research Paper Source Type: research

Knockdown of the long noncoding RNA XIST suppresses glioma progression by upregulating miR-204-5p
Conclusion: Our results provide evidence that XIST, miR-204-5p and Bcl-2 form a regulatory axis that controls glioma progression and can serve as a potential therapeutic target for glioma. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jun Shen, Jianhua Xiong, Xuefei Shao, Hao Cheng, Xinyun Fang, Yongkang Sun, Guangfu Di, Jie Mao, Xiaochun Jiang Tags: Research Paper Source Type: research

Efficacy and Safety of Thalidomide for Chemotherapy-induced Nausea and Vomiting
Conclusion: THD is an effective adjuvant and a potential alternative in reducing delayed and overall CINV. Other regimens might be added for CINV during the acute phase. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Nan Wang, Peng Xu, Yu Liu, Peng Zhao, Jian Ruan, Yi Zheng, Junpei Jin, Shuqian Wang, Jia Yao, Dong Xiang, Dai Zhang, Na Li, Huafeng Kang, Zhijun Dai Tags: Research Paper Source Type: research

Identification and validation of an alternative splicing-based prognostic signature for head and neck squamous cell carcinoma
In this study, we aimed to investigate the AS profile in HNSCC, and build up a robust AS-based prognostic signature for HNSCC. Our results revealed a total of 4068 overall survival (OS) associated AS events in the TCGA HNSCC cohort. The whole TCGA HNSCC cohort was randomly divided into discovery cohort and validation cohort. A prognostic signature including five AS events was developed with the discovery cohort based on the most significant OS-associated AS events. Then it was further successfully validated in the validation cohort. The AS-based risk signature was an independent prognostic indicator in both discovery cohor...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xinyuan Zhao, Shanshan Si, Xiaona Li, Wenjuan Sun, Li Cui Tags: Research Paper Source Type: research

Prognostic significance of Spinster homolog gene family in acute myeloid leukemia
Acute myeloid leukemia (AML) is a clonal and heterogeneous disease characterized by proliferation of immature myeloid cells, with impaired differentiation and maturation. Spinster homolog (SPNS) is a widely distributed transmembrane transporter, which assists sphingolipids in playing their roles through the cell membrane. However, the expression and clinical implication of the SPNS family has not been investigated in AML. From the Cancer Genome Atlas database, a total of 155 AML patients with complete clinical characteristics and SPNS1-3 expression data were contained in our study. In patients who received chemotherapy onl...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wenhui Huang, Tingting Qian, Zhiheng Cheng, Tiansheng Zeng, Chaozeng Si, Chaojun Liu, Cong Deng, Xu Ye, Yan Liu, Longzhen Cui, Lin Fu Tags: Research Paper Source Type: research

A Novel Pre-treatment Model Predicting Risk of Developing Refractoriness to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma
Background and aim: Refractoriness to transarterial chemoembolization is common during the therapeutic process of hepatocellular carcinoma, which is an intractable issue and may compromise the prognosis. We aim to establish a pre-treatment model to identify patients with high risks of refractoriness.Methods: From 2010 to 2016, 824 treatment-naive patients who had initially underwent at least two sessions of transarterial chemoembolization in Zhongshan Hospital, Fudan University were retrospectively enrolled. These patients were randomly allocated into a training cohort and a validation cohort. The pre-treatment scoring mod...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Keshu Hu, Shenxin Lu, Miao Li, Feng Zhang, Bei Tang, Jia Yuan, Yan Shan, Pengju Xu, Rongxin Chen, Zhenggang Ren, Xin Yin Tags: Research Paper Source Type: research

The impact of pre-existed and SERM-induced non-alcoholic fatty liver disease on breast cancer survival: a meta-analysis
Background: Non-alcoholic fatty liver disease (NAFLD) is a common disorder and a frequent side effect of endocrine therapy (ET) for breast cancer treatment. This was the first meta-analysis to investigate the impact of NAFLD on breast cancer survival.Material and Methods: We searched Pubmed, Embase and Cochrane Central Register of Controlled Trials database for relevant studies that investigated the correlation between NAFLD and breast cancer survival. Fixed- and random-effect meta-analyses were conducted according to the heterogeneity of enrolled studies. Subgroup analyses were performed based on whether NAFLD was induced...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Changjun Wang, Yidong Zhou, Wei Huang, Ziyuan Chen, Hanjiang Zhu, Feng Mao, Yan Lin, Xiaohui Zhang, Songjie Shen, Ying Zhong, Xin Huang, Chang Chen, Qiang Sun Tags: Research Paper Source Type: research

Do Higher Radiation Doses with Concurrent Chemotherapy in the Definitive Treatment of Esophageal Cancer Improve Outcomes? A Meta-Analysis and Systematic Review
Background: To investigate the effects and safety profile of radiation dose escalation utilizing computerized tomography (CT) based radiotherapy techniques (including 3-Dimensional conformal radiotherapy, intensity-modulated radiotherapy and proton therapy) in the definitive treatment of patients with esophageal carcinoma (EC) with definitive concurrent chemoradiotherapy (dCCRT).Methods: All relevant studies utilizing CT-based radiation planning, comparing high-dose (≥ 60 Gy) versus standard-dose (50.4 Gy) radiation for patients with EC were analyzed for this meta-analysis.Results: Eleven studies including 4946 patients...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Linlin Xiao, Brian G. Czito, Qingsong Pang, Zhouguang Hui, Shaowu Jing, Baoen Shan, Jun Wang Tags: Research Paper Source Type: research

Overexpression of Platelet-Derived Growth Factor Receptor Α D842V Mutants Prevents Liver Regeneration and Chemically Induced Hepatocarcinogenesis via Inhibition of MET and EGFR
In conclusion, continuous activation of PDGFRα signaling by expression of PDGFRαD842V does not promote, but inhibit hepatic regeneration and hepatocarcinogenesis, possibly through compensatory downregulation of MET and EGFR. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhao-Qing Du, Jian Dong, Mu-Xing Li, Jian-Fei Zhang, Jian-Bin Bi, Yi-Fan Ren, Li-Na Zhang, Rong-Qian Wu, Satdarshan P.S. Monga, Yi Lv, Xu-Feng Zhang, Hai-Chen Wang Tags: Research Paper Source Type: research

Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study
Conclusions: This study provided a population-based estimate of the proportion and prognosis for newly diagnosed ovary cancer with brain metastases. These findings may add materials to guidelines for preliminary screening and optimal treatment of OCBM patients. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Sujuan Xi, Zaiyi Li, Quan Guo, Wenjing Lin, Xiaokun Liang, Lin Ma Tags: Research Paper Source Type: research

Novel Metabolomics Serum Biomarkers for Pancreatic Ductal Adenocarcinoma by the Comparison of Pre-, Postoperative and Normal Samples
Conclusions: These three markers combined with CA199 displayed high sensitivity and specificity for detecting PDAC patients from NCs. The results indicated that these three metabolites could be regarded as potential biomarkers to distinguish PDAC from NCs. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaohan Zhang, Xiuyun Shi, Xin Lu, Yiqun Li, Chao Zhan, Muhammad Luqman Akhtar, Lijun Yang, Yunfan Bai, Jianxiang Zhao, Yu Wang, Yuanfei Yao, Yu Li, Huan Nie Tags: Research Paper Source Type: research

CYP1B1 gene: Implications in glaucoma and cancer
Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes damages to intraocular structures and affects the Schlemm's canal, collector channels, trabecular meshwork, and optic nerve's molecular structures. An important gene that is defective in patients with glaucoma is CYP1B1, a gene associated with optic nerve deterioration. CYP1B1is a key enzyme involved in the metabolism of exogenous and endogenous compounds. Also, it is critical in the detoxification of pre-carcinogens, such as polycyclic aromatic hy...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Arwa Alsubait, Wadha Aldossary, Mamoon Rashid, Amani Algamdi, Bahauddeen M. Alrfaei Tags: Review Source Type: research

GINS2 affects cell viability, cell apoptosis, and cell cycle progression of pancreatic cancer cells via MAPK/ERK pathway
Conclusions: GINS2 interference inhibited cell viability, induced cell cycle arrest, and promoted cell apoptosis of pancreatic cancer cell lines via the MAPK/ERK pathway, and our findings may be valuable for treating pancreatic cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Miao Zhang, Saifei He, Xing Ma, Ying Ye, Guoyu Wang, Juhua Zhuang, Yanan Song, Wei Xia Tags: Research Paper Source Type: research

Recent Progress for the Techniques of MRI-Guided Breast Interventions and their applications on Surgical Strategy
With a high sensitivity of breast lesions, MRI can detect suspicious lesions which are occult in traditional breast examination equipment. However, the lower and variable specificity of MRI makes the MRI-guided intervention, including biopsies and localizations, necessary before surgery, especially for patients who need the treatment of breast-conserving surgery (BCS). MRI techniques and patient preparation should be first carefully considered before the intervention to avoid lengthening the procedure time and compromising targeting accuracy. Doctors and radiologists need to reconfirm the target of the lesion and be very f...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Peng Gao, Xiangyi Kong, Ying Song, Yan Song, Yi Fang, Han Ouyang, Jing Wang Tags: Review Source Type: research

Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG)
As a highly aggressive pediatric brainstem tumor, diffuse intrinsic pontine glioma (DIPG) accounts for 10% to 20% of childhood brain tumors. The survival rate for DIPG remains very low, with a median survival time as less than one year even under radiotherapy, the current standard treatment. Moreover, over than 250 clinical trials have failed when trying to improve the survival compared to radiotherapy. The sphingolipid metabolism and related signaling pathways have been found closely related to cancer cell survival; however, the sphingolipid metabolism targeted therapies have never been investigated in DIPG. In the curren...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lu Dai, Jungang Chen, Zhen Lin, Zhaoxiong Wang, Shengyu Mu, Zhiqiang Qin Tags: Research Paper Source Type: research

mRNA Expression of FGFR1 as Potential Marker for Predicting Prognosis of Surgical Resection of Small Cell Lung Cancer may be better than Protein Expression and Gene Amplification
Conclusions: As novel FGFR1-targeted therapies are developed, FISH, IHC, especially mRNA were detected, which should be considered as biomarkers of FGFR1 pathway dysregulation in SCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jing Qin, Fajun Xie, Fenfang Wang, Hongyang Lu Tags: Research Paper Source Type: research

Acute Kidney Injury in Oncology Patients
With rapid progress in cancer diagnosis and treatment in the last two decades, outcomes in oncological patients have improved significantly. However, the incidence of acute kidney injury (AKI) in this population has also increased significantly. AKI complicates many aspects of patients' care and adversely affects their prognoses; thus, accurately diagnosing the risk factors for AKI ensures appropriate management. AKI may be caused by pre-renal, intrinsic renal, and post-renal reasons, as well as for combined reasons. This review summarizes the potential etiologies of AKI according to the three classifications. For each und...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Li-Yan Wang, Jia-Ni Wang, Zong-Li Diao, Yi-Ming Guan, Wen-Hu Liu Tags: Research Paper Source Type: research

Life-long follow-up of second primary lung and extra-pulmonary cancer in lung cancer patients is needed
Conclusions: LC survivors had an increased risk of SPC and factors associated with good prognosis often predicted SPC. Consideration should be given to increasing the duration of routine follow-up even after 10 years of initial diagnosis for those at the highest risk and site-specific follow-up strategy is also required. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Bingqing Ma, Guoyou Qin, Yue Zhang, Chang Su, Zhenyu Wu Tags: Research Paper Source Type: research

Chronic Periodontal Disease increases risk for Prostate Cancer in Elderly individuals in South Korea: a Retrospective Nationwide Population-based Cohort Study
This study aimed to determine whether the presence of chronic PD in old age increases the risk of PC using data in the large-scale elderly cohort.Materials and Methods: This nationwide population-based cohort study examined data of 121,240 South Korean individuals aged ≥ 60 years from the National Health Insurance Service-Elderly Cohort database who completed a national program between 2002 and 2015. For a maximum 10 years' observation period, patients with incident PC with chronic PD compared with those without chronic PD were retrospectively tracked, and Cox proportional hazard ratios and 95% confidence intervals (CIs...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Do-hyung Kim, Seong-Nyum Jeong, Jae-Hong Lee Tags: Research Paper Source Type: research

Exosomes Derived from Hypoxic Colorectal Cancer Cells Transfer miR-410-3p to Regulate Tumor Progression
In conclusion, our findings indicate that the hypoxic microenvironment in CRC may promote tumor cells to release miR-410-3p-rich exosomes that are transferred to normoxic cells to enhance tumor progression, revealing a new investigation into the therapeutic targets of exosome for CRC treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiufeng Hu, Yu Mu, Jie Liu, Xiaoqian Mu, Fangfang Gao, Lijuan Chen, Huijuan Wu, Hongbo Wu, Wenjing Liu, Yanqiu Zhao Tags: Research Paper Source Type: research

Identification of LCA-binding Glycans as a Novel Biomarker for Esophageal Cancer Metastasis using a Lectin Array-based Strategy
Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence and development of malignancy. However, the effects of glycans on EC progression are largely unexplored. Here, a lectin array was utilized to detect the glycan profiling of the normal esophageal mucosal epithelial cell line and two EC cell lines. The binding of Lens culinaris lectin (LCA) to EC cells was found to be stronger than that of the normal cells. Lectin immunohistochemical staining revealed that LCA-binding glycans were markedly elevated in EC t...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Min Xia, Jun Shao, Meimei Qiao, Zhiguo Luo, Xinzhou Deng, Qing Ke, Xiaoxia Dong, Li Shen Tags: Research Paper Source Type: research

SMADs binding site polymorphisms rs9911630 is associated with susceptibility but not prognosis of gastric cancer: a case control study
Conclusions: Our results suggested that rs9911630 polymorphism in SMADs target site might influence susceptibility but not prognosis of gastric cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Liyang Liu, Ming Lu, Xi Gu, Xiang Ma, Jiaxi Feng, Yang Cao, Weida Gong, Qinghong Zhao, Fulin Qiang Tags: Research Paper Source Type: research

Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
The mechanisms of signal transduction by interferon-tau (IFN-τ) are widely known during the gestation of ruminants. In trophoblast cells, IFN-τ involves the activation of the JAK-STAT pathway, and it can have effects on other cell types, such as tumor cells. Here we report that the HPV16-positive BMK-16/myc cell treated with ovine IFN-τ, results in the activation of the canonical JAK-STAT and non-canonical JAK-STAT pathway. The MAPK signaling pathway was activated, we detected the proteins MEK1, MEK2, Raf1, STAT3, STA4, STAT5 and STAT6. Moreover, IFN-τ induced the expression of MHC Class I, MX and IP10 in t...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Geny Fierros-Z á rate, Clarita Olvera, Gustavo Salazar-Guerrero, Ausencio Morales-Ortega, Fernando Reyna, Eva Hern á ndez-M á rquez, Eduardo Guzm á n-Olea, Ana I. Burguete-Garc í a, Vicente Madrid-Marina, Oscar Peralta-Zaragoza, Maril ú Ch á vez-C Tags: Research Paper Source Type: research

miR-532-3p Inhibits Proliferation and Promotes Apoptosis of Lymphoma Cells by Targeting β -Catenin
Conclusion: This study demonstrates that miR-532-3p functions as a tumor inhibitor in lymphoma progression by targeting β-catenin, suggesting miR-532-3p/β-catenin as a new diagnosis marker or potential therapeutic target in lymphoma. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yan Liu, Qiuying Li, Yongzhou Dai, Tinghui Jiang, Yongming Zhou Tags: Research Paper Source Type: research

LncRNA H19-Derived miR-675-3p Promotes Epithelial-Mesenchymal Transition and Stemness in Human Pancreatic Cancer Cells by targeting the STAT3 Pathway
Conclusions: The H19/miR-675-3p signaling axis plays a critical role in maintaining the EMT process and stemness of PC cells by directly targeting SOCS5 to activate the STAT3 pathway. These data provide new insights into the oncogenic function of H19 in human PC and reveal potential targets for the development of optimal treatment approaches for this disease. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Feng Wang, Long Rong, Zhengkui Zhang, Mingzhe Li, Ling Ma, Yongsu Ma, Xuehai Xie, Xiaodong Tian, Yinmo Yang Tags: Research Paper Source Type: research

Long noncoding RNA PANDAR inhibits the development of lung cancer by regulating autophagy and apoptosis pathways
Background: LncRNAs has been shown to play important roles in the progression of lung cancer, but it remains poorly understood whether lncRNAs affect the occurrence and development of lung cancer by regulating autophagy and apoptosis levels. Here, we investigated the roles of PANDAR in NSCLC.Materials and Methods: The expression profile and clinical application of PANDAR and its possible target gene BECN1 were tested in 276 cases of lung cancer tissues. Through some actual experiments, we explored functions of PANDAR about proliferation, apoptosis and autophagy of NSCLC cells in vitro.Results: PANDAR was found to downregul...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lan Zhang, Yuanhang Wang, Shengyuan Xia, Lei Yang, Di Wu, Yifeng Zhou, Jiachun Lu Tags: Research Paper Source Type: research

NK homeobox 2.2 functions as tumor suppressor in colorectal cancer due to DNA methylation
This study was designed to explore the epigenetic regulation and function of NKX2.2 in human CRC.Methods: The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were used to assess the methylation data of NKX2.2 in CRC. Six CRC cell lines (HCT116, SW480, HT29, LOVO, SW1116, SW640) and 20 pairs of primary CRC tumor and normal tissues were utilized to explore the function of NKX2.2 in CRC using Sequenom EpiTYPER®, verified by cloning-based bisulfite sequencing analysis, semi-quantitative reverse transcription PCR, western blot, cell viability assessment, plate clone formation assay , and transwell assa...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yuan He, Xiao-Yun Liu, Rui Gong, Kun-Wei Peng, Rong-Bin Liu, Fang Wang Tags: Research Paper Source Type: research

Nei Endonuclease VIII-like 2 Gene rs8191670 Polymorphism affects the Sensitivity of Non-small Cell Lung Cancer to Cisplatin by binding with MiR-548a
Conclusion: Our results demonstrated that NEIL2 gene rs8191670 polymorphism affects the PFS of advanced NSCLC patients, and the underlying molecular mechanisms may be that miR-548a can regulate NEIL2 expression by binding to its 3'UTR seed region containing rs8191670. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wei He, Lina Pang, Shuai Gong, Xin Wang, Lixia Hou Tags: Research Paper Source Type: research

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
The main reason for the failure of malignant glioma treatment is local tumor recurrence. Tumor cells in hypoxic microenvironment activate HIF-1 α transcription, and thus promoting tumor invasion and metastasis is one of the important reasons. In our previous study, we clearly established that borneol opens the blood-brain tumor barrier and its related mechanism. However, the effects of borneol itself on glioma proliferation have not yet been elucidated. Therefore, in this study, we evaluated the effect of borneol on glioma by constructing in vivo SD rat brain glioma model and in vitro human primary cultured glioma ce...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zeng Wang, Qinglin Li, Liang Xia, Xia Li, Caixing Sun, Qiong Wang, Xinjun Cai, Guonong Yang Tags: Research Paper Source Type: research

Research trends on the relationship between Microbiota and Gastric Cancer: A Bibliometric Analysis from 2000 to 2019
Conclusion: The annual number of publications would continue to grow. Besides the traditional Helicobacter pylori related researches, future research hotspots will focus on microbiota and its mechanism of action. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Tongchao Zhang, Xiaolin Yin, Xiaorong Yang, Jinyu Man, Qiufeng He, Qiyun Wu, Ming Lu Tags: Research Paper Source Type: research

Downregulation of miR-1 in colorectal cancer promotes radioresistance and aggressive phenotypes
Conclusion: miR-1 enhanced the radiosensitivity of CRC cells by inducing cell apoptosis and the synergic inhibition of aggressive phenotypes, which may serve as a promising therapeutic target for CRC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yong Wu, Ning Pu, Wenzhao Su, Xiaodong Yang, Chungen Xing Tags: Research Paper Source Type: research

Application of cAMP-dependent catalytic subunit β (PRKACB) Low Expression in Predicting Worse Overall Survival: A Potential Therapeutic Target for Colorectal Carcinoma
Low expressions of PRKACB are related to the occurrence of various human malignancies. However, the prognostic value of PRKACB expression in colorectal cancer (CRC) patients remains controversial. In this analysis, PRKACB expression in CRC tumors was evaluated across the GEO, TCGA, and Oncomine databases, and a PRKACB survival analysis was performed based on the TCGA profile. We detected PRKACB in 7 GEO series (GSE110225, GSE32323, GSE44076, GSE9348, GSE41328, GSE21510, GSE68468) and TCGA spectra (all P
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaoya Yao, Weixian Hu, Jie Zhang, Chengzhi Huang, Haibi Zhao, Xueqing Yao Tags: Research Paper Source Type: research

Overexpression of METTL3 associated with the metabolic status on 18F-FDG PET/CT in patients with Esophageal Carcinoma
This study analyzed the expression of METTL3 in ESCA and its relationship with clinicopathological features by The Cancer Genome Atlas (TCGA) database. Immunohistochemical staining was performed on 57 tumor tissues of ESCA patients who underwent PET/CT scan before surgery to evaluate the expression of METTL3, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) in tumor tissues and peritumoral tissues. Analyze the relationship between SUVmax with METTL3, HK2, and GLUT1 expression.Results: The expression of METTL3, GLUT1, and HK2 was significantly increased in ESCA tissues compared with normal tissues (p
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Lu-Meng Zhou, Jian-Wei Yang, Zhi-Jun Pei Tags: Research Paper Source Type: research

The Prevalence and associated Factors for Liver Metastases, Development and Prognosis in newly diagnosed Epithelial Ovarian Cancer: A large Population-Based Study from the SEER Database
Background: Primary Epithelial Ovarian Cancer (EOC), a malignant gynecologic disease, is considered one of the leading causes of mortality in women. The development of Liver Metastases (LM) in women with primary ovarian cancer commonly results in a poorer prognosis. This retrospective population-based study aims to measure the prevalence, prognostic factors, and associated risk factors for epithelial ovarian cancer patients with liver metastases (EOCLM).Materials and Methods: The current study cohort of patients based on the Surveillance, Epidemiology, and End Results (SEER) database identified with primary ovarian cancer ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Iftikhar Hussain, Jiaqin Xu, Kui Deng, Noor-ul-Amin, Ce Wang, Yue Huang, Shuang Li, Kang Li Tags: Research Paper Source Type: research

Identification of the Mutational Landscape of Gynecological Malignancies
Conclusion: In sum, our study identified 16 major genes that are broadly mutated in a large majority of gynecological malignancies and in some cases predict survival and recurrence in patients with gynecological malignancies. We predict that the functional studies will determine their relative role in the initiation and progression of gynecological malignancies and also establish if some of them represents drug targets for anti-cancer therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Suresh Chava, Romi Gupta Tags: Research Paper Source Type: research

Immune Microenvironment of Thyroid Cancer
This article presents a comprehensive review of the immune cells, secreted soluble mediators and immune checkpoints in the immune microenvironment, mechanisms that promoting TC cells immune evasion and existing immunotherapy strategies. Besides it provides new strategies for TC prognosis prediction and immunotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hongyu Yin, Yemei Tang, Yujia Guo, Shuxin Wen Tags: Review Source Type: research

Correction: MiR-940 inhibits TGF- β -induced epithelial-mesenchymal transition and cell invasion by targeting Snail in non-small cell lung cancer
(Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Kanqiu Jiang, Ting Zhao, Mingjing Shen, Fuquan Zhang, Shanzhou Duan, Zhe Lei, Yongbing Chen Tags: Erratum Source Type: research

Plasma Exosomal miRNA-139-3p is a Novel Biomarker of Colorectal Cancer
Conclusion: Our findings show that decreased exosomal miR-139-3p expression levels in CRC patient plasma may act as a novel biomarker for the early diagnosis and metastasis monitoring in CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wanchao Liu, Dianyu Yang, Longmei Chen, Qingqing Liu, Wenhui Wang, Zhenghua Yang, Anquan Shang, Wenqiang Quan, Dong Li Tags: Research Paper Source Type: research

Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma
Multiple myeloma (MM) is a highly invasive and incurable plasma cell malignant disease with frequent recurrence. DCZ0801 is a natural compound synthesized from osalmide and pterostilbene and has few adverse effects. Here, we aimed to observe the therapeutic effects of DCZ0801 on myeloma cells and clarify the specific molecular mechanism underlying its anti-tumor activity. The Cell Counting Kit-8 assay, apoptosis detection, cell cycle analysis, western blot analysis, and tumor xenograft models were used to determine the effect of DCZ0801 treatment both in vivo and in vitro. We revealed that DCZ0801 treatment suppressed MM c...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Qilin Feng, Qingchun Yao, Bo Li, Yongsheng Xie, Hui Zhang, Zhijian Xu, Kang Lu, Ke Hu, Yao Cheng, Bingqing Shi, Cheng Huang, Liping Li, Xiaosong Wu, Shanxi You, Jumei Shi, Weiliang Zhu Tags: Research Paper Source Type: research

EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3
Exonuclease 1 (EXO1), a member of the RAD2 nuclease family, was first described as possessing 5' to 3' nuclease activity and 5' structure-specific endonuclease activity. Here, we show that EXO1 is significantly upregulated in HCC tumor tissues and that high EXO1 expression is significantly correlated with liver cirrhosis. We further demonstrate that EXO1 knockdown decreases proliferation and colony forming abilities of HCC cells in vitro and tumorigenicity in vivo, as well as decreases migration and invasive capabilities of HCC cells. Alternatively, EXO1 overexpression significantly increases the proliferation, colony form...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Guang Yang, Keshuai Dong, Zunyi Zhang, Erlei Zhang, Binyong Liang, Xiaoping Chen, Zhiyong Huang Tags: Research Paper Source Type: research

The prognostic value of COL3A1/FBN1/COL5A2/SPARC-mir-29a-3p-H19 associated ceRNA network in Gastric Cancer through bioinformatic exploration
Increasing studies on malignant tumors have proposed a new competing endogenous RNA (ceRNA) regulatory mechanism that mRNA, miRNA and lncRNA interact with each other. However, the mRNA-miRNA-lncRNA associated ceRNA network in gastric cancer remains unknown. We used online bioinformatic softwares to predict the hub genes and their upstream miRNAs and lncRNAs in gastric cancer, and then performed survival analyses. After collecting gastric cancer tissue samples and performing PCR experiments, the correlations among predicted mRNA, miRNA and lncRNA were further verified. A total of 101 up-regulated significant differentially ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hongyu Shen, Lin Wang, Qinnan Chen, Juqing Xu, Jin Zhang, Leping Fang, Jun Wang, Weifei Fan Tags: Research Paper Source Type: research

Inflammation Score System using Preoperative Inflammatory Markers to Predict Prognosis for Hepatocellular Carcinoma after Hepatectomy: A Cohort Study
Conclusions: The inflammation score system based on five preoperative inflammatory markers well predicted the survival of HCC patients after surgery, especially in those at the early stage (Stage I). (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Qinjunjie Chen, Fengwei Li, Chengqian Zhong, Yiran Zou, Zheng Li, Yuzhen Gao, Qifei Zou, Yong Xia, Kui Wang, Feng Shen Tags: Research Paper Source Type: research

Concurrent or Sequential Chemoradiotherapy after 3-4 Cycles Induction Chemotherapy for LS-SCLC with Bulky Tumor
This study demonstrated that after the completion of 3-4 cycles of chemotherapy with a remission, concurrent chemoradiotherapy with oral etoposide and cisplatin improved survival compared with sequential chemoradiotherapy in LS-SCLC with bulky tumor. ClinicalTrials.gov Identifier: NCT01745445. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jingjing Zhao, Wencheng Zhang, Puchun Er, Xi Chen, Yong Guan, Dong Qian, Jun Wang, Zhiyong Yuan, Lujun Zhao, Ping Wang, Qingsong Pang Tags: Research Paper Source Type: research

Identification of the key genes and characterizations of Tumor Immune Microenvironment in Lung Adenocarcinoma (LUAD) and Lung Squamous Cell Carcinoma (LUSC)
In conclusion, we identified the key genes, and characterized the tumor immune microenvironment in LUAD and LUSC which may provide therapeutic targets for the treatment of NSCLC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lemeng Zhang, Jianhua Chen, Tianli Cheng, Hua Yang, Haitao Li, Changqie Pan Tags: Research Paper Source Type: research

High viral loads of circulating Epstein-Barr virus DNA copy number in peripheral blood is associated with inferior prognosis in patients with mantle cell lymphoma
The objective of this study was to determine whether EBV DNA load may influence the heterogeneity in the course of the disease in MCL patients. Eighty-eight MCL patients were retrospectively enrolled in the study. EBV DNA load was detected by real-time quantitative PCR for quantification. The univariate and multivariate Cox proportional hazards models were established for the estimation of prognostic factors. Twenty-seven patients were detected positive for EBV DNA and the median virus titer was 1.72×104 copies/mL (range, 8.20×102 to 4.14×105 copies/mL). With a median follow-up of 39 months (range, 9 to 1...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiao-Hui Zhou, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia-Zhu Wu, Yi Xia, Yue Li, Shu-Chao Qin, Lei Fan, Jian-Yong Li, Wei Xu Tags: Research Paper Source Type: research

A Retrospective Study of predicting risk of Metastasis among FDG-avid Bone Lesions in 18F-FDG PET/CT
Purpose: We evaluated the imaging and clinical features for discriminating the possibility of metastasis among FDG-avid bone lesions in 18F-FDG PET/CT in patients who have received bone biopsy.Methods: The retrospective study included patients who underwent both 18F-FDG PET/CT and bone biopsy for FDG-avid bone lesions. Bone lesions maximum standardized uptake value (SUVmax), CT findings, alongside with common clinical features were analyzed.Results: From the 338 patients enrolled in the final study, all of them were received bone biopsy. Biopsies confirm metastasis in 256 cases (75.74%) and benign tissue in 82 cases (24.26...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Guangyu Yao, Yiyi Zhou, Yifeng Gu, Zhiyu Wang, Mengdi Yang, Jing Sun, Quanyong Luo, Hui Zhao Tags: Research Paper Source Type: research

Identification of a Glucose Metabolism-related Signature for prediction of Clinical Prognosis in Clear Cell Renal Cell Carcinoma
In this study, we downloaded a gene expression profile and glucose metabolism-related gene set from TCGA (The Cancer Genome Altas) and MSigDB, respectively, to analyze the characteristics of glucose metabolism-related gene sets in ccRCC. We used a multivariable Cox regression analysis to develop a risk signature, which divided patients into low- and high- risk groups. In addition, a nomogram that combined the risk signature and clinical characteristics was created for predicting the 3- and 5-year overall survival (OS) of ccRCC. The accuracy of the nomogram prediction was evaluated using the area under the receiver operatin...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Sheng Wang, Ling Zhang, Zhihong Yu, Kequn Chai, Jiabin Chen Tags: Research Paper Source Type: research

Graphene Oxide Nanoparticles Induce Apoptosis in wild-type and CRISPR/Cas9-IGF/IGFBP3 knocked-out Osteosarcoma Cells
This study aimed to evaluate the toxicity of GO on osteosarcoma in vitro using tumor cell lines with and without knocking out the IGF and IGFBP3 genes. Human osteosarcoma cell lines, U2OS and SAOS2, and the normal osteoblast cell line hFOB1.19 were used. The IGF1 and IGFBP3 genes were eliminated using CRISPR/Cas9. Tumor cells were cultured and treated with GO. Apoptosis and reactive oxygen species (ROS) were analyzed by Annexin V-FITC and ROS assays. The nuclear factor erythroid 2-related factor 2 (NRF2), which is a crucial regulator of cellular resistance to oxidants, was investigated by Western blotting. We found a signi...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Mervin Burnett, Yasser Abuetabh, Ania Wronski, Fan Shen, Sujata Persad, Roger Leng, David Eisenstat, Consolato Sergi Tags: Research Paper Source Type: research