Journal of Bioactive and Compatible Polymers This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gellan gum/clay hydrogels for tissue engineering application: Mechanical, thermal behavior, cell viability, and antibacterial properties
In this study, sodium montmorillonite (Na-MMT) was successfully modified by using n-hexadecyl trimethyl ammonium bromide (CTAB) via cationic exchange to obtain an organophilic-montmorillonite (CTAB-MMT). The Na-MMT, CTAB-MMT, and a commercial montmorillonite, that is, Cloisite15A were incorporated into gellan gum (GG) hydrogel and their mechanical, physical, thermal properties, biocompatibility, and antibacterial activities were investigated. The mechanical performance results show that the GG hydrogels containing Cloisite15A required smallest volume to achieve optimum compression stress, modulus, and compression strain at...
Source: Journal of Bioactive and Compatible Polymers - October 24, 2016 Category: Research Authors: Mohd, S. S., Abdullah, M. A. A., Mat Amin, K. A. Tags: Original Articles Source Type: research

Development of bioresorbable bilayered systems for application as affordable wound dressings
The objective of this work was the preparation and evaluation of a bioresorbable bilayered system for application in the treatment of dermal lesions. The system was based on a polyesterurethane as the external layer and a gelatin membrane as the internal layer. The polyesterurethane was synthesized from poly(-caprolactone), polyethylene glycol of 1 or 10 kDa as a hydrophilic component or Pluronic F127 as an amphiphilic component and l-lysine ethyl ester diisocyanate as an urethane precursor. Gelatin membrane was obtained by crosslinking with the naturally occurring crosslinker genipin. Three important points were addressed...
Source: Journal of Bioactive and Compatible Polymers - October 24, 2016 Category: Research Authors: Santurdes, N., Gonzalez-Gomez, A., Martin del Campo-Fierro, M., Rosales-Ibanez, R., Oros-Ovalle, C., Vazquez-Lasa, B., San Roman, J. Tags: Original Articles Source Type: research

Trilayered sulfated silk fibroin vascular grafts enhanced with braided silk tube
The scaffold component is a major barrier to the development of a clinically useful small-diameter tissue-engineered vascular graft. Scaffold requirements include matching the mechanical and structural properties with those of native vessels and optimizing the microenvironment for cell integration, adhesion, and growth. Trilayered sulfated silk fibroin graft was developed to mimic native tissue structure and function. Physical properties and cell studies were assessed to evaluate the viability of their usage in small-diameter tissue-engineered vascular grafts. Compared with previously fabricated silk fibroin vascular graft...
Source: Journal of Bioactive and Compatible Polymers - October 24, 2016 Category: Research Authors: Ding, X., Zou, T., Gong, X., Ren, C., Kang, H., Xu, P., Liu, H., Fan, Y. Tags: Original Articles Source Type: research

Local biological effects of adipose stromal vascular fraction delivery systems after subcutaneous implantation in a murine model
The aim of this study was to test alginate beads and silk fibroin non-woven mats as stromal vascular fraction delivery systems to support cell implantation for tissue repair and regeneration, through trophic and immunomodulant paracrine signaling. Furthermore, in vivo scaffold biocompatibility was histologically analyzed in a murine model at different time endpoints, with particular focus on construct-induced vascularization and neoangiogenesis. The fibroin mat induced a typical foreign body reaction, recruiting macrophages and giant cells and concurrently promoted neovascularization of the implanted construct. Conversely,...
Source: Journal of Bioactive and Compatible Polymers - October 24, 2016 Category: Research Authors: Vigani, B., Mastracci, L., Grillo, F., Perteghella, S., Preda, S., Crivelli, B., Antonioli, B., Galuzzi, M., Tosca, M. C., Marazzi, M., Torre, M. L., Chlapanidas, T. Tags: Original Articles Source Type: research

The effect of anti-CD34 antibody orientation control on endothelial progenitor cell capturing cardiovascular devices
Efficient immobilization of the antibody to the substrate is of crucial importance in the development of anti-CD34-based endothelial progenitor cells capturing cardiovascular devices. This should go along with precise control of the antibody orientation by appropriate immobilization technology for retaining antibody activity, like in immunosensors. Recently, great attention was paid to immobilization of anti-CD34 antibody onto substrates by covalent binding, but at random orientation. Here, to investigate the biological effect of antibody orientation, we have prepared two kinds of anti-CD34 antibody coated surfaces, with r...
Source: Journal of Bioactive and Compatible Polymers - October 24, 2016 Category: Research Authors: Chen, J., Li, Q., Li, J., Maitz, M. F. Tags: Original Articles Source Type: research

Improved proliferation and osteogenic differentiation of human mesenchymal stem cells on a titanium biomaterial grafted with poly(sodium styrene sulphonate) and coated with a platelet-rich plasma proteins biofilm
This study shows an increased cell proliferation with Ti-poly(sodium styrene sulphonate)–platelet-rich plasma compared to foetal calf serum and an enhancement of the Ti-poly(sodium styrene sulphonate)–platelet-rich plasma effects on osteoblast differentiation. The results suggest that Ti-poly(sodium styrene sulphonate)–platelet-rich plasma would be a suitable scaffold for bone tissue engineering. (Source: Journal of Bioactive and Compatible Polymers)
Source: Journal of Bioactive and Compatible Polymers - October 24, 2016 Category: Research Authors: Oughlis, S., Changotade, S., Poirier, F., Cieutat, A.-M., Rohman, G., Peltzer, J., Migonney, V., Lataillade, J.-J., Lutomski, D. Tags: Original Articles Source Type: research

Enzyme immobilization on cellulose matrixes
Enzymes are excellent catalysts in many applications due to their biocompatibility, low energy consumption, unique selectivity, and mild reaction condition. However, some disadvantages limit the usage of enzymes in end uses, such as low stabilities and difficult recovery. In order to overcome these disadvantages, enzyme immobilization was developed. Among various kinds of substrates for attaching enzyme, cellulose and its derivatives are one of the ideal matrixes because they are low cost, nontoxic, renewable, biodegradable, and biocompatible. In this review, we summarize recent progress in the research of enzyme immobiliz...
Source: Journal of Bioactive and Compatible Polymers - October 24, 2016 Category: Research Authors: Liu, Y., Chen, J. Y. Tags: Communication Source Type: research

Microstructured chitosan/poly({gamma}-glutamic acid) polyelectrolyte complex hydrogels by computer-aided wet-spinning for biomedical three-dimensional scaffolds
The application of additive manufacturing principles to hydrogel processing represents a powerful route to develop porous three-dimensional constructs with a variety of potential biomedical applications, such as scaffolds for tissue engineering and three-dimensional in vitro tissue models. The aim of this study was to develop novel porous hydrogels based on a microstructured polyelectrolyte complex between chitosan and poly(-glutamic acid) by applying a computer-aided wet-spinning technique. The developed fabrication process was used to build up three-dimensional porous hydrogels by collecting microstructured layers made o...
Source: Journal of Bioactive and Compatible Polymers - August 23, 2016 Category: Research Authors: Puppi, D., Migone, C., Morelli, A., Bartoli, C., Gazzarri, M., Pasini, D., Chiellini, F. Tags: Original Articles Source Type: research

Physically entrapped gelatin in polyethylene glycol scaffolds for three-dimensional chondrocyte culture
Developing tissue-engineered constructs for clinical use must satisfy the fundamental biologic parameters of biocompatibility, cell adhesiveness, and biodegradability. Physical entrapment of bioactive agents into synthetic polymers, as three-dimensional scaffolds, holds great promise for cell culture applications. Here, in an attempt to elucidate the effects of physical interlocking of natural and synthetic gel networks on cell responses within three-dimensional microenvironments, gelatin (of different concentrations) was physically incorporated into macroporous polyethylene glycol (PEG) hydrogels to fabricate PEG-GEL1 (10...
Source: Journal of Bioactive and Compatible Polymers - August 23, 2016 Category: Research Authors: Zhang, J., Mujeeb, A., Feng, J., Li, Y., Du, Y., Lin, J., Ge, Z. Tags: Original Articles Source Type: research

Calcified and mechanically debilitated three-dimensional hydrogel environment induces hypertrophic trend in chondrocytes
This study investigates the potential of a composite scaffold consisting hydroxyapatite-integrated fluorenyl-9-methoxycarbonyl diphenylalanine hydrogels by focusing on the optimization of this hybrid scaffold for the development of an in vitro model of degenerative cartilage. Cell growth, chondrocyte proliferation, extracellular matrix production, hypertrophy marker monitoring, scaffold mechanical properties, and morphological analysis were evaluated. Fluorenyl-9-methoxycarbonyl diphenylalanine dipeptides were dissolved in null cell culture media and pH decreased sequentially to compel peptides to self-organize into fibrou...
Source: Journal of Bioactive and Compatible Polymers - August 23, 2016 Category: Research Authors: Celik, E., Bayram, C., Akcapınar, R., Türk, M., Denkbas, E. B. Tags: Original Articles Source Type: research

Injectable hydrogel from plum pectin as a barrier for prevention of postoperative adhesion
An injectable hydrogel was obtained from the high methyl-esterified plum Prunus domestica L. (PD) pectin and calcium ions (Ca2+). PD hydrogel showed a weak gel-like behavior and could be squeezed out of the syringe with an injection force of ca. 9 N. PD hydrogel was not suitable for the NIH/3T3 fibroblast cell adhesion in vitro. The live/dead fluorescence and MTT (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide) assays indicated that the PD hydrogel had a low cytotoxicity in relation to both the adhered and gel surrounding fibroblasts. PD hydrogel was found to inhibit adhesion formation in the sidewall defect-c...
Source: Journal of Bioactive and Compatible Polymers - August 23, 2016 Category: Research Authors: Popov, S. V., Popova, G. Y., Nikitina, I. R., Markov, P. A., Latkin, D. S., Golovchenko, V. V., Patova, O. A., Krachkovsky, N., Smirnov, V. V., Istomina, E. A., Shumikhin, K. V., Burkov, A. A., Martinson, E. A., Litvinets, S. G. Tags: Original Articles Source Type: research

Evaluation of antimicrobial efficacy of quaternized poly[bis(2-chloroethyl)ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] against targeted pathogenic and multi-drug-resistant bacteria
Here, we have investigated in vitro antimicrobial efficacy of a quaternized cationic polymer, poly[bis(2-chloroethyl)ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] (polyquaternium-2), against gram-positive as well as gram-negative bacteria along with several multi-drug-resistant bacterial strains. The antimicrobial efficacy of this polymer was first tested against some clinical pathogens followed by microorganisms isolated from acne lesions. Interestingly, polyquaternium-2 exhibited significant antimicrobial activity against methicillin-resistant Staphylococcus aureus, for which very limited drugs are available. Most impo...
Source: Journal of Bioactive and Compatible Polymers - August 23, 2016 Category: Research Authors: Kumar, B., Mathur, A., Pathak, R., Sardana, K., Gautam, H. K., Kumar, P. Tags: Original Articles Source Type: research

Potential of mannan or dextrin nanogels as vaccine carrier/adjuvant systems
Polymeric nanogels have been sophisticatedly designed promising a new generation of vaccine delivery/adjuvant systems capable of boosting immune response, a strategic priority in vaccine design. Here, nanogels made of mannan or dextrin were evaluated for their potential as carriers/adjuvants in vaccine formulations. Since lymph nodes are preferential target organs for vaccine delivery systems, nanogels were biotin-labeled, injected in the footpad of rats, and their presence in draining lymph nodes was assessed by immunofluorescence. Nanogels were detected in the popliteal and inguinal lymph nodes by 24 h upon subcutaneous ...
Source: Journal of Bioactive and Compatible Polymers - August 23, 2016 Category: Research Authors: Goncalves, C., Ferreira, S. A., Correia, A. L., Lopes, C., Fleming, C. E., Rocha, E., Vilanova, M., Gama, M. Tags: Original Articles Source Type: research

Synthesis and characterization of polyhydroxybutyrate-co-hydroxyvalerate nanoparticles for encapsulation of quercetin
Polyhydroxybutyrate-co-hydroxyvalerate has been identified as a useful polymer for biomedical application due to its biocompatibility and processability. Polyhydroxybutyrate-co-hydroxyvalerate nanoparticles loaded with quercetin, an antimicrobial, anti-inflammatory, and antiviral polyphenol with limited solubility, were obtained using a high-speed double-emulsion technique. The nanoparticle size and the dissolution of quercetin were controlled simultaneously through high-speed stirring (15,000 r/min) in the emulsification process. The size range of quercetin-loaded polyhydroxybutyrate-co-hydroxyvalerate nanoparticles was b...
Source: Journal of Bioactive and Compatible Polymers - August 23, 2016 Category: Research Authors: Lightfoot Vidal, S., Rojas, C., Bouza Padin, R., Perez Rivera, M., Haensgen, A., Gonzalez, M., Rodriguez-Llamazares, S. Tags: Original Articles Source Type: research

Morphology and surface chemistry of bicomponent scaffolds in terms of mesenchymal stromal cell viability
Biological interaction between cells and scaffolds is mediated through events at surfaces. Proteins present in the culture medium adsorb on substrates, generating a protein adlayer that triggers further downstream events governing cell adhesion. Polymer blends often combine the properties of the individual components, for example, can provide mechanical as well as surface properties in one fibre. Therefore, mixtures of synthetic polycaprolactone and gelatin as a denatured form of collagen were electrospun at selected conditions and polymer weight ratios. Fibre morphologies and chemical properties of the surfaces were analy...
Source: Journal of Bioactive and Compatible Polymers - June 20, 2016 Category: Research Authors: Kołbuk, D., Guimond-Lischer, S., Sajkiewicz, P., Maniura-Weber, K., Fortunato, G. Tags: Original Articles Source Type: research