Muscular sarcoidosis under anti TNF treatment in ankylosing spondylitis
Publication date: Available online 19 May 2018 Source:Joint Bone Spine Author(s): Daniel Wendling, Jean-Philippe Nueffer (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 20, 2018 Category: Orthopaedics Source Type: research

Vascular Involvement in Axial Spondyloarthropathies
Publication date: Available online 19 May 2018 Source:Joint Bone Spine Author(s): Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel Wendling Ankylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcom...
Source: Joint Bone Spine - May 20, 2018 Category: Orthopaedics Source Type: research

Gout furonculosis
Publication date: Available online 19 May 2018 Source:Joint Bone Spine Author(s): Frédéric Lioté (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 20, 2018 Category: Orthopaedics Source Type: research

Opioids Can Paradoxically Induce Severe Pain
Publication date: Available online 2 May 2018 Source:Joint Bone Spine Author(s): Jean-Marie Berthelot, Julien Nizard, Yves Maugars (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 3, 2018 Category: Orthopaedics Source Type: research

Non-infective endocarditis: expanding the phenotype of giant cell arteritis
Publication date: Available online 27 April 2018 Source:Joint Bone Spine Author(s): Alexandre Terré, Olivier Lidove, Odette Georges, Patrick Mesnildrey, Hélène Chennebault, Jean-Marc Ziza (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 28, 2018 Category: Orthopaedics Source Type: research

Burden of severe spondyloarthritis in France: A nationwide assessment of prevalence, associated comorbidities and cost
Conclusions The burden of severe SpA in France is substantial, due to the high prevalence, high direct costs, and associated comorbidities. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 28, 2018 Category: Orthopaedics Source Type: research

Pseudo-malignant osteolysis of the pelvis: unusual pattern of pubic bone fracture
Publication date: Available online 28 April 2018 Source:Joint Bone Spine Author(s): Youssef Jalal, Ali Zine, Abdelouahab Jaafar (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 28, 2018 Category: Orthopaedics Source Type: research

Extensive lytic tuberculosis of the humeral head
Publication date: Available online 28 April 2018 Source:Joint Bone Spine Author(s): Sabri Mahjoub, Ahmed Amine Lahmar, Mourad zaraa, Ghassen Belhaj, Mohamed Abdelkafi, Mondher Mbarek (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 28, 2018 Category: Orthopaedics Source Type: research

IMSYC IMmunologic SYnovitis sCore: A New Score for Synovial Membrane Characterization In Inflammatory And Non-Inflammatory Arthritis
Conclusion We propose a new synovitis score including immunohistochemistry. This score has a better sensitivity and specificity than the Krenn score and represents a more functional synovitis evaluation. IMSYC could be further used in better categorizing synovial tissue phenotype and give a basis for tissue driven therapy. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 27, 2018 Category: Orthopaedics Source Type: research

The confidence of rheumatologists about switching to biosimilars for their patients
Publication date: Available online 6 April 2018 Source:Joint Bone Spine Author(s): Guro L. Goll, Espen A. Haavardsholm, Tore K. Kvien (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2018 Category: Orthopaedics Source Type: research

Impact of ACR 2010 fibromyalgia criteria fulfillment on disease activity evaluation in patients with axial spondyloarthritis treated with infliximab
Publication date: Available online 20 April 2018 Source:Joint Bone Spine Author(s): Alexandra Dantu, Julien Michaud, Quentin Bréhier, Christopher Banse, Gilles Avenel, Thierry Lequerré, Sophie Pouplin, Olivier Vittecoq, Mathieu Verdet (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 20, 2018 Category: Orthopaedics Source Type: research

Anti PAD autoimmunity and Rheumatoid arthritis
Publication date: Available online 12 April 2018 Source:Joint Bone Spine Author(s): Jean Roudier, Nathalie Balandraud, Isabelle Auger (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 13, 2018 Category: Orthopaedics Source Type: research

2018 Update of French Recommendations on the Management of Postmenopausal Osteoporosis
Discussion and conclusion The updated recommendations place strong emphasis on the treatment of women with severe fractures, in whom the use of osteoporosis medications is recommended. All the available osteoporosis medications are suitable in patients with severe fractures; zoledronic acid deserves preference as the fist-line drug after a hip fracture. In patients with or without non-severe fractures, the decision to use osteoporosis medications is based on bone mineral density values and, in challenging cases, on probabilities supplied by prediction tools such as FRAX®. All osteoporosis medications are suitable; ralo...
Source: Joint Bone Spine - April 12, 2018 Category: Orthopaedics Source Type: research

Gut Microbiome and Bone
Publication date: Available online 11 April 2018 Source:Joint Bone Spine Author(s): Lidia Ibáñez, Matthieu Rouleau, Abdelilah Wakkach, Claudine Blin-Wakkach The gut microbiome is now viewed as a tissue that interacts bidirectionally with the gastrointestinal, immune, endocrine, and nervous systems, affecting the cellular responses in numerous organs. Evidence is accumulating of gut microbiome involvement in a growing number of pathophysiological processes, many of which are linked to inflammatory responses. More specifically, data acquired over the last decade point to effects of the gut microbiome on bone m...
Source: Joint Bone Spine - April 12, 2018 Category: Orthopaedics Source Type: research

Diagnostic Contribution of HLA-A,B,C,DR Genotyping in Inflammatory Joint Disease
Publication date: Available online 11 April 2018 Source:Joint Bone Spine Author(s): Jean Roudier, Emmanuel Massy, Nathalie Balandraud (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 12, 2018 Category: Orthopaedics Source Type: research

Decreased PD-1 expression on circulating CD4+T cell and PD-L1 expression on myeloid dendritic cell correlate with clinical manifestations in systemic juvenile idiopathic arthritis
Conclusions Our finding displayed decreased CD4+T cell, increased mDC and reduced PD-1/PD-L1 signal in sJIA PBMC comparing with other JIA subsets, which might be helpful in JIA differential diagnosis and responsible for distinct clinical manifestations via different mechanisms. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 11, 2018 Category: Orthopaedics Source Type: research

Camptocormia with trigeminal involvement revealing myositis with anti-Ku antibodies
Publication date: Available online 10 April 2018 Source:Joint Bone Spine Author(s): Sébastien De Almeida Chaves, Guillaume Moulis, Gregory Pugnet, Laurent Sailler, Léonardo Astudillo (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 11, 2018 Category: Orthopaedics Source Type: research

Adipokines and bone status in a cohort of anorexic patients
Conclusion Bone status in anorexia nervosa is mainly determined by BMI, leptin and adiponectin. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 11, 2018 Category: Orthopaedics Source Type: research

Effectiveness and safety of anakinra in gout patients with stage 4-5 chronic kidney disease or kidney transplantation: a multicentre, retrospective study
Conclusion Anakinra may be a safe therapeutic option for gout patients with advanced CKD. Further randomized controlled studies are required to confirm our results. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 11, 2018 Category: Orthopaedics Source Type: research

A 3-year back and forth between Modic type 1 and 2 on MRI in chronic low back pain
Publication date: Available online 11 April 2018 Source:Joint Bone Spine Author(s): A. Amouzougan, K. Boussoualim, H. Marotte, F.G. Barral, T. Thomas (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 11, 2018 Category: Orthopaedics Source Type: research

Dropped head syndrome with proximal myopathy revealing AL amyloidosis
Publication date: Available online 11 April 2018 Source:Joint Bone Spine Author(s): Charlotte Laurent, Jessie Aouizerate, Alexia Hourdille, Emmanuel Itti, François-Jérôme Authier, Xavier Chevalier (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 11, 2018 Category: Orthopaedics Source Type: research

Relevance and feasibility of a systematic screening of multimorbidities in patients with chronic inflammatory rheumatic diseases
Conclusion This study underlines the relevance of a systematic screening of multimorbidities in chronic inflammatory rheumatic diseases and its feasibility in a 1-day clinic. Spirometry and sleep apnea screening should be added to EULAR points to consider. The long-term impact of such screening needs to be evaluated. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 11, 2018 Category: Orthopaedics Source Type: research

Impact of obesity on the efficacy of different biologic agents in inflammatory diseases: a systematic review and meta-analysis
Conclusion Obesity hampered the effect of anti-TNF agents, but not those of abatacept and tocilizumab, suggesting that a personalized treatment strategy should be considered for obese patients with inflammatory diseases. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 8, 2018 Category: Orthopaedics Source Type: research

Hydroxychloroquine for the prevention of fetal growth restriction and prematurity in lupus pregnancy: a systematic review and meta-analysis
Conclusion This meta-analysis failed to prove the efficacy of HCQ in the prevention of prematurity as well as IUGR during SLE pregnancies. Due to the heterogeneity of the studies, these results should be interpreted cautiously. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 7, 2018 Category: Orthopaedics Source Type: research

Evaluation of bone quality with trabecular bone score in active spondyloarthritis
Conclusion Our results show that TBS provides information additional to BMD on the bone status of patients with SpA. They suggest that TBS may help in identifying those patients at risk of fracture. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 7, 2018 Category: Orthopaedics Source Type: research

Prevalence of shoulder calcification in pseudoxanthoma elasticum patients
Publication date: Available online 6 April 2018 Source:Joint Bone Spine Author(s): Emmanuel Hoppe, Maxime Etienne, Erick Legrand, Frank Rutsch, Georges Leftheriotis, Ludovic Martin (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 7, 2018 Category: Orthopaedics Source Type: research

The confidence of rheumatologists about switching to biosimilar for their patients
Publication date: Available online 6 April 2018 Source:Joint Bone Spine Author(s): Guro L. Goll, Espen A. Haavardsholm, Tore K. Kvien (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 7, 2018 Category: Orthopaedics Source Type: research

Cannabis for musculoskeletal pain and arthritis: Evidence is needed
Publication date: Available online 6 April 2018 Source:Joint Bone Spine Author(s): Serge Perrot, Anne-Priscille Trouvin (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 7, 2018 Category: Orthopaedics Source Type: research

Bone metastases from lung cancer: a paradigm for multidisciplinary onco-rheumatology management
Publication date: Available online 6 April 2018 Source:Joint Bone Spine Author(s): Cyrille B. Confavreux, Jean-Baptiste Pialat, Aurélie Bellière, Marie Brevet, Chantal Decroisette, Agnès Tescaru, Julien Wegrzyn, Cédric Barrey, Françoise Mornex, Pierre-Jean Souquet, Nicolas Girard Bone is the third metastatic site after liver and lungs. Bone metastases occur in one out of three lung cancers and are usually of osteolytic aspect. Osteolytic bone metastases are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely alte...
Source: Joint Bone Spine - April 7, 2018 Category: Orthopaedics Source Type: research

Biological Agents in the Management of Adult-Onset Still's disease
Publication date: Available online 6 April 2018 Source:Joint Bone Spine Author(s): Charlotte Girard-Guyonvarc’h, Cem Gabay (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 7, 2018 Category: Orthopaedics Source Type: research

Decreased PD-1 expression on circulating CD4+T cell and PD-L1 expression on myeloid dendritic cells correlate with clinical manifestations in systemic juvenile idiopathic arthritis
Conclusions Our finding displayed decreased CD4+T cell, increased mDC and reduced PD-1/PD-L1 signal in sJIA PBMC comparing with other JIA subsets, which might be helpful in JIA differential diagnosis and responsible for distinct clinical manifestations via different mechanisms. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 31, 2018 Category: Orthopaedics Source Type: research

Biosimilars: An Opportunity. Position Statement of the French Rheumatology Society (SFR) and Inflammatory Rheumatic Disease Club (CRI)
Publication date: Available online 21 March 2018 Source:Joint Bone Spine Author(s): Thierry Schaeverbeke, Thao Pham, Christophe Richez, Daniel Wendling (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 22, 2018 Category: Orthopaedics Source Type: research

Gout drugs use and risk of cancer: A case-control study
Conclusion In summary, our results suggest that gout drugs increase risk of the most common cancers, particularly in leukemia, non-Hodgkin's, endometrial, breast and cervical cancer. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 10, 2018 Category: Orthopaedics Source Type: research

2018 update of French Society for Rheumatology (SFR) recommendations about the everyday management of patients with spondyloarthritis
Conclusion This update incorporates recent data into a smaller number of more simply formulated recommendations, with the goal of facilitating their use for guiding the management of patients with SpA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 9, 2018 Category: Orthopaedics Source Type: research

Air Pollution as a Determinant of Rheumatoid Arthritis
Publication date: Available online 7 March 2018 Source:Joint Bone Spine Author(s): Johanna Sigaux, Jérôme Biton, Emma André, Luca Semerano, Marie-Christophe Boissier Pollution has long been incriminated in many cardiovascular and respiratory diseases. More recently, studies evaluated the potential role for particulate pollutants in autoimmune diseases, including rheumatoid arthritis (RA). The incidence of RA was found to be higher in urban areas. Living near air pollution emitters was associated with higher risks of developing RA and of producing RA-specific autoantibodies. Nevertheless, no strong epid...
Source: Joint Bone Spine - March 8, 2018 Category: Orthopaedics Source Type: research

Reply to the comment of Rothschild B. “Maltese cross interpretation”
Publication date: Available online 6 March 2018 Source:Joint Bone Spine Author(s): Guillaume Coiffier, Jean-David Albert, Francois Robin, Pascal Guggenbuhl (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 7, 2018 Category: Orthopaedics Source Type: research

Acral myxoinflammatory fibroblastic sarcoma simulating rheumatoid bursitis. Diffusion-weighted imaging
Publication date: Available online 31 January 2018 Source:Joint Bone Spine Author(s): Aline Serfaty, Flavia Costa, Ierecê Lins Aymore, Walter Meohas, Clarissa Canella, Edson Marchiori (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 3, 2018 Category: Orthopaedics Source Type: research

Whipple's disease mimicking an auto-inflammatory disease with myositis and soft tissue inflammation
Publication date: Available online 31 January 2018 Source:Joint Bone Spine Author(s): Barbara Ankli, Bettina Khanlari, Vassilios Pegios, Andreas Zettl, Thomas Daikeler (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 3, 2018 Category: Orthopaedics Source Type: research

High bone mass in adults
Publication date: Available online 31 January 2018 Source:Joint Bone Spine Author(s): Julien Paccou, Laetitia Michou, Sami Kolta, Françoise Debiais, Bernard Cortet, Pascal Guggenbuhl A finding of high bone mineral density (BMD) from routine dual-energy X-ray absorptiometry (DXA) screening is not uncommon. No consensus exists about the definition of high BMD, and T-score and/or Z-score cutoffs of ≥+2.5 or ≥+4 have been suggested. The many disorders that can result in high BMD are usually classified based on whether the BMD changes are focal vs. generalized or acquired vs. constitutional. In over half the cases...
Source: Joint Bone Spine - March 3, 2018 Category: Orthopaedics Source Type: research

Non-celiac gluten intolerance in patients with scleroderma.
Publication date: Available online 13 February 2018 Source:Joint Bone Spine Author(s): Renato Nisihara, Mariana Aguiar Koubik, Maitê Mateus, Lorete da Silva Kotze, Thelma Larocca Skare (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 3, 2018 Category: Orthopaedics Source Type: research

Monitoring of Epstein –Barr virus (EBV)/cytomegalovirus (CMV)/varicella-zoster virus (VZV) load in patients receiving tocilizumab for rheumatoid arthritis
Publication date: March 2018 Source:Joint Bone Spine, Volume 85, Issue 2 Author(s): Marc Scherlinger, Sophie Alain, Christophe Richez (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 28, 2018 Category: Orthopaedics Source Type: research

Pulmonary arterial hypertension in four patients treated by leflunomide
We report four cases of patients who developed PAH following a treatment by leflunomide for rheumatoid arthritis, psoriatic arthritis or undetermined connective tissue disease. All patients described a progressive dyspnea from grade II to IV of NYHA classification; clinical examination found signs of heart failure. PAH was finally diagnosed and confirmed by right heart catheterisation. Haemodynamic explorations found pre-capillary pulmonary hypertension with mean pulmonary arterial pressure above 25mmHg, and pulmonary capillary wedge pressure under 15mmHg. Explorations of this pre-capillary pulmonary hypertension were cond...
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Report of two cases of tocilizumab induced recurrent meningitis or meningoencephalitis
Publication date: Available online 31 January 2018 Source:Joint Bone Spine Author(s): Pauline Richebé, Florian Bailly, Louise Laure Mariani, Paola Sanchez Pena, Jean Michel Pedespan, Bruno Fautrel (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Whipple's disease: an untypical presentation
Publication date: Available online 31 January 2018 Source:Joint Bone Spine Author(s): Brabara Ankli, Bettina Khanlari, Vassilios Pegios, Andreas Zettl, Thomas Daikeler (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Acral Myxoinflammatory Fibroblastic Sarcoma Simulating Rheumatoid Bursitis – Diffusion-weighted Imaging
Publication date: Available online 31 January 2018 Source:Joint Bone Spine Author(s): Aline Serfaty, Flavia Costa, Ierecê Lins Aymore, Walter Meohas, Clarissa Canella, Edson Marchiori (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Teriparatide Persistence and Tolerance in Patients with Osteoporosis: Observational Data from Clinical Practice
Publication date: Available online 31 January 2018 Source:Joint Bone Spine Author(s): Nicolas Taisne, Marie-Amélie Mignot, Isabelle Legroux, Bernard Cortet, Julien Paccou (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Crystal-induced Oligoarthritis triggered by pembrolizumab, an immune checkpoint inhibitor
Publication date: Available online 4 February 2018 Source:Joint Bone Spine Author(s): Hèctor Corominas, Fadi Badlissi, Robert H. Shmerling (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Failure of conventional treatment and losartan in Camurati-Engelmann disease: a case report
Publication date: Available online 13 February 2018 Source:Joint Bone Spine Author(s): Alice Combier, Elisabeth Palazzo, Marine Forien, Anais Gardette, Philippe Dieudé, Sébastien Ottaviani (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Therapeutic strategy for Rheumatoid Arthritis Patients who have achieved Remission
Publication date: Available online 13 February 2018 Source:Joint Bone Spine Author(s): Bruno Fautrel Once remission or low disease activity (LDA) is attained in established rheumatoid arthritis (RA) patients, attempting disease-modifying anti-rheumatic drug (DMARD) tapering appears to be a viable option to avoid patient overtreatment. Potential benefits include reduction in the treatment burden and the risk of adverse events, although the latter has not been demonstrated convincingly.The feasibility of DMARD discontinuation has been tested in numerous studies or trials. All have revealed a high risk of relapse, ranging fr...
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

The Chondrocyte Channelome: A Narrative Review
Publication date: Available online 13 February 2018 Source:Joint Bone Spine Author(s): Ali Mobasheri, Csaba Matta, Ilona Uzielienè, Emma Budd, Pablo Martín-Vasallo, Eiva Bernotiene Chondrocytes are the main cells in the extracellular matrix of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The mem...
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research