Effect of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort
Conclusions In a cohort of early RA, young age at disease onset is associated with high rate of remission at 1year, no radiographic progression at 3years and low functional score during 3-year follow-up. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Evaluation of the immunogenicity of the 13-valent conjugated pneumococcal vaccine in rheumatoid arthritis patients treated with etanercept
Conclusions In RA patients treated with ETA, vaccination with PCV13 is effective and safe, resulting in pAR one and two months after vaccination. Higher age at vaccination was identified as predictors of impaired pAR. The efficacy of vaccination may be more pronounced in younger RA patients. The vaccine is safe in RA patients on ETA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Low back pain and femoral neuralgia revealing myeloid sarcoma with megakaryocytic differentiation
Publication date: Available online 16 March 2016 Source:Joint Bone Spine Author(s): Gonçalo Boleto, Matthias Michel, Nadia Salam, Jean-Paul Eschard, Jean-Hugues Salmon (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Atlantooccipital arthritis inaugurating axial spondyloarthritis
Publication date: Available online 14 March 2016 Source:Joint Bone Spine Author(s): Julien Michaud, Olivier Vittecoq, Paul Michelin, Thierry Lequerré, Christopher Banse (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 15, 2016 Category: Orthopaedics Source Type: research

Efficacy of zoledronic acid in Erdheim-Chester disease: A case report
We report a case of a biopsy proven bone Erdheim-Chester disease in a 65-year-old woman with history of breast cancer. Her pain was relieved after 3 perfusions of zoledronic acid and the efficiency remained at one year of follow-up. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 15, 2016 Category: Orthopaedics Source Type: research

Functional restoration programs in patients with chronic low back pain and body composition: No change in muscle mass assessed through Dual X-ray absorptiometry in 94 patients, a monocenter longitudinal study
Publication date: Available online 11 March 2016 Source:Joint Bone Spine Author(s): Carole Desthieux, Sabrina Dadoun, Violaine Foltz, Sylvie Rozenberg, Bruno Fautrel, Laure Gossec (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 12, 2016 Category: Orthopaedics Source Type: research

Backfill is a specific sign of axial spondyloarthritis seen on MRI
Conclusions We summarized the characteristics of backfill and found that backfill is a specific sign of axial SpA seen on T1SE MRI. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 11, 2016 Category: Orthopaedics Source Type: research

Rheumatoid arthritis and antisynthetase syndrome. A three cases report
Publication date: Available online 8 March 2016 Source:Joint Bone Spine Author(s): Daniel Wendling, Cécile Golden, Matthieu Monet, Frank Verhoeven, Xavier Guillot, Clément Prati (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 11, 2016 Category: Orthopaedics Source Type: research

Van Buchem's Disease
Publication date: Available online 8 March 2016 Source:Joint Bone Spine Author(s): Kawtar Nassar, Wafae Rachidi, Saadia Janani, Ouafa Mkinsi (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 11, 2016 Category: Orthopaedics Source Type: research

Trafficking of antigens from gut to sacroiliac joints and spine in reactive arthritis and spondyloarthropathies: Mainly through lymphatics?
Publication date: Available online 8 March 2016 Source:Joint Bone Spine Author(s): Jean-Marie Berthelot, Pascal Claudepierre Bacterial trafficking from gut to mesenteric lymph nodes is physiologic only for a few commensal species, like Alcaligenes which produces antimicrobial-substances inhibiting growth of pathogenic bacteria. In reactive arthritis, some living bacteria transiently manage to travel from gut to joints/enthesis within dendritic cells and/or macrophages. Migration of dead or dormant bacteria outside the gut in spondyloarthropathies, including those associated with Crohn's disease, can occur either throug...
Source: Joint Bone Spine - March 11, 2016 Category: Orthopaedics Source Type: research

Radiographic progression in patients with ankylosing spondylitis according to tumor necrosis factor blocker exposure: Observation Study of Korean Spondyloarthropathy Registry (OSKAR) data
Conclusion Our registry data showed that TNF blocker failed to affect the radiographic progression over 5 years in AS patients. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 3, 2016 Category: Orthopaedics Source Type: research

Myositis ossificans traumatica (circumscripta) and return to sport: A retrospective series of 19 cases
Conclusion Therapeutic abstention and persistence of ossification do not seem to be detrimental factors for resuming a sport at the earlier level with ultrasound monitoring. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 29, 2016 Category: Orthopaedics Source Type: research

MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes
Conclusion Taken together, these results indicate that miR-20a may play a pivotal role in the NLRP3-inflammasome by targeted inhibit TXNIP expression in AA FLSs. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 29, 2016 Category: Orthopaedics Source Type: research

GOSPEL 2 – Colchicine for the treatment of gout flares in France – a GOSPEL survey subgroup analysis. Doses used in common practices regardless of renal impairment and age
Conclusions This study draws attention to some misuse of colchicine in daily practice and the prescription of excessive doses especially in case of renal impairment. eGFR should be enforced in daily practice. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 24, 2016 Category: Orthopaedics Source Type: research

Comparison of continuation rates with three TNFα antagonists (adalimumab, infliximab, etanercept) in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: Retrospective 10-year study
Publication date: Available online 23 February 2016 Source:Joint Bone Spine Author(s): Benjamin Batteux, Agathe Devauchelle, Pauline Lasselin Boyard, Alice Sejourné, Patrice Fardellone, Vincent Goëb (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 24, 2016 Category: Orthopaedics Source Type: research

Cathepsin K inhibitors and antisclerostin antibodies. The next treatments for osteoporosis?
Publication date: Available online 23 February 2016 Source:Joint Bone Spine Author(s): Roland Chapurlat (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 24, 2016 Category: Orthopaedics Source Type: research

Pain assessment in rheumatology – How can we do better? A literature review
Publication date: Available online 15 February 2016 Source:Joint Bone Spine Author(s): Florian Bailly, Bruno Fautrel, Laure Gossec Patients’ symptoms have a place of prominence in the rheumatology landscape, and among them pain is the most conspicuous. Several pain assessment tools have been validated. One-dimensional pain scales such as visual analog scales (VASs) and numeric rating scales (NRSs) are fast to administer but have limitations that must be acknowledged. Some clinical situations require the use of multidimensional scales such as the McGill Pain Questionnaire or the Multidimensional Pain Inventory (M...
Source: Joint Bone Spine - February 17, 2016 Category: Orthopaedics Source Type: research

Pelvic digit: A rare congenital anomaly
Publication date: Available online 12 February 2016 Source:Joint Bone Spine Author(s): Habib Nouraly, Abdoulaye Toure, René Lahady, Ahmad Ahmad, Abdoul Kader Keita (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 13, 2016 Category: Orthopaedics Source Type: research

TNFα antagonist therapy in axial spondyloarthritis: Can we do better?
Publication date: Available online 10 February 2016 Source:Joint Bone Spine Author(s): Clément Prati, Pascal Claudepierre, Philippe Goupille, Thao Pham, Daniel Wendling (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 11, 2016 Category: Orthopaedics Source Type: research

Is it time for treat to target strategy in osteoporosis?
Publication date: Available online 10 February 2016 Source:Joint Bone Spine Author(s): Roland Chapurlat (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 11, 2016 Category: Orthopaedics Source Type: research

Proper site of corticosteroid injection for the treatment of idiopathic frozen shoulder: Results from a randomized trial
Conclusion The efficacy of corticosteroid injection into the SA space in idiopathic FS was inferior to IA injection up to 12 weeks; however, combination injections had an additive effect on increasing the internal rotation angle. These results indicate that although the glenohumeral joint is a major site in the pathogenesis of idiopathic FS, the SA space may be a contributing site. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 11, 2016 Category: Orthopaedics Source Type: research

Hereditary multiple exostoses: A case-report
Publication date: Available online 5 February 2016 Source:Joint Bone Spine Author(s): Saidou Diallo, Moustapha Niasse, Rama Diallo, Coumba Diouf, André Daniel Sané (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 6, 2016 Category: Orthopaedics Source Type: research

Molecular mechanisms of bone formation in spondyloarthritis
Publication date: Available online 3 February 2016 Source:Joint Bone Spine Author(s): Susana Aideé González-Chávez, Celia María Quiñonez-Flores, César Pacheco-Tena Spondyloarthritis comprise a group of inflammatory rheumatic diseases characterized by its association to HLA-B27 and the presence of arthritis and enthesitis. The pathogenesis involves both an inflammatory process and new bone formation, which eventually lead to ankylosis of the spine. To date, the intrinsic mechanisms of the pathogenic process have not been fully elucidated, and our progress is remarkable in the i...
Source: Joint Bone Spine - February 5, 2016 Category: Orthopaedics Source Type: research

Acknowledging our reviewers
Publication date: January 2016 Source:Joint Bone Spine, Volume 83, Issue 1 (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 30, 2016 Category: Orthopaedics Source Type: research

The roles of interferons in osteoclasts and osteoclastogenesis
Publication date: Available online 29 January 2016 Source:Joint Bone Spine Author(s): Qi Xiong, Lihai Zhang, Wei Ge, Peifu Tang Interferons (IFNs) play essential roles in regulating osteoclast differentiation and bone resorption. Over the last decade, we have seen tremendous developments in our understanding of the mechanisms by which interferons regulate osteoclastogenesis. Of the type I interferons, IFN-β inhibits osteoclastogenesis via autoregulatory or exogenous regulatory mechanisms, while IFN-α was recently shown to participate in regulating osteoclast formation. And the only member of type II interf...
Source: Joint Bone Spine - January 30, 2016 Category: Orthopaedics Source Type: research

Association between hip morphology and prevalence, clinical severity and progression of hip osteoarthritis over 3 years: The knee and hip osteoarthritis long-term assessment cohort results
Conclusions Acetabular obliquity and especially AI is strongly, and likely causally, associated with the existence, severity and progression of hip osteoarthritis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 30, 2016 Category: Orthopaedics Source Type: research

JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total B cells
Conclusion SHR0302 may attenuate the severity of AA rats, partially through reducing Th17 function and total B cell proportion by inhibiting JAK1-STAT3 phosphorylation. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 30, 2016 Category: Orthopaedics Source Type: research

Identification of upstream regulators for synovial expression signature genes in osteoarthritis
Conclusion This integrated analysis has identified the OA signature, providing clues to pathogenesis of OA at the molecular level, which may be also used as diagnostic markers for OA. Some crucial upstream regulators, such as NR4A2, EHF, and EGR1 may be considered as potential new therapeutic targets for OA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 30, 2016 Category: Orthopaedics Source Type: research

Hansen's disease: Descriptions of novel ultrasonographic findings
Publication date: Available online 27 January 2016 Source:Joint Bone Spine Author(s): José Alexandre Mendonça, José Roberto Provenza, Amilcar Castro de Mattos, Fernanda Sayuri Ota, Simone Appenzeller (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 27, 2016 Category: Orthopaedics Source Type: research

Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren's syndrome
Conclusions Sicca symptoms are associated with severe alterations in SF-36, HADS, and MFI scores regardless of objective test abnormalities and pSS diagnosis. Anxiety is more common than depression and should be taken into account when managing all patients with sicca symptoms. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 15, 2016 Category: Orthopaedics Source Type: research

Plasma cell mastitis in women with rheumatoid arthritis treated with TNFα antagonists: Report of 2 cases
Publication date: Available online 13 January 2016 Source:Joint Bone Spine Author(s): Marine Faccin, Ophélie Caillot, Jean Levêque, Aleth Perdriger (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 15, 2016 Category: Orthopaedics Source Type: research

Tocilizumab for refractory relapsing polychondritis–long-term response monitoring by magnetic resonance imaging
Publication date: Available online 29 December 2015 Source:Joint Bone Spine Author(s): Joerg Christoph Henes, Theodoros Xenitidis, Marius Horger (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 12, 2016 Category: Orthopaedics Source Type: research

Small, medium but not large arteries are involved in digital ulcers associated with systemic sclerosis
Conclusion The presence of DU is associated with increased Aix_75 whereas there is no relation with PWV. These data suggest that small and medium arteries are involved in the occurrence of DU whether large vessel stiffness does not contribute. Whether Aix_75 is predictive of further DU remained to be studied. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 12, 2016 Category: Orthopaedics Source Type: research

The clinical relevance of early anti-adalimumab antibodies detection in rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis: A prospective multicentre study
Conclusions Anti-ADA abs could be considered an early marker associated to a poor clinical response to adalimumab treatment. Routine ANA/anti-ENA/aPL monitoring did not reveal as useful tools to predict the development of anti-ADA abs. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 12, 2016 Category: Orthopaedics Source Type: research

Age at disease onset may help to further characterize the disease phenotype in psoriatic arthritis
Conclusion Age at disease onset exerts a strong influence on several domains of disease phenotype in PsA. Therefore, this descriptor should be considered a good stratification option for epidemiological and genetic studies in PsA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 12, 2016 Category: Orthopaedics Source Type: research

Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner
Conclusions Our results indicated that overactivated caspase-1 in neutrophils of RA was likely to mediate IL-18 activation and thus promote the progression of RA in a NLRP3 inflammasome independent manner. (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 12, 2016 Category: Orthopaedics Source Type: research

Epigenetics of cartilage diseases
We present in this short review an update of the role of these pathways in articular diseases. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 25, 2015 Category: Orthopaedics Source Type: research

Monitoring of Epstein-Barr virus (EBV)/cytomegalovirus (CMV)/varicella-zoster virus (VZV) load in patients receiving tocilizumab for rheumatoid arthritis
Conclusion TCZ does not seem to increase the VL of EBV, CMV or VZV. Studies involving larger patient populations are necessary. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 23, 2015 Category: Orthopaedics Source Type: research

Influenza and pneumococcal vaccine coverage in 584 patients taking biological therapy for chronic inflammatory joint: A retrospective study
Conclusion This study showed insufficient vaccine coverage rates, particularly against influenza, in a population at high risk because of exposure to biological therapy. Patient information by healthcare professionals about influenza and pneumococcal vaccination has a major impact and should be renewed as often as possible. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 23, 2015 Category: Orthopaedics Source Type: research

Eosinophilic gastrointestinal disorders associated with autoimmune connective tissue disease
Conclusion Clinicians should consider EGID as a possible diagnosis and perform gastrointestinal tract biopsies in patients with CTD presenting with gastrointestinal symptoms and unexplained eosinophilia. Conversely, more rarely extra-digestive features during follow-up in patients with EGID may lead to a diagnosis of an associated CTD. More research is needed to better understand the underlying pathophysiological processes leading to eosinophilic gastrointestinal infiltration in patients with CTD. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 20, 2015 Category: Orthopaedics Source Type: research

Risk of cutaneous adverse events with febuxostat treatment in patients with skin reaction to allopurinol. A retrospective, hospital-based study of 101 patients with consecutive allopurinol and febuxostat treatment
Conclusion The risk of skin reaction with febuxostat seems moderately increased in patients with a history of cutaneous adverse events with allopurinol. This moderate increase does not support the cross-reactivity of the two drugs. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 19, 2015 Category: Orthopaedics Source Type: research

Teriparatide for osteoporosis in patients with sarcoidosis: Report on risk-benefit ratio in four cases
Conclusions Even if the implication of teriparatide is unclear, the appearance of adverse events in 3 out of 4patients in this small series suggest caution in the use of teriparatide in patients with sarcoidosis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 19, 2015 Category: Orthopaedics Source Type: research

Fatigue in early axial spondyloarthritis. Results from the French DESIR cohort
Conclusion Fatigue levels were high in this population, both for patients fulfilling or not, the ASAS criteria for axSpA. High fatigue was closely related to disease-related variables, indicating fatigue may be an integral part of the disease process in axSpA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 19, 2015 Category: Orthopaedics Source Type: research

Musculoskeletal manifestations of Fabry disease: A retrospective study
Conclusion The diagnosis of Fabry disease is usually delayed, due to confusion with more common disorders. Musculoskeletal manifestations may constitute the presenting symptoms. Past or present pain in the extremities is typical. Osteoporosis may develop early and become severe. Together with the family history, the presence of musculoskeletal manifestations can lead to the correct diagnosis by prompting alpha-galactosidase assays in males and genetic testing in females. Fabry disease is often responsible for musculoskeletal manifestations, of which the most common are pain in the extremities and osteoporosis. These manife...
Source: Joint Bone Spine - December 15, 2015 Category: Orthopaedics Source Type: research

Effects of tumor necrosis factor-α inhibitors on new bone formation in ankylosing spondylitis
Conclusions In TNFi treated AS patients, baseline inflammation is linked with syndesmophyte development. An earlier initiation of TNFi therapy may slow the radiographic progression in AS, and TNFi may lose its benefit of retarding new bone formation at advanced stage of AS especially after the focal fat infiltration or syndesmophyte formation. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 11, 2015 Category: Orthopaedics Source Type: research

Giant synovial chondromatosis of the metacarpophalangeal joint
Publication date: Available online 9 December 2015 Source:Joint Bone Spine Author(s): Mickaël Ropars, Anthony Hervé, Nathalie Stock, Raphaël Guillin, Pascal Guggenbuhl (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 11, 2015 Category: Orthopaedics Source Type: research

Reliability, validity and feasibility of nail ultrasonography in psoriatic arthritis
Conclusion The feasibility and reliability of ultrasonography of the nail in psoriatic arthritis appear to be satisfactory. Among the eight parameters evaluated, power Doppler of the matrix which correlated with local inflammation (DIP joint and bed) and with VAS pain could become an interesting outcome measure, provided that it is also sensitive to change. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 11, 2015 Category: Orthopaedics Source Type: research

An unexpected and forbidding complication after total hip arthroplasty
Publication date: Available online 10 December 2015 Source:Joint Bone Spine Author(s): Alper Çıraklı, Birol Gülman, Çağatay Zengin, İsmail Büyükceran (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 11, 2015 Category: Orthopaedics Source Type: research

Can ARFI elastometry of the salivary glands contribute to the diagnosis of Sjögren's syndrome?
Conclusion ARFI elastometry may contribute to the diagnosis of pSS, as this noninvasive, fast, and inexpensive investigation can demonstrate abnormal architectural changes in the parotid glands. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 9, 2015 Category: Orthopaedics Source Type: research

Ankylosing spondylitis self-help organisations – do members differ from non-members?
Conclusion AS patients who are members of an AS self-help organisation have a higher educational level and are much better informed about the disease. Inferences on disease outcome measures, however, are hampered by potential confounders. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 9, 2015 Category: Orthopaedics Source Type: research