Risk of incident chronic obstructive pulmonary disease in patients with rheumatoid arthritis: A systematic review and meta-analysis
Conclusion Our study demonstrated a statistically significant increased risk of subsequent development of COPD among patients with RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 4, 2016 Category: Orthopaedics Source Type: research

Eosinophilic gastrointestinal disorder preceding Sjögren's syndrome
Publication date: Available online 27 April 2016 Source:Joint Bone Spine Author(s): Marie Lecouffe-Desprets, Matthieu Groh, Bruno Bour, Claire Le Jeunne, Xavier Puéchal (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 28, 2016 Category: Orthopaedics Source Type: research

GC/TOF-MS-based metabolomic profiling in cultured fibroblast-like synoviocytes from rheumatoid arthritis
Conclusions Our metabolic results suggested that the alteration of sugar metabolism, lipolysis, and amino acid metabolism in RA FLS is related to synovial hyperplasia and inflammation. This is the first metabolomic study to determine metabolic changes characteristic of RA FLS, which will provide valuable information to gain in-depth insights into the pathogenesis of RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 26, 2016 Category: Orthopaedics Source Type: research

Pembrolizumab-induced polymyalgia rheumatica in two patients with metastatic melanoma
Publication date: Available online 25 April 2016 Source:Joint Bone Spine Author(s): Bethsabée Garel, Nora Kramkimel, Anne-Priscille Trouvin, Camélia Frantz, Nicolas Dupin (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 26, 2016 Category: Orthopaedics Source Type: research

Painful and swollen hands 3 months after lungs graft: Suracute voriconazole-induced periostitis and exostosis
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Benoît Metayer, Caroline Bode-Milin, Catherine Ansquer, Alain Haloun, Yves Maugars, Jean-Marie Berthelot (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 24, 2016 Category: Orthopaedics Source Type: research

Very early renal relapse of microscopic polyangiitis after kidney transplantation
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Luca Moroni, Xavier Puéchal (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Glycated albumin increases with disease activity in rheumatoid factor positive rheumatoid arthritis patients with normal fasting glucose and HbA1c
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Jin-Su Park, Jungsik Song, Yong-Beom Park, Soo-Kon Lee, Sang-Won Lee (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Stress fractures healing with bisphosphonates in Paget's disease
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Ritesh Kumar, Jaya Kumar Selviambigapathy, Sadishkumar Kamalanathan, Jaya Prakash Sahoo (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Images of thoracic spinal cord compression due to intraspinal gouty tophus in two patients
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Kun Wang, Jinmin Zhao, Maolin He, Mitra Fowdur, Tenglong Jiang, Shuju Luo (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Comparison of modified disease-activity scores with original composite scores for prediction of structural damages in rheumatoid arthritis: Data from the ESPOIR cohort
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Marion Couderc, Bruno Pereira, Bernard Combe, Valérie Devauchelle-Pensec, Xavier Mariette, Martin Soubrier (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

A case of arthritis under pembrolizumab
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Jean-Hugues Salmon, Isabelle Lambrecht, Pascal Brochot, Florent Grange (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Antineutrophilic cytoplasmic antibody-associated vasculitis and malignant hemopathies, a retrospective study of 16 cases
Conclusion The association of ANCA-associated vasculitis and malignant hemopathy is rare but must nevertheless be recognized because: (i) the clinical signs of both pathologies are not specific, (ii) the survival scores that are used for ANCA-associated vasculitis do not appear to be applicable, (iii) both pathologies must be taken into account in order to implement an effective therapeutic strategy that limits the inherent risks. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Diminished bone resorption in overweight/obese women despite vitamin D insufficiency
Publication date: Available online 23 April 2016 Source:Joint Bone Spine Author(s): Michel Laroche, Jean Michel Pouilles, Florence Trémollières, Marion Vallet, Slim Lassoued, Delphine Nigon, Ivan Tack (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Risk of postoperative infections and the discontinuation of TNF inhibitors in patients with rheumatoid arthritis: A meta-analysis
Conclusion This meta-analysis showed an increased risk of SSI in patients under TNF inhibitor, and a decreased risk of SSI in case of interruption of treatment during the perioperative time. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Early clinical response predicts low disease activity at one year in rheumatoid arthritis patients on treatment with certolizumab in real-life settings. An appraisal of the Italian registry GISEA
Conclusions Our findings showed that attaining good EULAR response at 3months strongly predicted 1year LDA in RA patients treated with CZP in real-life settings. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 23, 2016 Category: Orthopaedics Source Type: research

Anterior horn syndrome: A rare manifestation of primary Sjögren's syndrome
Publication date: Available online 21 April 2016 Source:Joint Bone Spine Author(s): Safaa Zahlane, Nissrine Louhab, Meriem El Mellakh, Najib Kissani The authors report an exceptional case of an anterior horn syndrome associated with Sjögren's syndrome in a 58-year-old patient with a flaccid tetraparesis revealed by asymmetric atrophy and diffuse fasciculations associated with xerostomia and xerophthalmia. The electroneuromyography objectified a diffuse anterior horn syndrome. The brain MRI and spinal cord were normal. Laboratory tests revealed positive anti-SSA and anti-SSB antibody. The salivary glands biopsy o...
Source: Joint Bone Spine - April 22, 2016 Category: Orthopaedics Source Type: research

Focus on the bone in complex regional pain syndrome type I
Publication date: Available online 20 April 2016 Source:Joint Bone Spine Author(s): Michel Laroche (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 21, 2016 Category: Orthopaedics Source Type: research

Diagnostic contribution of a second percutaneous needle biopsy in patients with spontaneous diskitis and negative blood cultures and first biopsy
Conclusion In our study, a second needle biopsy was useful, providing the bacteriological diagnosis in 60% of cases of spontaneous diskitis with negative findings from blood cultures and the first biopsy. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 21, 2016 Category: Orthopaedics Source Type: research

The gut in spondyloarthritis
Publication date: Available online 14 April 2016 Source:Joint Bone Spine Author(s): Daniel Wendling The links between the bowel and spondyloarthritis, although demonstrated many years ago, have been placed under the spotlight by recent findings. Thus, studies have established that bowel inflammation is associated with the joint disease activity, sacroiliac joint inflammation by magnetic resonance imaging, and elevated levels of biomarkers for bowel inflammation (S100 proteins) or antimicrobial antibodies (anti-flagellin). IL-23/Th17 pathway activation originating in the bowel has been documented in studies demonstrating...
Source: Joint Bone Spine - April 15, 2016 Category: Orthopaedics Source Type: research

Kinases inhibitors and small molecules: A new treatment tool for axial spondyloarthropathy?
Publication date: Available online 14 April 2016 Source:Joint Bone Spine Author(s): Daniel Wendling, Clément Prati (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 15, 2016 Category: Orthopaedics Source Type: research

New therapeutic approach to hyperuricemia and gout in the light of recommendations
Publication date: Available online 13 April 2016 Source:Joint Bone Spine Author(s): Frédéric Lioté (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 14, 2016 Category: Orthopaedics Source Type: research

Effect of serum anti-tumour necrosis factor (TNF) drug trough concentrations and antidrug antibodies (ADAb) to further anti-TNF short-term effectiveness after switching in rheumatoid arthritis and axial spondyloarthritis
Publication date: Available online 8 April 2016 Source:Joint Bone Spine Author(s): Fabien Bernard Vincent, Stephan Pavy, Roman Krzysiek, Thierry Lequerré, Jérémie Sellam, Yassine Taoufik, Xavier Mariette, Corinne Miceli-Richard (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 9, 2016 Category: Orthopaedics Source Type: research

Inflammation of the infrapatellar fat pad
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Florent Eymard, Xavier Chevalier The infrapatellar fat pad (IFP) of Hoffa's fat pad is the main adipose structure within the knee joint. It is located between the joint capsule and the synovial membrane, which lines its posterior aspect. The IFP is composed chiefly of adipocytes and receives an abundant supply of blood vessels and nerves. Immune cells can infiltrate the IFP, which can become a major source of numerous proinflammatory mediators (cytokines and adipokines). The physiological role for the IFP remains unclear but may involve ...
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

Is colchicine an effective treatment in periodic fever, aphtous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome?
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Perrine Dusser, Véronique Hentgen, Bénédicte Neven, Isabelle Koné-Paut Introduction PFAPA syndrome is the most frequent periodic fever syndrome in non-Mediterranean patients. The pathogenesis is unclear and the treatment is purely symptomatic and not standardized. The aim of this study was to assess colchicine's efficacy as prophylactic treatment in PFAPA syndrome and to identify factors able to predict response to treatment. Methods We performed a retrospective, multicentric, cohort study of PFAPA patients...
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

The changing countenance of Paget's Disease of bone
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Laëtitia Michou, Philippe Orcel Paget's disease of bone (PDB) manifests fairly late in life and currently affects up to 3% of individuals older than 55 years of age. An about 60% decline in the prevalence of PDB between 1970 and 1990 was documented in England, particularly in Lancashire, where the disease was initially most common. Although wide regional variations exist, the overall prevalence is decreasing, as confirmed by a recent meta-analysis. This secular decline is associated with a decrease in mortality due to the disappeara...
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

How twin studies help to understand inflammatory joint disease
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Nathalie C. Lambert Inflammatory joint disease (IJD) is a group of conditions that target the joints and periarticular structures. The contribution of genetic factors to these conditions is often less than 50%, suggesting a major role for environmental influences. Twin studies are the best means of assessing the role for genetic factors in IJD. Conclusive evidence has been provided by a few studies in vast samples of monozygotic and dizygotic twins, with only one twin in each pair having IJD. These studies have been most successful in ank...
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

Contrast-enhanced ultrasound in coxitis
Conclusions In most cases, clinical parameters together with B-mode US findings are sufficient to diagnose coxitis. However, CEUS is capable of visualizing and quantifying the degree of hypervascularisation and enables the discrimination between effusion and proliferative synovial tissue. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

Villonodular synovitis shoulder complicated by rotator cuff rupture
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Amira Mhenni, Haifa Hachfi, Hichem Ben Brahim, Sameh Ben Hammouda, Mohamed Younes (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

Detection of a lumbar foraminal venous varix by Color Doppler Ultrasound
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Christelle Darrieutort-Laffite, Hubert Desal, Jean-Marie Berthelot, Benoît Le Goff Ultrasonography is currently widely used in the rheumatology practice. Although mainly performed to study peripheral joint, several articles have underlined its interest to study spinal anatomy. However, its ability to provide diagnostic features is unknown. We studied the case of a 25-year-old woman having low back pain. Three different imaging modalities (Computed Tomography [CT], Magnetic Resonance Imaging [MRI] and Ultrasound) were used to expl...
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

IgG4-related disease presenting as hypertrophic pachymeningitis and compressive optic neuropathy
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Gyuhwan Hwang, So-Young Jin, Hyun-Sook Kim (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

Coracoclavicular Joint
Publication date: Available online 7 April 2016 Source:Joint Bone Spine Author(s): Fethi Kraiem, Kamel Khardani, Ahmed Amine Lahmar, Imed Trigui, Slim Dhahak (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

Gout characteristics associate with depression, but not anxiety, in primary care: Baseline findings from a prospective cohort study
Conclusion Patients experiencing frequent gout attacks or attacks in multiple joints are likely to experience depressive symptoms, even when using allopurinol. Depression may influence medication adherence and participation in routine reviews, hence impacting adversely on gout management outcomes. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 8, 2016 Category: Orthopaedics Source Type: research

Management of acute HVE infection in a patient treated with rituximab for rheumatoid arthritis
Conclusion This case highlights the safety and the efficacy of the reintroduction of rituximab after 2 months of treatment with ribavirin and a negative PCR. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 5, 2016 Category: Orthopaedics Source Type: research

Fatigue in psoriatic arthritis – a cross-sectional study of 246 patients from 13 countries
Conclusions Fatigue is a priority for PsA patients. Fatigue levels were high in these patients and fatigue>5/10 was mainly associated with disease-related factors but also patient-related variables, indicating that the etiology of fatigue in PsA is multifactorial. (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 5, 2016 Category: Orthopaedics Source Type: research

New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab
Publication date: Available online 1 April 2016 Source:Joint Bone Spine Author(s): Guillermo Carvajal Alegria, Arnaud Uguen, Steeve Genestet, Pascale Marcorelles, Alain Saraux, Divi Cornec (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 2, 2016 Category: Orthopaedics Source Type: research

Patient-driven online survey on the clinical manifestations and diagnostic delay of granulomatosis with polyangiitis
Publication date: Available online 1 April 2016 Source:Joint Bone Spine Author(s): Elaine Yacyshyn, Andrea Johnson, Marta Rode, Christian Pagnoux (Source: Joint Bone Spine)
Source: Joint Bone Spine - April 2, 2016 Category: Orthopaedics Source Type: research

Baxter's syndrome
Publication date: Available online 25 March 2016 Source:Joint Bone Spine Author(s): Dominique Lechevalier, Lisa Bialé, Camille Glanowski, Isabelle Imbert, Evelyne Péroux, Frédéric Banal (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 26, 2016 Category: Orthopaedics Source Type: research

Crystal-induced arthritis after arthroplasty: 7 cases
Conclusion CIA may occur after arthroplasty, within synovial membrane remains or neosynovium developed around the prosthetic joint. CIA is a manifestation of a metabolic disease that persists and can reactivate after surgery. Routine testing for crystals is rarely performed in patients with sterile arthritis of a prosthetic joint, and crystals are difficult to detect in joints with hemarthrosis; consequently, the frequency of prosthetic-joint CIA may be underestimated. Although rare, CIA should be considered routinely when symptoms suggesting septic arthritis develop in a prosthetic joint, in order to avoid unnecessary pro...
Source: Joint Bone Spine - March 23, 2016 Category: Orthopaedics Source Type: research

Osteomalacia by a mesenchymal-FGF23-producing tumour: Successful treatment with radiofrequency ablation. A case report
Publication date: Available online 19 March 2016 Source:Joint Bone Spine Author(s): Annette Igney-Oertel, Ferruh Artunc, Jörg Henes, Ruediger Hoffmann, Stephan Clasen (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 20, 2016 Category: Orthopaedics Source Type: research

In arthritis the Doppler based degree of hypervascularisation shows a positive correlation with synovial leukocyte count and distinguishes joints with leukocytes greater and less than 5/nL
Publication date: Available online 19 March 2016 Source:Joint Bone Spine Author(s): Christian Löffler, Horst Sattler, Lena Peters, Anika Tuleweit, Uta Löffler, Daniel Wadsack, Michael Uppenkamp, Raoul Bergner Objectives Power Doppler ultrasound is used to assess joint vascularity in acute arthritis. PDUS signals have been correlated with synovial histology and bone deterioration. Little is known about the correlation between power Doppler signals and synovial white blood count. In our study, we analyzed power Doppler signals in inflammatory joint diseases including gout, calcium pyrophosphate deposition...
Source: Joint Bone Spine - March 20, 2016 Category: Orthopaedics Source Type: research

Tabetic arthropathy of the knee: MRI aspects
Publication date: Available online 17 March 2016 Source:Joint Bone Spine Author(s): Issam En-nafaa, Tarik Ziadi, Taoufik Africha (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 18, 2016 Category: Orthopaedics Source Type: research

Periodontal disease in patients with rheumatoid arthritis in Sub-Saharan Africa: A case-control study
Publication date: Available online 17 March 2016 Source:Joint Bone Spine Author(s): Dieu-Donné Ouédraogo, Joelle Tiendrébéogo, Patrice Laurent Wendpouiré Guiguimdé, Pascal Ismaël Nikiéma, Dieudonné Ouédraogo, Fulgence Kaboré, Enselme Zongo, Gilles Hayem (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 18, 2016 Category: Orthopaedics Source Type: research

Atypical femoral fracture in a 51-year-old woman: Revealing a hypophosphatasia
We report a 51-year old woman who suffered 2 atypical subtrochanteric femoral fractures (AFFs). She had a history of several metatarsal fractures. She had a normal bone densitometry. An adult form of hypophosphatasia (HPP) was diagnosed from low serum alkaline phosphatase (ALP), and tissue nonspecific isoenzyme of ALP (TNSALP) mutation analysis revealing 2 heterozygous mutations: c.299C>T (p. T100M) and c.571G>A (p. E191K). Low ALP is the hallmark of the diagnosis of HPP; which is associated in adults with premature loss of deciduous teeth, recurrent metatarsal stress fractures, and joints and tendons disorde...
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Management after first-line antiresorptive treatment for postmenopausal osteoporosis
Publication date: Available online 15 March 2016 Source:Joint Bone Spine Author(s): Julien Paccou (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Effects of bariatric surgery on bone
Publication date: Available online 15 March 2016 Source:Joint Bone Spine Author(s): Brigitte Uebelhart Bariatric surgery currently relies on combinations of restrictive and malabsorptive procedures. Early decreases in bone mineral density (BMD) have been reported. However, the accuracy of dual-energy X-ray absorptiometry used to measure BMD can be diminished by the major weight loss, whereas quantitative computed tomography (QCT) measurements are less affected. The nutritional deficiencies induced by mixed bariatric surgery procedures, together with changes in hormones produced by adipocytes and/or the gastrointestinal ...
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Anti-Saccharomyces cerevisiae antibodies (ASCA) in spondyloarthritis: Prevalence and associated phenotype
Conclusion Our results provided evidence that SpA patients had an increased prevalence of ASCA and that ASCA positivity might be associated with a particular phenotype, notably peripheral involvement and uveitis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Ankylosing spondylitis: A cause of death after minor trauma
Publication date: Available online 15 March 2016 Source:Joint Bone Spine Author(s): Mehmet Gazi Boyaci, Kamil Tunay, Usame Rakip, Mustafa Karademir, Ergun Karavelioglu (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Effect of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort
Conclusions In a cohort of early RA, young age at disease onset is associated with high rate of remission at 1year, no radiographic progression at 3years and low functional score during 3-year follow-up. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Evaluation of the immunogenicity of the 13-valent conjugated pneumococcal vaccine in rheumatoid arthritis patients treated with etanercept
Conclusions In RA patients treated with ETA, vaccination with PCV13 is effective and safe, resulting in pAR one and two months after vaccination. Higher age at vaccination was identified as predictors of impaired pAR. The efficacy of vaccination may be more pronounced in younger RA patients. The vaccine is safe in RA patients on ETA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research

Low back pain and femoral neuralgia revealing myeloid sarcoma with megakaryocytic differentiation
Publication date: Available online 16 March 2016 Source:Joint Bone Spine Author(s): Gonçalo Boleto, Matthias Michel, Nadia Salam, Jean-Paul Eschard, Jean-Hugues Salmon (Source: Joint Bone Spine)
Source: Joint Bone Spine - March 17, 2016 Category: Orthopaedics Source Type: research