Posterior epidural migration of herniated lumbar disc fragment
Publication date: Available online 29 December 2016 Source:Joint Bone Spine Author(s): Lauriane Chambard, Jean Wach, Pierre-Charles Andonian, Jacques-Guy Tebib, Fabienne Coury (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 30, 2016 Category: Orthopaedics Source Type: research

The Term “Seropositive” to Qualify Polyarthritis/Rheumatoid Arthritis Should Be Banned
Publication date: Available online 29 December 2016 Source:Joint Bone Spine Author(s): Vincent Goëb (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 30, 2016 Category: Orthopaedics Source Type: research

Does Anyone Still Need Meniscectomy?
Publication date: Available online 28 December 2016 Source:Joint Bone Spine Author(s): Philippe Beaufils, Nicolas Pujol (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 29, 2016 Category: Orthopaedics Source Type: research

Familial and Syndromic Lupus Share the Same Phenotype as other Early-Onset Forms of Lupus
Conclusions In this study, clinical and epidemiological data alone failed to identify a specific patient subgroup characterized by the same disease presentation or progression. This result may be related to the small sample size or indicate marked heterogeneity of juvenile-onset SLE. Genetic studies using new sequencing techniques in these patients might identify genetic factors responsible for marked phenotypic variability. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 28, 2016 Category: Orthopaedics Source Type: research

Mycophenolate Mofetil as induction and long-term maintaining treatment in Childhood Primary Angiitis of the Central Nervous System
Conclusion We report for the first time on the efficacy and safety of MMF in the induction and maintenance of clinical remission in cPACNS. Our single centre experience of MMF use in treating cPACNS seems represent an appealing, alternative and safe option in this clinical setting over a long term follow-up. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 27, 2016 Category: Orthopaedics Source Type: research

TNF inhibitors improve muscle lactate production upon maximal effort in spondyloarthritis: an open labelled study
Publication date: Available online 26 December 2016 Source:Joint Bone Spine Author(s): Romain Gastaldi, Michel Guinot, Sébastien Baillieul, Philippe Gaudin, Athan Baillet (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 27, 2016 Category: Orthopaedics Source Type: research

Prevalence of autoantibodies in the course of Gaucher disease type 1: a multicenter study comparing Gaucher disease patients to healthy subjects
Conclusions In type 1 Gaucher disease, autoantibodies were more frequent compared to a healthy population. However, they were not associated with an increased prevalence of clinical active autoimmune diseases. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 27, 2016 Category: Orthopaedics Source Type: research

Identification of a p.Arg708Gln variant in COL1A2 in atypical femoral fractures
Conclusion Genetic screening for variants in only 4 genes and 5 patients with AFF resulted in the identification of genetic variants in 3 patients including a rare variant in COL1A2, suggesting a possible genetic susceptibility to AFF. This finding should encourage clinician to further genotype patients with AFF in a collaborative multicentric project. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 23, 2016 Category: Orthopaedics Source Type: research

Patient and Physician agreement on reported Bath Ankylosing Spondylitis Disease Activity Index in patients with axial Spondyloarthritis
Publication date: Available online 23 December 2016 Source:Joint Bone Spine Author(s): Liana Ghukasyan, Adrien Etcheto, Maxime Dougados, Anna Moltó (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 23, 2016 Category: Orthopaedics Source Type: research

Action of Tocilizumab on Energy Expenditure in Rheumatoid Arthritis: a prospective study using calorimetry and actimetry
Publication date: Available online 23 December 2016 Source:Joint Bone Spine Author(s): Marie Hugo, Audrey Pierreisnard, Nadia Mehsen-Cetre, Henri Gin, Thierry Schaeverbeke, Vincent Rigalleau (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 23, 2016 Category: Orthopaedics Source Type: research

The autoimmune tautology. A summary of evidence
Publication date: Available online 23 December 2016 Source:Joint Bone Spine Author(s): Juan-Manuel Anaya (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 23, 2016 Category: Orthopaedics Source Type: research

IL-17, now an important target for treatment in arthritis
Publication date: Available online 23 December 2016 Source:Joint Bone Spine Author(s): Pierre Miossec (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 23, 2016 Category: Orthopaedics Source Type: research

Efficacy of triple association methotrexate, sulfasalazine and hydroxychloroquine in early treatment of rheumatoid arthritis with insufficient response to methotrexate: Meta-analysis of randomized controlled trials
Conclusion Biological treatment seems to be more efficient than triple combination in terms of radiological progression in RA with inadequate response to methotrexate. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 16, 2016 Category: Orthopaedics Source Type: research

Acute phospholipid microspherule associated arthritis: Is it rare?
Publication date: Available online 15 December 2016 Source:Joint Bone Spine Author(s): Guillaume Coiffier, Jean-David Albert, François Robin, Pascal Guggenbuhl Joint fluid analysis must be performed as part of the diagnostic workup for acute arthritis, most notably to rule out septic arthritis and to allow the identification of crystal-induced arthritis (gout or calcium pyrophosphate deposition disease), which is one of the most common causes. However, the detection of monosodium urate or calcium pyrophosphate microcrystals is not the only goal of the polarized light microscopy examination of joint fluid. Other, le...
Source: Joint Bone Spine - December 16, 2016 Category: Orthopaedics Source Type: research

Intravenous sodium thiosulfate for treating tumoral calcinosis associated with systemic disorders: Report of four cases
We report here 4 cases (3 adults and 1 child) of TC treated with ivSTS. TC was secondary to CREST syndrome, dermatomyositis (1 adult and 1 child) and systemic erythematous lupus and involved multiple sites in all cases. In all 4 patients, TC was responsible for joint pain, reduced mobility, inflammatory flares and skin fistulations. One patient experienced difficulty sitting due to the pain induced by calcified lesions on the buttock; another patient had major disability, moved only with wheelchair and was under opioid treatment for pain. For all patients, treatment with several medications be...
Source: Joint Bone Spine - December 8, 2016 Category: Orthopaedics Source Type: research

Febuxostat-associated eosinophilic polymyositis in marginal zone lymphoma
Publication date: Available online 7 December 2016 Source:Joint Bone Spine Author(s): Georges Chahine, Khalil Saleh, Claude Ghorra, Nathalie Khoury, Nadine Khalife, Fouad Fayad Febuxostat is an orally administered selective inhibitor of xanthine oxidase approved for the treatment of gout and prevention of tumor lysis syndrome. It is a relatively safe medication. Hypersensitivity reactions associated with the use of febuxostat are quite rare with only one reported case of DRESS syndrome. Recently, two case reports of rhabdomyolysis following the initiation of febuxostat were published. We hereby present the first case of r...
Source: Joint Bone Spine - December 8, 2016 Category: Orthopaedics Source Type: research

First cases of calcium pyrophosphate deposition disease after zoledronic acid therapy
We report 2 cases of acute CPDD after intravenous zoledronic acid therapy. Case #1: a 63-year-old female was admitted for vertebroplasty at the site of an osteoporotic fracture. She received an intravenous infusion of zoledronic acid 5mg on the day after the procedure. Acute CPDD developed in her right knee 24hours later. Findings from joint aspiration and standard radiography confirmed the diagnosis. Case #2: this 79-year-old woman had a history of CPDD was on glucocorticoid and hydroxychloroquine therapy for lupus. She was given an intravenous infusion of zoledronic acid 5mg as prophylaxis of glucocorticoid-induced osteo...
Source: Joint Bone Spine - December 7, 2016 Category: Orthopaedics Source Type: research

Severe gout: Strategies and innovations for effective management
Publication date: Available online 5 December 2016 Source:Joint Bone Spine Author(s): Eliseo Pascual, Mariano Andrés, Janitzia Vázquez-Mellado, Nicola Dalbeth Severe gout is characterised by frequent polyarticular flares, numerous tophi, joint damage, and musculoskeletal disability. This is a preventable condition and in many cases, represents a disease that has been insufficiently managed for years. Standard management recommendations may be insufficient for patients with severe gout; these patients frequently require intensive individualised pharmacological management with combinations of urate-lowering th...
Source: Joint Bone Spine - December 6, 2016 Category: Orthopaedics Source Type: research

Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis
Conclusion Detection of subclinical US enthesopathy is not so rare in both groups, unlike PD signal, but with no statistical difference. US are a good tool to evaluate the different components of psoriatic nails (loss of trilaminar appearance, nail thickening and inflammation of the skin thickness) which are significantly associated with nail psoriasis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 6, 2016 Category: Orthopaedics Source Type: research

Hydroxychloroquine and joint involvement in systemic sclerosis: Preliminary beneficial results from a retrospective case-control series of an EUSTAR center
Publication date: Available online 5 December 2016 Source:Joint Bone Spine Author(s): Cosimo Bruni, Emanuela Praino, Serena Guiducci, Silvia Bellando-Randone, Daniel E. Furst, Marco Matucci-Cerinic (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 6, 2016 Category: Orthopaedics Source Type: research

Nutcracker syndrome: A rare cause of left flank pain that can also manifest as unexplained pelvic pain
Publication date: Available online 5 December 2016 Source:Joint Bone Spine Author(s): Jean-Marie Berthelot, Frédéric Douane, Yves Maugars, Eric Frampas Nutcracker syndrome (NCS) is symptomatic unilateral renal venous hypertension due to compression of the left renal vein between the superior mesenteric artery and aorta (anterior NCS) or between the aorta and spine (posterior NCS). The left ovarian or spermatic vein empties into the left renal vein and is an additional site of venostasis in about half the cases of NCS. The presenting symptom of NCS in about half the cases is atypical left flank pain suggestin...
Source: Joint Bone Spine - December 6, 2016 Category: Orthopaedics Source Type: research

Patient-perceived flares in rheumatoid arthritis: A sub-analysis of the STRASS treatment tapering strategy trial
Conclusion The concept of flare refers to more than just RA disease activity. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 6, 2016 Category: Orthopaedics Source Type: research

Environmental factors associated with familial or non familial forms of Paget's disease of bone
Conclusions In conclusion, PDB was significantly associated with wood fired heating in childhood and/or adolescence, regardless of the form of PDB, familial or not. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 6, 2016 Category: Orthopaedics Source Type: research

Percutaneous sacroplasty for sacral fracture by osteoporotic insufficiency
Publication date: Available online 5 December 2016 Source:Joint Bone Spine Author(s): Frédéric Lioté, Jean-Denis Laredo (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 5, 2016 Category: Orthopaedics Source Type: research

Long noncoding RNAs in osteoarthritis
Publication date: Available online 3 December 2016 Source:Joint Bone Spine Author(s): Shi-de Jiang, Jian Lu, Zhen-han Deng, Yu-sheng Li, Guang-hua Lei Osteoarthritis (OA) is the most common form of arthritis that may affect all joint tissues. Unfortunately, the pathogenesis of OA is not fully understood yet and it cannot be cured totally. Long noncoding RNA (lncRNA) is a type of RNA molecule greater than 200 nucleotides, and deregulated expression of lncRNAs plays an important role in many types of inflammation-related diseases. In this review, we have focused on the association of lncRNAs in the development and progressi...
Source: Joint Bone Spine - December 4, 2016 Category: Orthopaedics Source Type: research

How to favour efficient networking of teams working in the field of rare diseases? Experience of the CeR éMAI reference centre for autoinflammatory diseases
Publication date: Available online 2 December 2016 Source:Joint Bone Spine Author(s): Isabelle Touitou, Florian Milhavet, Véronique Hentgen, Isabelle Koné-Paut (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 3, 2016 Category: Orthopaedics Source Type: research

Nutrition and chronic inflammatory rheumatic disease
Publication date: Available online 30 November 2016 Source:Joint Bone Spine Author(s): Luca Semerano, Chantal Julia, Ouidade Aitisha, Marie-Christophe Boissier Nutrition is a major environmental influence on human health. Epidemiological and interventional studies suggest a pathophysiological or therapeutic role, respectively, for nutrition in inflammatory rheumatic diseases (IRDs). Nevertheless, the associations between nutrition and IRDs are often weak and inconsistent, and the available clinical trials on nutrition are methodologically flawed. Experimental evidence is accumulating that micronutrients in the diet may in...
Source: Joint Bone Spine - December 1, 2016 Category: Orthopaedics Source Type: research

A pilot study of CXCL8 levels in crystal proven gout patients during allopurinol treatment and their association with cardiovascular disease
Conclusions This pilot study indicates that higher CXCL8 levels were associated cardiovascular diseases in gout patients. Short-term use of allopurinol does not decrease CXCL8 levels in gout patients, but longer use possibly does. Further studies are warranted to establish the potential mechanisms of treatment and effects on CXCL8 levels. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 26, 2016 Category: Orthopaedics Source Type: research

Maffucci syndrome with multiple hand calcifications
Publication date: Available online 25 November 2016 Source:Joint Bone Spine Author(s): Mohammed El Amine Ghembaza, Ali Lounici (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 26, 2016 Category: Orthopaedics Source Type: research

Soluble vascular endothelial (VE) cadherin and autoantibodies to VE-cadherin in rheumatoid arthritis patients treated with etanercept or adalimumab
Conclusions sVE is a biomarker associated with systemic RA activity under anti-TNF. AAVE are related to autoantibodies usually associated to RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 26, 2016 Category: Orthopaedics Source Type: research

Involvement of pubic symphysis in polymyalgia rheumatica: 18-FDG PET/CT evaluation
Publication date: Available online 9 November 2016 Source:Joint Bone Spine Author(s): Maxime Sondag, Frank Verhoeven, Clément Prati, Xavier Guillot, Oleg Blagosklonov, Hatem Boulahdour, Daniel Wendling (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 11, 2016 Category: Orthopaedics Source Type: research

First case of paraneoplastic subacute cutaneous lupus erythematosus associated with colon cancer
Publication date: Available online 9 November 2016 Source:Joint Bone Spine Author(s): Murielle Michel, François Comoz, Yann Ollivier, Boris Bienvenu (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 10, 2016 Category: Orthopaedics Source Type: research

Osteoporosis and ischemic cardiovascular disease
Publication date: Available online 9 November 2016 Source:Joint Bone Spine Author(s): Michel Laroche, Virginie Pécourneau, Hubert Blain, Véronique Breuil, Roland Chapurlat, Bernard Cortet, Bruno Sutter, Yannick Degboe Osteoporosis and cardiovascular disease were long viewed as independent of each other. However, numerous epidemiological studies, which are discussed in the first part of this review, have provided incontrovertible evidence of a link. Thus, the risk of coronary artery disease and stroke is higher in patients with a history of osteoporotic fracture or low bone mineral density than in non-osteopo...
Source: Joint Bone Spine - November 10, 2016 Category: Orthopaedics Source Type: research

Spontaneous resolution of a large lumbar disc herniation
Publication date: Available online 9 November 2016 Source:Joint Bone Spine Author(s): Jung-Ying Chiang, Der-Cherng Chen, Der-Yang Cho (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 10, 2016 Category: Orthopaedics Source Type: research

Exacerbation of hepatitis E virus infection during anti-TNF α treatment
Publication date: Available online 8 November 2016 Source:Joint Bone Spine Author(s): Patrick Behrendt, Stefan Lüth, Werner Dammermann, Svenja Drave, Richard J.P. Brown, Daniel Todt, Ulrike Schnoor, Eike Steinmann, Heiner Wedemeyer, Sven Pischke, Christof Iking-Konert Chronic hepatitis E virus (HEV) infection may occur in immunocompromised patients. Previous studies report that different immunosuppressive agents interfere with viral replication. However, the role of TNFα in HEV infection is currently unknown. Here, we describe a case of severe exacerbation of a chronic HEV infection in a patient undergoing trea...
Source: Joint Bone Spine - November 9, 2016 Category: Orthopaedics Source Type: research

GOSPEL 2  – Colchicine for the treatment of gout flares in France – a GOSPEL survey subgroup analysis. Doses used in common practices regardless of renal impairment and age
Conclusions This study draws attention to some misuse of colchicine in daily practice and the prescription of excessive doses especially in case of renal impairment. eGFR should be enforced in daily practice. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 6, 2016 Category: Orthopaedics Source Type: research

Does low bone mineral density predict mortality?
Publication date: December 2016 Source:Joint Bone Spine, Volume 83, Issue 6 Author(s): Bernard Cortet (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 6, 2016 Category: Orthopaedics Source Type: research

Efficacy and safety of febuxostat in 73 gouty patients with stage 4/5 chronic kidney disease: A retrospective study of 10 centers
Conclusion Febuxostat seemed efficient in gouty patients with stage 4/5 chronic kidney disease. However, safety data were not clear regarding renal function. Larger studies are needed to assess safety. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Prevalence of rheumatoid arthritis in the French West Indies: Results of the EPPPRA study in Martinique
Conclusion This work outlines low standardized prevalence of RA in a French Afro-Caribbean population with specific characteristics (high female predominance, high immune seropositivity, low tobacco use). Despite easy access to care and biotherapies, approximately half of RA patients still present destructive disease with functional impact. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Decreased patient exposure to ionizing radiation during interventional rheumatology procedures after optimization of protection
Conclusion Simple technical changes translate into large decreases in patient radiation exposure during fluoroscopically-guided injections, particularly at the facet joints and in obese patients. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Defective autophagy activity and its association with spinal damage in patients with ankylosing spondylitis
Conclusion AS patients have decreased autophagy-related gene expressions and AS patients with more advanced spinal damage have further decreased LC3 and beclin1 expression levels. These results suggest that AS patients have defective autophagy activity and that compromised autophagy may contribute to the progression of spinal damage in AS. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study
Publication date: Available online 4 November 2016 Source:Joint Bone Spine Author(s): Yoshinori Taniguchi, Hirofumi Nishikawa, Takashi Karashima, Yasuhiko Yoshinaga, Shimpei Fujimoto, Yoshio Terada (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Rheumatology: Craft, industry, or both?
Publication date: Available online 4 November 2016 Source:Joint Bone Spine Author(s): Jean-Marie Berthelot, Pascale Guillot, Benoît Le Goff, Yves Maugars (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Osteoarticular manifestations of celiac disease and non-celiac gluten hypersensitivity
Publication date: Available online 4 November 2016 Source:Joint Bone Spine Author(s): Stéphanie Dos Santos, Frédéric Lioté Celiac disease is a chronic inflammatory autoimmune enteropathy based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The global prevalence of 1% to 2% represents only the tip of the iceberg. The diagnosis is confirmed by positive specific antibody, anti-transglutaminase or anti-endomysium, specific lesions of the small intestine and a response to strict gluten-free diet. The diagnosis is difficult and often delayed because the ...
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Translation and adaptation of the French version of the Heart Disease Fact Questionnaire – Rheumatoid Arthritis (HDFQ-RA 1 & amp;2)
Conclusions The French-HDFQ-RA is valid for assessing patient knowledge of cardiovascular risk in general and associated with rheumatoid arthritis and its treatments. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Achilles tendon enthesis with double contour sign revealing gout
Publication date: Available online 4 November 2016 Source:Joint Bone Spine Author(s): Sébastien Ottaviani, Marine Forien, Philippe Dieudé (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

CRISPR-Cas9: A revolution in genome editing in rheumatic diseases
Publication date: Available online 4 November 2016 Source:Joint Bone Spine Author(s): Isabelle Duroux-Richard, Carine Giovannangeli, Florence Apparailly (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Failure of pneumococcal immunization during remission induction treatment of ANCA-associated vasculitis: The Pneumovas Pilot 1 study
Publication date: Available online 4 November 2016 Source:Joint Bone Spine Author(s): Matthieu Groh, Xavier Puéchal, Benjamin Terrier, Claire Le Jeunne, Frédéric Batteux, Odile Launay (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Cryotherapy decreases synovial Doppler activity and pain in knee arthritis: A randomized-controlled trial
Conclusion Local ice and cold CO2 applied twice equally reduced synovial Power Doppler activity and pain over 24h in knee arthritis. These effects remained significant the day after treatment. ClinicalTrials.gov identifier: NCT02573298. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research

Is the widely-used score in axial spondyloarthritis, Bath Ankylosing Spondylitis Disease Activity Index, influenced by patients ’ optimism? A cross-sectional study of 206 patients
Publication date: Available online 4 November 2016 Source:Joint Bone Spine Author(s): Stéphanie Fabre, Anna Molto, Sarah Kreis, Christophe Hudry, Bruno Fautrel, Edouard Pertuiset, Laure Gossec (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 5, 2016 Category: Orthopaedics Source Type: research