Clinical Characteristics and Outcomes in Polyarticular Septic Arthritis
Conclusions In this sample of patients with septic arthritis, patients with septic polyarthritis were more likely to have systemic infection at presentation than those with septic monoarthritis. Despite this difference, patients with septic monoarthritis and polyarthritis tended to have similar outcomes. While rheumatoid arthritis was observed more frequently among patients with septic polyarthritis, those with/without underlying rheumatoid arthritis had similar presenting features and outcomes.Bottom of Form (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 14, 2017 Category: Orthopaedics Source Type: research

Poor efficacy of TNF inhibitors in non-radiographic axial spondyloarthritis in the absence of objective signs: a bicentric retrospective study
Conclusion TNFi should be used with caution in axSpA when objective signs are absent as only 13.7% of these patients were BASDAI50 responders at 3 months. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 14, 2017 Category: Orthopaedics Source Type: research

Hip Inflammation MRI Scoring System (HIMRISS) to predict response to hyaluronic acid injection in hip osteoarthritis
Conclusion HIMRISS is reliable for total scores and sub-domains. It permits identification of responders to HA injection in hip OA patients. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Incidence of cancer in patients with spondyloarthritis treated with anti-tnf drugs
Conclusions The incidence of malignancies among SpA patients treated with the three TNFi was higher than in general population; having had a previous solid cancer is predictive of a new malignancy. (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Vitamin  D supplementation in patients treated for sarcoidosis: Controversy or consensus?
Publication date: October 2017 Source:Joint Bone Spine, Volume 84, Issue 5 Author(s): Nathalie Saidenberg-Kermanac’h, Dominique Valeyre, Marie-Christophe Boissier (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Ours r édaction
Publication date: October 2017 Source:Joint Bone Spine, Volume 84, Issue 5 (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 9, 2017 Category: Orthopaedics Source Type: research

Pain in osteoarthritis. Implications for optimal management
Publication date: Available online 6 September 2017 Source:Joint Bone Spine Author(s): Anne-Priscille Trouvin, Serge Perrot Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in various populations and is dramatically increasing in many countries, mostly related to age and obesity, leading to an increased number of people having OA pain, and creating a huge burden related to disability and health care costs. OA-related pain, has been classically considered to be a nociceptive pain condition. Clinicia...
Source: Joint Bone Spine - September 7, 2017 Category: Orthopaedics Source Type: research

Flexor tenosynovitis of the wrist including rice bodies
Publication date: Available online 27 July 2017 Source:Joint Bone Spine Author(s): Fatih Celikyay, Ruken Z. Yuksekkaya, Bora Bostan (Source: Joint Bone Spine)
Source: Joint Bone Spine - September 2, 2017 Category: Orthopaedics Source Type: research

Anti Citrullinated Peptide Antibodies profiling in established rheumatoid arthritis
Conclusions Higher number/levels of ACPA subtypes is associated with lung involvement but not with erosive disease. Moreover, a broader ACPA repertoire may identify patients treated with biological therapy, probably affected by a more severe disease.In conclusion, ACPA typing might be relevant for a better characterization of some disease features in established RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 5, 2017 Category: Orthopaedics Source Type: research

New Classification for Juvenile Idiopathic Arthritis: Is the Tower of Babel Falling?
Publication date: Available online 5 August 2017 Source:Joint Bone Spine Author(s): Alexandre Belot (Source: Joint Bone Spine)
Source: Joint Bone Spine - August 5, 2017 Category: Orthopaedics Source Type: research

Retroperitoneal fibrosis following a long-standing etanercept treatment in a spondyloarthritis patient
Publication date: Available online 6 June 2017 Source:Joint Bone Spine Author(s): Stefania Manganelli, Chiara Giannitti, Mauro Galeazzi, Marco Rossi (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 29, 2017 Category: Orthopaedics Source Type: research

Clinical predictors of magnetic resonance imaging-detected sacroiliitis in children with enthesitis related arthritis
Conclusion In children with enthesitis-related arthritis the presence of buttock pain or of abnormal sacroiliac joint examination is a strong predictor of magnetic sacroiliitis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 28, 2017 Category: Orthopaedics Source Type: research

Rheumatoid arthritis treated with tocilizumab in two patients with complicated chronic liver disease with portal hypertension.
We report the case of a woman and a man aged 52 and 66 years respectively having this combination of pathologies. Infusions of 4mg/kg of tocilizumab as monotherapy have produced a weaning from corticosteroids, both clinical and structural remission, with particular liver safety satisfactory at 10 and 18 months. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 28, 2017 Category: Orthopaedics Source Type: research

Motivators for and barriers to physical activity in people with knee osteoarthritis: a qualitative study
Conclusions The study population had an overall positive idea of the value of physical activity for knee osteoarthritis. The participants expressed beliefs and knowledge generally in line with current recommendations. Compliance with these recommendations remains moderate. An educational support for progressive adapted physical activity and identification of barriers and motivators could help improve adherence. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 28, 2017 Category: Orthopaedics Source Type: research

Flexor tenosynovitis of wrist including rice bodies
Publication date: Available online 27 July 2017 Source:Joint Bone Spine Author(s): Fatih Celikyay, Ruken Z. Yuksekkaya, Bora Bostan (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 28, 2017 Category: Orthopaedics Source Type: research

Retro-odontoid pseudo-tumor due to calcium pyrophosphate crystal deposits with spinal cord compression and histopathological confirmation
Publication date: Available online 27 July 2017 Source:Joint Bone Spine Author(s): Lambert Mijola, Adamah Amouzougan, Fabrice-Guy Barral, Fabien Forest, Marie-Jeannette Fotso, Thierry Thomas, Hubert Marotte (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 28, 2017 Category: Orthopaedics Source Type: research

Cardiovascular risk factors in patients with Spondyloarthritis from Northern European and Mediterranean countries: an ancillary study of the ASAS-COMOSPA project
Conclusions Our results suggest that SpA phenotype and geographical area are associated with the prevalence of cardiovascular risk factors and the cardiovascular risk itself, observed in patients in the ASAS-COMOSPA cohort. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 26, 2017 Category: Orthopaedics Source Type: research

Is the SCORE chart underestimating the Real Cardiovascular (CV) Risk of patients with Psoriatic arthritis? Prevalence of subclinical CV disease detected by carotid ultrasound
Conclusions A considerable number of psoriatic arthritis patients have a priori moderate or high risk of a fatal cardiovascular event. Carotid ultrasound detects subclinical vascular disease and increases the real risk in a substantial proportion of patients. Cardiovascular risk prediction clinical tools such as the SCORE underestimate the presence of subclinical cardiovascular disease in patients with psoriatic arthritis. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 15, 2017 Category: Orthopaedics Source Type: research

Bilateral capitato-hamato-trapezoidal synostosis
Publication date: Available online 13 July 2017 Source:Joint Bone Spine Author(s): Sabri Mahjoub, Ahmed Amine Lahmar, Mahdi Miladi, Mohamed Abdelkafi, Mondher Mbarek (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 14, 2017 Category: Orthopaedics Source Type: research

Effectiveness of vedolizumab for Crohn's disease with spondyloarthritis in fail with two TNF blocking agents
Publication date: Available online 11 July 2017 Source:Joint Bone Spine Author(s): Christopher Banse, Laura Armengol-Debeir, Olivier Vittecoq (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 12, 2017 Category: Orthopaedics Source Type: research

A case of Hajdu-Cheney syndrome associated with psoriatic rheumatism, two causes of acro-osteolysis
Publication date: Available online 6 June 2017 Source:Joint Bone Spine Author(s): Quitterie Rochoux, Nathalie Léon, Anne-Claire Bréhin, Murielle Michel, Philippe Orcel, Christian Marcelli (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2017 Category: Orthopaedics Source Type: research

Inflammation initiated by stressed organelles
Publication date: Available online 10 July 2017 Source:Joint Bone Spine Author(s): Fabio Martinon Key cellular functions including those related to energy metabolism, organization of the genetic information or production of membrane-bound and secreted proteins are compartmentalized within organelles. Various stresses such as differentiation programs, viral and bacterial infections, perturbations in protein production, mechanical constraints, changes in the environment and nutriment accessibility can impact cellular homeostasis and organelle integrity. Perturbations of these cellular compartments trigger repair and adaptat...
Source: Joint Bone Spine - July 11, 2017 Category: Orthopaedics Source Type: research

Development of a comorbidity self-questionnaire for patients with inflammatory joint disease
Publication date: Available online 10 July 2017 Source:Joint Bone Spine Author(s): Sophie Pouplin, Laure Gossec, Françoise Fayet, Carine Savel, Maryse Mezieres, Maxime Dougados (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2017 Category: Orthopaedics Source Type: research

Isolated trigeminal sensory neuropathy during etanercept therapy: A case report
Publication date: Available online 10 July 2017 Source:Joint Bone Spine Author(s): Sonia Rekik, Sirine Daldoul, Soumaya Boussaid, Zakaria Saiid, Mohamed Ben Amor, Mohamed Elleuch (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2017 Category: Orthopaedics Source Type: research

Vasculitides induced by cocaine and/or levamisole
Publication date: Available online 10 July 2017 Source:Joint Bone Spine Author(s): Antoine Néel, Christian Agard, Mohamed Hamidou (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 11, 2017 Category: Orthopaedics Source Type: research

Efficacy and Safety of biological DMARDs modulating B cells in Primary Sj ögren's syndrome: systematic review and meta-analysis
Conclusion Our review shows that rituximab is not effective in pSS with the designs and outcomes proposed in the trials. Controlled randomised trials are needed to prove the efficacy of belimumab and epratuzumab in this indication. The randomised controlled trial evaluating baminercept failed to achieve its primary endpoint. (Source: Joint Bone Spine)
Source: Joint Bone Spine - July 1, 2017 Category: Orthopaedics Source Type: research

Lewis –Sumner syndrome in a patient with rheumatoid arthritis: Link between rheumatoid arthritis and demyelinating polyradiculoneuropathies
We report the case of a patient who developed almost currently rheumatoid arthritis and Lewis–Sumner syndrome, which raised the problem of therapeutic intensification for his rheumatism when methotrexate proved to be ineffective. Finally, rituximab had been introduced by common consent with neurologists, and the patient noticed an improvement fifteen days after the first infusion. Even if it is striking that both dysimmune diseases had declared within a few months, the association between chronic inflammatory demyelinating polyradiculoneuropathies and rheumatoid arthritis is exceptional, since the only cases reported...
Source: Joint Bone Spine - June 27, 2017 Category: Orthopaedics Source Type: research

Do we need animal models to advance research on inflammatory joint disease?
Publication date: July 2017 Source:Joint Bone Spine, Volume 84, Issue 4 Author(s): Marie-Christophe Boissier, Natacha Bessis (Source: Joint Bone Spine)
Source: Joint Bone Spine - June 27, 2017 Category: Orthopaedics Source Type: research

Ours redaction
Publication date: July 2017 Source:Joint Bone Spine, Volume 84, Issue 4 (Source: Joint Bone Spine)
Source: Joint Bone Spine - June 27, 2017 Category: Orthopaedics Source Type: research

Salt, Inflammatory Joint Disease, and Autoimmunity
Publication date: Available online 23 June 2017 Source:Joint Bone Spine Author(s): Johanna Sigaux, Luca Semerano, Guillaume Favre, Natacha Bessis, Marie-Christophe Boissier Salt is a vital nutrient. Excess salt intake, however, has recently been blamed for triggering and/or worsening certain autoimmune diseases. In vitro, the cells involved in innate and adaptive immune responses exhibit an inflammatory profile when placed in hypertonic saline. More specifically, macrophages release increased amounts of proinflammatory cytokines, produce reactive oxygen species, and become capable of activating the inflammasome. T helper ...
Source: Joint Bone Spine - June 24, 2017 Category: Orthopaedics Source Type: research

Current Role for Radioisotope Synovectomy
Publication date: Available online 23 June 2017 Source:Joint Bone Spine Author(s): Vincent André, Vincent Dalibard, Emmanuelle Dernis, Stéphane Varin, Grégoire Cormier Radioisotope synovectomy has been extensively used to treat patients with chronic inflammatory joint disease but has moved to a less prominent position since the introduction of new and highly effective drugs. Remaining indications are refractory synovitis, pigmented villonodular synovitis as an adjunct to surgery, and hemophilic arthropathy. The three main radioisotopes used are yttrium-90, rhenium-186, and erbium-189. Radioisotope syn...
Source: Joint Bone Spine - June 24, 2017 Category: Orthopaedics Source Type: research

Antimalarial drug retinopathy: A typical « Bull's eyes » appearance of fundus
Publication date: Available online 13 May 2017 Source:Joint Bone Spine Author(s): Anaïs Guiot, Mathilde Couturier, Jacques Guy Tebib, Lucie Abouaf, Fabienne Coury (Source: Joint Bone Spine)
Source: Joint Bone Spine - June 8, 2017 Category: Orthopaedics Source Type: research

Apheresis to Treat Systemic Vasculitis
Publication date: Available online 7 June 2017 Source:Joint Bone Spine Author(s): Julie Moussi-Frances, Marion Sallée, Noémie Jourde-Chiche Apheresis has been used in the treatment of severe systemic vasculitides, in conjunction with immunosuppressive therapies, for over 40 years. The aim is to rapidly remove autoantibodies or circulating immune complexes from the plasma. The two main indications at present are vasculitis associated with antineutrophil cytoplasmic antibodies (ANCAs) manifesting as severe renal involvement and/or intraalveolar hemorrhage and antiglomerular basement membrane disease (Goodpastu...
Source: Joint Bone Spine - June 8, 2017 Category: Orthopaedics Source Type: research

Efficacy of local glucocorticoid after local anesthetic in low back pain with lumbosacral transitional vertebra: A randomized placebo-controlled double-blind trial
Conclusion In patients with chronic low back pain consistent with a symptomatic LSTV type II or IV in the Castellvi classification, a local injection of lidocaine with or without cortivazol may provide sustained improvements in pain and function. The underlying mechanism is unclear. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 31, 2017 Category: Orthopaedics Source Type: research

Validity of the Rheumatoid Arthritis Impact of Disease (RAID) score and definition of cut-off points for disease activity states in a population-based European cohort of patients with rheumatoid arthritis
Conclusions The cut-offs revealed good measurement characteristics in cross-validation analyses, had great discriminatory performance in distinguishing patients with different levels of disease activity and are suited for widespread use in everyday practice application and research. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 24, 2017 Category: Orthopaedics Source Type: research

Parsonage-Turner syndrome secondary to Lyme disease
Publication date: Available online 24 May 2017 Source:Joint Bone Spine Author(s): Marie Schmitt, Benoît Daubail, Amélie Bohm (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 24, 2017 Category: Orthopaedics Source Type: research

Potential metabolomic biomarkers for reliable diagnosis of Behcet's disease using gas chromatography with time-of-flight mass spectrometry
Conclusions This is the first report on characteristic metabolic profiles and potential metabolite biomarkers in serum for reliable diagnosis of BD using GC/TOF-MS. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 24, 2017 Category: Orthopaedics Source Type: research

Cerebrovascular events are associated with lower survival in giant cell arteritis: a case-controlled multicenter study
Publication date: Available online 19 May 2017 Source:Joint Bone Spine Author(s): Thibaud Chazal, Priscille Couture, Charlotte Rosso, Julien Haroche, Anne Léger, Baptiste Hervier, Sandrine Deltour, Pierre Rufat, Zahir Amoura, Fleur Cohen Aubart (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 20, 2017 Category: Orthopaedics Source Type: research

Markedly high salivary and lacrimal CXCL17 levels in primary Sj ögren's Syndrome
Publication date: Available online 19 May 2017 Source:Joint Bone Spine Author(s): Marcela Hernández-Ruiz, Albert Zlotnik, Luis Llorente, Gabriela Hernandez-Molina (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 20, 2017 Category: Orthopaedics Source Type: research

IL-23/Th17 targeted therapies in SAPHO syndrome. A case series
We report the results of six courses of IL-23 and IL-17 targeted therapies (3 ustekinumab and 3 secukinumab) in patients with SAPHO syndrome unresponsive to previous treatments (csDMARDs and bDMARDs). With a mean treatment duration of 5.5 months, improvement of skin symptoms was noticed in three cases, one improvement with secukinumab, and two remissions (one with secukinumab, one with ustekinumab). Regarding the rheumatic symptoms, no major improvement was obvious under any of the six treatment courses. No particular safety concerns were reported, except cases of paradoxical psoriasis flare in one under ustekinumab, and t...
Source: Joint Bone Spine - May 20, 2017 Category: Orthopaedics Source Type: research

Beware the cat: bartonella henselae infections and biologic therapies
Publication date: Available online 19 May 2017 Source:Joint Bone Spine Author(s): Camelia Rossi, Rakan Nasreddine, France Laurent, Nathalie Demeulenaere, Marc Léon (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 20, 2017 Category: Orthopaedics Source Type: research

Italian consensus Guidelines for the management of hepatitis B virus infections in patients with rheumatoid arthritis
Conclusions HBV Infection isn’t rare in clinical practice; a screening for HBV in all patients with early arthritis is not universally accepted, while it is considered mandatory before starting any immunosuppressive or hepato-toxic treatment. In fact, a specific risk, associated with the use of biologic treatments, exists for patients with HBV infection, although longitudinal studies of viral reactivation are generally reassuring. RA patients with HBV infection should be referred to the hepatologist and correctly classified into active or inactive carriers. Patients with active hepatitis B should undergo antiviral ...
Source: Joint Bone Spine - May 19, 2017 Category: Orthopaedics Source Type: research

Pneumococcal infection in patients with systemic lupus erythematosus
Conclusion SLE is a disease of high susceptibility for invasive pneumococcal infections. Our study points to the need for vaccination against Streptococcus pneumoniae in SLE. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 19, 2017 Category: Orthopaedics Source Type: research

New Markers for Adult-Onset Still's Disease
Publication date: Available online 18 May 2017 Source:Joint Bone Spine Author(s): Stéphane Mitrovic, Bruno Fautrel Adult-onset Still's disease (AOSD) is a rare systemic auto-inflammatory disorder (SAID). Although the pathogenesis of the disease is complex and far from being fully understood, recent progresses in pathophysiological knowledge have paved the way to new diagnostic approaches. Indeed, AOSD diagnosis can be a real challenge, owing to its infrequency, and to the lack of specificity of the principal clinical features (high fever, arthralgia or arthritis, skin rash) and laboratory findings (elevated acute p...
Source: Joint Bone Spine - May 19, 2017 Category: Orthopaedics Source Type: research

First validation of the gout activity score against gout impact scale in a primary care based gout cohort
Conclusion This first study to validate GAS against the GIS found moderate correlation. However, this study did not examine the predictive validity of GAS, and prospective studies are needed before GAS can be used widely. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 18, 2017 Category: Orthopaedics Source Type: research

Aortic involvement in relapsing polychondritis
Conclusions This study underlines that aortic involvement is severe in RP. Furthermore, we suggest that RP patients exhibiting poor prognostic factors, including panaortitis and higher values of ESR, may require more aggressive therapy. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 18, 2017 Category: Orthopaedics Source Type: research

Contribution of High resolution peripheral quantitative CT to the management of bone and joint diseases
This article gives an overview of this imaging technique. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 14, 2017 Category: Orthopaedics Source Type: research

Intraosseous Venous Drainage Anomaly at the Tibia
Publication date: Available online 13 May 2017 Source:Joint Bone Spine Author(s): Thibault Rabin, Franck Grados, Bruno Bonnaire, Vincent Goëb, Patrice Fardellone No abstract (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 14, 2017 Category: Orthopaedics Source Type: research

Stress fracture in athletes
Publication date: Available online 13 May 2017 Source:Joint Bone Spine Author(s): Jordane Saunier, Roland Chapurlat Stress fractures are widely encountered in sport medicine and rheumatology. Stress fractures result from abnormal and repetitive loading on normal bone that lead to microdamage and then fracture. They occur after sudden increase in physical activity. They appear mostly at lower limbs. Women are at higher risk than men. Patients complain of mechanical pain. Clinical findings include focused pain and sometimes swelling. No biological test is useful for diagnosis. Plain radiographs are normal in early stage dis...
Source: Joint Bone Spine - May 14, 2017 Category: Orthopaedics Source Type: research

Antimalarial drug retinopathy  : a typical « Bull's eyes » appearance of fundus
Publication date: Available online 13 May 2017 Source:Joint Bone Spine Author(s): Anaïs Guiot, Mathilde Couturier, Jacques Guy Tebib, Lucie Abouaf, Fabienne Coury No abstract (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 14, 2017 Category: Orthopaedics Source Type: research