Boundaries between familial Mediterranean fever and juvenile spondyloarthritis: Analysis of three French retrospective cohorts
Conclusions Familial Mediterranean fever may be associated with typical pattern of juvenile spondyloarthritis. These patients, with less response to colchicine, should be diagnosed earlier and treated as for jSpA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Spontaneous epidural hematoma of the cervical spine after caesarean section
Publication date: Available online 13 February 2018 Source:Joint Bone Spine Author(s): Xingxin Hu, Xiaopeng Guo (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Is there non-celiac gluten intolerance in patients with scleroderma?
Publication date: Available online 13 February 2018 Source:Joint Bone Spine Author(s): Renato Nisihara, Mariana Aguiar Koubik, Maitê Mateus, Lorete da Silva Kotze, Thelma Larocca Skare (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Effect of Biologics on Fatigue in Psoriatic Arthritis: A Systematic Literature Review with Meta-analysis
Conclusions Biological disease modifying antirheumatic drugs and apremilast had a small effect on fatigue at 24 weeks in psoriatic arthritis randomized controlled trials and a higher effect on pain. These results are important to take into account in shared decision-making. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Treatment and outcomes in patients with IgG4-related disease using the IgG4 responder index
Conclusions IgG4-RI is a promising outcome measure in IgG4 still in development. Treatment algorithms are ill defined. GC and RTX are the drugs with more evidence available. Disease modifying anti-rheumatic drugs may have a role in IgG4-RD and warrant more prospective studies. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Switching of biologics in RA patients who do not respond to the first biologic
Publication date: Available online 13 February 2018 Source:Joint Bone Spine Author(s): Patrick Durez (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Ultrasonography and detection of subclinical joints and tendons involvements in Systemic Lupus erythematosus (SLE) patients: a cross-sectional multicenter study
Conclusion US may be useful to assess joint involvement in SLE patients but did not significantly change SLEDAI score. (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Maltese cross interpretation. Comment on: “Acute phospholipid microspherule associated arthritis: Is it rare?” by Coiffier et al, Joint Bone Spine 2017;84;537-40
Publication date: Available online 23 February 2018 Source:Joint Bone Spine Author(s): Bruce Rothschild (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Diabetes at the time of rheumatoid arthritis diagnosis is an independent predictor of pejorative outcomes: data from the early arthritis ESPOIR cohort
Publication date: Available online 23 February 2018 Source:Joint Bone Spine Author(s): Claire I Daeen, Jeremie Sellam, Nathalie Rincheval, Bruno Fautrel, Alain Saraux, Jacques Morel, Francis Berenbaum, Jean-Pierre Daures, Bernard Combe (Source: Joint Bone Spine)
Source: Joint Bone Spine - February 26, 2018 Category: Orthopaedics Source Type: research

Epigenetics of bone diseases
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Laetitia Michou Histone deacetylation, DNA methylation, and micro-RNAs (miRNAs) are the three main epigenetic mechanisms that regulate gene expression. All the physiological processes involved in bone remodeling are tightly regulated by epigenetic factors. This review discusses the main epigenetic modifications seen in tumoral and non-tumoral bone diseases, with emphasis on miRNAs. The role for epigenetic modifications of gene expression in the most common bone diseases is illustrated by drawing on the latest publications in the field. ...
Source: Joint Bone Spine - January 9, 2018 Category: Orthopaedics Source Type: research

Effects and Management of Denosumab Discontinuation
Publication date: Available online 6 January 2018 Source:Joint Bone Spine Author(s): Roland Chapurlat (Source: Joint Bone Spine)
Source: Joint Bone Spine - January 6, 2018 Category: Orthopaedics Source Type: research

Assessment of subclinical atherosclerosis in systemic lupus erythematosus: a systematic review and meta-analysis
Conclusion SLE patients exhibit increased subclinical atherosclerosis compared to healthy controls. CIMT is a promising measure for cardiovascular risk evaluations because non-invasive, non-radiation-based, reproducible. Thus, CIMT can be proposed as an alternative to the reliable CP evaluation and to FMD, which is influenced by independent factors such as smoking. Future studies should focus on reducing the heterogeneity of these measures using standardized procedures. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 28, 2017 Category: Orthopaedics Source Type: research

Resilience in women with autoimmune rheumatic diseases
Conclusion Resilience in patients with autoimmune rheumatic diseases is a continuum process influenced by age and socioeconomic status. The ways in which these variables along with exercise influence resilience deserve further investigation. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 28, 2017 Category: Orthopaedics Source Type: research

Bitemporal scalp necrosis in giant-cell arteritis
Publication date: Available online 28 December 2017 Source:Joint Bone Spine Author(s): Philipp Jud, Franz Hafner (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 28, 2017 Category: Orthopaedics Source Type: research

No change in the efficacy of infectious spondylodiscitis bacteriological testing over 20 years period
Publication date: Available online 28 December 2017 Source:Joint Bone Spine Author(s): Julien. Lopez, Anne Tournadre, Marion Couderc, Bruno Pereira, Martin Soubrier, Jean-Jacques Dubost (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 28, 2017 Category: Orthopaedics Source Type: research

Chronic destructive polyarthritis due to Whipple's disease
Publication date: Available online 28 December 2017 Source:Joint Bone Spine Author(s): Sara El Rharras, Emeline Minichiello, Luca Semerano (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 28, 2017 Category: Orthopaedics Source Type: research

Atypical juxta-articular form of Dercum's disease in a patient treated with tocilizumab for rheumatoid arthritis
Publication date: Available online 2 December 2017 Source:Joint Bone Spine Author(s): Pauline Baudart, Johann Cesini, Christian Marcelli (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 27, 2017 Category: Orthopaedics Source Type: research

Inflammatory myopathies: A new landscape
Publication date: January 2018 Source:Joint Bone Spine, Volume 85, Issue 1 Author(s): Alain Meyer, Béatrice Lannes, Joëlle Goetz, Andoni Echaniz-Laguna, Dan Lipsker, Laurent Arnaud, Thierry Martin, Jacques Eric Gottenberg, Bernard Geny, Jean Sibilia Greater accuracy in clinical descriptions combined with advances in muscle histology and immunology have established that inflammatory myopathies (IMs), similarly to inflammatory rheumatic diseases, constitute a highly heterogeneous group of conditions. The topographic distribution, severity, and tempo of onset of the myopathy vary widely, and the histological find...
Source: Joint Bone Spine - December 22, 2017 Category: Orthopaedics Source Type: research

Remaining local subclinical joint inflammation is associated with deteriorated metacarpeal head bone microarchitecture in rheumatoid arthritis patients low disease activity
Conclusion In RA patients in low disease activity under bDMARDs, persistence of local inflammation was associated with alteration of the trabecular compartment. Trabecular density was the most strongly altered parameter and could be a candidate to assess drug effect on periarticular bone damage. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 16, 2017 Category: Orthopaedics Source Type: research

Diagnostic Uncertainty and Clinical Decision-Making Strategies
Publication date: Available online 13 December 2017 Source:Joint Bone Spine Author(s): Laurent Messer, Jean Sibilia, Aggée Célestin Lomo Miazhiom (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 14, 2017 Category: Orthopaedics Source Type: research

e-Health, Social Media, and Rheumatology: Can They Get Along?
Publication date: Available online 13 December 2017 Source:Joint Bone Spine Author(s): Francis Berenbaum (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 14, 2017 Category: Orthopaedics Source Type: research

An e-health interactive self-assessment website (Sanoia ®) in rheumatoid arthritis. A 12-month randomized controlled trial in 320 patients
Conclusion Giving RA patients access to the interactive Sanoia e-health platform led to a small improvement in patient-perceived patient-physician interactions. A disjunction between patient satisfaction and access to the platform was noted. E-Health platforms are promising in RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Epigenetics of Bone Disease
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Laetitia Michou Histone deacetylation, DNA methylation, and micro-RNAs (miRNAs) are the three main epigenetic mechanisms that regulate gene expression. All the physiological processes involved in bone remodeling are tightly regulated by epigenetic factors. This review discusses the main epigenetic modifications seen in tumoral and nontumoral bone diseases, with emphasis on miRNAs. The role for epigenetic modifications of gene expression in the most common bone diseases is illustrated by drawing on the latest publications in the field. I...
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Lessons learned from Rheumatoid Arthritis registries
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Axel Finckh, Delphine Couvoisier (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Teriparatide treatment in an adult patient with hypophosphatasia exposed to bisphosphonate and revealed by bilateral atypical fractures.
We report the case of a 67-year-old female with osteoporosis treated by alendronate during ten years.Radiographies showed atypical femoral fractures. Serum levels of total and bone-specific alkaline phosphatase were low. In order to accelerate bone healing, teriparatide was introduced. After one year of teriparatide treatment, pain and functional difficulty have decreased, and alkaline phosphatase levels were normalised. In view of this history of recurrent fractures, of atypical femoral fractures, of early spontaneous loss of teeth, and of low serum total and bone-specific alkaline phosphatase levels, the diagnosis of hyp...
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

The impact of smoking on rheumatoid arthritis outcomes
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Olivier Vittecoq, Laetitia Richard, Christopher Banse, Thierry Lequerré (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Controversies in rheumatoid arthritis glucocorticoid therapy
Publication date: Available online 12 December 2017 Source:Joint Bone Spine Author(s): Adeline Ruyssen-Witrand, Arnaud Constantin Despite therapeutic innovations in the past 20 years, glucocorticoids (GC) are still widely used for the symptomatic treatment of rheumatoid arthritis (RA). Studies have demonstrated the clinical and structural efficacy of moderate doses (i.e. 30-60 mg/d) GC in addition to disease modifying anti-rheumatic drug (DMARD) initiation in early RA. A combination of a low dose of GC (i.e. 7.5-10 mg/d) and DMARDs increases remission rates and decreases the risk of medium-term structural progre...
Source: Joint Bone Spine - December 13, 2017 Category: Orthopaedics Source Type: research

Enthesopathy in rheumatoid arthritis and spondyloarthritis: an ultrasound study
Conclusions RA and SpA patients did not differ in entheseal abnormalities seen on US. Such US features may have low specificity in inflammatory conditions affecting joints and enthesis such as SpA and RA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 10, 2017 Category: Orthopaedics Source Type: research

A case of Multiple Myeloma presenting with diffuse osteosclerosis and multiple bone infarcts
Publication date: Available online 9 December 2017 Source:Joint Bone Spine Author(s): Marguerite Vignon, Noémie Senot, Valérie Bousson, Véronique Meignin, Aline Frazier, Bertrand Arnulf (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 10, 2017 Category: Orthopaedics Source Type: research

Treatment of carpal tunnel syndrome : from ultrasonography to ultrasound guided carpal tunnel release
Publication date: Available online 16 November 2017 Source:Joint Bone Spine Author(s): David Petrover, Pascal Richette Carpal tunnel syndrome is the most common nerve entrapment syndrome. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. It is diagnosed clinically, often being confirmed by an electromyogram, while ultrasonography criteria have become increasingly useful for the diagnosis. Ultrasonography is better tolerated, less expensive, yet just as effective as other diagnostic methods. It provides a good indication of the severity of the condition and it allows anatom...
Source: Joint Bone Spine - December 9, 2017 Category: Orthopaedics Source Type: research

Remaining localsubclinical joint inflammation is associated with deteriorated metacarpeal head bone microarchitecture in rheumatoid arthritis patients low disease activity
Conclusion In RA patients in low disease activity under bDMARDs, persistence of local inflammation was associated with alteration of the trabecular compartment. Trabecular density was the most strongly altered parameter and could be a candidate to assess drug effect on periarticular bone damage. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 2, 2017 Category: Orthopaedics Source Type: research

A typical juxtaarticular form of Dercum's disease in a patient treated with tocilizumab for rheumatoid arthritis
Publication date: Available online 2 December 2017 Source:Joint Bone Spine Author(s): Pauline Baudart, Johann Cesini, Christian Marcelli (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 2, 2017 Category: Orthopaedics Source Type: research

Perihepatitis at the onset of Beh çet's disease: a case report
Publication date: Available online 2 December 2017 Source:Joint Bone Spine Author(s): Hirotaka Tsuno, Atsushi Hashimoto, Koichiro Horie, Akiko Komiya, Toshihiro Matsui, Shigeto Tohma (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 2, 2017 Category: Orthopaedics Source Type: research

Spondyloarthritis features in zymosan-induced SKG mice
Conclusions Zymosan-induced SKG mice developed articular and extra-articular features as well as molecular changes that resembled those of human SpA. These findings suggest that the zymosan-induced SKG mouse is a good animal model to reflect the complex features of human SpA. (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 1, 2017 Category: Orthopaedics Source Type: research

Promoting the consumption of dairy products for fracture prevention: a good value for money?
Publication date: Available online 29 November 2017 Source:Joint Bone Spine Author(s): Mickael Hiligsmann, Patrice Fardellone, Jean-Yves Reginster (Source: Joint Bone Spine)
Source: Joint Bone Spine - December 1, 2017 Category: Orthopaedics Source Type: research

Calcific tendonitis of the rotator cuff: from formation to resorption
Publication date: Available online 28 November 2017 Source:Joint Bone Spine Author(s): Christelle Darrieutort-Laffite, Frédéric Blanchard, Benoit Le Goff Calcific tendonitis of the rotator cuff is due to apatite deposits in the shoulder tendons. Patients affected by calcific tendonitis have chronic shoulder pain and disability. Although the disease is frequent, about 10 to 42% of painful shoulders, mechanisms leading to this pathological mineralization are still largely unknown. Research reported in the 90s suggested that the formation of calcific deposits is linked to cells looking like chondrocytes identif...
Source: Joint Bone Spine - November 29, 2017 Category: Orthopaedics Source Type: research

Anti-citrullinated peptides antibodies in systemic sclerosis: meta-analysis of frequency and meaning
Conclusions The prevalence of ACPA in scleroderma is 9.2%. Our meta-analysis shows an increased risk for erosive arthritis, pulmonary fibrosis, oesophagus involvement and diffuse skin involvement, in patients with ACPA-positive SSc. ACPA should be systematically included in SSc assessment. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 27, 2017 Category: Orthopaedics Source Type: research

Risk of autism spectrum disorder in children born to mothers with systemic lupus erythematosus and rheumatoid arthritis in Taiwan
Conclusions Children born to women with systemic lupus erythematosus or rheumatoid arthritis do not have a higher risk of autism spectrum disorder. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 27, 2017 Category: Orthopaedics Source Type: research

Bilateral striopallidodentate calcinosis associated with Sj ögren's syndrome and IgDλ monoclonal gammopathy of undetermined significance
We presented the first case of bilateral striopallidodentate calcinosis secondary to Sjögren's syndrome. Further consideration should be given to the association between Sjögren's syndrome and bilateral striopallidodentate calcinosis, because Sjögren's syndrome is latent, but more frequent than other autoimmune diseases. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 27, 2017 Category: Orthopaedics Source Type: research

Sciatica Due to Hydroxyapatite Deposition Disease
Publication date: Available online 22 November 2017 Source:Joint Bone Spine Author(s): Charlotte de Charry, Clément Derkenne, Sophie Morelon (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 23, 2017 Category: Orthopaedics Source Type: research

Treatment Strategies for Psoriatic Arthritis
The objectives of this review are to discuss new concepts, to describe and assess the new drug classes introduced for psoriatic arthritis and, whenever possible, to define the specific indications of each class based on the rheumatic disease phenotype and presence of extraarticular manifestations. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 22, 2017 Category: Orthopaedics Source Type: research

Small Fiber Neuropathy: Diagnosis, Causes, and Treatment
Publication date: Available online 16 November 2017 Source:Joint Bone Spine Author(s): Damien Sène Small fiber neuropathy, which affects the sensory A≏ and C fibers, is now a major diagnostic and therapeutic challenge. Nearly 7% of the general population have chronic neuropathic pain responsible for severe quality-of-life impairments. Awareness must therefore be raised among clinicians of the somatosensory and autonomic symptoms that can reveal small fiber neuropathy, appropriate diagnostic investigations, most common causes, and best treatment options for each patient profile. To help achieve this goal, the pres...
Source: Joint Bone Spine - November 17, 2017 Category: Orthopaedics Source Type: research

Treatment of carpal tunnel syndrome: from ultrasonography to ultrasound surgery
Publication date: Available online 16 November 2017 Source:Joint Bone Spine Author(s): David Petrover, Pascal Richette Carpal tunnel syndrome is the most common nerve entrapment syndrome. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. It is diagnosed clinically, often being confirmed by an electromyogram, while ultrasonography criteria have become increasingly useful for the diagnosis. Ultrasonography is better tolerated, less expensive, yet just as effective as other diagnostic methods. It provides a good indication of the severity of the condition and it allows anatom...
Source: Joint Bone Spine - November 17, 2017 Category: Orthopaedics Source Type: research

Switching from originator infliximab to biosimilar CT-P13 in real-life: the weight of patient acceptance
Conclusions Retention rate was lower after switching from OI to CT-P13 compared to our control cohorts. However, this difference faded after excluding patients without objective clinical activity, suggesting a reluctance of patients to the switch and a negative perception of the biosimilar. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 15, 2017 Category: Orthopaedics Source Type: research

Vertebral marrow adipose tissue adipokines as a possible cause of intervertebral disc inflammation
Publication date: Available online 5 October 2017 Source:Joint Bone Spine Author(s): Zvonimir Vrselja, Goran Curic (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 14, 2017 Category: Orthopaedics Source Type: research

Correlation between catastrophizing and Lequesne index in case of osteoarthritis of the knee: a prospective study
Conclusion psychological factors like catastrophizing correlated with Lequesne index. (Source: Joint Bone Spine)
Source: Joint Bone Spine - November 1, 2017 Category: Orthopaedics Source Type: research

Bone sarcoidosis
Publication date: Available online 28 October 2017 Source:Joint Bone Spine Author(s): Agathe Farge, Pauline Baudart, Sarah Jafari, Christian Marcelli (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 29, 2017 Category: Orthopaedics Source Type: research

High prevalence of sacrococcygeal pilonidal sinus disease in patients with ankylosing spondylitis
Publication date: Available online 13 October 2017 Source:Joint Bone Spine Author(s): Mehmet Soy, Pamir Atagündüz, Cemal Bes, Aysun Aksoy, Ozan Kocakaya (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 14, 2017 Category: Orthopaedics Source Type: research

Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial
Conclusion Among patients with knee OA, statin use was associated with radiological worsening over 3 years, regardless of other potential confounding factors (obesity, type 2 diabetes, hypertension, disease duration, symptom intensity and radiological severity). (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 14, 2017 Category: Orthopaedics Source Type: research

Economic analysis of a nurse-led programme for comorbidities management of rheumatoid arthritis patients
Conclusions From the hospital's perspective and from both a medical and economic point of view, a nurse-led programme to manage the comorbidities of RA is useful. (Source: Joint Bone Spine)
Source: Joint Bone Spine - October 5, 2017 Category: Orthopaedics Source Type: research