New insights into the functions of enamel matrices in calcified tissues
Publication date: May 2014 Source:Japanese Dental Science Review, Volume 50, Issue 2 Author(s): Satoshi Fukumoto , Takashi Nakamura , Aya Yamada , Makiko Arakaki , Kan Saito , Juan Xu , Emiko Fukumoto , Yoshihiko Yamada Ameloblasts secrete enamel matrix proteins, including amelogenin, ameloblastin, enamelin, amelotin, and Apin/odontogenic ameloblast-associated protein (Apin/ODAM). Amelogenin is the major protein component of the enamel matrix. Amelogenin, ameloblastin, and enamelin are expressed during the secretory stage of ameloblast, while amelotin and Apin/ODAM are expressed during the maturation. Amelogenin and amel...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Oral ulcerations due to drug medications
Publication date: May 2014 Source:Japanese Dental Science Review, Volume 50, Issue 2 Author(s): Yoshinori Jinbu , Toshio Demitsu Ulcers are common symptoms observed in the oral cavity and some ulcerations are induced by drug medications. When ulcers show typical clinical findings differential diagnosis may be easy, but the exact diagnosis is often difficult. We reviewed differential diagnosis of oral ulcerative diseases, clinical characteristics of drug-induced oral ulcerations and drugs inducing oral ulcerations. Many kinds of drugs have been reported to cause oral ulcerations. Among them, non-steroidal anti-inflammator...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Osteocyte function under compressive mechanical force
Publication date: May 2014 Source:Japanese Dental Science Review, Volume 50, Issue 2 Author(s): Teruko Takano-Yamamoto Mechanical stress is an essential factor for physiological response and maintaining homeostasis of living bodies. Bone changes its molphology and density in response to the physical circumstances such as mechanical stress. Bone tissue remodeling is regulated by the cells in bone: osteoblasts, osteoclasts and their progenitors. Recently, osteocytes terminally differentiated from osteoblasts have been considered to play significant role in bone remodeling and act as mechanosensitive cells. We have previous...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

The current status of the design of resin-bonded fixed partial dentures, splints and overcastings
Publication date: May 2014 Source:Japanese Dental Science Review, Volume 50, Issue 2 Author(s): Hiroshi Shimizu , Tomohiro Kawaguchi , Yutaka Takahashi This review article describes the current status of resin-bonded fixed partial denture, splint and overcasting design. Several such designs have been introduced through the years, but there is no typical standard yet for the design of anterior resin-bonded prostheses. On the other hand, the design of posterior resin-bonded prostheses has generally been a standard D-shaped structure. To splint abutment teeth, including pathological mobile teeth, the application of resin-bo...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Tooth brushing for oral prophylaxis
This article reviews these topics. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Progress of computer-aided detection/diagnosis (CAD) in dentistry<Runningtitle>CAD in dentistry</Runningtitle>
Publication date: August 2014 Source:Japanese Dental Science Review, Volume 50, Issue 3 Author(s): Akitoshi Katsumata , Hiroshi Fujita The development of computer-aided detection/diagnosis (CAD) systems for dental imaging is progressing. One expected use of CAD is to detect radiological signs of medical systemic disease in the panoramic screening radiograph. The target diseases for CAD include osteoporosis, arteriosclerosis, and maxillary sinusitis. CAD is also useful in the detection and evaluation of dental and maxillofacial lesions. Identifying alveolar bone resorption due to periodontitis and radiolucent jaw lesions ...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Current evidence and biological plausibility linking periodontitis to atherosclerotic cardiovascular disease
Publication date: August 2014 Source:Japanese Dental Science Review, Volume 50, Issue 3 Author(s): Koichi Tabeta , Hiromasa Yoshie , Kazuhisa Yamazaki The relationship between poor oral health and systemic diseases has been increasingly recognized over the past two decades. Atherosclerosis is an important basal component of atherosclerotic cardiovascular disease (ACVD), which is the primary cause of death worldwide, including Japan. The accumulation of multiple individual epidemiological studies has paved the way for subsequent systematic reviews that have demonstrated that periodontitis can be considered as an emerging ...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Applications of X-ray fluorescence analysis (XRF) to dental and medical specimens
Publication date: Available online 29 August 2014 Source:Japanese Dental Science Review Author(s): Motohiro Uo , Takahiro Wada , Tomoko Sugiyama Human tissues contain many kinds of minerals and trace essential elements that act as catalytic or structural components of large biochemical molecules. In addition, various metallic and inorganic materials are used in dental and medical materials and devices. In the dental and medical fields, specimens that are wet and/or have low heat resistance are often requested for elemental analysis. Therefore, a rapid and non-destructive method of elemental analysis is required. X-ray fl...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century?
Publication date: Available online 27 September 2014 Source:Japanese Dental Science Review Author(s): Takenobu Katagiri , Kenji Osawa , Sho Tsukamoto , Mai Fujimoto , Arei Miyamoto , Takato Mizuta Bone morphogenetic protein (BMP) was originally discovered by Marshall Urist a half century ago following the observation of a unique activity that induced heterotopic bone formation in skeletal muscle tissue. The molecular mechanisms underlying the induction of heterotopic bone formation in skeletal muscle by BMPs were elucidated through the purification and molecular cloning of BMPs and identification of their functional rece...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Molecular aspects in inflammatory events of temporomandibular joint: Microarray-based identification of mediators
Publication date: Available online 11 October 2014 Source:Japanese Dental Science Review Author(s): Naomi Ogura , Toshirou Kondoh Synovial inflammation (synovitis) frequently accompanies intracapsular pathologic conditions of the temporomandibular joint (TMJ) such as internal derangement (ID) and/or osteoarthritis (OA), and is suggested to be associated with symptom severity. To identify the putative factors associated with synovitis, we investigated interleukin (IL)-1β- and/or tumor necrosis factor (TNF)-α-responsive genes of fibroblast-like synoviocytes (FLS) from patients with ID and/or OA of TMJ using micr...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Molecular biological change in oral cancer, summary of our researches
Publication date: Available online 13 October 2014 Source:Japanese Dental Science Review Author(s): Nobuharu Yamamoto , Takeshi Onda , Keisuke Sugahara , Takeshi Nomura , Takahiko Shibahara Molecular biological search and identification of cancer have a variety of clinical significance. Microarray, proteomics and metabolome analyses are powerful analytical methods for rapid screening of tumor markers. From the results, it was revealed that a number of genes are specifically expressed in oral cancers. From the results of CAN and LOH analyses of the entire genome, three candidate gene loci (D1S1189, D1S2151, D1S2595) were ...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Morphological variation of the maxillary lateral incisor
Publication date: November 2014 Source:Japanese Dental Science Review, Volume 50, Issue 4 Author(s): Shintaro Kondo , Grant Townsend , Masanobu Matsuno The maxillary lateral incisor is a variable tooth morphologically. This tooth frequently shows reduction in size, and also various alterations in shape, for example, peg-shaped, cone-shaped, barrel-shaped and canine-shaped. The lateral incisor variant can be analyzed by family studies and using twin models, and these approaches have shown that genetic, epigenetic and environmental factors can all contribute to variation in the trait. Discordance of the phenotype in monozy...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Cancer/testis antigens: A prospective reagent as diagnostic and immunotherapeutic targets for squamous cell carcinoma of the head and neck
Publication date: November 2014 Source:Japanese Dental Science Review, Volume 50, Issue 4 Author(s): Shohei Domae , Toshiro Ono , Akira Sasaki Numerous tumor antigens have so far been identified from various tumors using the serological identification of antigens by recombinant expression cloning (SEREX) method. Among them, cancer/testis (CT) antigens are considered promising target molecules for immunotherapy for patients with various cancers. We performed several SEREX analyses of various cancers to identify CT antigens, including gastric adenocarcinoma, lung adenocarcinoma, and colon cancer, and consequently identifie...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Multidetector computed tomography of maxillofacial fractures
Publication date: November 2014 Source:Japanese Dental Science Review, Volume 50, Issue 4 Author(s): Ichiro Ogura , Yusuke Sasaki , Takashi Kaneda Fracture morphology of maxillofacial trauma is often complex, so the clinicians should be familiar with the imaging findings. Various radiographic methods have been used for diagnosing maxillofacial trauma. In recent years, multidetector computed tomography (MDCT) with multiplanar reformation (MPR) and three-dimensional (3D) images has become a standard part of the assessment of maxillofacial injury because of the exquisite sensitivity of this imaging technique for fracture. I...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research

Risks and complications of miniscrew anchorage in clinical orthodontics
Publication date: November 2014 Source:Japanese Dental Science Review, Volume 50, Issue 4 Author(s): Shingo Kuroda , Eiji Tanaka Miniscrew anchorage has greatly expanded the limit of clinical orthodontics. Even without patient compliance, miniscrews can provide stationary anchorages for various tooth movements and even make it possible to move the tooth in directions which have been impossible with traditional orthodontic mechanics. On the other hand, the clinical use of miniscrew anchorage includes some risks. Screw fracture might be one of the most undesirable side effects in clinical use of miniscrew anchorage, which ...
Source: Japanese Dental Science Review - November 3, 2014 Category: Dentistry Source Type: research