Application of computer-assisted navigation systems in oral and maxillofacial surgery
This report presents an overview and feasible applications of available navigation systems with a focus on the clinical feasibility of the application of navigation systems in the field of oral and maxillofacial surgery and solutions to current problems. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Role of Streptococcus mutans surface proteins for biofilm formation
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Michiyo Matsumoto-NakanoSummaryStreptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to mo...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell–cell adhesion through N-cadherin
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Naoyuki Chosa, Akira IshisakiSummaryMesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use in regenerative medicine and cell therapies. Upon activation by tissue damage, MSCs contribute to tissue repair through a multitude of processes such as self-renewal, migration, and differentiation. However, loss of self-renewal and multi-lineage differentiation potential occurs at a high rate during cell doubling. Effective MSC ther...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

A review on non-syndromic tooth agenesis associated with PAX9 mutations
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya LestariSummaryTooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of several genes for tooth epithelium and mesenchyme odont...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Cancer metabolism: New insights into classic characteristics
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Yasumasa Kato, Toyonobu Maeda, Atsuko Suzuki, Yuh BabaSummaryInitial studies of cancer metabolism in the early 1920s found that cancer cells were phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake and lactate production, even in the presence of oxygen. This property, called the Warburg effect, is considered a hallmark of cancer. The mechanism by which these cells acquire aerobic glycolysis has been uncovered. Acidic extracellular fluid, secreted by cancer cells, induces a malignant p...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

The shape of progress
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Masahito Sumitomo (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Regulatory mechanisms of branching morphogenesis in mouse submandibular gland rudiments
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Masanori Kashimata, Toru HayashiSummaryBranching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial–mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs)...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

The roles of odontoblasts in dental pulp innate immunity
Publication date: Available online 27 March 2018Source: Japanese Dental Science ReviewAuthor(s): Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi MatsuoSummaryOdontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbi...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Overview of innovative advances in bioresorbable plate systems for oral and maxillofacial surgery
This report presents an overview of currently available resorbable implant materials and their applications, with a focus on recent innovative advances and new developments in this field. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Uncovering the neural circuitry involved in the stress-attenuation effects of chewing
Publication date: Available online 6 April 2018Source: Japanese Dental Science ReviewAuthor(s): Kenichi Sasaguri, Kentaro Yamada, Toshiharu YamamotoAbstractPrevious animal studies have indicated that coupling restraint stress load with activation of the masticatory organs (chewing) causes a reduction in the systemic and central nervous system stress response. However, the brain mechanism underlying this effect is unknown. Therefore, in this review, we summarize the literature regarding brain regions involved in the attenuating effects of chewing and the systemic stress response attenuation effects induced by those brain re...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Wear of resin composites: Current insights into underlying mechanisms, evaluation methods and influential factors
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Akimasa Tsujimoto, Wayne W. Barkmeier, Nicholas G. Fischer, Kie Nojiri, Yuko Nagura, Toshiki Takamizawa, Mark A. Latta, Masashi MiazakiSummaryThe application of resin composites in dentistry has become increasingly widespread due to the increased aesthetic demands of patients, improvements in the formulation of resin composites, and the ability of these materials to bond to tooth structures, together with concerns about dental amalgam fillings. As resistance to wear is an important factor in determining the clinical success of re...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Implant treatment in ultra-aged society
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Yuji Sato, Noboru Kitagawa, Akio IsobeSummaryImplant therapy is gaining presence as a prosthodontic treatment option. However, the graying of the population has led to an increase in the number of older adults requiring special consideration in implant treatment because of their systemic health problems. Additionally, with the growth of the elderly population in need of long-term care, a greater number of older adults who have received implant treatment are receiving long-term care, raising various issues that need to be addresse...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Candida is a protractive factor of chronic oral ulcers among usual outpatients
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin KasuyaSummaryAlthough many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer associat...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Histological and immunological characteristics of the junctional epithelium
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Masanori NakamuraSummaryThe continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of J...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Regulation of defensive function on gingival epithelial cells can prevent periodontal disease
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi KuriharaSummaryPeriodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacteri...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Molecularly-targeted therapy for the oral cancer stem cells
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro NakajimaSummaryHuman cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Application of computer-assisted navigation systems in oral and maxillofacial surgery
This report presents an overview and feasible applications of available navigation systems with a focus on the clinical feasibility of the application of navigation systems in the field of oral and maxillofacial surgery and solutions to current problems. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Application of computer-assisted navigation systems in oral and maxillofacial surgery
This report presents an overview and feasible applications of available navigation systems with a focus on the clinical feasibility of the application of navigation systems in the field of oral and maxillofacial surgery and solutions to current problems. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - May 11, 2018 Category: Dentistry Source Type: research

Overview of innovative advances in bioresorbable plate systems for oral and maxillofacial surgery
This report presents an overview of currently available resorbable implant materials and their applications, with a focus on recent innovative advances and new developments in this field. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - April 6, 2018 Category: Dentistry Source Type: research

Uncovering the neural circuitry involved in the stress-attenuation effects of chewing
Publication date: Available online 6 April 2018 Source:Japanese Dental Science Review Author(s): Kenichi Sasaguri, Kentaro Yamada, Toshiharu Yamamoto Previous animal studies have indicated that coupling restraint stress load with activation of the masticatory organs (chewing) causes a reduction in the systemic and central nervous system stress response. However, the brain mechanism underlying this effect is unknown. Therefore, in this review, we summarize the literature regarding brain regions involved in the attenuating effects of chewing and the systemic stress response attenuation effects induced by those brain regions...
Source: Japanese Dental Science Review - April 6, 2018 Category: Dentistry Source Type: research

The roles of odontoblasts in dental pulp innate immunity
Publication date: Available online 27 March 2018 Source:Japanese Dental Science Review Author(s): Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi Matsuo Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbial p...
Source: Japanese Dental Science Review - March 27, 2018 Category: Dentistry Source Type: research

Implant treatment in ultra-aged society
Publication date: Available online 10 January 2018 Source:Japanese Dental Science Review Author(s): Yuji Sato, Noboru Kitagawa, Akio Isobe Implant therapy is gaining presence as a prosthodontic treatment option. However, the graying of the population has led to an increase in the number of older adults requiring special consideration in implant treatment because of their systemic health problems. Additionally, with the growth of the elderly population in need of long-term care, a greater number of older adults who have received implant treatment are receiving long-term care, raising various issues that need to be addresse...
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research

Candida is a protractive factor of chronic oral ulcers among usual outpatients
Publication date: Available online 12 January 2018 Source:Japanese Dental Science Review Author(s): Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin Kasuya Although many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer associat...
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research

Regulatory mechanisms of branching morphogenesis in mouse submandibular gland rudiments
Publication date: February 2018 Source:Japanese Dental Science Review, Volume 54, Issue 1 Author(s): Masanori Kashimata, Toru Hayashi Branching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial–mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs) hav...
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research

The shape of progress
Publication date: February 2018 Source:Japanese Dental Science Review, Volume 54, Issue 1 Author(s): Masahito Sumitomo (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research

Regulation of defensive function on gingival epithelial cells can prevent periodontal disease
Publication date: Available online 15 December 2017 Source:Japanese Dental Science Review Author(s): Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara Periodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacter...
Source: Japanese Dental Science Review - December 16, 2017 Category: Dentistry Source Type: research

Molecularly-targeted therapy for the oral cancer stem cells
Publication date: Available online 16 December 2017 Source:Japanese Dental Science Review Author(s): Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro Nakajima Human cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, th...
Source: Japanese Dental Science Review - December 16, 2017 Category: Dentistry Source Type: research

Wear of resin composites: Current insights into underlying mechanisms, evaluation methods and influential factors
Publication date: Available online 11 December 2017 Source:Japanese Dental Science Review Author(s): Akimasa Tsujimoto, Wayne W. Barkmeier, Robert L. Erickson, Kie Nojiri, Yuko Nagura, Toshiki Takamizawa, Mark A. Latta, Masashi Miazaki The application of resin composites in dentistry has become increasingly widespread due to the increased aesthetic demands of patients, improvements in the formulation of resin composites, and the ability of these materials to bond to tooth structures, together with concerns about dental amalgam fillings. As resistance to wear is an important factor in determining the clinical success of re...
Source: Japanese Dental Science Review - December 12, 2017 Category: Dentistry Source Type: research

Histological and immunological characteristics of the junctional epithelium
Publication date: Available online 7 December 2017 Source:Japanese Dental Science Review Author(s): Masanori Nakamura The continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of J...
Source: Japanese Dental Science Review - December 8, 2017 Category: Dentistry Source Type: research

Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell –cell adhesion through N-cadherin
Publication date: Available online 9 November 2017 Source:Japanese Dental Science Review Author(s): Naoyuki Chosa, Akira Ishisaki Mesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use in regenerative medicine and cell therapies. Upon activation by tissue damage, MSCs contribute to tissue repair through a multitude of processes such as self-renewal, migration, and differentiation. However, loss of self-renewal and multi-lineage differentiation potential occurs at a high rate during cell doubling. Effective MSC therapies...
Source: Japanese Dental Science Review - November 10, 2017 Category: Dentistry Source Type: research

A review on non-syndromic tooth agenesis associated with PAX9 mutations
Publication date: Available online 7 October 2017 Source:Japanese Dental Science Review Author(s): Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya Lestari Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of several genes for tooth epithelium and mesenchyme odontogenes...
Source: Japanese Dental Science Review - October 7, 2017 Category: Dentistry Source Type: research

Role of Streptococcus mutans surface proteins for biofilm formation
Publication date: Available online 29 September 2017 Source:Japanese Dental Science Review Author(s): Michiyo Matsumoto-Nakano Streptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to modul...
Source: Japanese Dental Science Review - September 30, 2017 Category: Dentistry Source Type: research

Cancer metabolism: New insights into classic characteristics
Publication date: Available online 29 September 2017 Source:Japanese Dental Science Review Author(s): Yasumasa Kato, Toyonobu Maeda, Atsuko Suzuki, Yuh Baba Initial studies of cancer metabolism in the early 1920s found that cancer cells were phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake and lactate production, even in the presence of oxygen. This property, called the Warburg effect, is considered a hallmark of cancer. The mechanism by which these cells acquire aerobic glycolysis has been uncovered. Acidic extracellular fluid, secreted by cancer cells, induces a malignant phen...
Source: Japanese Dental Science Review - September 30, 2017 Category: Dentistry Source Type: research

Molecular mechanisms of Porphyromonas gingivalis-host cell interaction on periodontal diseases
Publication date: Available online 9 August 2017 Source:Japanese Dental Science Review Author(s): Masaaki Nakayama, Naoya Ohara Porphyromonas gingivalis (P. gingivalis) is a major oral pathogen and associated with periodontal diseases including periodontitis and alveolar bone loss. In this review, we indicate that two virulence factors, which are hemoglobin receptor protein (HbR) and cysteine proteases “gingipains”, expressed by P. gingivalis have novel functions on the pathogenicity of P. gingivalis. P. gingivalis produces three types of gingipains and concomitantly several adhesin domains. Among the adhesin ...
Source: Japanese Dental Science Review - August 9, 2017 Category: Dentistry Source Type: research

Neuropeptides and ATP signaling in the trigeminal ganglion
Publication date: Available online 15 March 2017 Source:Japanese Dental Science Review Author(s): Tetsuya Goto, Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite glial...
Source: Japanese Dental Science Review - March 15, 2017 Category: Dentistry Source Type: research

Epstein –Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity
Publication date: Available online 15 March 2017 Source:Japanese Dental Science Review Author(s): Kentaro Kikuchi, Harumi Inoue, Yuji Miyazaki, Fumio Ide, Masaru Kojima, Kaoru Kusama Epstein–Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary gl...
Source: Japanese Dental Science Review - March 15, 2017 Category: Dentistry Source Type: research

Muscle power during intravenous sedation
Publication date: Available online 9 March 2017 Source:Japanese Dental Science Review Author(s): Nobuyuki Matsuura Intravenous sedation is effective to reduce fear and anxiety in dental treatment. It also has been used for behavior modification technique in dental patients with special needs. Midazolam and propofol are commonly used for intravenous sedation. Although there have been many researches on the effects of midazolam and propofol on vital function and the recovery profile, little is known about muscle power. This review discusses the effects of intravenous sedation using midazolam and propofol on both grip streng...
Source: Japanese Dental Science Review - March 10, 2017 Category: Dentistry Source Type: research

English education for healthcare professionals in Japan
This article will review the current status of English education for dental healthcare professionals in Japan. After conducting a literature search using the keywords: English education, Japan, and dental, only a few studies were found that investigated and proposed suggestions for dental professional English education. Even so, these were still in the early stages with outcomes yet to be fully evaluated. Even though English is thought indispensable for global professionals, and that increasing chances for communication skills is necessary, little attention has been addressed to English education for dental professionals o...
Source: Japanese Dental Science Review - March 3, 2017 Category: Dentistry Source Type: research

Thirst sensation and oral dryness following alcohol intake
Publication date: Available online 27 February 2017 Source:Japanese Dental Science Review Author(s): Kiyotoshi Inenaga, Kentaro Ono, Suzuro Hitomi, Ayu Kuroki, Izumi Ujihara Substantial acute and chronic intakes of alcohol or ethanol (EtOH) severely influence oral sensations, such as thirst and oral dryness (dry mouth, xerostomia). Thirst sensation and oral dryness are primarily caused by the activation of neurons in brain regions, including the circumventricular organs and hypothalamus, which are referred to as the dipsogenic center, and by a decrease in salivary secretion, respectively. The sensation of thirst experienc...
Source: Japanese Dental Science Review - February 28, 2017 Category: Dentistry Source Type: research

The New Year has begun. Let ’s move forward!
Publication date: Available online 25 January 2017 Source:Japanese Dental Science Review Author(s): Masahito Sumitomo (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - January 25, 2017 Category: Dentistry Source Type: research

Role of Streptococcus mutans two-component systems in antimicrobial peptide resistance in the oral cavity
Publication date: Available online 13 January 2017 Source:Japanese Dental Science Review Author(s): Miki Kawada-Matsuo, Hitoshi Komatsuzawa Approximately 100 trillion microorganisms exist in the oral cavity. For the commensal bacteria of the oral cavity, it is important to adapt to environmental stimuli, including human- or bacteria-derived antimicrobial agents. Recently, bacterial-specific signal transduction regulatory systems, called two-component systems (TCSs), which appear to be focused on sensing and adapting to the environment, were discovered. Streptococcus mutans is an oral commensal bacteria and is also known a...
Source: Japanese Dental Science Review - January 13, 2017 Category: Dentistry Source Type: research

Therapeutic strategies with oral fluoropyrimidine anticancer agent, S-1 against oral cancer
Publication date: Available online 19 December 2016 Source:Japanese Dental Science Review Author(s): Koji Harada, Tarannum Ferdous, Yoshiya Ueyama Oral cancer has been recognized as a tumor with low sensitivity to anticancer agents. However, introduction of S-1, an oral cancer agent is improving treatment outcome for patients with oral cancer. In addition, S-1, as a main drug for oral cancer treatment in Japan can be easily available for outpatients. In fact, S-1 exerts high therapeutic effects with acceptable side effects. Moreover, combined chemotherapy with S-1 shows higher efficacy than S-1 alone, and combined chemo-r...
Source: Japanese Dental Science Review - December 20, 2016 Category: Dentistry Source Type: research

Ultrastructural and biochemical aspects of matrix vesicle-mediated mineralization
Publication date: Available online 5 November 2016 Source:Japanese Dental Science Review Author(s): Tomoka Hasegawa, Tomomaya Yamamoto, Erika Tsuchiya, Hiromi Hongo, Kanako Tsuboi, Ai Kudo, Miki Abe, Taiji Yoshida, Tomoya Nagai, Naznin Khadiza, Ayako Yokoyama, Kimimitsu Oda, Hidehiro Ozawa, Paulo Henrique Luiz de Freitas, Minqi Li, Norio Amizuka Matrix vesicle-mediated mineralization is an orchestrated sequence of ultrastructural and biochemical events that lead to crystal nucleation and growth. The influx of phosphate ions into the matrix vesicle is mediated by several proteins such as TNAP, ENPP1, Pit1, annexin and so f...
Source: Japanese Dental Science Review - November 5, 2016 Category: Dentistry Source Type: research

Presage of oncolytic virotherapy for oral cancer with herpes simplex virus
Publication date: Available online 5 November 2016 Source:Japanese Dental Science Review Author(s): Yoshiaki Yura A virus is a pathogenic organism that causes a number of infectious diseases in humans. The oral cavity is the site at which viruses enter and are excreted from the human body. Herpes simplex virus type 1 (HSV-1) produces the primary infectious disease, gingivostomatitis, and recurrent disease, labial herpes. HSV-1 is one of the most extensively investigated viruses used for cancer therapy. In principle, HSV-1 infects epithelial cells and neuronal cells and exhibits cytotoxicity due to its cytopathic effects o...
Source: Japanese Dental Science Review - November 5, 2016 Category: Dentistry Source Type: research

The potential of enriched mesenchymal stem cells with neural crest cell phenotypes as a cell source for regenerative dentistry
Publication date: Available online 5 November 2016 Source:Japanese Dental Science Review Author(s): Kunimichi Niibe, Maolin Zhang, Kosuke Nakazawa, Satoru Morikawa, Taneaki Nakagawa, Yumi Matsuzaki, Hiroshi Egusa Effective regenerative treatments for periodontal tissue defects have recently been demonstrated using mesenchymal stromal/stem cells (MSCs). Furthermore, current bioengineering techniques have enabled de novo fabrication of tooth-perio dental units in mice. These cutting-edge technologies are expected to address unmet needs within regenerative dentistry. However, to achieve efficient and stable treatment outcome...
Source: Japanese Dental Science Review - November 5, 2016 Category: Dentistry Source Type: research

The role of dentistry other than oral care in patients undergoing radiotherapy for head and neck cancer
Publication date: Available online 19 October 2016 Source:Japanese Dental Science Review Author(s): Hidenobu Matsuzaki, Kumiko Tanaka-Matsuzaki, Fuminobu Miyazaki, Hideki Aoyama, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Kengo Himei, Tetsuo Takeuchi, Tomoo Onoda, Yoshihiro Kimata, Jun-ichi Asaumi The usefulness of dental approaches, such as oral management, has gained recognition among patients treated for head and neck cancer. In particular, oral management plays a very important role before, during, and after treatment in patients undergoing radiotherapy, chemotherapy, or a combination of both. However, specializ...
Source: Japanese Dental Science Review - October 29, 2016 Category: Dentistry Source Type: research

Magnetic resonance and sonographic imagings of masticatory muscle myalgia in temporomandibular disorder patients
This article reviews recently published studies investigating the MRI and sonographic diagnosis of masticatory muscle myalgia in temporomandibular disorder patients. The MRI and sonographic features of muscle after treatment are also discussed. Literature published within the last 15 years was obtained from the PubMed database using the following Mesh terms: magnetic resonance imaging (MRI) or sonography, masticatory muscle pain, and treatment. MRI and sonography enable accurate visualization and evaluation of the masticatory muscles, thereby increasing our understanding of pathology and cause of pain associated with these...
Source: Japanese Dental Science Review - September 6, 2016 Category: Dentistry Source Type: research

Shedding quantitative fluorescence light on novel regulatory mechanisms in skeletal biomedicine and biodentistry
Publication date: Available online 6 September 2016 Source:Japanese Dental Science Review Author(s): Ji-Won Lee, Tadahiro Iimura Digitalized fluorescence images contain numerical information such as color (wavelength), fluorescence intensity and spatial position. However, quantitative analyses of acquired data and their validation remained to be established. Our research group has applied quantitative fluorescence imaging on tissue sections and uncovered novel findings in skeletal biomedicine and biodentistry. This review paper includes a brief background of quantitative fluorescence imaging and discusses practical applic...
Source: Japanese Dental Science Review - September 6, 2016 Category: Dentistry Source Type: research

The usefulness of diagnostic imaging for the assessment of pain symptoms in temporomandibular disorders
Publication date: Available online 5 September 2016 Source:Japanese Dental Science Review Author(s): Shigeaki Suenaga, Kunihiro Nagayama, Taisuke Nagasawa, Hiroko Indo, Hideyuki J. Majima The causes of pain symptoms in the temporomandibular joint (TMJ) and masticatory muscle (MM) regions may not be determined by clinical examination alone. In this review, we document that pain symptoms of the TMJ and MM regions in patients with temporomandibular disorders (TMDs) are associated with computed tomography and magnetic resonance (MR) findings of internal derangement, joint effusion, osteoarthritis, and bone marrow edema. Howev...
Source: Japanese Dental Science Review - September 5, 2016 Category: Dentistry Source Type: research

Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
Publication date: Available online 27 June 2016 Source:Japanese Dental Science Review Author(s): Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with ch...
Source: Japanese Dental Science Review - July 28, 2016 Category: Dentistry Source Type: research