Adverse Events as End Points: The Need to Account for Both Sides of the Same Coin [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Aizpuru, F. Tags: Clinical Studies Editorial Source Type: research

Maternal Macronutrient Intake and Offspring Blood Pressure 20 Years Later [Epidemiology]
ConclusionsHigher maternal dietary protein intake at the expense of carbohydrates was associated with a modest increase in offspring blood pressure in young adulthood. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Hrolfsdottir, L., Halldorsson, T. I., Rytter, D., Bech, B. H., Birgisdottir, B. E., Gunnarsdottir, I., Granstrom, C., Henriksen, T. B., Olsen, S. F., Maslova, E. Tags: Cardiovascular Disease, Diet and Nutrition, Epidemiology, Pregnancy, High Blood Pressure Original Research Source Type: research

Clinical Significance of Postinfarct Fever in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study [Coronary Heart Disease]
BackgroundLittle is known about causality and pathological mechanism underlying association of postinfarct fever with myocardial injury in patients with ST‐segment elevation myocardial infarction.Methods and ResultsIn 276 patients undergoing primary percutaneous coronary intervention for ST‐segment elevation myocardial infarction, cardiac magnetic resonance imaging was performed a median of 3.4 days after the index procedure. Forty‐five patients had postinfarct fever (peak body temperature within 4 days after primary percutaneous coronary intervention ≥37.7°C; Fever group) whereas 231 did not (no‐Fever group)....
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Jang, W. J., Yang, J. H., Song, Y. B., Chun, W. J., Oh, J. H., Park, Y. H., Lee, M. R., Hwang, J. K., Hwang, J.-W., Hahn, J.-Y., Choi, S.-H., Lee, S.-C., Choe, Y. H., Gwon, H.-C. Tags: Myocardial Infarction, Magnetic Resonance Imaging (MRI), Percutaneous Coronary Intervention, Coronary Artery Disease Original Research Source Type: research

Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection [Coronary Heart Disease]
ConclusionsAn integrated collection of end points and serious AEs is feasible in a multinational trial and illustrates the shared characteristics of events. Tailoring event collection to fit the phase and purpose of the trial is achievable and informative.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00831441. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Guimaraes, P. O., Lopes, R. D., Stevens, S. R., Zimerman, A., Wruck, L., James, S. K., Haque, G., Giraldez, R. R. C. V., Alexander, J. H., Alexander, K. P. Tags: Clinical Studies, Cardiovascular Disease, Myocardial Infarction, Acute Coronary Syndromes Original Research Source Type: research

Short Length of Stay After Elective Transfemoral Transcatheter Aortic Valve Replacement is Not Associated With Increased Early or Late Readmission Risk [Valvular Heart Disease]
ConclusionsAmong elderly survivors of elective transfemoral TAVR, a short postprocedural length of stay was not associated with an increased risk readmission within 30 days or 1 year. However, the risk of 1‐year readmission increased with longer post‐TAVR lengths of stay. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Sud, M., Qui, F., Austin, P. C., Ko, D. T., Wood, D., Czarnecki, A., Patel, V., Lee, D. S., Wijeysundera, H. C. Tags: Valvular Heart Disease, Quality and Outcomes Original Research Source Type: research

Association of Tenofovir Use With Risk of Incident Heart Failure in HIV-Infected Patients [Heart Failure]
ConclusionsAmong a large national cohort of human immunodeficiency virus–infected patients, TDF use was strongly associated with lower risk of incident HF. These findings warrant confirmation in other populations, both with TDF and the recently approved tenofovir alafenamide fumarate. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Chen, R., Scherzer, R., Hsue, P. Y., Jotwani, V., Estrella, M. M., Horberg, M. A., Grunfeld, C., Shlipak, M. G. Tags: Risk Factors, Cardiomyopathy, Heart Failure Original Research Source Type: research

Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves [Valvular Heart Disease]
ConclusionsIn AVICs of calcified valves, increased levels of miR‐486 induce myofibroblastic transition to upregulate Runx2 and Osx expression and synergize with miR‐204 deficiency to elevate cellular and valvular pro‐osteogenic activity. These novel findings indicate that modulation of the epigenetic mechanism underlying valvular pro‐osteogenic activity has therapeutic potential for prevention of calcific aortic valve disease progression. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Song, R., Fullerton, D. A., Ao, L., Zhao, K.-s., Reece, T. B., Cleveland, J. C., Meng, X. Tags: Cell Biology/Structural Biology, Cell Signaling/Signal Transduction, Vascular Biology, Gene Expression & Regulation, Valvular Heart Disease Original Research Source Type: research

Comparative Effectiveness and Safety of Dabigatran and Rivaroxaban in Atrial Fibrillation Patients [Arrhythmia and Electrophysiology]
ConclusionsRivaroxaban therapy was associated with a statistically significant increase in all‐cause death compared with dabigatran therapy in atrial fibrillation patients. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Lai, C.-L., Chen, H.-M., Liao, M.-T., Lin, T.-T., Chan, K. A. Tags: Arrhythmias, Anticoagulants, Pharmacology, Cerebrovascular Disease/Stroke Original Research Source Type: research

Total Thrombus-formation Analysis System Predicts Periprocedural Bleeding Events in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention [Interventional Cardiology]
ConclusionsPL24‐AUC10 measured by the Total Thrombus‐formation Analysis System is a potentially useful predictor of periprocedural bleeding events in coronary artery disease patients undergoing elective percutaneous coronary intervention. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Oimatsu, Y., Kaikita, K., Ishii, M., Mitsuse, T., Ito, M., Arima, Y., Sueta, D., Takahashi, A., Iwashita, S., Yamamoto, E., Kojima, S., Hokimoto, S., Tsujita, K. Tags: Complications, Coronary Artery Disease Original Research Source Type: research

Use and Customization of Risk Scores for Predicting Cardiovascular Events Using Electronic Health Record Data [Health Services and Outcomes Research]
ConclusionsWe conclude that published cardiovascular risk models can be successfully applied to EHD to estimate cardiovascular risk; the FRS remains valid and is not obsolete; and model refitting does not meaningfully improve the accuracy of risk estimates. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Wolfson, J., Vock, D. M., Bandyopadhyay, S., Kottke, T., Vazquez-Benitez, G., Johnson, P., Adomavicius, G., O'Connor, P. J. Tags: Cardiovascular Disease, Risk Factors, Quality and Outcomes Original Research Source Type: research

Marital History and Survival After Stroke [Corrections]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Tags: Correction Source Type: research

Incidence of First Stroke in Pregnant and Nonpregnant Women of Childbearing Age: A Population-Based Cohort Study From England [Epidemiology]
ConclusionsAlthough the absolute risk of first stroke is low in women of childbearing age, healthcare professionals should be aware of a considerable increase in relative risk during the peripartum and early postpartum periods. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 21, 2017 Category: Cardiology Authors: Ban, L., Sprigg, N., Abdul Sultan, A., Nelson-Piercy, C., Bath, P. M., Ludvigsson, J. F., Stephansson, O., Tata, L. J. Tags: Epidemiology, Pregnancy, Women, Cerebrovascular Disease/Stroke Original Research Source Type: research

In Situ Laser Fenestration Is a Feasible Method for Revascularization of Aortic Arch During Thoracic Endovascular Aortic Repair [Cardiovascular Surgery]
ConclusionsIn situ laser fenestration is a feasible, effective, rapid, repeatable, and safe option for the reconstruction of aortic arch during thoracic endovascular aortic repair, which might be available to revascularize the 3 branches. However, follow‐up periods should be extended to evaluate the robustness of this technique. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 21, 2017 Category: Cardiology Authors: Qin, J., Zhao, Z., Wang, R., Ye, K., Li, W., Liu, X., Liu, G., Cui, C., Shi, H., Peng, Z., Yuan, F., Yang, X., Lu, M., Huang, X., Jiang, M., Wang, X., Yin, M., Lu, X. Tags: Aneurysm, Aortic Dissection, Thrombosis Original Research Source Type: research

Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy [Heart Failure]
ConclusionsThese data indicated that TIM50 could attenuate pathological cardiac hypertrophy primarily by reducing oxidative stress. TIM50 could be a promising target for the prevention and therapy of cardiac hypertrophy and heart failure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 21, 2017 Category: Cardiology Authors: Tang, K., Zhao, Y., Li, H., Zhu, M., Li, W., Liu, W., Zhu, G., Xu, D., Peng, W., Xu, Y.-w. Tags: Basic Science Research, Hypertrophy Original Research Source Type: research

Progression of Coronary Artery Calcium and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis [Imaging]
ConclusionsCAC progression was associated with incident HF and modestly increased LV end diastolic volume and LV end systolic volume at follow‐up exam independent of overt coronary heart disease. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - April 20, 2017 Category: Cardiology Authors: Bakhshi, H., Ambale-Venkatesh, B., Yang, X., Ostovaneh, M. R., Wu, C. O., Budoff, M., Bahrami, H., Wong, N. D., Bluemke, D. A., Lima, J. A. C. Tags: Heart Failure, Computerized Tomography (CT), Magnetic Resonance Imaging (MRI) Original Research Source Type: research