JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Observed Cost and Variations in Short Term Cost-Effectiveness of Therapy for Ischemic Stroke in Interventional Management of Stroke (IMS) III [Health Services and Outcomes Research]
ConclusionsDetailed economic and resource utilization data from IMS III provide powerful evidence for the large effect that patient outcome has on the economic value of medical and endovascular reperfusion therapies. These data can be used to inform process improvements for stroke care and to estimate the cost‐effectiveness of endovascular therapy in the US health system for stroke intervention trials.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Registration number: NCT00359424. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 8, 2017 Category: Cardiology Authors: Simpson, K. N., Simpson, A. N., Mauldin, P. D., Palesch, Y. Y., Yeatts, S. D., Kleindorfer, D., Tomsick, T. A., Foster, L. D., Demchuk, A. M., Khatri, P., Hill, M. D., Jauch, E. C., Jovin, T. G., Yan, B., von Kummer, R., Molina, C. A., Goyal, M., Schonewi Tags: Cost-Effectiveness, Health Services, Cerebrovascular Procedures, Ischemic Stroke Original Research Source Type: research

Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment [Contemporary Review]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 5, 2017 Category: Cardiology Authors: Smith, E. E., Cieslak, A., Barber, P., Chen, J., Chen, Y.-W., Donnini, I., Edwards, J. D., Frayne, R., Field, T. S., Hegedus, J., Hanganu, V., Ismail, Z., Kanji, J., Nakajima, M., Noor, R., Peca, S., Sahlas, D., Sharma, M., Sposato, L. A., Swartz, R. H., Tags: Secondary Prevention, Cerebrovascular Disease/Stroke, Cognitive Impairment, Neuroprotectants Contemporary Review Source Type: research

Long-Term Outcomes of Patients With Mediastinal Radiation-Associated Severe Aortic Stenosis and Subsequent Surgical Aortic Valve Replacement: A Matched Cohort Study [Valvular Heart Disease]
BackgroundCardiac disease after mediastinal radiotherapy for thoracic malignancy (chest radiotherapy [XRT]) often manifests as progressive aortic stenosis. In patients with XRT‐induced severe aortic stenosis undergoing surgical aortic valve replacement (SAVR), we sought to: (1) study long‐term survival and compare these patients with a matched cohort undergoing SAVR during the same time frame; and (2) identify potential predictors of long‐term mortality.Methods and ResultsWe studied patients with symptomatic severe aortic stenosis undergoing SAVR at our institution, of which there were 172 mediastinal XRT patients (6...
Source: JAHA:Journal of the American Heart Association - May 5, 2017 Category: Cardiology Authors: Donnellan, E., Masri, A., Johnston, D. R., Pettersson, G. B., Rodriguez, L. L., Popovic, Z. B., Roselli, E. E., Smedira, N. G., Svensson, L. G., Griffin, B. P., Desai, M. Y. Tags: Valvular Heart Disease Original Research Source Type: research

Traditional Cardiovascular Risk Factors and Their Relation to Future Surgery for Valvular Heart Disease or Ascending Aortic Disease: A Case-Referent Study [Valvular Heart Disease]
ConclusionsThis is the first truly prospective study of traditional cardiovascular risk factors and their association with valvular heart disease and disease of the ascending aorta. We confirm the strong association between traditional risk factors and aortic stenosis, but only in patients with concomitant coronary artery disease. In isolated valvular heart disease, the impact of traditional risk factors is varying. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 5, 2017 Category: Cardiology Authors: Lȷungberg, J., Johansson, B., Engstrom, K. G., Albertsson, E., Holmer, P., Norberg, M., Bergdahl, I. A., Soderberg, S. Tags: Risk Factors, Valvular Heart Disease Original Research Source Type: research

Prognostic Value of Dehydroepiandrosterone Sulfate for Patients With Cardiovascular Disease: A Systematic Review and Meta–Analysis [Systematic Review and Meta-Analysis]
BackgroundThe aim of the present study was to estimate the impact of dehydroepiandrosterone sulfate (DHEAS) on the prognosis of patients with cardiovascular disease by performing a systematic review and meta‐analysis.Methods and ResultsThe Embase, PubMed, Web of Science, CNKI, and WanFang databases were searched up to September 5, 2016, to identify eligible studies. The quality of each study was assessed using the Newcastle‐Ottawa Scale. The association between DHEAS, either on admission or at discharge, and cardiovascular disease outcomes were reviewed. The overall risk ratio for the effect of DHEAS on all‐cause mor...
Source: JAHA:Journal of the American Heart Association - May 5, 2017 Category: Cardiology Authors: Wu, T.-T., Chen, Y., Zhou, Y., Adi, D., Zheng, Y.-Y., Liu, F., Ma, Y.-T., Xie, X. Tags: Cardiovascular Disease, Meta Analysis, Mortality/Survival Systematic Review and Meta ‐ Source Type: research

Initiation Patterns of Statins in the 2 Years After Release of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Cholesterol Management Guideline in a Large US Health Plan [Health Services and Outcomes Research]
ConclusionsPrescriber implementation of the guideline recommendations has gradually increased, with the most marked change in the increased initiation of high‐intensity statins in patients with ASCVD and in those treated by a specialist. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 4, 2017 Category: Cardiology Authors: Olufade, T., Zhou, S., Anzalone, D., Kern, D. M., Tunceli, O., Cziraky, M. J., Willey, V. J. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Health Services Original Research Source Type: research

Ranolazine in Symptomatic Diabetic Patients Without Obstructive Coronary Artery Disease: Impact on Microvascular and Diastolic Function [Imaging]
ConclusionsIn symptomatic diabetic patients without obstructive coronary artery disease, ranolazine did not change exercise‐stimulated myocardial blood flow or CFR but did modestly improve diastolic function. Patients with more severe baseline impairment in CFR may derive more benefit from ranolazine.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01754259. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 4, 2017 Category: Cardiology Authors: Shah, N. R., Cheezum, M. K., Veeranna, V., Horgan, S. J., Taqueti, V. R., Murthy, V. L., Foster, C., Hainer, J., Daniels, K. M., Rivero, J., Shah, A. M., Stone, P. H., Morrow, D. A., Steigner, M. L., Dorbala, S., Blankstein, R., Di Carli, M. F. Tags: Coronary Circulation, Diabetes, Type 2, Nuclear Cardiology and PET Original Research Source Type: research

Post-Myocardial Infarction T-tubules Form Enlarged Branched Structures With Dysregulation of Junctophilin-2 and Bridging Integrator 1 (BIN-1) [Heart Failure]
ConclusionsThis study reveals previously unidentified remodeling of the t‐t nano‐architecture in the post‐MI heart that extends to the remote region. Our findings highlight that targeting JP2 may be beneficial for preserving the orientation of the t‐ts, attenuating the development of hypocontractility post‐MI. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 4, 2017 Category: Cardiology Authors: Pinali, C., Malik, N., Davenport, J. B., Allan, L. J., Murfitt, L., Iqbal, M. M., Boyett, M. R., Wright, E. J., Walker, R., Zhang, Y., Dobryznski, H., Holt, C. M., Kitmitto, A. Tags: Cell Biology/Structural Biology, Heart Failure, Myocardial Infarction, Remodeling Original Research Source Type: research

Performance of AHEAD Score in an Asian Cohort of Acute Heart Failure With Either Preserved or Reduced Left Ventricular Systolic Function [Heart Failure]
ConclusionsThe AHEAD score was useful in predicting long‐term mortality in the Asian acute heart failure cohort with either HFrEF or HFpEF. The new AHEAD‐U score may further improve risk stratification. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 4, 2017 Category: Cardiology Authors: Chen, Y.-J., Sung, S.-H., Cheng, H.-M., Huang, W.-M., Wu, C.-L., Huang, C.-J., Hsu, P.-F., Yeh, J.-S., Guo, C.-Y., Yu, W.-C., Chen, C.-H. Tags: Heart Failure Original Research Source Type: research

Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction [Coronary Heart Disease]
BackgroundPlaque erosion causes 30% of ST‐segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in erosion compared with rupture in autopsy studies. We hypothesized that erosion and rupture are associated with significant differences in intracoronary cytokines in vivo.Methods and ResultsForty ST‐segment elevation myocardial infarction patients with (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 3, 2017 Category: Cardiology Authors: Chandran, S., Watkins, J., Abdul-Aziz, A., Shafat, M., Calvert, P. A., Bowles, K. M., Flather, M. D., Rushworth, S. A., Ryding, A. D. Tags: Biomarkers, Inflammation, Myocardial Infarction, Optical Coherence Tomography (OCT), Percutaneous Coronary Intervention Original Research Source Type: research

Intracoronary Administration of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial Infarction [Coronary Heart Disease]
ConclusionsIn this porcine acute myocardial infarction model, allogeneic ATMSCs‐based therapy was associated with increased cardioprotective and reparative mechanisms and with better cardiac magnetic resonance–measured perfusion. No effect on left ventricular volumes or ejection fraction was observed. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 3, 2017 Category: Cardiology Authors: Bobi, J., Solanes, N., Fernandez-Jimenez, R., Galan-Arriola, C., Dantas, A. P., Fernandez-Friera, L., Galvez-Monton, C., Rigol-Monzo, E., Aguero, J., Ramirez, J., Roque, M., Bayes-Genis, A., Sanchez-Gonzalez, J., Garcia-Alvarez, A., Sabate, M., Roura, S., Tags: Cell Therapy, Stem Cells, Translational Studies, Myocardial Infarction Original Research Source Type: research

Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study [Epidemiology]
This study aimed to evaluate the relationship between circulating levels of PCSK9 and arterial stiffness, an early instrumental biomarker of cardiovascular disease risk, in a large sample of overall healthy participants.Methods and ResultsFrom the historical cohort of the Brisighella Heart Study, after exclusion of active smokers, participants in secondary prevention for cardiovascular disease, and patients in treatment with statins or vasodilating agents, we selected 227 premenopausal women and 193 age‐matched men and 460 postmenopausal women and 416 age‐matched men. In these participants, we evaluated the correlation...
Source: JAHA:Journal of the American Heart Association - May 3, 2017 Category: Cardiology Authors: Ruscica, M., Ferri, N., Fogacci, F., Rosticci, M., Botta, M., Marchiano, S., Magni, P., D'Addato, S., Giovannini, M., Borghi, C., Cicero, A. F. G., the Brisighella Heart Study Group Tags: Epidemiology, Primary Prevention, Risk Factors, Women Original Research Source Type: research

Association Between Self-Reported Potentially Modifiable Cardiac Risk Factors and Perceived Need to Improve Physical Health: A Population-Based Study [Preventive Cardiology]
ConclusionsThe cumulative burden of PMRFs is positively associated with PNIPH; however, individual PMRFs differentially contribute to this perception. Among those at highest cardiac risk, ≈1 in 5 denied PNIPH. A better understanding of factors underlying health perceptions and behaviors is needed to capitalize on cardiovascular preventive efforts. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 3, 2017 Category: Cardiology Authors: Ramirez, F. D., Chen, Y., Di Santo, P., Simard, T., Motazedian, P., Hibbert, B. Tags: Cardiovascular Disease, Epidemiology, Lifestyle, Risk Factors Original Research Source Type: research

Long-Term Effects of Unprovoked Venous Thromboembolism on Mortality and Maȷor Cardiovascular Events [Epidemiology]
BackgroundPatients with unprovoked venous thromboembolism (VTE) are at an increased risk of mortality, but whether their cardiovascular risks also increase remains to be determined. We aimed to investigate the factors associated with overall mortality and major adverse cardiovascular events in patients with unprovoked VTE.Methods and ResultsWe identified 2154 patients newly diagnosed with unprovoked VTE from Taiwan's National Health Insurance Database between 2000 and 2013, excluding those with reversible etiologies, underlying cancer, or autoimmune diseases. These patients with VTE were compared with an age‐, sex‐, an...
Source: JAHA:Journal of the American Heart Association - May 3, 2017 Category: Cardiology Authors: Chang, W.-T., Chang, C.-L., Ho, C.-H., Hong, C.-S., Wang, J.-J., Chen, Z.-C. Tags: Epidemiology, Embolism, Thrombosis Original Research Source Type: research

Comparison of Expert Adjudicated Coronary Heart Disease and Cardiovascular Disease Mortality With the National Death Index: Results From the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study [Epidemiology]
ConclusionsThe modest accuracy and differential performance of NDI‐derived cause of death may impact CHD and CVD mortality statistics. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - May 3, 2017 Category: Cardiology Authors: Olubowale, O. T., Safford, M. M., Brown, T. M., Durant, R. W., Howard, V. J., Gamboa, C., Glasser, S. P., Rhodes, J. D., Levitan, E. B. Tags: Cardiovascular Disease, Epidemiology Original Research Source Type: research