JAHA:Journal of the American Heart Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Development of Coronary Pulse Wave Velocity: New Pathophysiological Insight Into Coronary Artery Disease [Coronary Heart Disease]
ConclusionsCoPWV seems associated with acute coronary events more closely than aortic PWV. High coronary compliance, whether per se or because it leads to a distal shift in compliance mismatch, may expose vulnerable plaques to high cyclic stretch. CoPWV is a new tool to assess local compliance at the coronary level; it paves the way for a new field of research. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Harbaoui, B., Courand, P.-Y., Cividjian, A., Lantelme, P. Tags: Coronary Circulation, Biomarkers, Coronary Artery Disease, Vascular Disease Original Research Source Type: research

Outcomes of Physician-Staffed Versus Non-Physician-Staffed Helicopter Transport for ST-Elevation Myocardial Infarction [Coronary Heart Disease]
BackgroundThe effect of physician‐staffed helicopter emergency medical service (HEMS) on ST‐elevation myocardial infarction (STEMI) patient transfer is unknown. The purpose of this study was to evaluate the characteristics and outcomes of physician‐staffed HEMS (Physician‐HEMS) versus non‐physician‐staffed (Standard‐HEMS) in patients with STEMI.Methods and ResultsWe studied 398 STEMI patients transferred by either Physician‐HEMS (n=327) or Standard‐HEMS (n=71) for primary or rescue percutaneous coronary intervention at 2 hospitals between 2006 and 2014. Data were collected from electronic medical records ...
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Gunnarsson, S. I., Mitchell, J., Busch, M. S., Larson, B., Gharacholou, S. M., Li, Z., Raval, A. N. Tags: Percutaneous Coronary Intervention, Quality and Outcomes, Acute Coronary Syndromes Original Research Source Type: research

Heritability of Vascular Structure and Function: A Parent-Child Study [Genetics]
BackgroundUnderstanding the heritable contribution of vascular measures, from parent to offspring, may aid in risk stratification and atherosclerosis prevention efforts. We hypothesized that measures of vascular structure and function would be heritable in this cohort of parents and their adolescent offspring.Methods and ResultsHigh‐resolution ultrasound scans of the brachial and carotid arteries were obtained in parents (n=558) and their offspring (n=369). Lumen diameter and flow‐mediated dilation were measured in the brachial artery. Intima‐media thickness, lumen diameter, incremental elastic modulus, diameter dist...
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Ryder, J. R., Pankratz, N. D., Dengel, D. R., Pankow, J. S., Jacobs, D. R., Sinaiko, A. R., Gooty, V., Steinberger, J. Tags: Endothelium/Vascular Type/Nitric Oxide, Vascular Biology, Risk Factors, Genetic, Association Studies, Ultrasound Original Research Source Type: research

Prognostic Significance of Plasma High-Sensitivity C-Reactive Protein in Patients With Hypertrophic Cardiomyopathy [Heart Failure]
BackgroundElevated high‐sensitivity C‐reactive protein (hsCRP) has been associated with increased risks of adverse outcomes of various cardiovascular diseases. The relationship between hsCRP and the prognosis of hypertrophic cardiomyopathy remains to be evaluated.Methods and ResultsThe study used an observational cohort methodology. A total of 490 patients were enrolled in the Fuwai Hospital from 2001 to 2011 and were followed for 3.7±2.0 years. According to the risk category of hsCRP, subjects in the high hsCRP group (>3.0 mg/L) had a higher risk of developing adverse events than the low hsCRP group ( (Source: JAHA...
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Zhu, L., Zou, Y., Wang, Y., Luo, X., Sun, K., Wang, H., Jia, L., Liu, Y., Zou, J., Yuan, Z., Hui, R., Kang, L., Song, L., Wang, J. Tags: Cardiomyopathy, Hypertrophy Original Research Source Type: research

Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study [Epidemiology]
ConclusionsBoth HOMA‐IR and the McAuley index demonstrate strong associations with CHD but not stroke risk in blacks. The logHOMA‐IR and CHD association was present in men, but not in women. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Effoe, V. S., Wagenknecht, L. E., Echouffo Tcheugui, J. B., Chen, H., Joseph, J. J., Kalyani, R. R., Bell, R. A., Wu, W.-C. H., Casanova, R., Bertoni, A. G. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Research Source Type: research

Less Than Ideal Cardiovascular Health Is Associated With Shorter Leukocyte Telomere Length: The National Health and Nutrition Examination Surveys, 1999-2002 [Epidemiology]
ConclusionsThe findings suggest that less‐than‐ideal CVH is associated with shorter LTL, but this association varies by sex and race/ethnicity. Future longitudinal research is needed to elucidate the mechanisms that underlie the association between CVH and LTL. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Gebreab, S. Y., Manna, Z. G., Khan, R. J., Riestra, P., Xu, R., Davis, S. K. Tags: Inflammation, Aging, Cardiovascular Disease, Epidemiology, Race and Ethnicity Original Research Source Type: research

Cardiovascular Health and Healthcare Utilization and Expenditures Among Medicare Beneficiaries: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study [Health Services and Outcomes Research]
ConclusionsBetter cardiovascular health is associated with lower risk for inpatient encounters and lower inpatient and outpatient healthcare expenditures. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 1, 2017 Category: Cardiology Authors: Aaron, K. J., Colantonio, L. D., Deng, L., Judd, S. E., Locher, J. L., Safford, M. M., Cushman, M., Kilgore, M. L., Becker, D. J., Muntner, P. Tags: Cardiovascular Disease, Risk Factors, Cost-Effectiveness, Health Services, Statements and Guidelines Original Research Source Type: research

Mental Health Among Parents of Children With Critical Congenital Heart Defects: A Systematic Review [Systematic Review and Meta-Analysis]
ConclusionsThere is an urgent need for additional research on the severity, course, persistence, and moderators of these mental health problems over time, and for the development and testing of screening approaches and interventions that can be feasibly delivered in the context of ongoing pediatric cardiac care. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 1, 2017 Category: Cardiology Authors: Woolf-King, S. E., Anger, A., Arnold, E. A., Weiss, S. J., Teitel, D. Tags: Mental Health, Congenital Heart Disease Systematic Review and Meta ‐ Analysis Source Type: research

Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium [Epidemiology]
ConclusionsAlthough effect sizes were small, our results suggest that environmental exposure to lead, cadmium, or both might be a risk factor for systolic LV dysfunction, a condition often proceeding to heart failure. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 1, 2017 Category: Cardiology Authors: Yang, W.-Y., Zhang, Z.-Y., Thijs, L., Cauwenberghs, N., Wei, F.-F., Jacobs, L., Luttun, A., Verhamme, P., Kuznetsova, T., Nawrot, T. S., Staessen, J. A. Tags: Cardiovascular Disease, Epidemiology, Heart Failure Original Research Source Type: research

Factors Associated With New-Onset Depression Following Ischemic Stroke: The Women's Health Initiative [Epidemiology]
ConclusionsThere is a difference in the relationship of prestroke psychosocial status and risk of NPSD depending on stroke severity; thus it may be that the same preventive interventions might not work for all stroke patients. One size does not fit all. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - February 1, 2017 Category: Cardiology Authors: Salinas, J., Ray, R. M., Nassir, R., Lakshminarayan, K., Dording, C., Smoller, J., Wassertheil-Smoller, S., Rosand, J., Dunn, E. C. Tags: Epidemiology, Risk Factors, Women, Quality and Outcomes, Ischemic Stroke Original Research Source Type: research

Postmenopausal Women With Greater Paracardial Fat Have More Coronary Artery Calcification Than Premenopausal Women: The Study of Women's Health Across the Nation (SWAN) Cardiovascular Fat Ancillary Study [Epidemiology]
ConclusionsThe findings suggest that PAT is a potential menopause‐specific coronary artery disease risk marker, supporting the need to monitor and target this fat depot for intervention in women at midlife. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - January 29, 2017 Category: Cardiology Authors: El Khoudary, S. R., Shields, K. J., Janssen, I., Budoff, M. J., Everson-Rose, S. A., Powell, L. H., Matthews, K. A. Tags: Aging, Cardiovascular Disease, Epidemiology, Risk Factors, Women Original Research Source Type: research

Transforming Growth Factor-{beta} in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant? [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - January 24, 2017 Category: Cardiology Authors: Daugherty, A., Chen, Z., Sawada, H., Rateri, D. L., Sheppard, M. B. Tags: Aneurysm, Aortic Dissection, Vascular Disease Editorial Source Type: research

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor {beta} Signaling [Vascular Medicine]
ConclusionsIn young Fbn1C1039G/+ mice, aortopathy develops in the absence of detectable alterations in SMC TGF‐β signaling. Loss of physiologic SMC TGF‐β signaling exacerbates MFS‐associated aortopathy. Our data support a protective role for SMC TGF‐β signaling during early development of MFS‐associated aortopathy. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - January 24, 2017 Category: Cardiology Authors: Wei, H., Hu, J. H., Angelov, S. N., Fox, K., Yan, J., Enstrom, R., Smith, A., Dichek, D. A. Tags: Animal Models of Human Disease, Growth Factors/Cytokines, Genetically Altered and Transgenic Models, Aneurysm, Vascular Disease Original Research Source Type: research

Iron and Sex Cross Paths in the Heart [Editorials]
(Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - January 23, 2017 Category: Cardiology Authors: Shapiro, J. S., Chang, H.-C., Ardehali, H. Tags: Editorial Source Type: research

Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress [Heart Failure]
ConclusionsMale and female mice respond differently to iron‐overload‐mediated effects on heart structure and function, and females are markedly protected from iron‐overload cardiomyopathy. Ovariectomy in female mice exacerbated iron‐induced myocardial injury and precipitated severe cardiac dysfunction during iron‐overload conditions, whereas 17β‐estradiol therapy was protective in male iron‐overloaded mice. (Source: JAHA:Journal of the American Heart Association)
Source: JAHA:Journal of the American Heart Association - January 23, 2017 Category: Cardiology Authors: Das, S. K., Patel, V. B., Basu, R., Wang, W., DesAulniers, J., Kassiri, Z., Oudit, G. Y. Tags: Oxidant Stress, Pathophysiology, Cardiomyopathy, Heart Failure Original Research Source Type: research