Turtles in Their Natural Habitats
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Marcus, A., Giorgadze, T. Tags: Images in Pathology Source Type: research

Emojis for the Surgical Pathologist
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Pai, S. A. Tags: Images in Pathology Source Type: research

Elastofibroma With Amyloid Deposition
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Hashimoto, H., Yamada, T., Horiuchi, H. Tags: Images in Pathology Source Type: research

A Rare Polypoid Lesion of the Jejunum
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Pitto, F., Ponte, R., Mastracci, L., Pigozzi, S., Grillo, F. Tags: Images in Pathology Source Type: research

Mesothelial Cells Within Vascular Transformation of Mediastinal Lymph Node Sinuses: An Unusual Benign Collision Mimicking Colliding Malignancies
Vascular transformation of lymph node sinuses represents a rare benign entity mimicking malignant counterparts such as nodal Kaposi sarcoma. The presence of mildly atypical benign mesothelial cells within nodal sinuses raises the possibility of metastatic malignancy. Herein, a rare case of vascular transformation of lymph node sinuses with reactive sinusoidal mesothelial cells is outlined as a unique benign pathology and a potential mimicker of a malignant collision tumor. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Jabbour, M. N., Tawil, A. N., Boulos, F. I. Tags: Pitfalls in Pathology Source Type: research

FGF23-Associated Tumor-Induced Osteomalacia in a Patient With Small Cell Carcinoma: A Case Report and Regulatory Mechanism Study
Tumor-induced osteomalacia (TIO) is typically caused by phosphaturic mesenchymal tumor (PMT) that secretes the phosphaturic hormone, fibroblast growth factor-23 (FGF23), resulting in decreased phosphate reabsorption in kidneys, hypophosphatemia, and finally osteomalacia. Rare cases of malignant tumor manifesting with TIO other than PMT had been reported, although in most of these reports, except one, circulating FGF23 levels were not evaluated and tissue expressing of FGF23 was not confirmed. In this article, we report a case of TIO in a patient with pulmonary small cell carcinoma with liver metastasis. The patient manifes...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Sauder, A., Wiernek, S., Dai, X., Pereira, R., Yudd, M., Patel, C., Golden, A., Ahmed, S., Choe, J., Chang, V., Sender, S., Cai, D. Tags: Molecular Surgical Pathology Source Type: research

Frozen Section Interpretation of Pancreatic Margins: Subspecialized Gastrointestinal Pathologists Versus General Pathologists
Intraoperative assessment of pancreatic parenchymal margin during pancreatectomies is challenging and misinterpretation by the pathologist is a cause of incorrect frozen section (FS) diagnosis. Although the current literature supports that pancreatic margin FS diagnosis and its accuracy has no impact on the patient outcome for pancreatic ductal adenocarcinoma (PDAC) patients and reexcision in an attempt to achieve a negative intraoperative pancreatic margin after positive FS is not associated with increased overall survival; still it remains a routine practice in many institutions. To this end, we sought to assess the inte...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Liu, Y.-J., Smith-Chakmakova, F., Rassaei, N., Han, B., Enomoto, L. M., Crist, H., Hollenbeak, C. S., Karamchandani, D. M. Tags: Original Articles Source Type: research

Ki67 Heterogeneity in Estrogen Receptor-Positive Breast Cancers: Which Tumor Type Has the Most Heterogeneity?
Heterogeneity of Ki67 expression, often seen in breast cancer, can make evaluation of the expression of this marker difficult and give rise to confusion when considering adjuvant treatments for patients. Herein, we investigated estrogen receptor–positive breast cancers to reveal the tumor characteristics associated with Ki67 heterogeneity. Surgical specimens from 85 invasive ductal carcinomas of no special type and 13 invasive lobular carcinomas were examined. We first calculated the differences between Ki67 expression in a hot spot and those in 4 random fields on the same slide. We then evaluated Ki67 heterogeneity ...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Himuro, T., Horimoto, Y., Arakawa, A., Tanabe, M., Saito, M. Tags: Original Articles Source Type: research

Solid Variant of Adenoid Cystic Carcinoma of the Breast: A Case Series With Proposal of a New Grading System
Adenoid cystic carcinoma (ACC) of the breast is a low-grade malignancy "triple negative" breast tumor. ACC of the breast can present a great variety of morphological features having a prognostic impact. Recently, cases of ACC having solid-basaloid features (SBACC) have been described. In the present study, 6 cases of SBACC have been reported. All the cases affected female patients aged 47 to 69 years (mean = 54 years). Two patients had metastases to the axillary lymph nodes, and 2 patients experienced local recurrences. No deaths due to the tumor were observed. A review of the literature on breast SBACC showed that local r...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Foschini, M. P., Rizzo, A., De Leo, A., Laurino, L., Sironi, M., Rucco, V. Tags: Original Articles Source Type: research

Lanthanum Deposition Is Frequently Observed in the Gastric Mucosa of Dialysis Patients With Lanthanum Carbonate Therapy: A Clinicopathologic Study of 13 Cases, Including 1 Case of Lanthanum Granuloma in the Colon and 2 Nongranulomatous Gastric Cases
(Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - January 12, 2016 Category: Pathology Authors: Goto, K., Ogawa, K. Tags: Letters to the Editor Source Type: research

The Gross Appearance of a NUT Midline Carcinoma
In this report, we provide what is to the best of our knowledge the first complete gross description of NMC resected in toto and without prior treatment. The patient in this case underwent a pneumonectomy for a lung mass with curative intent. On gross examination, the tumor was found to be arising from the mediastinum with a smooth border, and demonstrated only minimal invasion of the surrounding structures. However, lymphovascular invasion was present throughout and there was extensive involvement of surrounding lymph nodes. The gross appearance of the tumor in this case reaffirms that NMC is an aggressive malignancy that...
Source: International Journal of Surgical Pathology - January 12, 2016 Category: Pathology Authors: Wasserman, J. K., Purgina, B., Sekhon, H., Gomes, M. M., Lai, C. Tags: Case Reports Source Type: research

Giant Cell Arteritis of the Female Genital Tract With Occult Temporal Arteritis and Marginal Zone Lymphoma Harboring Novel 20q Deletion: A Case Report and Literature Review
Giant cell arteritis (GCA) is an immunologically mediated vasculitis of large and medium-sized vessels, typically affecting the cranial arteries and usually occurring in the elderly. GCA of the female genital tract is extremely rare with only 31 cases reported in the English literature. An 83-year-old white female with postmenopausal vaginal bleeding revealed an endometrial polyp on pelvic ultrasonography following which polypectomy and subsequently hysterectomy with bilateral salpingo-oophorectomy was done. Microscopy revealed a well-differentiated endometrioid adenocarcinoma. Interestingly, classic GCA involving numerous...
Source: International Journal of Surgical Pathology - January 12, 2016 Category: Pathology Authors: Pradhan, D., Amin, R. M., Jones, M. W., Surti, U., Parwani, A. V. Tags: Case Reports Source Type: research

Composite Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorder and Tubular Adenoma in a Rectal Polyp
We present the first case of composite Epstein–Barr virus–associated B-cell lymphoproliferative disorder and tubular adenoma in a rectal polyp with a benign endoscopic appearance. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - January 12, 2016 Category: Pathology Authors: Lo, A. A., Gao, J., Rao, M. S., Yang, G.-Y. Tags: Case Reports Source Type: research

Coexistent Nodal Diffuse Large B-Cell Lymphoma With Extrapulmonary Tuberculosis: A Rare Case
Extrapulmonary tuberculosis coexistent with lymphomas in the same organ are rare and have been reported in the literature. The most common organs that are involved are small bowel, bronchus, kidney, and lymph nodes. Interestingly, the lymphoma that is commonly present with extrapulmonary tuberculosis is Hodgkin’s lymphoma followed by low-grade non-Hodgkin’s lymphoma. In the present study, we report a 60-year-old man with complaints of fever, loss of appetite, and generalized weakness. On investigation, generalized lymphadenopathy was noted, and the biopsy of cervical lymph node revealed coexistence of diffuse l...
Source: International Journal of Surgical Pathology - January 12, 2016 Category: Pathology Authors: Sachdev, R., Duggal, R., Agrawal, K., Goel, S. Tags: Case Reports Source Type: research

Acute Appendicitis and Pneumatosis in a Duplicated Appendix With Schistosoma Remnants
In conclusion, we report a case of appendiceal pneumatosis occurring in the context of acute appendicitis in a duplicated appendix, with presence of calcified structures suggestive of pathogenic organisms. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - January 12, 2016 Category: Pathology Authors: Handra-Luca, A., Bisseret, D., Dragoescu, E. Tags: Case Reports Source Type: research