International Journal of Surgical Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Prognostic Significance of Lymphatic Vessel Density Detected by D2-40 and Its Relation to Claudin-4 Expression in Prostatic Adenocarcinoma
Conclusion. Increased peritumoral mean LVD in prostatic adenocarcinoma is associated with lymphovascular invasion and positive lymph node metastasis. High claudin-4 expression is associated with high tumor grade, lymphocascular invasion, positive lymph node metastasis, and high mean peritumoral LVD suggesting that D2-40 and claudin-4 may represent different mechanisms of lymphatic vessel invasion with both biomarkers is related to poor prognosis. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: Radi, D. A., Abd-Elazeem, M. A. Tags: Original Articles Source Type: research

Diagnostic Accuracy of Renal Mass Biopsy: An Ex Vivo Study of 100 Nephrectomy Specimens
We investigated the diagnostic accuracy of renal mass biopsy in an ex vivo model, as well as compared the agreement of the preoperative radiological diagnosis with the final pathologic diagnosis. Two 18-gauge needle-core and 2 vacuum-needle biopsies were performed ex vivo from the tumors of 100 consecutive patients undergoing radical nephrectomy between 2006 and 2010. The median tumor size was 5.5 cm. There was no significant difference with regard to cylinder length or tissue quality between the sampling methods. At least 1 of 4 needle cores contained diagnostic tissue in 88% of patients. Biopsy specimens identified clear...
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: von Rundstedt, F.-C., Mata, D. A., Kryvenko, O. N., Roth, S., Degener, S., Dreger, N. M., Goedde, D., Assaid, A., Kamper, L., Haage, P., Stoerkel, S., Lazica, D. A. Tags: Original Articles Source Type: research

Incidence of Clear Cell Papillary Renal Cell Carcinoma in Low-Grade Renal Cell Carcinoma Cases: A 12-Year Retrospective Clinicopathologic Study From a Single Cancer Center
In conclusion, CCPRCC is not uncommon among small low-grade RCC tumors. CCPRCC can be correctly recognized by its unique histomorphological features and confirmed by immunohistochemistry studies, which is important due to the excellent clinical outcome following resection. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: Gill, S., Kauffman, E. C., Kandel, S., George, S., Schwaab, T., Xu, B. Tags: Original Articles Source Type: research

Spitz Tumors: Comparison of Histological Features in Relationship to Immunohistochemical Staining for ALK and NTRK1
In conclusion, this study confirms that although not specific, the growth pattern of intersecting fascicles of amelanotic fusiform melanocytes is strongly associated with ALK expression. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: Kiuru, M., Jungbluth, A., Kutzner, H., Wiesner, T., Busam, K. J. Tags: Original Articles Source Type: research

Pathology and Genetics of Syndromic Gastric Polyps
Gastric polyps are found in 1% to 4% of patients undergoing gastroscopy. The vast majority are sporadic, but some gastric polyps indicate an underlying syndrome. Gastric polyps can manifest in each of the gastrointestinal polyposis syndromes, including the recently described gastric adenocarcinoma and proximal polyposis of the stomach syndrome. In addition, gastric polyps occur in Lynch syndrome and in a few rare conditions that are not primarily gastrointestinal. While some of these syndromes are clearly associated with an increased risk of gastric cancer, others are not. Interestingly, even in disorders with a well-estab...
Source: International Journal of Surgical Pathology - April 24, 2016 Category: Pathology Authors: Brosens, L. A. A., Wood, L. D., Offerhaus, G. J., Arnold, C. A., Lam-Himlin, D., Giardiello, F. M., Montgomery, E. A. Tags: Review Source Type: research

Giant Myelolipoma in the Spleen: A Rare Case Report and Literature Review
Myelolipomas are benign tumors, consisting of hematopoietic cells and mature adipose tissue, which mainly occur within the adrenal gland. Extra-adrenal myelolipomas are rare, and fewer than 60 cases have been reported in the literature. Here, we report a case of intrasplenic myelolipoma in a 42-year-old man with more than 1 month of abdominal pain. Computed tomography scanning revealed a giant, heterogeneous, well-demarcated mass in the spleen. Splenectomy was performed, and an intrasplenic giant mass was completely excised. The diagnosis of myelolipoma was made based on morphological examination. To the best of our knowle...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Zeng, Y., Ma, Q., Lin, L., Fu, P., Shen, Y., Luo, Q.-Y., Zhao, L.-H., Mou, J.-H., Xiao, H.-L. Tags: Case Reports Source Type: research

Mucinous Variant of Follicular Carcinoma of the Thyroid Gland: Case Report and Review of the Literature
We report the fourth case of mucinous variant of follicular carcinoma displaying a minimally invasive tumor with diffuse expression of thyroglobulin, TTF-1, CD56, PAX-8, cytokeratins 7 and 19, in the absence of monoclonal carcinoembryonic antigen (CEA), cytokeratin 20, chromogranin, HBME-1, P63 expression, and BRAF gene mutation, in a 51-year-old woman who is alive without signs of disease 13 months after total thyroidectomy, bilateral neck dissection, and radioactive iodine. Herein, fine-needle aspiration cytology disclosed "worrisome" cytologic features consisting of large epithelial cells arranged in clusters or singula...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Squillaci, S., Pitino, A., Spairani, C., Ferrari, M., Carlon, E., Cosimi, M. F. Tags: Case Reports Source Type: research

Postirradiation Leiomyosarcoma of Rectum Presenting as a Polyp: Case Report and Review of the Literature
We present a case of post-irradiation leiomyosarcoma presenting as a rectal polyp and review the literature. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Jayakumar, R., Basu, P. P., Huang, T., Axiotis, C. A. Tags: Case Reports Source Type: research

"Sclerosing" Pelvic Floor Rhabdomyoma
Conclusions. Skeletal muscle rhabdomyomas are rare benign tumors, generally divided into 3 major categories depending on their clinical and morphological characteristics: fetal, adult, and genital. An unusual histological variant of the genital form has recently been reported in men, characterized by the presence of predominantly mature muscle fibers and marked sclerosis. We document such a lesion in a female patient for the first time. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Quijano Moreno, S. L., Lozano Salazar, A. D., del Mar Berenguel Ibanez, M., Reina Duarte, A., Gonzales Campora, R. Tags: Case Reports Source Type: research

Mesonephric Adenocarcinoma of the Uterine Corpus: A Case Report and Diagnostic Pitfall
We report a case of mesonephric adenocarcinoma of the uterine corpus in a 66-year-old woman who presented with vaginal bleeding. Pelvic magnetic resonance imaging revealed a 2.7-cm-sized irregular thickening and enhancement of the uterine body. The diagnosis following endometrial curettage biopsy was endometrioid adenocarcinoma, and the patient underwent a total hysterectomy with bilateral salpingo-oophorectomy. The tumor was composed of small tubular and ductal components, and a retiform appearance was also observed in the deeper areas. The tumor cells were immunopositive for cytokeratin, vimentin, CD10 with a luminal sta...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Kim, S. S., Nam, J. H., Kim, G.-E., Choi, Y. D., Choi, C., Park, C. S. Tags: Case Reports Source Type: research

Autoimmune-Like Hepatitis: A "Hepatitic" Manifestation of Chronic Graft Versus Host Disease in Post-Stem Cell Transplant
A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. After being successfully treated with prednisone for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as evidenced by jaundice, elevated liver enzymes, and increased bilirubin. Liver biopsy showed histology suggestive of autoimmune-like hepatitis, which is a rare manifestation of chronic "hepatitic" graft versus host disease. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Baniak, N. M., Kanthan, R. Tags: Case Reports Source Type: research

A Rare Case of Sarcina ventriculi of the Stomach in an Asymptomatic Patient
We report the first ever case of S ventriculi, including the morphological and immunohistochemical features, occurring in an asymptomatic patient with a history of Helicobacter pylori gastric ulcers. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Haroon Al Rasheed, M. R., Kim, G. J., Senseng, C. Tags: Case Reports Source Type: research

Gynecomastia With Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ Associated With Invasive Breast Carcinoma in a Male Patient on Antiretroviral Therapy: A Case Report
Breast carcinoma in males is rare although a 4-fold increased incidence is reported in HIV-infected men. Herein we report a case of invasive breast carcinoma in a HIV-positive man on antiretroviral therapy. The carcinoma was associated with features of florid gynecomastia, atypical ductal hyperplasia, ductal carcinoma in situ, and columnar cell change. This combination of morphological changes has not previously been reported in the context of male breast carcinoma and their etiopathological associations are discussed. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Coyne, J. D. Tags: Case Reports Source Type: research

The First Case of Pulmonary Alveolar Proteinosis With Small Cell Lung Carcinoma
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterized by alveolar accumulation of surfactant lipids and proteins. It is usually autoimmune and secondary to hematologic malignancy or infection. To date, only 5 case reports of PAP associated with lung cancers, including 2 cases of squamous cell carcinoma and 3 cases of adenocarcinoma, have been published. To the best of our knowledge, no case of PAP with small cell lung carcinoma has been reported thus far. We herein report the first case of PAP associated with small cell lung carcinoma. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Hiraki, T., Goto, Y., Kitazono, I., Tasaki, T., Higashi, M., Hatanaka, K., Tanimoto, A. Tags: Case Reports Source Type: research

A Case of Ectopic ACTH-Producing Pulmonary Carcinoid Arising in an Extralobar Pulmonary Sequestration
Ectopic adrenocorticotrophic hormone (ACTH)–producing bronchopulmonary carcinoid arising in a bronchopulmonary sequestration is extremely rare. The case of a 67-year-old woman with a 1.7-cm nodule in the mediastinal side of the left lower lobe is presented. At 52 years of age, she was diagnosed as having ACTH-dependent Cushing’s syndrome (CS). However, no ectopic source of ACTH-secretion was detected. Seven years later, she underwent a bilateral adrenalectomy because of aggravation of her health condition. This time, tumor excision was performed by thoracoscopic surgery. The tumor adhered sparsely to the medias...
Source: International Journal of Surgical Pathology - March 2, 2016 Category: Pathology Authors: Sato, S., Kitahara, A., Koike, T., Hashimoto, T., Ohashi, R., Kameda, Y., Tsuchida, M. Tags: Case Reports Source Type: research