International Journal of Mycobacteriology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Rapid detection of Mycobacterium tuberculosis complex in sputum Samples using PURE TB-LAMP assay
Conclusion For accurate diagnostic of pulmonary TB, TB-LAMP could be used as a tool of the first intention. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 9, 2016 Category: Infectious Diseases Source Type: research
Nontuberculosis Mycobacteria: Isolation from clinical samples in Iraq
Conclusion GenoType testing of Mycobacteria species using GenoType MTBC and GenoType Mycobacterium CM constitutes a reliable, rapid, simple, and easy-to-interpret assay. Moreover, it appears suitable for use in our region, since it identified all mycobacterial species. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 9, 2016 Category: Infectious Diseases Source Type: research
Identification of novel Mycobacterium tuberculosis dihydrofolate reductase inhibitors through rational drug design
Publication date: Available online 9 November 2016 Source:International Journal of Mycobacteriology Author(s): Mymoona Akhter Dihydrofolate reductase (DHFR) is one of the validated drug targets in Mycobacterium tuberculosis infection. DHFR inhibitors have been used to treat various life-threatening diseases such as cancer, malaria, and several bacterial infections. However, all clinically effective DHFR inhibitors are nonselective, and inhibit both human and pathogenic DHFRs more or less to a similar extent. The crystal structure of various DHFRs complexed with nicotinamide adenine dinucleotide phosphate and different i...
Source: International Journal of Mycobacteriology - November 8, 2016 Category: Infectious Diseases Source Type: research
Mycobacterium haemophilum: A report of cutaneous Infection in a Patient with end-stage renal disease
Conclusion Cutaneous lesions in immunocompromised patients with positive results in acid-fast staining and negative results for M. tuberculosis should be further assessed using skin culture and molecular techniques to identify rare, atypical mycobacterial species like M. haemophilum. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 8, 2016 Category: Infectious Diseases Source Type: research
Genotypic analysis of multidrug-resistant tuberculosis isolates from extra pulmonary tuberculosis cases in tertiary care centers in Northern India
Conclusion The prevalence (13.4%) of MDR-TB among EPTB was high, and the most prominent mutations in rpoB, katG, and inhA genes were S531L (67.3%), S315T1 (94.5%), and C15T (20%), respectively. Beijing stains are significantly associated with MDR-TB among EPTB in this region. We found that the transmission of prominent mutations contributes to an unexpected increase in primary resistance, including MDR-TB cases in Northern India. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 8, 2016 Category: Infectious Diseases Source Type: research
Common features of tuberculosis and sarcoidosis
In conclusion, diagnosis of sarcoidosis in areas with a high burden of TB poses a significant challenge. Improved diagnostic tests including genetic tests can improve our knowledge and help in distinguishing these two diseases. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 8, 2016 Category: Infectious Diseases Source Type: research
Xpert MTB/RIF for rapid detection of rifampicin-resistant Mycobacterium tuberculosis from pulmonary tuberculosis patients in Southwest Ethiopia
Conclusion Xpert MTB/RIF was highly effective at identifying RIF-resistant strains in smear- or culture-positive samples. RIF resistance based on Xpert MTB/RIF results could be used to estimate MDR and allow rapid initiation of MDR-TB treatment in regions with high levels of drug-resistant TB. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 5, 2016 Category: Infectious Diseases Source Type: research
Mixed metal oxide nanoparticles inhibit growth of Mycobacterium tuberculosis into THP-1 cells
Conclusion Although Ag NPs exhibited low cytotoxicity, they were unable to inhibit Mtb growth in vitro. ZnO NPs exhibited strong anti-Mtb activity and inhibited bacterial growth, but exhibited high cytotoxicity to human macrophage cells. By mixing Ag and ZnO NPs at a ratio of 8ZnO/2Ag, we acquired a mixture that exhibited potent antibacterial activity against Mtb and no cytotoxic effects on THP-1 cells, resulting in inhibition of both in vitro and ex vivo Mtb growth Figs. 1–3, Tables 1–3. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 4, 2016 Category: Infectious Diseases Source Type: research
Comparison of two molecular methods and an automated liquid culture system for the early detection of Mycobacterium tuberculosis from both pulmonary and extrapulmonary specimens in Kuwait
Conclusion The performance of the Xpert MTB/RIF assay was superior to ProbTec PCR for the early detection of MTB from both pulmonary and extrapulmonary specimens. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - November 2, 2016 Category: Infectious Diseases Source Type: research
Drug development: The cell wall as a drug target
Publication date: Available online 18 October 2016 Source:International Journal of Mycobacteriology Author(s): Jonathan A.G. Cox (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research
Evaluation of rifampicin resistance and 81-bp rifampicin resistant determinant region of rpoB gene mutations of Mycobacterium tuberculosis detected with XpertMTB/Rif in Cross River State, Nigeria
Conclusion In our setting, 6.0% of tuberculosis isolates are rifampicin resistant. Mutations associated with probe E commonly due to codon 531 are the most predominant cause of rifampicin resistance. Mutations at probe C (codons 518–523) were uncommon. A change in mutation may have occurred in one of the patients. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research
Design and development of novel inhibitors for the treatment of latent tuberculosis
Conclusion Our results indicated that the hit molecule showed activity against both active and persistent forms of infection, which is ideal for new anti-TB agents. This molecule requires further pharmacokinetic and dynamic screening for development as new drug candidate. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research
Comparative evaluation of diagnostic tests for the detection of Mycobacterium avium subsp. paratuberculosis in the tissues of sheep affected with distinct pathology of paratuberculosis
Conclusion The sensitivity of all the tests in the detection of MAP was lower in PB sheep than in MB sheep. Bacterial culture detected MAP in only 50% of sheep and was found less sensitive than other tests used in the present study. Comparing the overall sensitivity of both the PCR assays, 251 gene PCR was found superior to IS900 gene PCR. The sensitivity of IPT was found superior (95%) to the ZN staining (80%) in the demonstration of acid-fast bacteria in the tissues. In the present study, IPT was found superior in the detection of MAP in PB and MB form of ovine paratuberculosis. This test can be used in the confirmation ...
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research
Paying attention to the details in Mycobacterium tuberculosis: Strain-specific single-nucleotide polymorphisms and clonal variants
Publication date: Available online 21 October 2016 Source:International Journal of Mycobacteriology Author(s): Darío García de Viedma (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research
Best approaches to drug-resistance surveillance at the country level
Publication date: Available online 21 October 2016 Source:International Journal of Mycobacteriology Author(s): A.M. Cabibbe, D.M. Cirillo In 2014, the World Health Organization (WHO) recommendation to include the endorsed rapid molecular technologies (Xpert MTB/RIF, line probe assays) into surveillance systems and surveys allowed the testing of more tuberculosis (TB) patients for drug resistance at country level than ever before. The whole genome sequencing (WGS) approach is emerging as a more powerful tool for epidemiological and drug-resistant routine surveillances, promising a rapid and simultaneous screening of all...
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research
