Antimycobacterial potency and cytotoxicity study of three medicinal plants
Conclusion The results achieved from this preliminary antimycobacterial drug discovery study supported the traditional claims of C. patens, A. reticulata, and G. suaveolens in the treatment of mycobacterial infections. Meanwhile, further fractionation is required to characterize the active ingredients. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

HIV and tuberculosis trends and survival of coinfection in a referral center in Tehran: A 12-year study
Conclusion Our retrospective review of coinfected TB-HIV patients hospitalized in Tehran showed that the management and monitoring of coinfection, pneumothorax and other adverse effects, as well as early initiation of ART, improved patient survival. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Isolation and molecular identification of Mycobacterium from commercially available pasteurized milk and raw milk samples collected from two infected cattle farms in Alborz Province, Iran
Publication date: Available online 27 October 2016 Source:International Journal of Mycobacteriology Author(s): M . Eftekhari, N. Mosavari Mycobacterium avium subsb. paratuberculosis (MAP) is an etiological agent of Johne’s disease in ruminant animals, including cattle, sheep, and goats. This disease is considered an economically important disease in cattle. Animals with paratuberculosis shed viable MAP, particularly in their milk and feces. MAP may be involved in the development of Crohn’s disease in humans through the consumption of contaminated milk and dairy products. Common methods of milk pasteurization are no...
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Performance comparison of a pair of Lowenstein –Jensen media supplemented with pyruvate or glycerol, and the combination of both supplements in a single Lowenstein–Jensen medium for the growth support of the Mycobacterium Tuberculosis complex
Conclusion A single LJPG slope was not significantly different, compared with the usual pair of LJG or LJP slopes. This is a promising new culturing approach that could be used in Mycobacterium africanum-endemic in West African countries. It significantly reduces labor time and consumable costs and more quickly detects the M. tuberculosis complex. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Drug susceptibility testing of Mycobacterium Avium subsp. Avium isolates from naturally infected domestic pigeons to avian tuberculosis
Conclusion We suggest drug susceptibility testing for more nontuberculous mycobateria, particularly M. avium complex isolated from infected birds and humans, as well as molecular basics of drug sensitivity in order to detect resistance genes of pathogenic M. avium subsp. avium. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Cloning, expression, and purification of recombinant protein MPT-64 from a virulent strain of Mycobacterium bovis in a prokaryotic system
Conclusion These results indicated successful expression and purification of recombinant MPT-64 protein in a prokaryotic system. This protein can be used for serological diagnosis, improved detection of pathogenicity and non-pathogenicity between infected cattle, and for verification of suspected cases of bovine TB. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Passive case finding for tuberculosis is not enough
Publication date: Available online 28 October 2016 Source:International Journal of Mycobacteriology Author(s): Jennifer Ho, G.J. Fox, B.J. Marais Current World Health Organisation targets calling for an end to the global tuberculosis (TB) epidemic by 2035 require a dramatic improvement in current case-detection strategies. A reliance on passive case finding (PCF) has resulted consistently, in over three million infectious TB cases per year, being missed by the health system, leading to ongoing transmission of infection within families and communities. Active case finding (ACF) for TB has been recognized as an importan...
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Evaluation of sodium hydroxide –N-acetyl-l-cysteine and 0.7% chlorhexidine decontamination methods for recovering Mycobacterium tuberculosis from contaminated sputum samples: A comparative analysis (The Gambia Experience)
Conclusion The 0.7% chlorhexidine decontamination method is rapid and has less contamination rate in terms of mycobacterial recovery compared with the standard NaOH–NALC method. Therefore, the 0.7% chlorhexidine decontamination method would be an ideal alternative option for decontamination of sputum samples and recovery/isolation of M. tuberculosis in resource-poor countries. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Next-generation sequencing-based user-friendly platforms for drug-resistant tuberculosis diagnosis: A promise for the near future
Publication date: Available online 28 October 2016 Source:International Journal of Mycobacteriology Author(s): David L. Dolinger, Rebecca E. Colman, David M. Engelthaler, Timothy C. Rodwell Since 2002, there has been a gradual worldwide 1.3% annual decrease in the incidence of tuberculosis (TB). This is an encouraging statistic; however, it will not achieve the World Health Organization’s goal of eliminating TB by 2050, and it is being compounded by the persistent global incidence of drug-resistant tuberculosis (DR-TB) acquired by transmission and by treatment pressure. One key to effectively control tuberculosis a...
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Using competing risks model and competing events in outcome of pulmonary tuberculosis patients
Conclusions Use of competing risks model with competing events can provide a better way to understand the associated risk factors co-related with outcome of the pulmonary TB process, especially among DR-TB patients. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 28, 2016 Category: Infectious Diseases Source Type: research

Two cases of sternal osteomyelitis due to Mycobacterium africanum: a casual or causal association
Publication date: Available online 20 June 2016 Source:International Journal of Mycobacteriology Author(s): Jessica Mencarini, Sara Veloci, Maria Tullia Simonetti, Antonio Carocci, Massimo Meli, Enrico Tortoli, Gian Maria Rossolini, Alessandro Bartoloni, Filippo Bartalesi The sternal localization of bone and joint tuberculosis (TB) is rare, has an insidious clinical presentation, and usually affects young adults living in endemic areas. Mycobacterium africanum causes a relevant proportion of human TB in West Africa and in migrants from endemic countries. Here, we report two cases of sternal osteomyelitis due to ...
Source: International Journal of Mycobacteriology - October 14, 2016 Category: Infectious Diseases Source Type: research

Fluorescein diacetate vital staining for detecting viability of acid-fast bacilli in patients on antituberculosis treatment
Conclusion: FDA microscopy can be used as a simple and rapid TB treatment monitoring tool in resource limited settings to identify those patients requiring immediate culture and DST test. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 14, 2016 Category: Infectious Diseases Source Type: research

Drug-resistant tuberculosis among previously treated patients in Yangon, Myanmar
Publication date: Available online 23 June 2016 Source:International Journal of Mycobacteriology Author(s): Thanda Tun, Wint Wint Nyunt, Khin Zaw Latt, Ari Samaranayaka, John A. Crump, Kyi Kyi Thinn, Gregory M. Cook, Htin Lin Aung (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 14, 2016 Category: Infectious Diseases Source Type: research

Assuming the role of mitochondria in mycobacterial infection
Publication date: Available online 24 June 2016 Source:International Journal of Mycobacteriology Author(s): Rikesh K. Dubey Tuberculosis is one of the leading causes of death by Mycobacterium tuberculosis (Mtb) affecting millions of people worldwide. Mycobacterium species enter host macrophages during infection and target various cellular organelles and their function for their own benefit. Mitochondria appear to be among the important targets for bacterial pathogens. Mtb and other pathogenic bacteria secrete various proteins that initiate structural changes in mitochondria to modulate its function. Additionally, virule...
Source: International Journal of Mycobacteriology - October 14, 2016 Category: Infectious Diseases Source Type: research

Rapid drug-susceptibility testing of Mycobacterium tuberculosis clinical isolates to first-line antitubercular drugs by nitrate reductase assay: A comparison with proportion method
Conclusion Nitrate reductase assay can be used as a rapid and inexpensive method for drug-susceptibility testing of M. tuberculosis for first-line antitubercular drugs without compromising accuracy of standard methods. (Source: International Journal of Mycobacteriology)
Source: International Journal of Mycobacteriology - October 14, 2016 Category: Infectious Diseases Source Type: research