International Journal for Parasitology: Drugs and Drug Resistance This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models
In conclusion, CBR417 or CBR490 are pre-clinical candidates for filarial diseases, which achieve long-term clearance of Wolbachia endosymbionts of filarial nematodes, inhibit filarial embryogenesis and clear microfilaremia with treatments as short as 7 days.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - December 10, 2019 Category: Parasitology Source Type: research

Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa
ConclusionsThese data are cause for great concern and call for continued surveillance of the efficacy of SP in source and recipient populations, and should be considered when developing treatment policy for imported malaria cases in China and elsewhere.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - November 30, 2019 Category: Parasitology Source Type: research

Mutations in the TaPIN1 peptidyl prolyl isomerase gene in Theileria annulata parasites isolated in Sudan
Publication date: Available online 26 November 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Bashir Salim, Elisha Chatanga, Guillaume Jannot, Ehab Mossaad, Ryo Nakao, Jonathan B. WeitzmanAbstractThe tick-borne parasite Theileria annulata is the causative agent of tropical theileriosis or Mediterranean theileriosis. Infection of bovine leukocytes by the obligate intracellular parasites induces proliferative and invasive phenotypes associated with activated signaling pathways. The transformed phenotypes of infected cells are reversible by treatment with the theilericidal drug buparva...
Source: International Journal for Parasitology: Drugs and Drug Resistance - November 27, 2019 Category: Parasitology Source Type: research

Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment
Publication date: Available online 11 November 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Ander Burgaña Agoües, Rosa Abellana, Stanislav Zlatanov Yordanov, Rabee Kazan, A. Mauricio Pérez Ortiz, Cristina Castillo Ramos, Christian Garavito Hernández, Miriam Molina Rivero, Alessandra Queiroga Gonçalves, Emma Padilla, Josefa Pérez, Roger García Puig, Tomas M. Perez-PorcunaABSTRACTDientamoeba fragilis is a trichomonad parasite of the human intestine that is found worldwide. However, the biological cycle and transmission of this parasite have yet to be elucidated. Although its ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - November 12, 2019 Category: Parasitology Source Type: research

Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia
Publication date: Available online 22 October 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Monica M. Kangussu-Marcolino, Gretchen M. Ehrenkaufer, Emily Chen, Anjan Debnath, Upinder SinghAbstractThe free-living amebae Naegleria, Acanthamoeba, and Balamuthia cause rare but life-threatening infections. All three parasites can cause meningoencephalitis. Acanthamoeba can also cause chronic keratitis and both Balamuthia and Acanthamoeba can cause skin and systemic infections. There are minimal drug development pipelines for these pathogens despite a lack of available treatment regimens ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 23, 2019 Category: Parasitology Source Type: research

Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB
Publication date: Available online 22 October 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Yolanda Pérez-Pertejo, José M. Escudero-Martínez, Rosa M. Reguera, Rafael Balaña-Fouce, Pablo A. García, Pablo G. Jambrina, Arturo San Feliciano, María-Ángeles CastroAbstractLeishmania is the aethiological agent responsible for the visceral leishmaniasis, a serious parasite-borne disease widely spread all over the World. The emergence of resistant strains makes classical treatments less effective; therefore, new and better drugs are necessary. Naphthoquinones are interesting compounds...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 23, 2019 Category: Parasitology Source Type: research

Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta
Publication date: Available online 6 October 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Frank Turnbull, Eileen Devaney, Alison A. Morrison, Roz Laing, Dave J. BartleyAbstractRecent reports of monepantel (MPTL) resistance in UK field isolates of Teladorsagia circumcincta has highlighted the need for a better understanding of the mechanism of MPTL-resistance in order to preserve its anthelmintic efficacy in this economically important species.Nine discrete populations of T. circumcincta were genotypically characterised; three MPTL-susceptible isolates, three experimentally selecte...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 7, 2019 Category: Parasitology Source Type: research

Profiles of Kelch mutations in Plasmodium falciparum across South Asia and their implications for tracking drug resistance
Publication date: Available online 4 October 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Jyoti Chhibber-Goel, Amit SharmaAbstractArtemisinin-based combination therapy (ACT) offers highly successful treatment of malaria. Emergence and spread of Plasmodium falciparum (Pf) parasites with decreased susceptibility to ACT in South-East Asia has caused concern worldwide. The current accepted criteria to assess artemisinin (ART) resistance relies upon data on treatment failure, delayed parasite clearance at day 3 (DPC3), parasite clearance half-life (PCHL) and in-vitro/ex-vivo ring stage...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 6, 2019 Category: Parasitology Source Type: research

Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis
Publication date: Available online 23 September 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Mahmoud Reza Jaafari, Mahdi Hatamipour, Seyedeh Hoda Alavizadeh, Azam Abbasi, Zahra Saberi, Sima Rafati, Yasaman Taslimi, Akram Miramin Mohammadi, Ali KhamesipourAbstractBackgroundCurrently, there is no topical treatment available for any form of cutaneous leishmaniasis (CL) in most of the endemic areas. The aim of the current study was to develop a topical nano-liposomal Amphotericin B (AmB) for the treatment of CL.Methodology/Principal Findings: Liposomes containing 0.1, 0.2 and 0.4% AmB...
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 24, 2019 Category: Parasitology Source Type: research

Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum
This report shows for the first time the effect of a series of synthetic indenoisoquinolines on histone H2A phosphorylation, which represents a primary signal of double stranded DNA break in genus Leishmania.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 21, 2019 Category: Parasitology Source Type: research

Anti-schistosomal action of the calcium channel agonist FPL-64176
Publication date: Available online 14 September 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Paul McCusker, John D. ChanAbstractSubversion of parasite neuromuscular function is a key strategy for anthelmintic drug development. Schistosome Ca2+ signaling has been an area of particular interest for decades, with a specific focus on L-type voltage-gated Ca2+ channels (Cavs). However, the study of these channels has been technically challenging. One barrier is the lack of pharmacological probes that are active on flatworms, since the dihydropyridine (DHP) based ligands typically used ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 15, 2019 Category: Parasitology Source Type: research

Impaired development of a miltefosine-resistant Leishmania infantum strain in the sand fly vectors Phlebotomus perniciosus and Lutzomyia longipalpis
ConclusionThe MIL resistant L. infantum LEM3323 line is significantly hampered in its development and transmissibility potential in two sand fly vector species. Additional studies are warranted to evaluate whether this applies to other visceral Leishmania parasites with acquired MIL-resistance.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 12, 2019 Category: Parasitology Source Type: research

Similarities and differences in the biotransformation and transcriptomic responses of Caenorhabditis elegans and Haemonchus contortus to five different benzimidazole drugs
Publication date: Available online 9 September 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): S.J. Stasiuk, G. MacNevin, M. Workentine, D. Gray, E. Redman, D. Bartley, A. Morrison, N. Sharma, D. Colwell, D.K. Ro, J.S. GilleardAbstractWe have undertaken a detailed analysis of the biotransformation of five of the most therapeutically important benzimidazole anthelmintics - albendazole (ABZ), mebendazole (MBZ), thiabendazole (TBZ), oxfendazole (OxBZ) and fenbendazole (FBZ) - in Caenorhabditis elegans and the ruminant parasite Haemonchus contortus. Drug metabolites were detected by LC-M...
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 10, 2019 Category: Parasitology Source Type: research

Prevalence of Plasmodium falciparum Pfcrt and Pfmdr1 alleles in settings with different levels of Plasmodium vivax co-endemicity in Ethiopia
This study thus assessed the prevalence of Pfcrt-K76T and Pfmdr1-N86Y point mutations in P. falciparum. 18S RNA gene based nested PCR confirmed P. falciparum samples (N = 183) collected through community and health facility targeted cross-sectional surveys from settings with varying P. vivax and P. falciparum endemicity were used. The proportion of Plasmodium infections that were P. vivax was 62.2% in Adama, 41.4% in Babile, 30.0% in Benishangul-Gumuz to 6.9% in Gambella. The Pfcrt-76T mutant haplotype was observed more from samples with higher endemicity of P. vivax as being 98.4% (61/62), 100% (31/31), 65.2% (15/23) ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 10, 2019 Category: Parasitology Source Type: research

Successful treatment by adding thalidomide to meglumine antimoniate in a case of refractory anthroponotic mucocutaneous leishmaniasis
Publication date: Available online 27 August 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Vahid Mashayekhi Goyonlo, Sadegh Vahabi-Amlashi, Faezeh TaghaviAbstractMucosal leishmaniasis (ML) is mostly associated with Leishmania braziliensis; however, a few cases of Leishmania tropica induced mucocutaneous leishmaniasis have been reported. The standard treatment for leishmaniasis is pentavalent antimonials, but several other drugs for resistant cases have been proposed including amphotericin and miltefosine. Here we present a case of multiple treatment resistant mucocutaneous leishman...
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 3, 2019 Category: Parasitology Source Type: research