Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products
Publication date: Available online 24 May 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Phanankosi Moyo, William Shamburger, Mariëtte E. van der Watt, Janette Reader, Ana Carolina C. de Sousa, Timothy J. Egan, Vinesh J. Maharaj, Gerhard Bringmann, Lyn-Marie Birkholtz (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - May 25, 2020 Category: Parasitology Source Type: research

Dicyclanil resistance in the australian sheep blowfly, Lucilia cuprina, substantially reduces flystrike protection by dicyclanil and cyromazine based products
Publication date: Available online 11 May 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Narelle Sales, Monica Suann, Kim Koeford (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - May 11, 2020 Category: Parasitology Source Type: research

Impact of clinically acquired miltefosine resistance by Leishmania infantum on mouse and sand fly infection
Publication date: Available online 1 May 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Lieselotte Van Bockstal, Dimitri Bulté, Sarah Hendrickx, Jovana Sadlova, Petr Volf, Louis Maes, Guy Caljon (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - May 2, 2020 Category: Parasitology Source Type: research

Cholinergic receptors on intestine cells of Ascaris suum and activation of nAChRs by levamisole
Publication date: Available online 25 April 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Mark McHugh, Paul Williams, Saurabh Verma, Jo Anne Powell-Coffman, Alan P. Robertson, Richard J. Martin (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 29, 2020 Category: Parasitology Source Type: research

Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs
Publication date: Available online 20 April 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Pablo D. Jimenez Castro, Abdelmoneim Mansour, Samuel Charles, Joe Hostetler, Terry Settje, Daniel Kulke, Ray M. Kaplan (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 22, 2020 Category: Parasitology Source Type: research

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Publication date: Available online 10 April 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Anastasia R. Rugel, Meghan A. Guzman, Alexander B. Taylor, Frédéric D. Chevalier, Reid S. Tarpley, Stanton F. McHardy, Xiaohang Cao, Stephen P. Holloway, Timothy J.C. Anderson, P. John Hart, Philip T. LoVerde (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 10, 2020 Category: Parasitology Source Type: research

MRPA-independent mechanisms of antimony resistance in Leishmania infantum
Publication date: Available online 2 April 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Noélie Douanne, Victoria Wagner, Gaetan Roy, Philippe Leprohon, Marc Ouellette, Christopher Fernandez-Prada (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 3, 2020 Category: Parasitology Source Type: research

Schistosome TRP channels: an appraisal
Publication date: Available online 24 March 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Swarna Bais, Robert M. Greenberg (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 25, 2020 Category: Parasitology Source Type: research

Drug resistance in liver flukes
Publication date: April 2020Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 12Author(s): I. Fairweather, G.P. Brennan, R.E.B. Hanna, M.W. Robinson, P.J. Skuce (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 14, 2020 Category: Parasitology Source Type: research

An image-based Pathogen Box screen identifies new compounds with anti-Giardia activity and highlights the importance of assay choice in phenotypic drug discovery
Publication date: Available online 13 March 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Snigdha Tiash, Jake Saunders, Christopher J.S. Hart, John H. Ryan, Andrew G. Riches, Tina S. Skinner-Adams (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 13, 2020 Category: Parasitology Source Type: research

Large scale screening for benzimidazole resistance mutations in Nematodirus battus, using both pyrosequence genotyping and deep amplicon sequencing, indicates the early emergence of resistance on UK sheep farms.
Publication date: Available online 6 March 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Lynsey Melville, Elizabeth Redman, Alison A. Morrison, Pai Chia Rebecca Chen, Russell Avramenko, Sian Mitchell, Jan Van Dijk, Giles Innocent, Fiona Sargison, Catriona Aitken, John S. Gilleard, Dave J. Bartley (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 7, 2020 Category: Parasitology Source Type: research

Evaluation of a plant-based food supplement to control flea populations in dogs: a prospective double-blind randomized study
Publication date: Available online 15 February 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Fabien MOOG, Gaetan Vetea PLICHART, B.L.U.A. Jean-Louis, C.A.D.I.E.R.G.U.E.S. Marie-ChristineAbstractA prospective double-blind randomized placebo-controlled study evaluated the tolerance and efficacy of the biological plant-based food supplement Bioticks® (extracts of thyme, rosemary, melissa, fenugreek, absinthe and lemongrass) as a flea-control product. Twelve dogs were used as placebo controls (group A). Ten dogs under similar housing conditions received the same food daily but supplem...
Source: International Journal for Parasitology: Drugs and Drug Resistance - February 17, 2020 Category: Parasitology Source Type: research

Drug resistance in liver flukes.
Publication date: Available online 10 January 2020Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): I. Fairweather, G.P. Brennan, R.E.B. Hanna, M.W. Robinson, P.J. SkuceAbstractLiver flukes include Fasciola hepatica, Fasciola gigantica, Clonorchis sinensis, Opisthorchis spp., Fascioloides magna, Gigantocotyle explanatum and Dicrocoelium spp. The two main species, F. hepatica and F. gigantica, are major parasites of livestock and infections result in huge economic losses. As with C. sinensis, Opisthorchis spp. and Dicrocoelium spp., they affect millions of people worldwide, causing severe h...
Source: International Journal for Parasitology: Drugs and Drug Resistance - January 10, 2020 Category: Parasitology Source Type: research

Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins
This study consisted of a field study and two computer simulations to evaluate the efficacy of a moxidectin-oxibendazole (MOX-OBZ) combination against the same cyathostomin population. In the field study, anthelmintic treatments occurred when ten horses exceeded 100 eggs per gram. Fecal egg counts and efficacy evaluations were performed every two weeks. The two simulations utilized weather data as well as equine and parasite population parameters from the field study. The first simulation repeated the treatment schedule used in the field study over a 40 year period. The second evaluated efficacies of combination treatments...
Source: International Journal for Parasitology: Drugs and Drug Resistance - December 17, 2019 Category: Parasitology Source Type: research

Current trends in the pharmacological management of Chagas disease
Publication date: Available online 10 December 2019Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Vanessa Ribeiro, Nayra Dias, Taís Paiva, Luciana Hagström-Bex, Nadjar Nitz, Riccardo Pratesi, Mariana HechtAbstractChagas disease (CD) is a tropical neglected illness, affecting mainly populations of low socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are infected with Trypanosoma cruzi, the etiological agent of CD. Despite being one of the main global health problems, this disease continues without effective treatment during the chronic phase of the in...
Source: International Journal for Parasitology: Drugs and Drug Resistance - December 12, 2019 Category: Parasitology Source Type: research