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No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Elevated C-Reactive Protein in Asymptomatic Crohn's Disease Patients: Listen to the Sound of Silence
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Online Only: Letters to the Editor Source Type: research
Evidence of Bidirectional Associations Between Perceived Stress and Symptom Activity: A Prospective Longitudinal Investigation in Inflammatory Bowel Disease
Conclusions: The analysis revealed prospective bidirectional relationships between perceived stress and IBD symptoms but no relationship between perceived stress and change in intestinal inflammation as assessed by fecal calprotectin. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Comparative Effectiveness of Mesalamine, Sulfasalazine, Corticosteroids, and Budesonide for the Induction of Remission in Crohn's Disease: A Bayesian Network Meta-analysis
Background: Induction treatment of mild-to-moderate Crohn's disease is controversial.
Purpose: To compare the induction of remission between different doses of mesalamine, sulfasalazine, corticosteroids, and budesonide for active Crohn's disease.
Data sources: We identified randomized controlled trials from existing Cochrane reviews and an updated literature search in Medline, EMBASE, and CENTRAL to November 2015.
Study selection: We included randomized controlled trials (n = 22) in adult patients with Crohn's disease that compared budesonide, sulfasalazine, mesalamine, or corticosteroids with placebo or each other, for...
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Long-term Efficacy and Safety of Adalimumab in Pediatric Patients with Crohn's Disease
Conclusions: Efficacy and safety profiles of prolonged adalimumab treatment in children with Crohn's disease were consistent with IMAgINE 1 and adult Crohn's disease adalimumab trials. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol–Thiopurine Combination Therapy
Conclusions: The prevalence of histologically assessed NRH in patients with IBD, who were treated with allopurinol–thiopurine combination therapy, was 5%. This percentage is in line with thiopurine-naive and thioguanine-using patients with IBD. None of the included patients had clinical symptoms or signs suggestive of (noncirrhotic) portal hypertension. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Methotrexate for Refractory Crohn's Disease Compared with Thiopurines: A Retrospective Non-head-to-head Controlled Study
Conclusions: MTX is effective in inducing and maintaining CR and achieving mucosal healing in patients with refractory Crohn's disease, and its efficacy is comparable to that of TPs for naive patients. The side effects of MTX were mild and tolerable. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Development and Validation of a Questionnaire to Assess the Quality of Life in Patients with Inflammatory Bowel Disease in Mainland China
Conclusions: The IBDQOL-22 is a valid, reliable, and responsive instrument for assessing disease-specific quality-of-life in patients with IBD in Mainland China. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Ultrasound Shear Wave Elastography and Contrast Enhancement: Effective Biomarkers in Crohn's Disease Strictures
Background: Inflammation, fibrosis, and muscular hypertrophy lead to thickened bowel in Crohn's disease forming strictures. Ultrasound shear wave elastography (SWE) measures bowel wall stiffness. Contrast-enhanced ultrasound (CEUS) uniquely detects bowel wall inflammation. We aim to correlate SWE of ileal Crohn's disease in vivo to CEUS peak enhancement and pathology grades of inflammation, fibrosis, and muscular hypertrophy.
Methods: In a prospective institutional review board–approved study, 105 consecutive ileal patients with Crohn's disease received ultrasound. At maximal bowel wall thickness (>4 mm), SWE and CEUS w...
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Factors Associated with Discontinuation of Anti-TNF Inhibitors Among Persons with IBD: A Population-Based Analysis
Conclusions: Approximately two-fifths of anti-TNF users discontinue use within 1 year of initiation, and three-fifths will have discontinued at 5 years. Concomitant IM therapy has a modest effect on discontinuation rates. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Efficacy and Safety of Vedolizumab for Induction of Remission in Inflammatory Bowel Disease—the Israeli Real-World Experience
Conclusions: In a large real-world Israeli cohort of anti–tumor necrosis factor–experienced patients with inflammatory bowel disease, VDZ was effective and safe in induction of clinical remission and steroid-free clinical remission. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis
Conclusions: Our results provide evidence that aberrant, elevated TLR5 expression is present in the ileal epithelium of SAMP mice, is augmented in the presence of the gut microbiome, and that TLR5 activation in response to bacterial flagellin results in a deficiency to maintain appropriate epithelial barrier integrity. Together, these findings represent a potential mechanistic pathway leading to the exacerbation and perpetuation of chronic gut inflammation in experimental ileitis and possibly, in patients with Crohn's disease. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
The α4β1 Homing Pathway Is Essential for Ileal Homing of Crohn's Disease Effector T Cells In Vivo
Conclusions: Our findings suggest that Teff cell homing to the ileum through the axis α4β1–VCAM-1 is an essential and nonredundant pathway in CD in vivo, possibly affecting efficacy of clinical treatment with antiadhesion compounds. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis
Conclusions: The UC pouch, well before histologic inflammation, already displays a systems-level gain of colon-associated genes and loss of ileum-associated genes. Patients with UC exhibit a unique transcriptomic response to ileal pouch creation that can be observed well before disease and may in part explain their susceptibility to the development of pouchitis. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - February 28, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
