Multicentric Case–Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease
This study evaluated azathioprine doses, metabolite concentrations, and their associations with patients' age in children with IBD treated at 6 tertiary pediatric referral centers.
Methods: Azathioprine doses, metabolites, and clinical effects were assessed after at least 3 months of therapy in 17 early-onset (age 12 and (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Novel Insights into the Mechanisms of Gut Homing and Antiadhesion Therapies in Inflammatory Bowel Diseases
Abstract: Therapeutic compounds interfering with T cell trafficking are a new column of inflammatory bowel disease (IBD) treatment. Currently, the anti-α4β7 integrin antibody vedolizumab is successfully used in the clinic and further drugs are likely to follow. Despite these clinical advances, the precise mechanistic background of their action is only gradually elucidated and still a matter of intensive research. Only recently, advances made with the help of new in vivo models and human studies have contributed to shape our concept of T cell trafficking in IBD by deciphering some important and so far unanswered questions...
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
The Different Effects of VEGFA121 and VEGFA165 on Regulating Angiogenesis Depend on Phosphorylation Sites of VEGFR2
In this study, we found that VEGFA121 and VEGFA165, 2 isoforms of VEGFA, exerted the opposing effects of antiangiogenesis and proangiogenesis on regulating vascular endothelia cells proliferation and tube formation. The 2 isoforms affected the protein expression of Ras-related protein 1-GTPase-activating protein 1 (Rap1GAP) and thrombospondin 1, 2 important signal molecules of Rap1GAP/thrombospondin 1 signal pathway in primary human umbilical vein endothelial cells by regulating 2 different phosphorylating sites of VEGFR2, Tyr(1175) and Tyr(1214). We also found that VEGFA121 and VEGFA165 regulating angiogenesis was related...
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Protease-activated Receptor 1 Plays a Proinflammatory Role in Colitis by Promoting Th17-related Immunity
Conclusions: This study demonstrates a strong link between PAR1 expression, Th17-type immunity, and disease severity in both pediatric patients with Crohn's disease and C. rodentium–induced colitis in mice. The data presented suggest PAR1 exerts a proinflammatory role in colitis in both humans and mice by promoting a Th17-type immune response, potentially by supporting the production of IL-23. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Commentary on Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early-onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Commentary Source Type: research
Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey
Conclusions: This study identified genotypes and phenotypes of Chinese VEO-IBD infants with IL10 receptor mutations. Our study expands the current knowledge on the involvement of the IL10 axis in patients with VEO-IBD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Risk for Overall Infection with Anti-TNF and Anti-integrin Agents Used in IBD: A Systematic Review and Meta-analysis
Conclusions: Anti–tumor necrosis factor therapy but not anti-integrin therapy is associated with a greater infection risk than placebo in treating UC. Neither class of therapy is associated with increased infection risk over placebo in treating CD. Our findings can help guide patient-centered discussions regarding the risk for infection with biological agents. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
The Influence of Methotrexate Treatment on Male Fertility and Pregnancy Outcome After Paternal Exposure
Conclusions: This review reveals the lack of studies on the safety of MTX with regard to male reproduction. It is not clear whether MTX transiently influences male fertility and sperm DNA integrity, and more studies are needed. Comparative cohort studies found no increased risk of adverse pregnancy outcomes. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Diagnostic Accuracy of Blood-Based Tests and Histopathology for Cytomegalovirus Reactivation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Conclusions: Although blood-based tests seem to predict colonic CMV reactivation, they are insensitive tests. Similarly, histopathology has poor sensitivity for detecting colonic CMV. In agreement with current guidelines, these tests should not replace IHC or tissue PCR for detecting CMV reactivation in inflammatory bowel disease. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Antidepressants in Inflammatory Bowel Disease: A Systematic Review
Conclusions: This research indicates that antidepressants may have a beneficial effect on IBD course. However, it is currently not possible to determine their efficacy for certain because of the lack of randomized trials. Further trials using objective measures of IBD activity, longer follow-up periods, and larger sample sizes are needed. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Clinical Review Articles Source Type: research
Type 1 Interferon in the Human Intestine—A Co-ordinator of the Immune Response to the Microbiota
Abstract: The human gut is in constant complex interaction with the external environment. Although much is understood about the composition and function of the microbiota, much remains to be learnt about the mechanisms by which these organisms interact with the immune system in health and disease. Type 1 interferon (T1IFN), a ubiquitous and pleiotropic family of cytokines, is a critical mediator of the response to viral, bacterial, and other antigens sampled in the intestine. Although inflammation is enhanced in mouse model of colitis when T1IFN signaling is lost, the action of T1IFN is context specific and can be pro- or ...
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Basic Science Review Article Source Type: research
Supplementation with 2000 IU of Cholecalciferol Is Associated with Improvement of Trabecular Bone Mineral Density and Muscle Power in Pediatric Patients with IBD
Background: Inflammatory bowel diseases (IBD) are associated with altered bone health and increased risk for fractures. Vitamin D deficiency is frequently found in IBD; however, the effect of vitamin D supplementation on bone health of children with IBD is poorly understood. We aimed to observe the changes in volumetric bone density and dynamic muscle functions after vitamin D substitution in a cohort of pediatric patients with IBD.
Methods: This was a prospective observational study of 55 patients (aged 5–19 years) with IBD. Bone quality was assessed using peripheral quantitative computed tomography and muscle function...
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Future Directions and Methods in IBD Research Source Type: research
Endoscopic Stricturotomy with Needle Knife in the Treatment of Strictures from Inflammatory Bowel Disease
Conclusions: Endoscopic NKSt is effective and safe for treating the primary and secondary IBD-related strictures, which may provide an alternative for endoscopic balloon dilation and surgical intervention. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: Future Directions and Methods in IBD Research Source Type: research
Communication Between Physicians and Patients with Ulcerative Colitis: Reflections and Insights from a Qualitative Study of In-Office Patient–Physician Visits
Conclusions: Alignment between patients and physicians on ulcerative colitis QoL impact, treatment goals, and requirement of advanced therapies is poor. New tools are needed to cover this gap. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: IBD LIVE Source Type: research
Development and Feasibility Study of a Telemedicine Tool for All Patients with IBD: MyIBDcoach
Conclusions: We developed myIBDcoach, which enables integrated care for all patients with IBD, regardless of disease severity or medication use. The feasibility study showed high satisfaction and compliance of patients and health care providers. To study myIBDcoach's efficacy, a multicenter randomized controlled trial has been initiated. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - March 21, 2017 Category: Gastroenterology Tags: IBD LIVE Source Type: research
