Immunogenicity of Pertussis Booster Vaccination in Children and Adolescents with Inflammatory Bowel Disease: A Controlled Study
Conclusions: Booster dose of pertussis vaccine was immunogenic and safe in pediatric patients with IBD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Etiopathogenesis of Nephrolithiasis in Ulcerative Colitis Patients with the Ileal Pouch Anal Anastomosis
Conclusions: Ulcerative colitis–IPAA patients are at risk for the development of calcium oxalate and calcium phosphate stones. Nephrolithiasis is symptomatic in a majority of the patients and frequently requires procedural intervention for treatment. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Long-term Maintenance of Clinical, Endoscopic, and Radiographic Response to Ustekinumab in Moderate-to-Severe Crohn's Disease: Real-world Experience from a Multicenter Cohort Study
Conclusions: Subcutaneous ustekinumab is an effective treatment option for maintaining long-term clinical, endoscopic, and radiographic response in patients with moderate-to-severe CD failing antitumor necrosis factor therapy. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
2.4 g Mesalamine (Asacol 400 mg tablet) Once Daily is as Effective as Three Times Daily in Maintenance of Remission in Ulcerative Colitis: A Randomized, Noninferiority, Multi-center Trial
Conclusions: QD dosing with Asacol is as effective and safe as TID for maintenance of remission in patients with ulcerative colitis. Additionally, this study indicated that maintaining a good mucosal state is the key for longer maintenance of remission. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
The Association Between CMV Viremia or Endoscopic Features and Histopathological Characteristics of CMV Colitis in Patients with Underlying Ulcerative Colitis
Background: Cytomegalovirus (CMV) infection has been shown to be related to severe or steroid-refractory ulcerative colitis (UC) flare-ups. The aim of this study was to evaluate the endoscopic and pathological characteristics of CMV colitis in patients with UC and to assess the predictive value of the endoscopic and pathological features of CMV colitis.
Methods: A total of 50 consecutive UC patients with CMV infection who were admitted to Peking Union Medical College Hospital from 2010 to 2015 were enrolled in this study.
Results: Twenty-five UC patients with CMV infection (50.0%) had concurrent CMV colitis. When the cut...
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
CYP3A4 Activity is Markedly Lower in Patients with Crohn's Disease
Conclusions: Midazolam and fexofenadine disposition profile did not predict budesonide clearance. However, we observed a marked reduction in vivo CYP3A4 activity among individuals with CD. Therefore, changes in CYP3A4 activity in disease states such as CD may be a heretofore underappreciated determinant of variation in drug responsiveness in CD. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Patient-Reported Outcomes of Quality of Life, Functioning, and GI/Psychiatric Symptom Severity in Patients with Inflammatory Bowel Disease (IBD)
Conclusions: PROMIS instruments provide valid assessment of HRQOL and functioning in ambulatory adults with IBD. Of note, patients with Crohn's disease demonstrated significantly worse impairments than those with ulcerative colitis. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Anti-TNFα Treatment After Surgical Resection for Crohn's Disease Is Effective Despite Previous Pharmacodynamic Failure
Conclusions: Pediatric patients with Crohn's disease who failed anti-TNFα therapy despite adequate drug levels and underwent intestinal resection can be re-treated with the same agent for postoperative recurrence with high success rate similar to that of anti-TNFα naive patients. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Results at Up to 30 Years After Ileal Pouch–Anal Anastomosis for Chronic Ulcerative Colitis
Background: Ileal pouch–anal anastomosis (IPAA) has become the surgical procedure of choice for patients with chronic ulcerative colitis. No study to date has examined functional and quality-of-life outcomes 30 years after pouch construction.
Methods: Using data from a prospectively maintained database with annually distributed questionnaires, functional outcomes, pouch complications, and quality of life after IPAA were determined.
Results: Overall, 93.3% of patients had a functioning pouch at 30 years. Stool frequency during the day increased slightly from a mean of 5.7 (SD, 2.3) at 1 year to 6.2 (SD, 2.9) at 30 years...
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Factors Associated with Fecal Incontinence in Women of Childbearing Age with Crohn's Disease
Conclusions: Fecal incontinence is a significant complaint in at least one-third of women of childbearing age with Crohn's disease. Patients'disease and treatment histories seem to have a comparable effect to their childbirth history concerning the presence of fecal incontinence. Both physicians and surgeons who are involved in the management of Crohn's disease need to keep this in mind. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Race Differences in Initial Presentation, Early Treatment, and 1-year Outcomes of Pediatric Crohn's Disease: Results from the ImproveCareNow Network
We examined the effect of race on remission rate and treatment at diagnosis and 1 year from diagnosis using t-tests, Wilcoxon rank-sum tests, χ2 statistic, and Fisher's exact tests, where appropriate, followed by univariate regression models.
Results: Nine hundred seventy-six patients (Black = 118 (12%), White = 858 (88%), mean age = 13 years, 63% male) from 39 sites were included. Black children had a higher percentage of Medicaid insurance (44% versus 11%, P (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis
Conclusions: These results show that the iron formulations used to treat iron deficiency influence the gut microbiota and colitis in mice and suggest that distinct iron compounds may be of particular relevance to patients with IBD. In addition, the beneficial action of probiotics in IBD may be enhanced by oral iron supplementation. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Expression and Localization of miR-21 and miR-126 in Mucosal Tissue from Patients with Inflammatory Bowel Disease
Conclusions: This study shows that miR-126 levels are increased in UC and expressed in endothelial cells. miR-21 is expressed in subsets of monocytes/macrophages and T cells and may work as a potential biomarker to distinguish UC from CD. Quantitative in situ hybridization may be a powerful tool for such analysis as it combines overall expression with validation of cellular origin. Studies in larger cohorts may confirm this for clinical diagnostics. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines
Conclusions: This study has shown for the first time that treatment with digoxin can ameliorate murine experimental colitis. This finding suggests that the suppression of Th17 using reagents such as digoxin could be effective in treating Crohn's disease refractory to anti–tumor necrosis factor alpha therapy. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: Original Basic Science Articles Source Type: research
Delivery Mode in Pregnant Patients with IBD: Uncertainty Remains
No abstract available (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - April 28, 2017 Category: Gastroenterology Tags: IBD Live Articles Source Type: research
