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Dominance of international high-risk clones in carbapenemase-producing Pseudomonas aeruginosa: Multicentric molecular epidemiology report from India
Conclusion: This is the first large study from India to report the baseline data on the molecular resistance mechanisms and its association with genetic relatedness of CP P. aeruginosa circulating in Indian hospitals. blaVIM- and blaNDM-producing P. aeruginosa is the most prevalent carbapenemase seen in India. Majority of the isolates belongs to the high-risk international clones ST235, ST357 and ST664 which is a concern. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Agila Kumari Pragasam Balaji Veeraraghavan Shalini Anandan Vignesh Narasiman Sujatha Sistla Arti Kapil Purva Mathur Pallab Ray Chand Wattal Sanjay Bhattacharya Vijayashri Deotale K Subramani JV Peter TD Hariharan I Ramya S Iniyan Kamini Walia VC Ohri Source Type: research

Newer & #946;-Lactam/ & #946;-Lactamase inhibitor for multidrug-resistant gram-negative infections: Challenges, implications and surveillance strategy for India
Balaji Veeraraghavan, Agila Kumari Pragasam, Yamuna Devi Bakthavatchalam, Shalini Anandan, V Ramasubramanian, Subramanian Swaminathan, Ram Gopalakrishnan, Rajeev Soman, OC Abraham, Vinod C Ohri, Kamini WaliaIndian Journal of Medical Microbiology 2018 36(3):334-343Antimicrobial resistance (AMR) is a major public health concern across the globe, and it is increasing at an alarming rate. Multiple classes of antimicrobials have been used for the treatment of infectious diseases. Rise in the AMR limits its use and hence the prerequisite for the newer agents to combat drug resistance. Among the infections caused by Gram-negative...
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Balaji Veeraraghavan Agila Kumari Pragasam Yamuna Devi Bakthavatchalam Shalini Anandan V Ramasubramanian Subramanian Swaminathan Ram Gopalakrishnan Rajeev Soman OC Abraham Vinod C Ohri Kamini Walia Source Type: research

Legionella and Legionnaires & #39; disease: Time to explore in India
This article also summarises the progress of research related to Legionella in this country, identifying the research gaps and discussing priorities to explore this unexplored pathogen in India. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Rama Chaudhry K Sreenath Sonu Kumari Agrawal Arvind Valavane Source Type: research

Hepatitis E virus infection: An old virus with a new story!
Ekta Gupta, Pragya AgarwalaIndian Journal of Medical Microbiology 2018 36(3):317-323Hepatitis E virus (HEV) infection is an important public health problem. HEV infection has been identified as a major cause of enterically transmitted acute sporadic hepatitis in India especially in adult age group. India is hyperendemic for HEV, with the disease presenting both as outbreaks and as cases of acute sporadic viral hepatitis. Most of these outbreaks can be traced to contamination of drinking water supplies with human fecal matter. The last decade has witnessed tremendous change in our understanding of the virus in its epidemiol...
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Ekta Gupta Pragya Agarwala Source Type: research

An update on antimicrobial resistance and the role of newer antimicrobial agents for Pseudomonas aeruginosa
Agila Kumari Pragasam, Balaji Veeraraghavan, E Nalini, Shalini Anandan, Keith S KayeIndian Journal of Medical Microbiology 2018 36(3):303-316Infections due to Pseudomonas aeruginosa is a major health concern, especially hospital-acquired infections, in critically ill individuals. Antimicrobial resistance (AMR) increases the morbidity and mortality rates associated with pseudomonal infections. In this review, we aim to address two major aspects of P. aeruginosa. The first part of the review will focus on the burden of AMR and its prevailing mechanisms seen in India, while the second part will focus on the challenges and app...
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Agila Kumari Pragasam Balaji Veeraraghavan E Nalini Shalini Anandan Keith S Kaye Source Type: research

Pseudomonas aeruginosa - Difficult to outmanoeuvre
Payal K Patel, Twisha S Patel, Keith S KayeIndian Journal of Medical Microbiology 2018 36(3):301-302 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Payal K Patel Twisha S Patel Keith S Kaye Source Type: research

The continuing scourge of congenital syphilis in the face of declining seropositivity: A challenge to control efforts
Srujana Mohanty, Tapas Som, Ashok Kumar PraharajIndian Journal of Medical Microbiology 2018 36(2):295-297 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Srujana Mohanty Tapas Som Ashok Kumar Praharaj Source Type: research

High prevalence of varicella seronegativity in nurses at a tertiary care private hospital in Mumbai, India
Sweta Shah, Tanu Singhal, Reshma Naik, Pooja ThakkarIndian Journal of Medical Microbiology 2018 36(2):294-295 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Sweta Shah Tanu Singhal Reshma Naik Pooja Thakkar Source Type: research

Oral administration of Klebsiella pneumoniae-specific bacteriophage eradicates the bacteria in albino mice
Ashutosh Chaturvedi, Gopal NathIndian Journal of Medical Microbiology 2018 36(2):293-294 (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Ashutosh Chaturvedi Gopal Nath Source Type: research

Clinical spectrum, susceptibility profile, treatment and outcome of culture-confirmed brucellosis from South India
This study was conducted to determine the clinical manifestations, antibiotic susceptibility pattern, treatment and outcome of culture confirmed brucellosis. Adult patients with culture confirmed brucellosis who presented to a large teaching hospital in South India between 2009 and 2015 were included. A diagnosis of brucellosis was confirmed on automated culture. Clinical profile, laboratory parameters, drug susceptibility, treatment and outcome were documented by reviewing the medical records. The cohort comprised of 22 patients with mean ± SD age of 42 ± 13 years. Twenty one (95.5%) was...
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Selvin Sundar Raj Mani Karthik Gunasekaran Ramya Iyyadurai John Antony Jude Prakash Balaji Veeraraghavan Ajay Kumar Mishra Kirti Sabnis Punitha John Victor Sherry Martin Vignesh Kumar Chandiraseharan Samuel George Hansdak George M Varghese Source Type: research

Alarming resistance of Neisseria gonorrhoeae in a tertiary care hospital of North India
Conclusion: Alarming increase in the resistance to commonly used antimicrobials for gonorrhoea in our study, especially of fluoroquinolones, is a clarion call for the urgent need for prudence in prescribing them. Observing the rampant resistance exhibited by N. gonorrhoeae, it is clear that the day is not far when it will acquire a superbug status and become intractable to treatment by the available antibiotics. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Mohit Sharma Meher Rizvi Richa Gupta Mohd Azam Haris M Khan Anjum Parvez Indu Shukla Source Type: research

Twenty-one episodes of peritonitis in a continuous ambulatory peritoneal dialysis patient: What is the root cause ?
Victorine B Nzana, Anusha Rohit, Deepu George, Madhusudan Vijayan, Milly Mathew, Sundar Sankaran, Palaniappan Nagarajan, Georgi AbrahamIndian Journal of Medical Microbiology 2018 36(2):282-284A 51-year-old female, with non-alcoholic liver cirrhosis, portal hypertension, type 2 diabetes mellitus, autosomal dominant polycystic kidney disease with a clipped cerebral aneurysm and chronic kidney disease stage 5 was on continuous ambulatory peritoneal dialysis (CAPD) for 6.5 years elsewhere. She came for opinion on continuation of CAPD as she had 21 episodes of peritonitis in 76 months. Her blood pressure was 80/50 mmHg. She was...
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Victorine B Nzana Anusha Rohit Deepu George Madhusudan Vijayan Milly Mathew Sundar Sankaran Palaniappan Nagarajan Georgi Abraham Source Type: research

Intraventricular haemorrhage as the first manifestation of congenital Cytomegalovirus infection
Malgorzata Sobolewska-Pilarczyk, Katarzyna Pawlak-Osinska, Sylwia Drewa, Beata Smok, Małgorzata PawlowskaIndian Journal of Medical Microbiology 2018 36(2):279-281Congenital Cytomegalovirus infection (CCMV) is the most common intrauterine infection. Early diagnosis of CCMV is hindered by three factors: There is no screening programme for CMV infection in pregnant women; a high percentage of infections in neonates are asymptomatic; the clinical signs of CCMV infection are uncharacteristic. The aim of this article is to analyse the clinical picture and course of CCMV treatment in a 3-week-old newborn, analyse adve...
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Malgorzata Sobolewska-Pilarczyk Katarzyna Pawlak-Osinska Sylwia Drewa Beata Smok Ma & #322;gorzata Pawlowska Source Type: research

Identification of prevalent dengue serotypes by reverse transcriptase polymerase chain reaction and correlation with severity of dengue as per the recent World Health Organization classification (2009)
Conclusions: DENV-3 and DENV-2 serotypes are prevalent in the region and are associated with a more serious clinical profile than other serotypes. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Tanmay K Mehta Parul D Shah Source Type: research

Antibiotic resistance in Helicobacter pylori: A mutational analysis from a tertiary care hospital in Kashmir, India
Conclusions: Tetracycline and quinolones could be the antibiotics of choice in the eradication of H. pylori in this region, while recurrence of the infection with H. pylori could be expected among patients receiving either metronidazole or clarithromycin, for eradication therapy. DST should be done on a routine basis utilising both phenotypic and genotypic methods to prevent further emergence of resistance in this region. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - August 7, 2018 Category: Microbiology Authors: Fayaz Ahmad Wani Gulnaz Bashir Mushtaq Ahmad Khan Showkat Ali Zargar Zubaida Rasool Qurteeba Qadri Source Type: research