Genetic diversity of human respiratory syncytial virus in children with acute respiratory infections in Chennai, South India
Conclusion: This study underlines the genetic diversity of HRSV and emphasises the need for continued molecular surveillance for infection management and prevention strategies. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Anusha Hindupur Thangam Menon Prabu Dhandapani Source Type: research

Evaluation of loop-mediated isothermal amplification assay for detection and typing of human papilloma virus 16 and 18 from endocervical samples
Conclusions: We evaluated the LAMP assay for simultaneous detection and typing of HPV 16 and 18. The assay had good agreement with NM-PCR for detection of both HPV 16 and 18. The LAMP assay is a promising tool for HPV genotyping along with routine cervical cytology, especially in resource-constrained settings. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Nagaraja Mudhigeti Usha Kalawat Narendra Hulikal Meenakshi Kante Source Type: research

A descriptive study on prevalence pattern of Japanese encephalitis in State of Manipur
Conclusions: The changing pattern of JE cases among different age groups was also observed in our study. The present study reveals the changing pattern of the prevalence of JE in the State of Manipur and initiated a systematic approach of JE surveillance also highlights the need for further expanding of surveillance across the state. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Leimapokpam Shivadutta Singh Huidrom Lokhendro Singh Natasha Thokchom RK Manojkumar Singh Source Type: research

Infectious hepatitis: A 3-year retrospective study at a tertiary care hospital in India
Conclusions: A higher seroprevalence of HEV as compared to HAV together with a co-infection rate of 2.07% mandates screening for HEV in all suspected cases of acute hepatitis, particularly pregnant women in whom the outcomes of HEV infection are poor. Health and civic authorities should make necessary efforts to counter epidemic or outbreak situations, thus reducing morbidity, mortality and economic burden. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Arghadip Samaddar Shripad Taklikar Pradnya Kale Chaya A Kumar Sujata Baveja Source Type: research

The prevalence of anti-hepatitis C antibody among acute febrile illness cases in Idar Taluk, Gujarat, West India
Conclusion: The estimated seroprevalence of hepatitis C in Idar Taluk, Sabarkantha district, west India was 2.3%. HCV genotypes 1b and 3a were observed to be circulating in the study area. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Shekara Nikitha Sasidharanpillai Sabeena Sudandiradas Robin Dodia Hiren Varamballi Prasad Sushama Aswathyraj Santhosha Devadiga Jayaram Anup Govindakarnavar Arunkumar Source Type: research

Characteristics of treatment-na & #239;ve HBV-infected individuals with HIV-1 coinfection: A cross-sectional study from South India
Conclusion: These findings conclude that HIV-1 coinfection can have serious implications on the outcome of HBV-related liver disease. To the contrary, HBV infection had no consequence on the progression of HIV-1 disease but distinctly lowered CD4+ T-cells. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: John Paul Demosthenes Jaiprasath Sachithanandham Gnanadurai John Fletcher Uday George Zachariah George Mathew Varghese Hubert Darius John Daniel Lakshmanan Jeyaseelan Priya Abraham Rajesh Kannangai Source Type: research

Characterisation of virulence genes associated with pathogenicity in Klebsiella pneumoniae
Conclusion: Pathogenic K. pneumoniae can harbour single to multiple virulence genes. Invasive infection with even a single virulence gene-harbouring K. pneumoniae can lead to poor outcomes. Both multidrug-resistant (MDR) and non-MDR K. pneumoniae can harbour a variety of virulence genes. None of the virulence genes have a significant association with mortality. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: PA Remya M Shanthi Uma Sekar Source Type: research

Review of a 7-year record of the bacteriological profile of airway secretions of children with cystic fibrosis in North India
Conclusions: The pattern of airway colonisation in the Indian setting is different from the Caucasian population, and P. aeruginosa and Burkholderia cepacia complex appear early. Colonisation with P. aeruginosa benefits from therapy. In case of infection, care must be taken while initiating empiric therapy. It should be based on local antibiograms to prevent the emergence of resistant microbes. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Vikas Gautam Parinitha Kaza Joseph L Mathew Varpreet Kaur Megha Sharma Pallab Ray Source Type: research

An emerging threat of ceftriaxone-resistant non-typhoidal salmonella in South India: Incidence and molecular profile
Conclusion: This study shows that ceftriaxone resistance is mainly mediated by β-lactamases such as ESBL and AmpC. As the incidence of ceftriaxone resistance is rising gradually over the years, it is imperative to monitor the AMR in this species. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Agila Kumari Pragasam Shalini Anandan James John Ayyanraj Neeravi Vignesh Narasimman Dhiviya Prabaa Muthuirulandi Sethuvel Divyaa Elangovan Balaji Veeraraghavan Source Type: research

Assessment of efficacy of palm polymerase chain reaction with microscopy, rapid diagnostic test and conventional polymerase chain reaction for diagnosis of malaria
Conclusion: Palm PCR is sensitive, rapid and works on battery with simple laboratory facility requirements. Portable electrophoresis and transilluminator combined with Palm PCR could be implemented as an important diagnostic tool in resource-limited and rural areas. Similar studies with wider parameters in rural areas will help us evaluate and maybe establish Palm PCR as PCR platform of choice for such specific set-ups. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Paras Mahale Rajas Warke Mira Ramaiya Deepa Balasubramanian Suvin Shetty Ranjit Mankeshwar Abhay Chowdhary Source Type: research

Clinico-microbiological analysis of toxigenic clostridium difficile from hospitalised patients in a tertiary care hospital, Mangalore, Karnataka, India
Conclusion: The presence of toxigenic C. difficile in our locality is a matter of concern. Constant supervision, appropriate treatment and preventive measures are crucial in controlling C. difficile infection. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Sherin Justin Beena Antony Source Type: research

RNA-seq analysis reveals resistome genes and signalling pathway associated with vancomycin-intermediate Staphylococcus aureus
Conclusion: Further studies on understanding the role of the identified molecular targets such as SAA6008_00181, SAA6008_01127, agrA, agrC and coa in adapting to the pressure of antibiotics at sub-inhibitory concentrations can help in learning the molecular mechanisms causing resistance to the pathogens as well as finding other potential therapeutics. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Devika Subramanian Jeyakumar Natarajan Source Type: research

Experience of Indian association of medical microbiology external quality assurance scheme centre, New Delhi: Challenges and quality assessment of clinical microbiology laboratories
Conclusion: A large number of the participating laboratories (77%) had an overall score of >80% for all exercises, demonstrating acceptable baseline performance of EQAS registered laboratories. However, continued EQAS participation could further improve the quality of results. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Chand Wattal Jaswinder Kaur Oberoi Neeraj Goel Sanghamitra Datta Reena Raveendran KJ Prasad Source Type: research

Current strategy for local- to global-level molecular epidemiological characterisation of global antimicrobial resistance surveillance system pathogens
Dhiviya Prabaa Muthuirulandi Sethuvel, Naveen Kumar Devanga Ragupathi, Yamuna Devi Bakthavatchalam, Saranya Vijayakumar, Rosemol Varghese, Chaitra Shankar, Jobin John Jacob, Karthick Vasudevan, Divyaa Elangovan, Veeraraghavan BalajiIndian Journal of Medical Microbiology 2019 37(2):147-162 The prime goal of molecular epidemiology is to identify the origin and evolution of pathogens, which can potentially influence the public health worldwide. Traditional methods provide limited information which is not sufficient for outbreak investigation and studying transmission dynamics. The recent advancement of next-generation sequen...
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Dhiviya Prabaa Muthuirulandi Sethuvel Naveen Kumar Devanga Ragupathi Yamuna Devi Bakthavatchalam Saranya Vijayakumar Rosemol Varghese Chaitra Shankar Jobin John Jacob Karthick Vasudevan Divyaa Elangovan Veeraraghavan Balaji Source Type: research

Pneumococcal conjugate vaccine rollout in India: Expectations and challenges
Rosemol Varghese, Balaji Veeraraghavan, Yuvraj Jeyaraman, Girish Kumar, Narendra Kumar Arora, S BalasubramanianIndian Journal of Medical Microbiology 2019 37(2):141-146 India is one among the four Asian countries with the greatest number of deaths due to pneumococcal infection among children under 5 years. pneumococcal conjugate vaccine (PCV) has been introduced in a phased manner in five major Indian states. Ambiguity remains in choosing the appropriate type of PCV and optimum schedule with maximum effectiveness specific for each country. Here, we discuss the evidences with respect to serotype coverage, immunogenicity, r...
Source: Indian Journal of Medical Microbiology - November 18, 2019 Category: Microbiology Authors: Rosemol Varghese Balaji Veeraraghavan Yuvraj Jeyaraman Girish Kumar Narendra Kumar Arora S Balasubramanian Source Type: research