Artesunate-induced severe autoimmune hemolytic anemia in complicated malaria
Sarvinder Singh, Santosh Kumar Singh, Ajai Kumar Tentu, Anshu Kumar, Bhaskar Shahbabu, Vani Singh, Nidhi SinghIndian Journal of Critical Care Medicine 2018 22(10):753-756Autoimmune hemolytic anemia (AIHA) is a very rare cause of anemia in a case of malaria and drug-induced AIHA is even rarer. A 50-year old patient with a history of fever for 8 days was diagnosed with a case of complicated malaria with mixed infection having initial parasite index of 45%. He showed good response on initial therapy with artesunate (parasite count reduced to <1%) but his haemoglobin (Hb) continued to drop from...
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Sarvinder Singh Santosh Kumar Singh Ajai Kumar Tentu Anshu Kumar Bhaskar Shahbabu Vani Singh Nidhi Singh Source Type: research

Refractory status asthmaticus: A case for unconventional therapies
We present successful use of Extracorporeal Membrane Oxygenation and isoflurane in a child with Refractory Status Asthmaticus. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Rohit Vohra Anil Sachdev Dhiren Gupta Neeraj Gupta Suresh Gupta Source Type: research

Anti-voltage-gated potassium channel antibody syndrome: A rare cause of hyponatremia in intensive care unit
Sulakshana Sulakshana, Shashi PrakashIndian Journal of Critical Care Medicine 2018 22(10):746-748Hyponatremia causing seizure is a common cause for admission in the critical care unit. Here, we describe a peculiar case of seizure due to hyponatremia, associated with anti-voltage-gated potassium channel antibody syndrome. This case emphasizes that how a proper workup can unveil unusual but potentially treatable causes of hyponatremia. The hallmark of this syndrome is that neurological symptoms may relapse or progress if the disorder is not recognized in time. This case report emphasizes the point that how a keen observation...
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Sulakshana Sulakshana Shashi Prakash Source Type: research

Calming the electrical storm: Use of stellate ganglion block and thoracic epidural in intractable ventricular tachycardia
Supriya D'souza, Shalini Saksena, Manju ButaniIndian Journal of Critical Care Medicine 2018 22(10):743-745Imbalances in the autonomic nervous system contribute to ventricular tachyarrhythmias. Sympatholysis with thoracic epidural analgesia or a stellate ganglion block attenuates myocardial excitability and the proarrhythmic effects of sympathetic hyperactivity. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Supriya D ' souza Shalini Saksena Manju Butani Source Type: research

Methotrexate-induced toxic epidermal necrolysis: A rare case report and review of literature
Pritam Kataria, Pradip Kendre, Apurva Patel, Nahush Tahiliani, Sushant IkharIndian Journal of Critical Care Medicine 2018 22(10):740-742Acute lymphoblastic leukemia (ALL) is the most common malignancy in pediatric patients, and it is characterized by the presence of malignant lymphoblasts within the bone marrow and peripheral blood. The treatment of ALL involves induction, consolidation, reinduction, and maintenance therapy. Consolidation therapy in ALL-Berlin-Frankfurt-Münster 90 protocol involves the use of high-dose methotrexate (HDMTX, 5 g/m2) over 24 h as continuous infusion. The adverse effects due to HDM...
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Pritam Kataria Pradip Kendre Apurva Patel Nahush Tahiliani Sushant Ikhar Source Type: research

Bilateral phrenic nerve palsy in a diabetic causing respiratory failure
We presented a 64-year-old male who was a case of type 2 DM for >6 years. He presented with orthopnea and respiratory failure secondary to bilateral phrenic neuropathy and resultant diaphragmatic palsy. Clinical examination, ultrasound, and nerve conduction studies confirmed the bilateral involvement of the phrenic nerves. Phrenic neuropathy may be an important, albeit a rare complication of diabetes, and hence, diaphragmatic dysfunction associated with diabetic phrenic neuropathy should be considered in any patient with unexplained breathlessness, orthopnea, and respiratory failure. (Source: Indian Journal of C...
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Robert Da Costa Pezad Doctor Kaustubh Mahajan Vidyadhara G Lakkappan Source Type: research

Diagnostic usefulness of serum albumin as a predictor of diabetic ketoacidosis
Conclusions: Serum albumin levels may predict the occurrence of ketosis in diabetic patients. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Jayagowri Karthikeyan Sujatha Rajaragupathy Source Type: research

Timing of renal replacement therapy in acute kidney injury: Shedding new light on an old controversy
Helmut SchifflIndian Journal of Critical Care Medicine 2018 22(10):730-732Critically ill patients with severe acute kidney injury (AKI-D) require renal replacement therapy (RRT) increasingly. However, the optimal timing of initiation of RRT for non-life-threatening indications of AKI remains unknown. There is a debate as to whether different philosophies of RRT initiation (early vs. delayed) confer a survival benefit. Lowering the threshold for RRT initiation, however, inevitably leads to more critically ill patients receiving unnecessary RRT. The relevant proportion of nonprogressing early stage AKI patients with spontane...
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Helmut Schiffl Source Type: research

A multicentric, prospective, observational antibacterial utilization study in Indian tertiary referral centers
Conclusions: More generic prescriptions and more number of prescriptions as per the sensitivity pattern are required at each public and private hospital. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Nitin Bhagwan Mali Siddharth P Deshpande Niteen D Karnik Nithya J Gogtay Renuka P Munshi Jigeeshu V Divatia Sanjay C Wagle Kannan Sridharan Urmila Mukund Thatte Source Type: research

Clinical and laboratory features associated with acute kidney injury in severe malaria
Conclusion: P. vivax is an important cause of severe malaria with AKI in our setting. Various other clinical features are associated with AKI and related mortality. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Hiren Anghan Prayas Sethi Manish Soneja Sandeep Mahajan Naveet Wig Source Type: research

Spectrum of diseases/conditions exhibiting hemostatic abnormalities in patients admitted to a medical intensive care unit of a tertiary care hospital
Conclusions: Tropical diseases formed the majority of admissions with bleeding manifestations. Thrombocytopenia is an important marker to predict mortality and also has a significant association with MICU stay. APACHE II score was found to be a good predictor of blood transfusion requirements. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Girish Chandrakant Rajadhyaksha Ameena Meah Source Type: research

Critical illness scoring systems: Sequential organ failure assessment, Acute Physiology and Chronic Health Evaluation II, and quick sequential organ failure assessment to predict the clinical outcomes in scrub typhus patients with organ dysfunctions
Conclusion: Among the three CISSs studied, the SOFA score correlated with in-hospital stay duration and mortality, whereas the qSOFA score formed a simple as well as a convenient tool in predicting the mortality in patients of cST with organ dysfunction. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Prasanth Balasubramanian Navneet Sharma Manisha Biswal Ashish Bhalla Susheel Kumar Vivek Kumar Source Type: research

Early pH change predicts intensive care unit mortality
Conclusions: Metabolic acidosis is associated with higher mortality in ICU. The rate of change in pH may better predict ICU mortality than other metabolic indices. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Sujay Samanta Ratender Kumar Singh Arvind K Baronia Prabhaker Mishra Banani Poddar Afzal Azim Mohan Gurjar Source Type: research

Clinical profile and outcome of patients with acute poisoning admitted in intensive care unit of tertiary care center in Eastern Nepal
Conclusion: Organophosphorous poisoning was the most common acute poisoning in young population leading to the ICU admission. Older age, delayed initiation of the resuscitative measures, need for mechanical ventilation, and hepatic failure significantly affected the mortality. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Lalit Kumar Rajbanshi Batsalya Arjyal Rakesh Mandal Source Type: research

Organ donation rate in brain-dead patients in a tertiary referral center
Shivakumar Mutnal, Pradeep Rangappa, Ipe Jacob, Karthik RaoIndian Journal of Critical Care Medicine 2018 22(9):685-686 (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - September 17, 2018 Category: Intensive Care Authors: Shivakumar Mutnal Pradeep Rangappa Ipe Jacob Karthik Rao Source Type: research