Medical Versus Surgical Treatment of Primary Aldosteronism [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: David A. Calhoun Tags: Clinical Studies, Hypertension Editorial Commentaries Source Type: research
Role of AT2R (Angiotensin Type 2 Receptor) in Maintaining Sodium-Potassium Balance [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Sanket Patel, Tahir Hussain Tags: Hypertension Editorial Commentaries Source Type: research
Cocaine-Responsive miRNA and Blood Pressure Elevation [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Shengyu Mu, William E. Fantegrossi, Nancy J. Rusch Tags: Basic Science Research, Oxidant Stress, Vascular Biology, High Blood Pressure, Hypertension Editorial Commentaries Source Type: research
Genetic Susceptibility to Hypertension-Induced Renal Injury [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Richard J. Roman, Fan Fan Tags: Genetics, Hypertension Editorial Commentaries Source Type: research
Under Pressure [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Sabine Kossmann, Philip Wenzel Tags: Hypertension Editorial Commentaries Source Type: research
Should Maternal Hemodynamics Guide Antihypertensive Therapy in Preeclampsia? [Brief Review]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Kelsey McLaughlin, Ralph R. Scholten, John C. Kingdom, John S. Floras, John D. Parker Tags: Hemodynamics, Pregnancy, Hypertension, Preeclampsia Brief Reviews Source Type: research
Jacques Genest Sr [In Memoriam]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Ernesto L. Schiffrin Tags: Hypertension In Memoriam Source Type: research
Management of a Pregnant Woman With Fibromuscular Dysplasia [Clinical-Pathological Conference]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Elena Berra, Anna F. Dominiczak, Rhian M. Touyz, Sophie Pierard, Frank Hammer, Gian Paolo Rossi, Ruben Gabriel Micali, Jan A. Staessen, Michael Bursztyn, Thomas Kahan, Alexandre Persu Tags: Clinical – Pathological Conference Source Type: research
Clinical Implications [Clinical Implications]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Tags: Clinical Implications Source Type: research
Correction to: Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction [Corrections]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Tags: Correction Source Type: research
Prevalence of Cardiovascular Disease and Its Risk Factors in Primary AldosteronismNovelty and Significance [Primary Aldosteronism]
There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) in patients with primary aldosteronism (PA); however, their results have left it unclear whether CVD is affected by the plasma aldosterone concentration or hypokalemia. We assessed the PA database established by the multicenter JPAS (Japan Primary Aldosteronism Study) and compared the prevalence of CVD among patients with PA with that among age-, sex-, and blood pressure-matched essential hypertension patients and participants with hypertension in a general population cohort. We also performed binary logistic regress...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Toshinari Yamasaki, Osamu Ogawa, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichiȷo, Takuyuki Katabami, Yasushi Tanaka, Norio Wada, Yui Shibayama, Takanobu Yosh Tags: Cardiovascular Disease, Risk Factors, Hypertension, Vascular Disease Original Articles Source Type: research
STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial HypertensionNovelty and Significance [Pulmonary Hypertension]
An increase in cytosolic free Ca2+ concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs) triggers pulmonary vasoconstriction and stimulates PASMC proliferation leading to vascular wall thickening. Here, we report that STIM2 (stromal interaction molecule 2), a Ca2+ sensor in the sarcoplasmic reticulum membrane, is required for raising the resting [Ca2+]cyt in PASMCs from patients with pulmonary arterial hypertension (PAH) and activating signaling cascades that stimulate PASMC proliferation and inhibit PASMC apoptosis. Downregulation of STIM2 in PAH-PASMCs reduces the resting [Ca2+]cyt, whereas overexpre...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Shanshan Song, Shane G. Carr, Kimberly M. McDermott, Marisela Rodriguez, Aleksandra Babicheva, Angela Balistrieri, Ramon J. Ayon, Jian Wang, Ayako Makino, Jason X.-J. Yuan Tags: Pulmonary Hypertension, Vascular Disease Original Articles Source Type: research
Akap1 Regulates Vascular Function and Endothelial Cells BehaviorNovelty and Significance [Vascular Function]
MitoAKAPs (mitochondrial A kinase anchoring proteins), encoded by the Akap1 gene, regulate multiple cellular processes governing mitochondrial homeostasis and cell viability. Although mitochondrial alterations have been associated to endothelial dysfunction, the role of mitoAKAPs in the vasculature is currently unknown. To test this, postischemic neovascularization, vascular function, and arterial blood pressure were analyzed in Akap1 knockout mice (Akap1−/−) and their wild-type (wt) littermates. Primary cultures of aortic endothelial cells (ECs) were also obtained from Akap1−/− and wt mice, and ECs migration, prol...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Gabriele Giacomo Schiattarella, Fabio Cattaneo, Albino Carrizzo, Roberta Paolillo, Nicola Boccella, Mariateresa Ambrosio, Antonio Damato, Gianluigi Pironti, Anna Franzone, Giusi Russo, Fabio Magliulo, Marinella Pirozzi, Marianna Storto, Michele Madonna, G Tags: Basic Science Research, Endothelium/Vascular Type/Nitric Oxide, Vascular Biology Original Articles Source Type: research
Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary DiseaseNovelty and Significance [Chronic Obstructive Pulmonary Disease]
Cardiovascular disease is a common comorbidity and cause of mortality in chronic obstructive pulmonary disease. A better understanding of mechanisms of cardiovascular risk in chronic obstructive pulmonary disease patients is needed to improve clinical outcomes. We hypothesized that such patients have increased arterial stiffness, wave reflections, and subclinical atherosclerosis compared with controls and that these findings would be independent of smoking status and other confounding factors. A total of 458 patients with a diagnosis of chronic obstructive pulmonary disease and 1657 controls (43% were current or ex-smokers...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Marie Fisk, Carmel M. McEniery, Nichola Gale, Kaisa Maki–Petaȷa, Julia R. Forman, Margaret Munnery, Jean Woodcock–Smith, Joseph Cheriyan, Divya Mohan, Jonathan Fuld, Ruth Tal–Singer, Michael I. Polkey, John R. Cockcroft, Ian B. Wi Tags: Clinical Studies, Hemodynamics, Aging, Cardiovascular Disease, Risk Factors Original Articles Source Type: research
Blood Pressure Profile 1 Year After Severe PreeclampsiaNovelty and Significance [Preeclampsia]
Preeclampsia increases the long-term risk of cardiovascular disease, possibly through occurrence of hypertension after delivery, such as masked hypertension, night-time hypertension, and an adverse systolic night-to-day blood pressure (BP) ratio. These types of hypertension are often unnoticed and can only be detected with ambulatory BP monitoring (ABPM). We aimed to determine hypertension prevalence and 24-hour BP pattern with ABPM and office BP measurements in women 1 year after severe preeclampsia. This is a retrospective cohort study. As part of a follow-up program after severe preeclampsia, 200 women underwent ABPM an...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Laura Benschop, Johannes J. Duvekot, Jorie Versmissen, Valeska van Broekhoven, Eric A.P. Steegers, Jeanine E. Roeters van Lennep Tags: High Blood Pressure, Hypertension, Preeclampsia Original Articles Source Type: research
