TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in PreeclampsiaNovelty and Significance [Preeclampsia]
In conclusion, TLR9 is capable of robustly suppressing angiogenesis by differentially regulating the expression of VEGFA and sFLT1 at the fetomaternal interface, potentially contributing to the development of preeclampsia. (Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Biwei He, Xingyu Yang, Yamei Li, Ding Huang, Xin Xu, Wenjun Yang, Yan Dai, Huijuan Zhang, Zhengjun Chen, Weiwei Cheng Tags: Preeclampsia Original Articles Source Type: research
Maternal and Paternal Height and the Risk of PreeclampsiaNovelty and Significance [Preeclampsia]
The etiology of preeclampsia is unknown. Tall women have been found to have lower incidence of preeclampsia. This points to a possible biological causal effect but may be because of socioeconomic confounding. We used paternal height as an unexposed control to examine confounding. The MoBa (Norwegian Mother and Child Cohort Study) was used to extract data on parental heights, maternal prepregnancy weight, other background factors, and pregnancy outcomes for 99 968 singleton births. Multiple logistic regression was used to estimate odds ratios for preeclampsia according to parental height. The adjusted odds ratio for preec...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Yunsung Lee, Per Magnus Tags: Preeclampsia Original Articles Source Type: research
Assessment of the fullPIERS Risk Prediction Model in Women With Early-Onset PreeclampsiaNovelty and Significance [Preeclampsia]
Early-onset preeclampsia is associated with severe maternal and perinatal complications. The fullPIERS model (Preeclampsia Integrated Estimate of Risk) showed both internal and external validities for predicting adverse maternal outcomes within 48 hours for women admitted with preeclampsia at any gestational age. This ability to recognize women at the highest risk of complications earlier could aid in preventing these adverse outcomes through improved management. Because the majority (≈70%) of the women in the model development had late-onset preeclampsia, we assessed the performance of the fullPIERS model in women with ...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: U. Vivian Ukah, Beth Payne, Jennifer A. Hutcheon, J. Mark Ansermino, Wessel Ganzevoort, Shakila Thangaratinam, Laura A. Magee, Peter von Dadelszen Tags: Pregnancy, Preeclampsia Original Articles Source Type: research
Dysregulated Pseudogene HK2P1 May Contribute to Preeclampsia as a Competing Endogenous RNA for Hexokinase 2 by Impairing DecidualizationNovelty and Significance [Preeclampsia]
In this study, we verified the expression of long noncoding RNA HK2P1 (hexokinase 2 pseudogene 1) and its cognate gene HK2 (hexokinase 2), which were found by our previous RNA-sequencing analysis in the decidua of severe preeclampsia patients and matched control subjects. Besides that, we also investigated the function and the mechanism of HK2P1 and HK2 during decidualization. HK2 is the crucial enzyme involved in glycolysis. The HK2P1 and HK2 genes are homologous to each other. The results demonstrated that HK2P1, like HK2, stimulated the glucose uptake and lactate production of human endometrial stromal cells. In additio...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Hong Lv, Jing Tong, Jieqiong Yang, Shijian Lv, Wei-Ping Li, Cong Zhang, Zi-Jiang Chen Tags: Preeclampsia Original Articles Source Type: research
VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibition Induces Cardiovascular Damage via Redox-Sensitive ProcessesNovelty and Significance [Oxidative Stress]
Although VEGF (vascular endothelial growth factor) inhibitors (VEGFIs), are effective anticancer therapies, they cause hypertension through unknown mechanisms. We questioned whether changes in vascular redox state may be important, because VEGF signaling involves nitric oxide (NO) and reactive oxygen species. Molecular mechanisms, including NOS, NADPH oxidase (Nox)–derived reactive oxygen species, antioxidant systems, and vasoconstrictor signaling pathways, were probed in human endothelial cells and vascular smooth muscle exposed to vatalanib, a VEGFI. Vascular functional effects of VEGFI were assessed ex vivo in mouse a...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Karla B. Neves, Francisco J. Rios, Lucas van der Mey, Rheure Alves-Lopes, Alan C. Cameron, Massimo Volpe, Augusto C. Montezano, Carmine Savoia, Rhian M. Touyz Tags: Basic Science Research, Oxidant Stress, Vascular Biology Original Articles Source Type: research
Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary FactorsNovelty and Significance [Dietary Sodium and Blood Pressure]
Available data indicate that dietary sodium (as salt) relates directly to blood pressure (BP). Most of these findings are from studies lacking dietary data; hence, it is unclear whether this sodium–BP relationship is modulated by other dietary factors. With control for multiple nondietary factors, but not body mass index, there were direct relations to BP of 24-hour urinary sodium excretion and the urinary sodium/potassium ratio among 4680 men and women 40 to 59 years of age (17 population samples in China, Japan, United Kingdom, and United States) in the INTERMAP (International Study on Macro/Micronutrients and Blood Pr...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Jeremiah Stamler, Queenie Chan, Martha L. Daviglus, Alan R. Dyer, Linda Van Horn, Daniel B. Garside, Katsuyuki Miura, Yangfeng Wu, Hirotsugu Ueshima, Liancheng Zhao, Paul Elliott Tags: Diet and Nutrition, Epidemiology, High Blood Pressure, Hypertension Original Articles Source Type: research
AT2R (Angiotensin II Type 2 Receptor)-Mediated Regulation of NCC (Na-Cl Cotransporter) and Renal K Excretion Depends on the K Channel, Kir4.1Novelty and Significance [Kidney]
AT2R (AngII [angiotensin II] type 2 receptor) is expressed in the distal nephrons. The aim of the present study is to examine whether AT2R regulates NCC (Na-Cl cotransporter) and Kir4.1 of the distal convoluted tubule. AngII inhibited the basolateral 40 pS K channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule treated with losartan but not with PD123319. AT2R agonist also inhibits the K channel, indicating that AT2R was involved in tonic regulation of Kir4.1. The infusion of PD123319 stimulated the expression of tNCC (total NCC) and pNCC (phosphorylated NCC; Thr53) by a time-dependent way with the peak at ...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Peng Wu, Zhong-Xiuzi Gao, Xin-Peng Duan, Xiao-Tong Su, Ming-Xiao Wang, Dao-Hong Lin, Ruimin Gu, Wen-Hui Wang Tags: Hypertension Original Articles Source Type: research
Smooth Muscle Cell-Mineralocorticoid Receptor as a Mediator of Cardiovascular Stiffness With AgingNovelty and Significance [Mineralocorticoid Receptor]
Stiffening of the vasculature with aging is a strong predictor of adverse cardiovascular events, independent of all other risk factors including blood pressure, yet no therapies target this process. MRs (mineralocorticoid receptors) in smooth muscle cells (SMCs) have been implicated in the regulation of vascular fibrosis but have not been explored in vascular aging. Comparing SMC-MR–deleted male mice to MR-intact littermates at 3, 12, and 18 months of age, we demonstrated that aging-associated vascular stiffening and fibrosis are mitigated by MR deletion in SMCs. Progression of cardiac stiffness and fibrosis and the decl...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Seung Kyum Kim, Amy T. McCurley, Jennifer J. DuPont, Mark Aronovitz, M. Elizabeth Moss, Isaac E. Stillman, S. Ananth Karumanchi, Demetra D. Christou, Iris Z. Jaffe Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Basic Science Research, Physiology, Vascular Biology Original Articles Source Type: research
Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone’s Antifibrotic ActivityNovelty and Significance [Mineralocorticoid Receptor]
This study demonstrates that the nonsteroidal MRA finerenone potently prevents cardiac fibrosis and improves strain parameters in mice. Cardiac antifibrotic actions of finerenone may result from the inhibition of profibrotic TNX gene expression mediated by differential MR cofactor binding. Selective MR cofactor modulation provides a molecular basis for distinct (pre)-clinical actions of nonsteroidal and steroidal MRAs. (Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Jana Grune, Niklas Beyhoff, Elia Smeir, Remigiusz Chudek, Annelie Blumrich, Zsofia Ban, Sarah Brix, Iris R. Betz, Michael Schupp, Anna Foryst–Ludwig, Robert Klopfleisch, Philipp Stawowy, Rene Houtman, Peter Kolkhof, Ulrich Kintscher Tags: Fibrosis, Heart Failure, Remodeling Original Articles Source Type: research
Downregulated Serum 14, 15-Epoxyeicosatrienoic Acid Is Associated With Abdominal Aortic Calcification in Patients With Primary AldosteronismNovelty and Significance [Primary Aldosteronism]
Patients with primary aldosteronism (PA) have increased risk of target-organ damage, among which vascular calcification is an important indicator of cardiovascular mortality. 14, 15-Epoxyeicosatrienoic acid (14, 15-EET) has been shown to have beneficial effects in vascular remodeling. However, whether 14, 15-EET associates with vascular calcification in PA is unknown. Thus, we aimed to investigate the association between 14, 15-EET and abdominal aortic calcification (AAC) in patients with PA. Sixty-nine patients with PA and 69 controls with essential hypertension, matched for age, sex, and blood pressure, were studied. 14,...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Pinming Liu, Shaoling Zhang, Jingwei Gao, Ying Lin, Guangzi Shi, Wanbing He, Rhian M. Touyz, Li Yan, Hui Huang Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Biomarkers, Hypertension, Computerized Tomography (CT), Vascular Disease Original Articles Source Type: research
Adrenalectomy Lowers Incident Atrial Fibrillation in Primary Aldosteronism Patients at Long TermNovelty and Significance [Primary Aldosteronism]
Primary aldosteronism (PA) causes cardiovascular damage in excess to the blood pressure elevation, but there are no prospective studies proving a worse long-term prognosis in adrenalectomized and medically treated patients. We have, therefore, assessed the outcome of PA patients according to treatment mode in the PAPY study (Primary Aldosteronism Prevalence in Hypertension) patients, 88.8% of whom were optimally treated patients with primary (essential) hypertension (PH), and the rest had PA and were assigned to medical therapy (6.4%) or adrenalectomy (4.8%). Total mortality was the primary end point; secondary end points ...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Gian Paolo Rossi, Giuseppe Maiolino, Alberto Flego, Anna Belfiore, Giampaolo Bernini, Bruno Fabris, Claudio Ferri, Gilberta Giacchetti, Claudio Letizia, Mauro Maccario, Francesca Mallamaci, Maria Lorenza Muiesan, Massimo Mannelli, Aurelio Negro, Gaetana P Tags: Hypertension Original Articles Source Type: research
Socioeconomic Status and Hypertension Control in Sub-Saharan AfricaNovelty and Significance [Socioeconomic Status and Hypertension in Africa]
Systemic hypertension is a rapidly growing epidemic in Africa. The role of socioeconomic status on blood pressure control has not been well studied in this part of the world. We, therefore, aimed to quantify the association of socioeconomic status both at the individual and at the country level with blood pressure control in Sub-Saharan Africa. We conducted a cross-sectional survey in urban clinics of 12 countries, both low income and middle income, in Sub-Saharan Africa. Standardized blood pressure measures were made among the hypertensive patients attending the clinics. Blood pressure control was defined as blood pressur...
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Marie Antignac, Ibrahima Bara Diop, Diane Macquart de Terline, Kouadio Euloge Kramoh, Dadhi M. Balde, Anastase Dzudie, Beatriz Ferreira, Martin Dedonougbo Houenassi, Dominique Hounsou, Meo Stephane Ikama, Adama Kane, Suzy Gisele Kimbally–Kaki, Samue Tags: Epidemiology, High Blood Pressure, Hypertension Original Articles Source Type: research
Calpain [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Styliani Goulopoulou Tags: Basic Science Research, Cell Signaling/Signal Transduction, Endothelium/Vascular Type/Nitric Oxide, Inflammation, Oxidant Stress Editorial Commentaries Source Type: research
Incremental Value of Echocardiography in Patients With or Without Hypertension [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Jonathan N. Bella, Richard B. Devereux Tags: Hypertension, Echocardiography Editorial Commentaries Source Type: research
Accurately Predicting the Risk of Serious Maternal Morbidity in Preterm Preeclampsia [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Kirsten R. Palmer, Stephen Tong Tags: Preeclampsia Editorial Commentaries Source Type: research
