Psychoneuroimmunology: Methods and Protocols (Methods in Molecular Biology) Edited by Qing Yan, Humana Press, New Jersey, 2012. Price £99, pp xi + 1‐405, ISBN: 978‐1‐62703‐070‐0.
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 9, 2013 Category: Psychiatry Authors: Ruihua Hou Tags: Book Review Source Type: research

Pharmacogenetic polymorphisms and response to escitalopram and venlafaxine over 8 weeks in major depression
The objective of this study is to investigate the influence of the 5‐HTTLPR (serotonin transporter‐linked promoter region), cytochrome P450 2C19, and cytochrome P450 2D6 polymorphisms on escitalopram (ESC) and venlafaxine (VEN) responses in major depressive disorder. MethodA prospective multi‐site study of 106 patients (Caucasian and Han Chinese ethnicities) with major depressive disorder treated with either ESC or VEN was conducted. The 17‐item Hamilton Depression scale (HDRS), Clinical Global Impression Scale, and an adverse events scale (UKU) were assessed over 8 weeks, blind to genotype. ResultsAt the 8...
Source: Human Psychopharmacology: Clinical and Experimental - September 9, 2013 Category: Psychiatry Authors: Chee Ng, Jerome Sarris, Ajeet Singh, Chad Bousman, Keith Byron, Lai Huat Peh, Deidre Joy Smith, Chay Hoon Tan, Isaac Schweitzer Tags: Research Article Source Type: research

Longitudinal missing data strategies for substance use clinical trials using generalized estimating equations: an example with a buprenorphine trial
ConclusionsFuture researchers may find utilization of the MI procedure in conjunction with the common method of GEE analysis as a helpful analytic approach when the missing at random assumption is justifiable. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 9, 2013 Category: Psychiatry Authors: Sterling McPherson, Celestina Barbosa‐Leiker, Michael McDonell, Donelle Howell, John Roll Tags: Research Article Source Type: research

Effect of food on the pharmacokinetics of lurasidone: results of two randomized, open‐label, crossover studies
This study aimed to investigate the effect of prandial status and caloric and fat composition of meals on the pharmacokinetics of lurasidone. MethodsTwo randomized, open‐label, crossover studies were conducted in clinically stable adults with schizophrenia or schizoaffective disorder. Study 1 (n = 16) evaluated the effect of fasting and three meal types (100 kcal/medium fat, 200 kcal/medium fat, and 800–1000 kcal/high fat), and Study 2 (n = 26) evaluated the effect of fasting and five meal types (350 kcal/high fat, 500 kcal/low fat, 500 kcal/high...
Source: Human Psychopharmacology: Clinical and Experimental - September 9, 2013 Category: Psychiatry Authors: Sheldon Preskorn, Larry Ereshefsky, Yu‐Yuan Chiu, Nagaraju Poola, Antony Loebel Tags: Research Article Source Type: research

The effect of lisdexamfetamine dimesylate on body weight, metabolic parameters, and attention deficit hyperactivity disorder symptomatology in adults with bipolar I/II disorder
ObjectivesWe primarily sought to determine the effect of adjunctive lisdexamfetamine dimesylate (LDX) on anthropometric and metabolic parameters. Our secondary aim was to evaluate the effect of LDX on attention deficit hyperactivity disorder (ADHD) symptom severity in adults with bipolar I/II disorder. MethodsForty‐five stable adults (i.e., non‐rapid cycling, absence of clinically significant hypo/manic symptoms) with bipolar I/II disorder and comorbid ADHD were enrolled in a phase IV, 4‐week, flexible dose, open‐label study of adjunctive LDX. All subjects were initiated at 30 mg/day of adjunctive LDX for th...
Source: Human Psychopharmacology: Clinical and Experimental - September 9, 2013 Category: Psychiatry Authors: Roger S. McIntyre, Mohammad Alsuwaidan, Joanna K. Soczynska, Isaac Szpindel, Timothy S. Bilkey, Doron Almagor, Hanna O. Woldeyohannes, Alissa M. Powell, Danielle S. Cha, Laura Ashley Gallaugher, Sidney H. Kennedy Tags: Research Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 9, 2013 Category: Psychiatry Tags: Issue Information Source Type: research

Interleukin 1 beta gene and risk of schizophrenia: detailed case–control and family‐based studies and an updated meta‐analysis
ConclusionsThe present study does not support a role for IL1B in schizophrenia susceptibility. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2013 Category: Psychiatry Authors: Masako Shibuya, Yuichiro Watanabe, Ayako Nunokawa, Jun Egawa, Naoshi Kaneko, Hirofumi Igeta, Toshiyuki Someya Tags: Research Article Source Type: research

Prediction and structural equation model of sertraline treatment response in Japanese patients with major depressive disorder
ConclusionConsidering the combination of four factors extracted may be useful for predicting a worse response to sertraline treatment and selecting different treatment other than sertraline. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2013 Category: Psychiatry Authors: Gentaro Nishioka, Hideaki Yashima, Yuji Kiuchi, Sumiko Nakamura, Hideto Oyamada, Masakazu Ishii, Ikuo Kudo Tags: Research Article Source Type: research

Abnormal maximal finger tapping in abstinent cannabis users
ConclusionsRhythmicity of finger tapping is abnormal in individuals with a history of cannabis use. The abnormality appears to be long lasting and adds to the list of functional changes present in abstinent cannabis users. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - September 1, 2013 Category: Psychiatry Authors: Stanley C. Flavel, Jason M. White, Gabrielle Todd Tags: Short Communication Source Type: research

Novel pharmacological agents targeting memory and cognition in the treatment of anxiety disorders
ConclusionThere are a number of promising new therapies, but these require further studies before they can enter routine clinical practice. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 29, 2013 Category: Psychiatry Authors: Harpal Singh Nandhra, Catherine Louise Murphy, Akeem Sule Tags: Research Article Source Type: research

Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder
ConclusionsAdult patients with BPD show an avoidant response to social threat, a reaction that is linked with traumatic experiences during childhood. This response pattern is altered by oxytocin, possibly by reducing stress and inhibiting social withdrawal from distressing social stimuli. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - August 16, 2013 Category: Psychiatry Authors: Martin Brüne, Andreas Ebert, Meike Kolb, Cumhur Tas, Marc‐Andreas Edel, Patrik Roser Tags: Research Article Source Type: research

Classical and novel psychoactive substances: rethinking drug misuse from an evolutionary psychiatric perspective
In this article, ontogenetic and phylogenetic causes of drug abuse and links to human emotional development are considered. Some evolutionary perspectives (e.g. that under certain conditions, consumption of otherwise toxic alkaloids may confer both physical and cultural advantages) are reviewed. As described in the ‘mismatch theory’, the capacity of the human genome to evolve defences against toxins has been outstripped by the pace of cultural change and technological development, such as purposeful fermentation of alcohol and more recently distillation of alcohol; purification and chemical manipulation of plan...
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Paul St John‐Smith, Daniel McQueen, Lindsey Edwards, Fabrizio Schifano Tags: Special Issue on Novel Psychoactive Substances Source Type: research

The 12‐month prevalence and nature of adverse experiences resulting in emergency medical presentations associated with the use of synthetic cannabinoid products
ConclusionsSynthetic cannabinoid use appears to be associated with a high prevalence of adverse experiences among users, especially younger users. Further research is required to determine whether particular compounds carry a higher risk of harm than others and to assess potential consequences of longer term use. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Adam R. Winstock, Monica J. Barratt Tags: Special Issue on Novel Psychoactive Substances Source Type: research

“Spiceophrenia”: a systematic overview of “Spice”‐related psychopathological issues and a case report
ConclusionsAlthough a clear causal link may not be here identified, the available evidence suggests that SC can trigger the onset of acute psychosis in vulnerable individuals and/or the exacerbation of psychotic episodes in those with a previous psychiatric history. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Duccio Papanti, Fabrizio Schifano, Giulia Botteon, Francesca Bertossi, Jason Mannix, Daniela Vidoni, Matteo Impagnatiello, Elisabetta Pascolo‐Fabrici, Tommaso Bonavigo Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Computer‐aided (in silico) approaches in the mode‐of‐action analysis and safety assessment of Ostarine and 4‐methylamphetamine
ConclusionFrom the two case studies, we showed that in silico target prediction appears to have potential in assessing new psychoactive compounds where experimental data are scarce. The applicability domain of target predictions when applied to psychoactive compounds needs to be established in future work. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Fazlin Mohd Fauzi, Alexios Koutsoukas, Andrew Cunningham, Ana Gallegos, Roumen Sedefov, Andreas Bender Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Recreational use of 1‐(2‐naphthyl)‐2‐(1‐pyrrolidinyl)‐1‐pentanone hydrochloride (NRG‐1), 6‐(2‐aminopropyl) benzofuran (Benzofury/ 6‐APB) and NRG‐2 with review of available evidence‐based literature
ConclusionsThe arrival of hundreds of novel psychoactive substances for sale online has raised a number of public health and legal issues. Although evidence‐based literature remains limited, few studies identified that most products do not contain the ingredients as advertised. Better levels of international cooperation and rapid share of available information may be needed to tackle this emerging problem. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Jeshoor Jebadurai, Fabrizio Schifano, Paolo Deluca Tags: Special Issue on Novel Psychoactive Substances Source Type: research

MDAI (5,6‐methylenedioxy‐2‐aminoindane; 6,7‐dihydro‐5H‐cyclopenta[f][1,3]benzodioxol‐6‐amine; ‘sparkle’; ‘mindy’) toxicity: a brief overview and update
ConclusionIt is vital that any other cases, including non‐fatal overdoses, are documented so that a scientific evidence base can be established for them. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: John M Corkery, Simon Elliott, Fabrizio Schifano, Ornella Corazza, A Hamid Ghodse Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Presence and composition of cathinone derivatives in drug samples taken from a Drug Test Service in Spain (2010–2012)
ConclusionsCathinone derivatives were markedly present in the Spanish drug market during the studied period. There is no evidence to conclude that use of CDs will become widespread or relevant for public health, but the phenomenon must be followed, as the potential risks of these new drugs of abuse are substantial. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Fernando Caudevilla‐Gálligo, Mireia Ventura, Blanca Iciar Indave Ruiz, Iván Fornís Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Consumption of new psychoactive substances in a Spanish sample of research chemical users
ConclusionsThere is a specific RC user profile with extensive knowledge and consumption of substances, using different strategies to reduce risks associated to its consumption. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Débora González, Mireia Ventura, Fernando Caudevilla, Marta Torrens, Magi Farre Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Novel psychoactive substances as a novel challenge for health professionals: results from an Italian survey
DiscussionNovel psychoactive substances prevalence of misuse was not considered to be an unusual phenomenon in Italy, and most health professionals appeared to have concerns relating to associated medical and psychopathological risks, especially in terms of aggression/psychomotor agitation. Overall, most respondents reported the need to have better access to NPS‐related reliable sources of information. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Pierluigi Simonato, Ornella Corazza, Paolo Santonastaso, John Corkery, Paolo Deluca, Zoe Davey, Ursula Blaszko, Fabrizio Schifano Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Promoting innovation and excellence to face the rapid diffusion of Novel Psychoactive Substances in the EU: the outcomes of the ReDNet project
ConclusionsWeb‐monitoring activities are essential for mapping the diffusion of NPS and the use of technological tools can be successfully incorporated in specific prevention programmes. Furthermore, the involvement of multi‐disciplinary international partnerships was and continues to be fundamental for responding to such a prominent challenge. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Ornella Corazza, Sulaf Assi, Pierluigi Simonato, John Corkery, Saverio Bersani, Zsolt Demetrovics, Jacqueline Stair, Suzanne Fergus, Cinzia Pezzolesi, Manuela Pasinetti, Paolo Deluca, Colin Drummond, Zoe Davey, Ursula Blaszko, Jacek Moskalewicz, Barbara M Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Substitutional potential of mephedrone: an analysis of the subjective effects
ConclusionsBy having similar subjective effects as MDMA and other entactogens, mephedrone seems able to substitute other enactogenic stimulants. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Máté Kapitány‐Fövény, Máté Kertész, Adam Winstock, Paolo Deluca, Ornella Corazza, Judit Farkas, Gábor Zacher, Róbert Urbán, Zsolt Demetrovics Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Human psychobiology of MDMA or ‘Ecstasy’: an overview of 25 years of empirical research
ConclusionsThe damaging effects of Ecstasy/MDMA are far more widespread than was realized a few years ago, with new neuropsychobiological deficits still emerging. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Andrew C. Parrott Tags: Special Issue on Novel Psychoactive Substances Source Type: research

Novel psychoactive substances: first international conference
(Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Authors: Ornella Corazza, Fabrizio Schifano, Andrew C. Parrott Tags: Editorial Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 23, 2013 Category: Psychiatry Tags: Issue Information Source Type: research

Safety of non‐therapeutic atomoxetine exposures—a national poison data system study
ConclusionsNon‐therapeutic atomoxetine exposures were largely safe, but seizures were rarely observed. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 17, 2013 Category: Psychiatry Authors: Andrew A. Monte, Alessandro Ceschi, Michael Bodmer Tags: Research Article Source Type: research

Patterns of atypical antipsychotic therapy use in adults with bipolar I disorder in the USA
ConclusionAdherence to and persistence with AA treatment were low in new users with bipolar I disorder. Most patients discontinued the index AA and did not restart any antipsychotic treatment. Future study should distinguish physician‐directed discontinuation versus patient non‐adherence. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 17, 2013 Category: Psychiatry Authors: Wenjia Chen, Angela M. DeVeaugh‐Geiss, Liisa Palmer, Nicole Princic, Ya‐Ting Chen Tags: Research Article Source Type: research

Advances in the neuroimaging of panic disorder
Models of the neuroanatomy of panic disorder (PD) have relied on both animal work on fear and on clinical data from neuroimaging. Early work hypothesised a network of brain regions involved in fear processing (e.g. the amygdala), but more recent work has also pointed to the involvement of other cortical areas and other brain circuitry (e.g. the insula and anterior cingulate cortex). Studies investigating functional and structural brain connectivity in PD may ultimately shed light on the extent to which the neuroanatomy of PD is localised versus distributed, and on how current treatments alter this neuroanatomy. Copyright &...
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2013 Category: Psychiatry Authors: Justine Nienke Pannekoek, Steven J.A. Werff, Dan J. Stein, Nic J.A. Wee Tags: Short Communication Source Type: research

Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: a double‐blind, placebo‐controlled study of orthostatic challenge, blood pressure and heart rate
It is generally thought that venlafaxine raises blood pressure at higher doses; however, some studies have found no effect or a decrease in blood pressure. The aim of this study was to evaluate the cardiovascular (CV) effects of 3 weeks of dosing with venlafaxine, pregabalin and placebo on young healthy adults. Fifty‐four participants, of mean age 23.1 years (sd 4.68), 29 male, were randomised into three parallel groups. Each group received one of the three drugs, dosed incrementally over a 3‐week period to reach daily doses of 150 mg/day venlafaxine and 200 mg/day pregabalin. Blood pressure...
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2013 Category: Psychiatry Authors: Alison Diaper, Ann S. Rich, Sue J. Wilson, Kevin Craig, Colin T. Dourish, Gerry R. Dawson, David J. Nutt, Jayne E. Bailey Tags: Research Article Source Type: research

Effects of alcohol on attentional mechanisms involved in figure reversals
Conclusions: The effect of alcohol on reversal rate is observed only during intentional reversals of semantically meaningful stimuli and only when the stimulus is biased. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2013 Category: Psychiatry Authors: Claire O'Brien, Mike Harris, Suzanne Higgs Tags: Research Article Source Type: research

Depression and alterations in hypothalamic–pituitary–adrenal and hypothalamic–pituitary–thyroid axis function in male abstinent methamphetamine abusers
The present study was to investigate depression and alterations in the hypothalamic–pituitary–adrenal (HPA) and hypothalamic–pituitary–thyroid (HPT) axis function in methamphetamine (METH) abusers after abstinence. Depression was assessed using the 13‐item Beck Depression Inventory (BDI‐13) scale; blood samples from in‐patients who were METH abusers and age‐matched and sex‐matched healthy controls were collected. The demographic characteristics and history of METH abuse also was assessed. We found that serum levels of adrenocorticotropic hormone (ACTH) and thyroxine were increased; and ser...
Source: Human Psychopharmacology: Clinical and Experimental - July 1, 2013 Category: Psychiatry Authors: Su‐Xia Li, Shi‐Yan Yan, Yan‐Ping Bao, Zhi Lian, Zhi Qu, Ya‐Ping Wu, Zhi‐Min Liu Tags: Research Article Source Type: research

Plasma levels of interleukin‐6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder
ConclusionThese results suggest that the plasma levels of IL‐6 reflect the severity of MDD and that plasma IL‐6 levels might be another biological‐state marker for the depressive state. In addition, the 5‐HTTLPR polymorphism might be independent of plasma IL‐6 levels. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - June 30, 2013 Category: Psychiatry Authors: Reiji Yoshimura, Hikaru Hori, Atsuko Ikenouchi‐Sugita, Wakako Umene‐Nakano, Asuka Katsuki, Kiyokazu Atake, Jun Nakamura Tags: Research Article Source Type: research

Changes in adherence and treatment costs following initiation of oral or depot typical antipsychotics among previously non‐adherent patients with schizophrenia
This study assessed the impact of depot formulations on adherence and treating costs in the naturalistic treatment of previously non‐adherent outpatients with schizophrenia. MethodsData were taken from the European Schizophrenia Outpatient Health Outcomes (SOHO) study. Medication adherence and treating costs during an 18‐month follow‐up were assessed and compared for non‐adherent patients initiated on depot typical (n = 262) or oral typical antipsychotics (n = 169) as monotherapy at the index visit. Multivariate analyses were employed to adjust for differences between the two groups at t...
Source: Human Psychopharmacology: Clinical and Experimental - June 15, 2013 Category: Psychiatry Authors: Jihyung Hong, Diego Novick, Roberto Brugnoli, Jordan Bertsch, Josep Maria Haro Tags: Research Article Source Type: research

Acute mood effect of donepezil in young, healthy volunteers
ConclusionsAcute donepezil administration in participants with unaltered cholinergic and dopaminergic tone led to positive and negative changes in affect. These results call for further research on the direct mood effects of donepezil. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 8, 2013 Category: Psychiatry Authors: Sabine Pompeia, Juliana Ramos Gouveia, José Carlos Fernandes Galduróz Tags: Research Article Source Type: research

Neuroimaging of resilience to stress: current state of affairs
Resilience is defined as a dynamic, multidimensional process encompassing positive adaptation within the context of significant adversity. The complex nature of this construct makes it a difficult topic to study in neuroimaging research; however, in this article, we propose ways to operationalize resilience. The limited amount of structural and functional neuroimaging studies specifically designed to examine resilience have mainly focused on investigating alterations in regions of the brain involved in emotion and stress regulation circuitry. In the future, neuroimaging of resilience is expected to benefit from functional ...
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2013 Category: Psychiatry Authors: Steven J. A. Werff, J. Nienke Pannekoek, Dan J. Stein, Nic J. A. Wee Tags: Short Communication Source Type: research

Effects of low‐dose mirtazapine on driving performance in healthy volunteers
ConclusionsMirtazapine 7.5 mg did not cause driving impairment compared with mirtazapine 15 mg, while both doses of mirtazapine produced subjective somnolence. The increase in mirtazapine had no detrimental effects on psychomotor performance. Initial low‐dose mirtazapine may be safer for automobile driving than the normal starting dose. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2013 Category: Psychiatry Authors: Kunihiro Iwamoto, Naoko Kawano, Kazumi Sasada, Kunihiro Kohmura, Maeri Yamamoto, Kazutoshi Ebe, Yukihiro Noda, Norio Ozaki Tags: Short Communication Source Type: research

Salvia divinorum: from Mazatec medicinal and hallucinogenic plant to emerging recreational drug
Salvia divinorum is a sage endemic to a small region of Mexico and has been traditionally used by the Mazatec Indians for divination and spiritual healing. Recently, it has gained increased popularity as a recreational drug, used by adolescents and young adults as an alternative to marijuana and LSD. Salvinorin A, the major active ingredient of the plant, is considered to be the most potent known hallucinogen of natural origin. This review surveys the current state of knowledge on the neurochemical, pharmacokinetic, and pharmacological properties of salvinorin A, the trends and motivation behind S. divinorum use, an...
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2013 Category: Psychiatry Authors: Jolanta B. Zawilska, Jakub Wojcieszak Tags: Review Article Source Type: research

Attitude towards second‐generation antipsychotics among patients with schizophrenia and their relatives
ConclusionsEffective antipsychotic treatment, which improves functioning and minimises side effects could lead to more favourable attitudes towards antipsychotics among patients. Increasing awareness of illness, enhancing treatment satisfaction and involving relatives in treatment could also be of help. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2013 Category: Psychiatry Authors: MS Karthik, Parmanand Kulhara, Subho Chakrabarti Tags: Research Article Source Type: research

Two weeks of pretreatment with escitalopram facilitates extinction learning in healthy individuals
ConclusionsEscitalopram administered for 14 days prior to a fear conditioning paradigm did not influence acquisition of a conditioned fear response but did facilitate extinction learning. Impairments in extinction learning have been identified as a key component of posttraumatic stress disorder; our preliminary findings suggest that additional experimental and clinical studies assessing the efficacy of selective serotonin reuptake inhibitors for posttraumatic stress disorder prevention are warranted. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2013 Category: Psychiatry Authors: Eric Bui, Scott P. Orr, Ryan J. Jacoby, Aparna Keshaviah, Nicole J. LeBlanc, Mohammed R. Milad, Mark H. Pollack, Naomi M. Simon Tags: Research Article Source Type: research

Quality of case reports of adverse drug reactions with psychotropic drugs: a 25‐year review
Case reports of adverse reactions with psychotropic drugs can be useful in raising hypotheses, to be tested with more rigorous study designs. However such reports have significant methodological drawbacks, making it hard to determine causality. We undertook a systematic assessment of the quality of case reports and small case series published within Human Psychopharmacology over 25 years. For reports of adverse drug reactions, modified Bradford Hill criteria for causality (for consistency, strength, specificity, temporal relationship and plausibility) were used to ascertain the quality of the account. Reports which ...
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2013 Category: Psychiatry Authors: Bilal Talat, Andrew Mayers, David S. Baldwin Tags: Review Article Source Type: research

Issue Information
No abstract is available for this article. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - May 1, 2013 Category: Psychiatry Tags: Issue Information Source Type: research

Polymorphisms influencing olanzapine metabolism and adverse effects in healthy subjects
ConclusionsSeveral polymorphisms can explain differences in the pharmacokinetics, pharmacodynamics, and safety of olanzapine in healthy subjects. Whether these genetic factors influence the risk of therapeutic failure or tolerability in patients remains to be established. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - April 5, 2013 Category: Psychiatry Authors: Teresa Cabaleiro, Rosario López‐Rodríguez, Dolores Ochoa, Manuel Román, Jesús Novalbos, Francisco Abad‐Santos Tags: Research Article Source Type: research

Plasma catecholamine metabolite levels and the activities of psychiatric symptoms in systemic lupus erythematosus
ConclusionHyperactivity of noradrenergic neurons and/or sympathetic nerves might be involved in SLE pathophysiology. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 27, 2013 Category: Psychiatry Authors: Atsuko Ikenouchi–Sugita, Reiji Yoshimura, Hikaru Hori, Wakako Umene–Nakano, Asuka Katsuki, Kazuyoshi Saito, Yoshiya Tanaka, Jun Nakamura Tags: Short Communication Source Type: research

Movement disorders in patients with schizophrenia and a history of substance abuse
ConclusionsHistory or current use of alcohol or drug abuse did not predict EPS, except for alcohol abuse at the time of diagnosis which was associated with current akathisia. Length of illness was correlated with EPS, whereas suicidality was not linked to akathisia. Neither chlorpromazine equivalent antipsychotic dose nor whether the patient received first‐generation or second‐generation antipsychotic medication was significantly associated with EPS or substance abuse. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 27, 2013 Category: Psychiatry Authors: Lars K. Hansen, Bina Nausheen, Deborah Hart, David Kingdon Tags: Short Communication Source Type: research

Inferring about individual drug and schizotypy effects on cognitive functioning in polydrug using mephedrone users before and after clubbing
ConclusionResults suggest that polydrug use and depressive symptoms in the general population negatively affect cognition. For schizotypy, only elevated cognitive disorganisation showed potential links to a pathological cognitive profile previously reported along the psychosis dimension. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 27, 2013 Category: Psychiatry Authors: Daniela A. Herzig, Rowan Brooks, Christine Mohr Tags: Research Article Source Type: research

Levels of TNF‐α, soluble TNF receptors (sTNFR1, sTNFR2), and cognition in bipolar disorder
ConclusionsHigh levels of sTNFR1 and sTNFR2 in euthymic patients showed that it may support that proinflammatory process continues in euthymic period. This is the first study which showed increased sTNFR2 levels in euthymic period, which could be interpreted as a compensatory mechanism and again the first which deals with verbal memory. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 27, 2013 Category: Psychiatry Authors: Ozge Doganavsargil‐Baysal, Buket Cinemre, Umut Mert Aksoy, Halide Akbas, Ozmen Metin, Cıgıl Fettahoglu, Zehra Gokmen, Fatih Davran Tags: Research Article Source Type: research

Efficacy of the novel antidepressant agomelatine for anxiety symptoms in major depression
ConclusionOnce‐a‐day oral agomelatine is a new, efficacious alternative option for the treatment of anxiety in patients with major depression. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 27, 2013 Category: Psychiatry Authors: Dan J Stein, Francoise Picarel‐Blanchot, Sidney H Kennedy Tags: Research Article Source Type: research

Randomized controlled study of the T‐type calcium channel antagonist MK‐8998 for the treatment of acute psychosis in patients with schizophrenia
ConclusionsMK‐8998 was not effective in treating acutely psychotic inpatients with schizophrenia, as measured by PANSS score at week 4. Because of the limited efficacy of the active comparator, we cannot exclude the possibility that T‐type calcium channel antagonists could prove to be effective in schizophrenia. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 27, 2013 Category: Psychiatry Authors: Michael F. Egan, Xin Zhao, Andrew Smith, Matthew D. Troyer, Victor N. Uebele, Valerii Pidkorytov, Kevin Cox, Michael Murphy, Duane Snavely, Christopher Lines, David Michelson Tags: Research Article Source Type: research

Psychiatric outpatients' self‐reported adherence versus psychiatrists' impressions on adherence in affective disorders
ConclusionsAdherence was principally compromised by patient‐related factors, especially their beliefs and attitudes toward their treatment and its duration. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 8, 2013 Category: Psychiatry Authors: Carlos De las Cuevas, Wenceslao Peñate, Emilio J. Sanz Tags: Research Article Source Type: research

Effects of repeated dosing with mirtazapine, trazodone, or placebo on driving performance and cognitive function in healthy volunteers
ConclusionsAcute treatment of mirtazapine impaired road‐tracking performance and increased sleepiness, but sedative effects disappeared under repeated administrations. Trazodone did not affect driving performance or cognitive function under acute or repeated administrations. Both initial sedative effects and pharmacological profiles should be taken into consideration when using sedative antidepressants. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - March 1, 2013 Category: Psychiatry Authors: Kazumi Sasada, Kunihiro Iwamoto, Naoko Kawano, Kunihiro Kohmura, Maeri Yamamoto, Branko Aleksic, Kazutoshi Ebe, Yukihiro Noda, Norio Ozaki Tags: Short Communication Source Type: research