Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid Angiomyolipoma: series of 4 primary tumors and 2 metastases
Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is a novel entity of rare tumors with rather unique morphology and immunohistochemical profile. Until recently these tumors were characterized by indolent behavior. Herein we describe a series of six primary and metastatic ESC-RCCs morphologically and immunophenotypically mimicking epithelioid angiomyolipoma (eAML). Retrospective review of unclassified RCCs with oncocytic phenotype yielded several candidate cases, 4 of which fulfilled diagnostic criteria after additional work-up. (Source: Human Pathology)
Source: Human Pathology - June 6, 2018 Category: Pathology Authors: Maria S Tretiakova Tags: Original contribution Source Type: research
TP53 mutations in peripheral mature T and NK cell lymphomas: a whole-exome sequencing study with correlation to p53 expression
In this study, fifty-seven formalin-fixed paraffin-embedded samples were collected for whole-exome sequencing and immunohistochemical study. Ten cases had TP53 mutation variant allele frequency (VAF) of more than 5%, predominantly in intestinal T-cell lymphoma (60%), peripheral T-cell lymphoma, not otherwise specified (22.2%), and extranodal nasal-type NK/T-cell lymphoma (21.7%). (Source: Human Pathology)
Source: Human Pathology - June 6, 2018 Category: Pathology Authors: Hui-Shan Huang, Chun-Kai Liao, Ting-Ting Liu, Huey-Ling You, Ming-Chung Wang, Wan-Ting Huang Tags: Original Contributions Source Type: research
DICER1 mutation-positive Giant Botryoid Fibroepithelial polyp of the urinary bladder mimicking embryonal rhabdomyosarcoma
Fibroepithelial polyps of the urinary tract are rare lesions. They occur mainly in the upper urinary tract of children. A high disease prevalence has been reported in families with pleuropulmonary blastoma. Here we present a case of a 46-year-old woman who presented with a giant botryoid fibroepithelial polyp of the urinary bladder. Histologically, the lesion showed prominent botryoid features with an embryonal rhabdomyosarcoma-like cambium layer lacking nuclear or cellular atypia. Immunohistochemical analysis ruled out rhabdomyoblastic differentiation. (Source: Human Pathology)
Source: Human Pathology - June 5, 2018 Category: Pathology Authors: Markus Eckstein, Abbas Agaimy, Joachim Woenckhaus, Alexander Winter, Iris Bittmann, Joerg Janzen, Simone Bertz, Florian Haller, Arndt Hartmann Tags: Case study Source Type: research
Tumor infiltrating lymphocyte volume is a better predictor of neoadjuvant therapy response and overall survival in triple negative invasive breast Cancer
Triple-negative breast cancer (TNBC) has an aggressive behavior, limited therapeutic options, and high mortality rate. Neoadjuvant chemotherapy (NACT) is a standard treatment for TNBC and patients with pathological complete response (pCR) have a favorable outcome. We conducted a comprehensive evaluation of cancer clinicopathologic parameters, and correlated these parameters with the pCR rate and the overall survival. Fifty-eight patients with TNBC of no special type who underwent breast biopsy, neoadjuvant therapy, and mastectomy in our institution during 2005 –2016 were included in this study. (Source: Human Pathology)
Source: Human Pathology - June 5, 2018 Category: Pathology Authors: Lin Zhang, Xiaohong I Wang, Songlin Zhang Tags: Original Contributions Source Type: research
Alanine-Glyoxylate Aminotransferase 1 (AGXT1) is a Novel Marker for Hepatocellular Carcinomas
Arginase-1 has been demonstrated as a marker for hepatocellular carcinoma with higher sensitivity and specificity than HepPar-1 and glypican-3. However, its sensitivity is diminished in moderately and poorly differentiated hepatocellular carcinomas. In current study, we evaluated the utility of AGXT1 as a diagnostic marker. Immunostains for AGXT1 and arginase-1 were performed in tissue microarrays of 139 hepatocellular carcinomas (HCCs) and 374 gastrointestinal and non-gastrointestinal carcinomas. (Source: Human Pathology)
Source: Human Pathology - June 5, 2018 Category: Pathology Authors: Chaohui Lisa Zhao, Yiang Hui, Li Juan Wang, Dongfang Yang, Evgeny Yakirevich, Shamlal Mangray, Chiung-Kuei Huang, Shaolei Lu Tags: Original Contributions Source Type: research
The phrase NIFTP accentuates, rather than resolves, the current issues with thyroid neoplasia classification —reply
Ricardo V. Lloyd MD, PhD rvlloyd@wisc.edu (Source: Human Pathology)
Source: Human Pathology - June 4, 2018 Category: Pathology Tags: Correspondence Source Type: research
The phrase NIFTP accentuates, rather than resolves, the current issues with thyroid neoplasia classification
Cheng Liu, BmedSci, MBBS, FRCPA john.liu@qimrberghofer.edu.au (Source: Human Pathology)
Source: Human Pathology - June 4, 2018 Category: Pathology Tags: Correspondence Source Type: research
Aberrant expression of stress-induced phosphoprotein 1 in colorectal cancer and its clinicopathologic significance
Stress-Inducible Phosphoprotein1 (STIP1) is an adaptor protein that bridges HSP70 and HSP90 folding and a secretory protein that regulates malignant tumor progression. The aim of the present study was to demonstrate the clinicopathological significance and prognostic role of STIP1 in colorectal cancer (CRC). We used data from The Cancer Genome Atlas (TCGA) to analyze STIP1 expression in CRC and utilized 8 pairs of fresh-frozen tissue samples to investigate STIP1 expression in CRC tissues and adjacent normal tissues using quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays. (Source: Human Pathology)
Source: Human Pathology - June 4, 2018 Category: Pathology Authors: Zhimei Zhang, Hui Ren, Liang Yang, Xinhua Zhang, Wei Liang, Hui Wu, Leilei Huang, Jihui Kang, Jianbo Xu, Ertao Zhai, Shirong Cai, Yulong He Tags: Original Contributions Source Type: research
Masthead
(Source: Human Pathology)
Source: Human Pathology - June 1, 2018 Category: Pathology Source Type: research
Table of Contents
(Source: Human Pathology)
Source: Human Pathology - June 1, 2018 Category: Pathology Source Type: research
Editorial Board
(Source: Human Pathology)
Source: Human Pathology - June 1, 2018 Category: Pathology Source Type: research
In This Issue
(Source: Human Pathology)
Source: Human Pathology - June 1, 2018 Category: Pathology Source Type: research
Frequent expression of somatostatin receptor 2a in olfactory neuroblastomas: a new and distinctive feature
Olfactory neuroblastoma (ONB) is a malignant neuroendocrine neoplasm with a usually slow course, but with considerable recurrence rate. Many neuroendocrine tumors have shown good response to the treatment with somatostatin analogues and somatostatin radioreceptor therapy. In ONBs, there are scarce data on somatostatin-based treatment and the cellular expression of somatostatin receptors (SSTR), the prerequisite for binding and effect of somatostatin on normal and tumor cells. The aim of our study was to investigate the immunohistochemical expression of somatostatin receptor (SSTR) 2A and 5 in a cohort of 40 ONBs. (Source: Human Pathology)
Source: Human Pathology - May 25, 2018 Category: Pathology Authors: Piotr Czapiewski, Micha ł Kunc, Adam Gorczyński, Johannes Haybaeck, Krzysztof Okoń, Joanna Reszec, Anna Lewczuk, Jaroslaw Dzierzanowski, Joanna Karczewska, Wojciech Biernat, Mario Turri-Zanoni, Paolo Castelnuovo, Cecilia Taverna, Alessandro Franchi, St Tags: Original Contributions Source Type: research
Initial diagnosis of insignificant Cancer, HGPIN, ASAP and negative have the same rate of upgrade to Gleason ≥7 on repeat prostate biopsy
Extended prostate needle core biopsies are standard of care for the diagnosis of prostatic carcinoma. Subsequent biopsies may be performed for a variety of indications. Knowledge of biopsy characteristics indicating risk for progression may have utility to guide therapeutic management. Prostate needle core biopsies performed between 2008 –2014 were reviewed. Patients with at least 1 subsequent biopsy were identified. Cases were categorized by worst initial diagnosis. Gleason ≤6 carcinoma was further classified as significant or insignificant with insignificant defined as: ≤2 cores with carcinoma, sites with ≤50% ca...
Source: Human Pathology - May 24, 2018 Category: Pathology Authors: Saranya Prathibha, Kashika G. Goyal, Debra L. Zynger Tags: Original contribution Source Type: research
The diagnostic role of BAP1 in serous effusions
The aim of this study was to analyze the diagnostic role of BAP1 in effusion cytology. Effusions (n=258), consisting of 53 malignant mesotheliomas and 205 other cancers, the majority carcinomas (62 breast, 60 ovarian, 31 lung, 51 carcinomas of other origin, 1 melanoma), were analyzed for BAP1 expression using immunohistochemistry. BAP1 was lost in 46 (87%) mesotheliomas, compared to 4/205 (2%) loss in other cancers (P (Source: Human Pathology)
Source: Human Pathology - May 23, 2018 Category: Pathology Authors: Ben Davidson, Martin T ötsch, Jeremias Wohlschlaeger, Thomas Hager, Maurizio Pinamonti Tags: Original Contributions Source Type: research
