Diagnostic criterion of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): absence of papillae
Pedro Weslley Rosario MD pedrowsrosario@gmail.com (Source: Human Pathology)
Source: Human Pathology - July 5, 2018 Category: Pathology Tags: Correspondence Source Type: research
Co-expression of CDX2 and CK20 in hepatocellular carcinoma, an exceedingly rare co-incidence with potential diagnostic pitfall - reply
Dear Editor, (Source: Human Pathology)
Source: Human Pathology - July 4, 2018 Category: Pathology Authors: Vishal S. Chandan, Sejal S. Shah, Michael S. Torbenson, Tsung-Teh Wu Tags: Correspondence Source Type: research
Clonality assessment of multifocal lung adenocarcinoma by pathology evaluation and molecular analysis
The aim of this study was to explore morphologic and molecular features distinguishing between multifocal lung adenocarcinoma (MLA) and intrapulmonary metastases (IM). Sixteen patients with MLAs, a total of 34 tumors, were reviewed. Four approaches were used: (1) array-comparative genomic hybridization (CGH) as a standard clonality assessment; (2) EGFR and KRAS mutational profiles as a supplementary method; (3) comprehensive histologic assessment (CHA) was method I in pathology evaluation; (4) CHA combined with lepidic (scaling) component analysis was method II. (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Wei Sun, Lin Feng, Xin Yang, Lin Li, Yu Liu, Ning Lv, Dongmei Lin Tags: Original Contributions Source Type: research
Targeted gene sequencing of lynch syndrome-related and sporadic endometrial carcinomas
About one third of endometrial carcinomas (ECs), mainly of endometrioid histology, harbor the mismatch repair (MMR) defects and microsatellite instability (MSI). Among these, ECs arising in women with Lynch Syndrome (LS) account for a large proportion. To date, no somatic genetic analyses have been published comparing LS-ECs with sporadic ECs. In this work, we examined the mutational profiles of a well-characterized series of sporadic and LS-related ECs, performing exonic targeted sequencing of 16 genes mainly involved in MSI ECs. (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Laura Libera, Ilaria Craparotta, Nora Sahnane, Anna Maria Chiaravalli, Laura Mannarino, Roberta Cerutti, Cristina Riva, Sergio Marchini, Daniela Furlan Tags: Declarations of interest: none Source Type: research
Neuropilin-1 (NRP-1) upregulated by IL-6/STAT3 signalling contributes to invasion in pancreatic neuroendocrine neoplasms
In this study, the expression of NRP-1 in pNEN tissue samples and pNEN cell line BON1 was analysed by Western blot, polymerase chain reaction (PCR) and immunocytochemistry upon exposure to interleukin-6 (IL-6). (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Yongchao Yang, Linfei Yang, Yixiong Li Tags: Original Contributions Source Type: research
IgA dominant glomerulonephritis with a membranoproliferative pattern of injury
IgA dominant membranoproliferative glomerulonephritis (MPGN) is a descriptive term for renal biopsies in which differential diagnoses of unusual IgA nephropathy (IgAN), infection-related GN, or other etiologies are considered. We sought to understand clinical and pathologic features of this finding. Native kidney biopsies with IgA dominant immune deposits and diffuse MPGN features without significant exudative features or subepithelial deposits were retrospectively reviewed. Two groups (n=27, 33 biopsies) were identified, patients with chronic liver disease and those without. (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Nicole K. Andeen, J. Ashley Jefferson, Shreeram Akilesh, Charles E. Alpers, Mei Lin Bissonnette, Laura S. Finn, John Higgins, Donald C. Houghton, Neeraja Kambham, Alex Magil, Behzad Najafian, Roberto F. Nicosia, Megan L. Troxell, Kelly D. Smith Tags: Original Contributions Source Type: research
Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma
This study aimed to explore DSN1 expression in HCC tissues and investigated DSN1 functions in HCC cells. We obtained data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) to analyze DSN1 expression in HCC. (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Chengjun Sun, Shanzhou Huang, Weiqiang Ju, Yuchen Hou, Ziming Wang, Youjie Liu, Linwei Wu, Xiaoshun He Tags: Original Contributions Source Type: research
Exploration of BRAFV600E as a diagnostic adjuvant in the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecular features. CPTCPFA frequently harbor the oncogenic variant BRAFV600E while NIFTP and EFVPTC are largely RAS-driven. CPTCPFA have rare papillae and intranuclear pseudoinclusions that may distinguish them from NIFTP or EFVPTC. (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Daniel N. Johnson, Peter M. Sadow Tags: Original Contributions Source Type: research
Atypical mitoses are present in otherwise classical pleomorphic lipomas —reply
To the Editor: (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: David Creytens, Thomas Mentzel, Liesbeth Ferdinande, Joost van Gorp, Jo Van Dorpe, Uta Flucke Tags: Correspondence Source Type: research
Atypical mitoses are present in otherwise classical pleomorphic lipomas
Dear Editor, (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Berrin Babao ğlu, Mustafa Emre Ercin, Kemal Kosemehmetoğlu Tags: Correspondence Source Type: research
Conflicting IDH1/IDH2, ATRX, and 1p/19q results in diffuse gliomas: a commentary
Valeria Barresi, MD, PhD vbarresi@unime.it (See Fig..) (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Tags: Correspondence Source Type: research
Eps8, a therapeutic potential target for cancer
Dear Editor, (Source: Human Pathology)
Source: Human Pathology - July 3, 2018 Category: Pathology Authors: Qianqian Wang, Liu Yong Tags: Correspondence Source Type: research
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall
This study is aimed to: (i) characterize the presence/distribution of benign TdT-positive cells in pediatric and adult reactive lymph nodes; (ii) define the phenotype and nature of such elements. This retrospective study considered 141 reactive lymph nodes from pediatric and adult patients without history of neoplastic disease. (Source: Human Pathology)
Source: Human Pathology - July 2, 2018 Category: Pathology Authors: Marco Pizzi, Stefano Brignola, Simona Righi, Claudio Agostinelli, Clara Bertuzzi, Marta Pillon, Gianpietro Semenzato, Massimo Rugge, Elena Sabattini Tags: Original Contributions Source Type: research
PD-L1 expression in tumor cells and the immunologic milieu of bladder carcinomas: a pathologic review of 165 cases
Programmed death ligand 1 (PD-L1) is a transmembrane protein that plays a major role in immune suppression. Its interaction with the receptor PD-1 results in downregulation of antitumoral immunity. Humanized monoclonal antibodies that interrupt the PD-L1/PD-1 interaction have shown therapeutic efficacy in patients with advanced urothelial cancer. However, immunohistochemical staining of PD-L1 in bladder tumors and its relationship to tumor histologic type, grade, and overall survival has been incompletely analyzed. (Source: Human Pathology)
Source: Human Pathology - July 2, 2018 Category: Pathology Authors: Jonathan J. Davick, Henry F. Frierson, Mark Smolkin, Alejandro A. Gru Tags: Original Contributions Source Type: research
The Role of Next Generation Sequencing in the Differential Diagnosis of Composite Neoplasms
Composite neoplasms (CN) are rare and diagnostically challenging lesions that require differentiating between mixed clonal tumors with divergent phenotypes (MT), collision of two independent tumors adjacent to each other (CT) and tumor-to-tumor metastasis (TTM). To that end, pathologists have traditionally used Immunohistochemistry and limited molecular studies, such as Sanger sequencing. Herein we evaluate the potential application of NGS in the differential diagnosis of these rare neoplasms. Four CNs were included in the study. (Source: Human Pathology)
Source: Human Pathology - June 26, 2018 Category: Pathology Authors: Andres M. Acosta, Mohamed R.H. Al Rasheed, Michael R. Pins, Kristina R. Borgen, Dipti Panchal, Magdalena Rogozinska, Elizabeth L. Wiley, Frederick G. Behm, Gayatry Mohapatra Tags: Original Contributions Source Type: research
