Frozen section evaluation via dynamic real-time non-robotic Telepathology system in a university Cancer center by resident / faculty cooperation team
Frozen section telepathology interpretation experience has been largely limited to practices with locations significantly distant from one another with sporadic need for frozen section diagnosis. In 2010 we established a real-time non-robotic telepathology system in a very active cancer center for daily frozen section service. Herein, we evaluate its accuracy compared to direct microscopic interpretation performed in the main hospital by the same faculty and its cost-efficiency over a 1-year period. (Source: Human Pathology)
Source: Human Pathology - April 30, 2018 Category: Pathology Authors: Aram Vosoughi, Paul Taylor Smith, Joseph A. Zeitouni, Gregori M. Sodeman, Merce Jorda, Carmen Gomez-Fernandez, Monica Garcia-Buitrago, Carol K. Petito, Jennifer R. Chapman, German Campuzano-Zuluaga, Andrew E. Rosenberg, Oleksandr N. Kryvenko Source Type: research
Non-small cell lung cancers with Isocitrate dehydrogenase 1 or 2 (IDH1/2) mutations
In this study, we examine the prevalence and features of non-small cell lung cancers (NSCLC) with IDH1/2 mutations. From May 2013 – March 2017, 800 lung cancer samples were successfully sequenced for s omatic mutations on the Ion Torrent PGM with the 50 gene AmpliSeq Cancer Hotspot Panel v2 on the Ion Torrent PGM (318 chip). (Source: Human Pathology)
Source: Human Pathology - April 30, 2018 Category: Pathology Authors: Laura N. Toth, Francine B. de Abreu, Laura J. Tafe Source Type: research
Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors
Follicular-patterned tumors of the thyroid gland are characterized by a predominantly follicular growth pattern. They frequently harbor RAS mutations, not BRAF mutations. Technological advances in molecular testing have discovered novel RAS-type mutations. However, clinical significance of these mutations remains unknown. We investigated the prevalence and clinical impact of mutations of BRAF, NRAS, HRAS, KRAS, EZH1, EIF1AX, and TERT genes by Sanger sequencing in a series of 201 follicular-patterned thyroid tumors including follicular adenoma (n=40), H ürthle cell adenoma (n=54), noninvasive follicular thyroid neoplasms w...
Source: Human Pathology - April 30, 2018 Category: Pathology Authors: Chan Kwon Jung, Yourha Kim, Sora Jeon, Kwanhoon Jo, Sohee Lee, Ja Seong Bae Tags: Original contribution Source Type: research
Morphological changes induced by Intraprostatic PSA-based vaccine in prostate Cancer biopsies (phase I clinical trial)
This study evaluated the histopathological effects in prostate biopsies of recombinant fowlpox (rF) virus-based vaccine engineered to present the PSA and three costimulatory molecules (collectively labeled as PSA-TRICOM). This vaccine has shown that it can break tolerance of the PSA, and its administration directly into a tumor enables the affected tumor cells to act as antigen-presenting cells activating new T-cells, and broadening the immune response to recognize and kill tumor. (Source: Human Pathology)
Source: Human Pathology - April 28, 2018 Category: Pathology Authors: Maria J Merino, A Peter, Vanessa Moreno, Sara Gil, Jeffrey Schlom, James L Gulley Source Type: research
Histopathological variables in liver metastases of patients with stage IV colorectal cancer: potential prognostic relevance of poorly differentiated clusters
The prognosis of patients with colorectal liver metastases (LM) is mostly established on clinical variables or on the anatomic extent of colorectal cancer (CRC). Histopathological factors of LM which may actually reflect the biological aggressiveness of the tumor are not routinely considered to define the risk of worse clinical outcome in those patients. The number of poorly differentiated clusters (PDC) of neoplastic cells in primary CRC is associated with metastatic risk and bad prognosis, but PDC presence in LM has been barely analyzed thus far. (Source: Human Pathology)
Source: Human Pathology - April 28, 2018 Category: Pathology Authors: Simona Lionti, Luca Reggiani Bonetti, Stefania Bettelli, Andrea Spallanzani, Fabio Gelsomino, Valeria Barresi Source Type: research
Glomeruloid hemangioma associated with TAFRO syndrome
Glomeruloid hemangioma is a rare cutaneous lesion which has been considered as a specific cutaneous marker of POEMS syndrome. Herein, we present the first case of glomeruloid hemangioma associated with TAFRO syndrome, a unique variant of idiopathic multicentric Castleman's disease (iMCD). The patient is a 74-year-old female presented with fever, cervical lymphadenopathy, thrombocytopenia, bilateral pleural effusions and ascites. Biopsy of the lymph node revealed MCD-like histology and bone marrow biopsy showed mild reticulin fibrosis, consistent with TAFRO syndrome. (Source: Human Pathology)
Source: Human Pathology - April 25, 2018 Category: Pathology Authors: Aya Shinozaki-Ushiku, Takaaki Higashihara, Masako Ikemura, Junichiro Sato, Masaomi Nangaku, Tetsuo Ushiku, Masashi Fukayama Source Type: research
Up-regulation of long noncoding RNA M26317 correlates with tumor progression and poor prognosis in gastric cancer
To investigate the expression and clinical significance of long noncoding RNA (lncRNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein-coding genes and lncRNAs in tumor and paired adjacent nontumor tissues. We found that 41 lncRNAs were up-regulated and 31 lncRNAs were down-regulated more than 2-fold in gastric cancer versus noncancerous tissues (ratio>2.0, P (Source: Human Pathology)
Source: Human Pathology - April 23, 2018 Category: Pathology Authors: Li Li, Yuan-Yu Wang, Xiao Zhou Mou, Zai-Yuan Ye, Zhong-Sheng Zhao Tags: Original contribution Source Type: research
Upregulation of long non-coding RNA M26317 correlates with tumor progression and poor prognosis in gastric cancer
To investigate the expression and clinical significance of long non-coding RNA (lnc RNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein coding genes and lncRNAs in tumor and paired adjacent non-tumor tissues. We found that 41 lncRNAs were upregulated and 31 lncRNAs were downregulated more than 2-fold in gastric cancer versus noncancerous tissues (ratio>2.0, P (Source: Human Pathology)
Source: Human Pathology - April 23, 2018 Category: Pathology Authors: Li Li, Yuan-Yu Wang, Xiao Zhou Mou, Zai-Yuan Ye, Zhong-Sheng Zhao Source Type: research
Bim is an Independent Prognostic Marker in Intrahepatic Cholangiocarcinoma
In this study, we investigated the role of an important cell apoptosis initiator, Bcl-2 interacting mediator of cell death (Bim), by evaluating its expression and association with other clinicopathologic features in ICCs. We analyzed 56 cases of ICC with clinical follow-up. The expression of Bim in ICC cells and other cellular components was evaluated by immunohistochemistry. (Source: Human Pathology)
Source: Human Pathology - April 23, 2018 Category: Pathology Authors: Henan Zhang, Sarah M. Jenkins, Chuang-Ta Lee, Susan M. Harrington, Zhuogang Liu, Haidong Dong, Lizhi Zhang Source Type: research
Mucinous intrahepatic cholangiocarcinoma: a distinct variant
Mucinous variant of intrahepatic cholangiocarcinoma (iCC) is rare, and its clinicopathological features and prognosis are far less clear. Six patients who had iCCs with more than 50% of mucinous component and 79 conventional iCCs were included in the study. The mean size of mucinous and conventional iCCs was 6.2cm and 6.0cm, respectively. The majority of patients (83%) with mucinous iCC presented at T3 stage or above, compared to 28% of the conventional group (p (Source: Human Pathology)
Source: Human Pathology - April 23, 2018 Category: Pathology Authors: Zhikai Chi, Amarpreet Bhalla, Omer Saeed, Liang Cheng, Kendra Curless, Hanlin L. Wang, Deepa T. Patil, Jingmei Lin Tags: Original contribution Source Type: research
Upregulation of long non-coding RNA M26317 correlates with tumor progression and poor prognosis in gastric cancer
To investigate the expression and clinical significance of long non-coding RNA (lnc RNA) in gastric cancer, we applied microarray analysis to obtain expression profiles of protein coding genes and lncRNAs in tumor and paired adjacent non-tumor tissues. We found that 41 lncRNAs were upregulated and 31 lncRNAs were downregulated more than 2-fold in gastric cancer versus noncancerous tissues (ratio>2.0, P (Source: Human Pathology)
Source: Human Pathology - April 23, 2018 Category: Pathology Authors: Li Li, Yuan-Yu Wang, Xiao Zhou Mou, Zai-Yuan Ye, Zhong-Sheng Zhao Source Type: research
Bim is an Independent Prognostic Marker in Intrahepatic Cholangiocarcinoma
In this study, we investigated the role of an important cell apoptosis initiator, Bcl-2 interacting mediator of cell death (Bim), by evaluating its expression and association with other clinicopathologic features in ICCs. We analyzed 56 cases of ICC with clinical follow-up. The expression of Bim in ICC cells and other cellular components was evaluated by immunohistochemistry. (Source: Human Pathology)
Source: Human Pathology - April 23, 2018 Category: Pathology Authors: Henan Zhang, Sarah M. Jenkins, Chuang-Ta Lee, Susan M. Harrington, Zhuogang Liu, Haidong Dong, Lizhi Zhang Source Type: research
Mucinous intrahepatic cholangiocarcinoma: a distinct variant
Mucinous variant of intrahepatic cholangiocarcinoma (iCC) is rare, and its clinicopathological features and prognosis are far less clear. Six patients who had iCCs with more than 50% of mucinous component and 79 conventional iCCs were included in the study. The mean size of mucinous and conventional iCCs was 6.2cm and 6.0cm, respectively. The majority of patients (83%) with mucinous iCC presented at T3 stage or above, compared to 28% of the conventional group (p (Source: Human Pathology)
Source: Human Pathology - April 23, 2018 Category: Pathology Authors: Zhikai Chi, Amarpreet Bhalla, Omer Saeed, Liang Cheng, Kendra Curless, Hanlin L. Wang, Deepa T. Patil, Jingmei Lin Tags: Original contribution Source Type: research
Whole-exome sequencing identifies unique mutations and copy number losses in calcifying fibrous tumor of the pleura: report of 3 cases and review of the literature
Calcifying fibrous tumor of the pleura (CFTP) is a rare mesenchymal tumor of unknown pathogenesis. The diagnosis often requires exclusion of other common entities. Our aim was to determine if genomic changes were associated with CFTP that could contribute to mechanisms underlying tumorigenesis. Three cases of CFTP with their corresponding uninvolved control lung tissue were identified. Two patients were male, and 1 was female (age range, 21-32 years). Tumors were multifocal in 2 cases and solitary in 1. (Source: Human Pathology)
Source: Human Pathology - April 21, 2018 Category: Pathology Authors: Mitra Mehrad, William A. LaFramboise, Maureen A. Lyons, Humberto E. Trejo Bittar, Samuel A. Yousem Tags: Original contribution Source Type: research
IL-13 is produced by tumor cells in breast implant –associated anaplastic large cell lymphoma: implications for pathogenesis
More than 500 women worldwide have developed a CD30+ T-cell lymphoma around breast implants, strongly suggesting a cause-and-effect relationship, and designated as breast implant –associated anaplastic large cell lymphoma (BIA-ALCL). The mechanism of lymphomagenesis is unknown. Recently, a bacterial biofilm containing gram-negative bacilli was discovered on the surface of breast implants associated with ALCL. We and others have described overexpression of the proto-oncogen e JUNB and mutations of JAK1/2, TP53 and STAT3 in BIA-ALCL. (Source: Human Pathology)
Source: Human Pathology - April 21, 2018 Category: Pathology Authors: Marshall E. Kadin, John Morgan, Haiying Xu, Alan L. Epstein, David Sieber, Bradley A. Hubbard, William P. Adams, Carlos E. Bacchi, Joao C.S. Goes, Mark W. Clemens, L. Jeffrey Medeiros, Roberto N. Miranda Tags: Original contribution Source Type: research
