Coagulation Failure in Patients With Acute ‐on‐Chronic Liver Failure and Decompensated Cirrhosis: Beyond the International Normalized Ratio
Conclusion: Patients with ACLF frequently show hypocoagulable features with prolonged time to initial fibrin formation and clot formation time and reduced clot firmness; these alterations worsen after admission, correlate with systemic inflammation, and translate into higher short ‐term mortality; hypofibrinolysis could contribute to organ failure in ACLF. (Source: Hepatology)
Source: Hepatology - November 9, 2018 Category: Internal Medicine Authors: Annabel Blasi,
Andrea Calvo,
Ver ónica Prado,
Enric Reverter,
Juan Carlos Reverter,
María Hernández‐Tejero,
Fátima Aziz,
Alex Amoros,
Andres Cardenas,
Javier Fernández Tags: Original Article Source Type: research
Human Leukocyte Antigen F Locus Adjacent Transcript 10 Overexpression Disturbs WISP1 Protein and mRNA Expression to Promote Hepatocellular Carcinoma Progression
Conclusion: Our study demonstrated that overexpression of FAT10 results in expression discordance between WISP1 protein and mRNA, thereby promoting HCC progression by down ‐regulating WISP1 protein expression. (Hepatology 2018; 00:000 ‐000). (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Jinlong Yan,
Jun Lei,
Leifeng Chen,
Huan Deng,
Dingxiang Dong,
Tao Jin,
Xiuxia Liu,
Rongfa Yuan,
Yumin Qiu,
Jin Ge,
Xiaogang Peng,
Jianghua Shao Tags: Original Article Source Type: research
PI3K δ Is a Therapeutic Target in Hepatocellular Carcinoma
Conclusion: Our data identify PI3K δ inhibition, recently approved for the treatment of human B‐cell malignancies, as a potential treatment for HCC. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eunkyong Ko,
Hyun ‐Wook Seo,
Eun Sun Jung,
Soomi Ju,
Baek‐hui Kim,
Hyeki Cho,
Yoon Jun Kim,
Young Min Park,
Jong‐Seo Kim,
Guhung Jung Tags: Original Article Source Type: research
Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma
Conclusion: these findings indicate that human intratumoral CD 96+ NK cells are functionally exhausted and patients with higher intratumoral CD96 expression exhibit poorer clinical outcomes. Blocking CD96 ‐CD155 interaction or TGF‐β1 restores NK cell immunity against tumors by reversing NK cell exhaustion, suggesting a possible therapeutic role of CD96 in fighting liver cancer.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Haoyu Sun,
Qiang Huang,
Mei Huang,
Hao Wen,
Renyong Lin,
Meijuan Zheng,
Kun Qu,
Kun Li,
Haiming Wei,
Weihua Xiao,
Rui Sun,
Zhigang Tian,
Cheng Sun Tags: Original Article Source Type: research
The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis
Conclusion: AREG ‐EGFR signaling protects from cholestatic injury and participates in the physiological regulation of BA synthesis.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eva Santamar ía,
Carlos M Rodríguez‐Ortigosa,
Iker Uriarte,
Maria U Latasa,
Raquel Urtasun,
Gloria Alvarez‐Sola,
Marina Bárcena‐Varela,
Leticia Colyn,
Sara Arcelus,
Maddalen Jiménez,
Kathleen Deutschmann,
Ana Peleteiro‐Vigil,
Julia Tags: Original Article Source Type: research
Human Leukocyte Antigen F Locus Adjacent Transcript 10 Overexpression Disturbs WISP1 Protein and mRNA Expression to Promote Hepatocellular Carcinoma Progression
Conclusion: Our study demonstrated that overexpression of FAT10 results in expression discordance between WISP1 protein and mRNA, thereby promoting HCC progression by down ‐regulating WISP1 protein expression. (Hepatology 2018; 00:000 ‐000). (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Jinlong Yan,
Jun Lei,
Leifeng Chen,
Huan Deng,
Dingxiang Dong,
Tao Jin,
Xiuxia Liu,
Rongfa Yuan,
Yumin Qiu,
Jin Ge,
Xiaogang Peng,
Jianghua Shao Tags: Original Article Source Type: research
PI3K δ Is a Therapeutic Target in Hepatocellular Carcinoma
Conclusion: Our data identify PI3K δ inhibition, recently approved for the treatment of human B‐cell malignancies, as a potential treatment for HCC. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eunkyong Ko,
Hyun ‐Wook Seo,
Eun Sun Jung,
Soomi Ju,
Baek‐hui Kim,
Hyeki Cho,
Yoon Jun Kim,
Young Min Park,
Jong‐Seo Kim,
Guhung Jung Tags: Original Article Source Type: research
Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma
Conclusion: these findings indicate that human intratumoral CD 96+ NK cells are functionally exhausted and patients with higher intratumoral CD96 expression exhibit poorer clinical outcomes. Blocking CD96 ‐CD155 interaction or TGF‐β1 restores NK cell immunity against tumors by reversing NK cell exhaustion, suggesting a possible therapeutic role of CD96 in fighting liver cancer.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Haoyu Sun,
Qiang Huang,
Mei Huang,
Hao Wen,
Renyong Lin,
Meijuan Zheng,
Kun Qu,
Kun Li,
Haiming Wei,
Weihua Xiao,
Rui Sun,
Zhigang Tian,
Cheng Sun Tags: Original Article Source Type: research
The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis
Conclusion: AREG ‐EGFR signaling protects from cholestatic injury and participates in the physiological regulation of BA synthesis.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 8, 2018 Category: Internal Medicine Authors: Eva Santamar ía,
Carlos M Rodríguez‐Ortigosa,
Iker Uriarte,
Maria U Latasa,
Raquel Urtasun,
Gloria Alvarez‐Sola,
Marina Bárcena‐Varela,
Leticia Colyn,
Sara Arcelus,
Maddalen Jiménez,
Kathleen Deutschmann,
Ana Peleteiro‐Vigil,
Julia Tags: Original Article Source Type: research
Estimating Prevalence of Hepatitis C Virus Infection in the United States, 2013 ‐2016
Conclusion: Over 2 million people in the United States had current HCV infection during 2013 ‐2016; compared to past estimates based on similar methodology, HCV antibody prevalence may have increased, while RNA prevalence may have decreased, likely reflecting the combination of the opioid crisis, curative treatment for HCV infection, and mortality among the HCV‐infected population; effo rts on multiple fronts are needed to combat the evolving HCV epidemic, including increasing capacity for and access to HCV testing, linkage to care, and cure. (Source: Hepatology)
Source: Hepatology - November 6, 2018 Category: Internal Medicine Authors: Megan G. Hofmeister,
Elizabeth M. Rosenthal,
Laurie K. Barker,
Eli S. Rosenberg,
Meredith A. Barranco,
Eric W. Hall,
Brian R. Edlin,
Jonathan Mermin,
John W. Ward,
A. Blythe Ryerson Tags: Original Article Source Type: research
Immunosuppression minimization trials in liver transplantation: can we predict humoral response to asses eligibility?
This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Magdalena Meszaros,
Jose Ursic ‐Bedoya,
Stéphanie Faure,
Georges‐Philippe Pageaux Tags: Correspondence Source Type: research
A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
Conclusion AATF drives NAFLD and hepatocarcinogenesis, offering a potential target for therapeutic intervention.This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Divya P. Kumar,
Prasanna K. Santhekadur,
Mulugeta Seneshaw,
Faridoddin Mirshahi,
Cora Uram Tuculescu,
Arun J. Sanyal Tags: Original Article Source Type: research
B Cell ‐Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration
Conclusion: We identified CD169+ cells to be a central trigger for liver regeneration, by inducing key signaling pathways important for liver regeneration. (Source: Hepatology)
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Kristina Behnke,
Yuan Zhuang,
Haifeng C. Xu,
Balamurugan Sundaram,
Maria Reich,
Prashant V. Shinde,
Jun Huang,
Nastaran Fazel Modares,
Alexei V. Tumanov,
Robin Polz,
J ürgen Scheller,
Carl F. Ware,
Klaus Pfeffer,
Verena Keitel,
Dieter Häus Tags: Original Article Source Type: research
