Is an accessory nipple associated with an intrapancreatic accessory spleen?
We described a rare case of a male patient with a unilateral accessory nipple and a solitary hypervascular lesion in the pancreas. The patient underwent a distal pancreaticosplenectomy, and IPAS was finally diagnosed. An accessory nipple has limited clinical value. Nevertheless, it may suggest a congenital anomaly in the body and may be associated with other inherited diseases. The case indicates that IPAS should be considered in an individual with accessory organs if he or she is diagnosed with a solitary hypervascular lesion in the pancreas. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - October 1, 2019 Category: Gastroenterology Source Type: research

Clinical value of circular RNAs and autophagy-related miRNAs in the diagnosis and treatment of pancreatic cancer
CONCLUSIONScircRNAs act as the miRNA sponges and there is an association between miRNAs and autophagy, which provides a new concept to broaden the knowledge about the mechanisms underlying the development, progression and metastasis of pancreatic cancer. Additionally, clinical value of circRNAs and autophagy-related miRNAs in the diagnosis and treatment of pancreatic cancer would be further verified with in-depth researches. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 29, 2019 Category: Gastroenterology Source Type: research

Endoscopic ultrasound-guided drainage of pancreatic fluid collections: The impact of evolving experience and new technologies in diagnosis and treatment over the last two decades
ConclusionsDuring our long-term survey using EUS-guided endoscopic drainage of PFCs, significantly better outcomes in term of improved success rate and decrease complications rate were observed during the late period. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 29, 2019 Category: Gastroenterology Source Type: research

Factors associated with failure of enhanced recovery after surgery (ERAS) program in patients undergoing pancreaticoduodenectomy
ConclusionsPatients with high ASA score, low ALB level or age>70 years were at high risk of ERAS failure in pancreaticoduodenectomy. These preoperative demographic and clinical characteristics are important determinants to obtain successful postoperative recovery in ERAS program. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 14, 2019 Category: Gastroenterology Source Type: research

Six2 is negatively correlated with prognosis and facilitates epithelial-mesenchymal transition via TGF-β/Smad signal pathway in hepatocellular carcinoma
ConclusionsElevated Six2 expression in HCC tumor patients was associated with negative prognosis. Upregulated Six2 promoted tumor growth and facilitated HCC metastasis via TGF-β/Smad signal pathway. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 14, 2019 Category: Gastroenterology Source Type: research

PD-1 inhibitors monotherapy in hepatocellular carcinoma: meta-analysis and systematic review
ConclusionsPembrolizumab and nivolumab are the only checkpoint inhibitors with data in HCC. Meta-analysis of their effectiveness discloses rates not dissimilar to other systemic therapies available for this disease. Of interest also are the observed long responses in a sub-set of responders. Further development is clearly warranted. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 14, 2019 Category: Gastroenterology Source Type: research

Hemobilia with acute pancreatitis secondary to biliary tract infection
Publication date: Available online 12 September 2019Source: Hepatobiliary & Pancreatic Diseases InternationalAuthor(s): Dong-Bao Li, Zu-Xiong Tang, Jian-Xin Ye, Zhi Li, Xiao-Hua Yang, Lei Qin, Hua Zhao (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 13, 2019 Category: Gastroenterology Source Type: research

Bile acid synthetic defects: simplified approach in a nutshell
Publication date: Available online 12 September 2019Source: Hepatobiliary & Pancreatic Diseases InternationalAuthor(s): Aathira Ravindranath, Moinak Sen Sarma, Surender Kumar Yachha (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 13, 2019 Category: Gastroenterology Source Type: research

Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients
ConclusionsEUS-EA is a safe procedure with a very low rate of severe AEs. It seems possible to predict the AEs according to the features of the procedure and PCLs. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 12, 2019 Category: Gastroenterology Source Type: research

Long-term outcomes after hepatectomy of huge hepatocellular carcinoma: A single-center experience in China
ConclusionsHuge HCC is not a contraindication of hepatectomy. Although most of these patients experienced recurrence after surgery, OS and DFS were not significantly different from those of patients with large HCC after resection. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - September 12, 2019 Category: Gastroenterology Source Type: research

Secondary non-resectable liver tumors: A single-center living-donor and deceased-donor liver transplantation case series
ConclusionsThe more recent LDLT series compared favorably to our DDLT series in the treatment of secondary liver malignancies. The absence of portal hypertension and the use of smaller left grafts make recipient and donor surgeries safe. The safety of the procedures and lack of interference with the scarce allograft pool are expected to lead to a more frequent use of LDLT in the field of transplant oncology. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - August 26, 2019 Category: Gastroenterology Source Type: research

Retinoblastoma binding protein 4 up-regulation is correlated with hepatic metastasis and poor prognosis in colon cancer patients
ConclusionsRBBP4 was upregulated in the colon cancer. RBBP4 may be a novel predictor for poor prognosis of colon cancer and colon cancer hepatic metastasis. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - August 24, 2019 Category: Gastroenterology Source Type: research

Acute onset of autoimmune hepatitis in children and adolescents
ConclusionRapid and accurate diagnosis of A-AIH may be difficult. However, timely start of immunosuppressive therapy improves prognosis and decreases number of indicated liver transplantations in children with AIH. (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - August 24, 2019 Category: Gastroenterology Source Type: research

Mismatch repair proteins and microsatellite instability in solid pseudopapillary neoplasm of the pancreas
Publication date: Available online 22 August 2019Source: Hepatobiliary & Pancreatic Diseases InternationalAuthor(s): Claudia Covelli, Paola Parente, Francesco Pepe, Pasquale Pisapia, Fabiola Fiordelisi, Umberto Malapelle (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - August 24, 2019 Category: Gastroenterology Source Type: research

Accuracy of pipeline blood glucose monitoring in patients with severe liver injury undergoing artificial liver support system treatment
Publication date: Available online 22 August 2019Source: Hepatobiliary & Pancreatic Diseases InternationalAuthor(s): Hua-Fen Zhang, Zhong-Yang Xie, Xiao-Xi Ouyang, Xiao-Wei Xu, Xiao-Yan Wang, Jian-Rong Huang, Lan-Juan Li (Source: Hepatobiliary and Pancreatic Diseases International)
Source: Hepatobiliary and Pancreatic Diseases International - August 24, 2019 Category: Gastroenterology Source Type: research