Expression of excision repair cross-complementation group 1 (ERCC1), ribonucleotide reductase M1 (RRM1) and class III beta-tubulin in head and neck carcinoma and its clinical significance.
Conclusions:Unlike lung carcinoma, expression of ERCC1 or RRM1 did not correlate with clinical parameters or HPV status. However, p16 and TUBB3 might be useful predictive biomarkers in HNCa. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Sublingual gland flap for reconstruction of anterior and antero-lateral floor of mouth defects.
Conclusions:
The sublingual flap should be considered as a reliable reconstructive option for most T1 and smaller T2 lesions for the anterior and antero-lateral floor of mouth or mandible. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Effects of oral glutamine on radiation-induced laryngeal mucosal damage.
Conclusion: Glutamine can accelerate mucosal healing and regeneration in laryngeal mucosa after experimental head and neck irradiation. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Radiobiological and quality of life study of conventional and accelerated fractionated radiotherapy in patients with head and neck squamous cell carcinoma: Correlation of efficacy with cell cycle analysis parameters.
Conclusions
This study identified that both radiotherapy arms were equivalent in terms of QoL and toxicity. The number of cells in S phase correlated negatively but not-significantly with overall survival. A statistical significant improvement of quality of life was observed one month after the end of irradiation in both arms. More patients with eligible for analysis specimens are needed for the extraction of safe results. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Clinical optical coherence tomography in head and neck oncology: overview and outlook.
Objective
Optical coherence tomography is a high-resolution and minimally invasive optical imaging method, which provides in vivo cross-sectional images of living tissue in real-time. Our intention is to present a contemporary and comprehensive review on the role of optical coherence tomography in head and neck oncology.
Recent findings
Promising results have been published in small, single-centre studies applying optical coherence tomography in clinical settings for the diagnostic workup of superficial pathologies of the upper aerodigestive tract, showing that it can be a helpful adjunct to standard white l...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Expression of Epstein-Barr virus-encoded BamH1a rightward transcript 7 microRNA in nasopharyngeal carcinoma cells modulates the responsiveness to irradiation treatment.
Conclusion
Our results suggest that patients with nasopharyngeal carcinoma have elevated ebv-miR-BART7 expression levels in the primary and recurrent nasopharyngeal carcinoma tissues. Higher expression of ebv-miR-BART7 increased the sensitivity of nasopharyngeal carcinoma cells to irradiation treatment. Further investigation with regard to the clinical value of ebv-miR-BART7 to aid therapeutic response is warranted in order to evaluate the potential use of ebv-miR-BART7 as a molecular biomarker in monitoring patients with nasopharyngeal carcinoma. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Sustained remission of relapsed high-grade mucoepidermoid carcinoma of the parotid gland following multimodal treatment including epidermal growth factor receptorantibody cetuximab and autologous haematopoietic stem cell transplantation.
In this report we are presenting the case of an 18-year-old adolescent with a high grade mucoepidermoid carcinoma of the parotid gland, suffering from multiple local and distinct relapses despite adequate surgical and radiation treatment.
After initial treatment with surgery and radiation the patient showed local and distant metastases. He received a novel multimodal treatment including epidermal growth factor receptor-antibody cetuximab in combination with cisplatin leading to partial remission followed with consolidating chemotherapy including ifosfamid, cisplatin and adriamycin. Due to the high risk of recurrent disea...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Relationship between histological and computer-based assessment of melanoma diameter and thickness in head versus trunk melanomas.
Conclusion
Melanoma diameter should be assessed digitally to avoid tissue shrinkage after biopsy and imprecise in vivo measurements. Although nearly 10% of melanomas might escape an early diagnosis based only on the D parameter of the ABCD rule (diameter), melanoma diameter maybe related to its thickness. Evaluation with a computer vision system should be recommended for small pigmented lesions (<6mm) in order to reduce the percentage of misdiagnosed smaller melanomas and to better evaluate the parameter E of the ABCDE rule (evolving lesion). (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Aggressive course of carcinoma showing thymus-like differentiation with distant metastasis and temporary activity of cisplatin and irinotecan.
Introduction
Carcinoma showing thymus-like differentiation is a rare type of thyroid cancer arising from a remnant of thymic epithelium. Patients with carcinoma showing thymus-like differentiation have a relatively better prognosis when diagnosed in the early stage. Surgery plays a crucial role, and patients with metastatic carcinoma showing thymus-like differentiation are treated with chemotherapy; however, metastatic carcinoma showing thymus-like differentiation is reported to be refractory to chemotherapy.
Case report
A 54-year-old male patient presented with hoarseness and a left cervical tumour. The pat...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Lymph node ratio as a survival risk factor for oropharyngeal squamous cell carcinoma patients with lymph node metastasis: A surveillance, epidemiology and end results-based analysis.
Conclusion
Lymph node ratio is a significant prognostic factor for the survival of oropharyngeal cancer patients and should be used for postoperative staging to complement the N classification of oropharyngeal cancer. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
The clinical utility of narrow band imaging in the surveillance of mucosa and submucosa lesions in head and neck regions.
Conclusion
The diagnostic value of NBI varies in different anatomical locations of head and neck. In comparison with the WLI, NBI offers better diagnostic value in the screening of carcinoma originating from the head and neck mucosa and the use of NBI in complement with the conventional WLI in head and neck cancer screening is recommended. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
New perspectives to respiratory tract cancers.
Respiratory tract cancers (RTCs) which include the lung and head and neck squamous cell carcinoma are public health problem with incidence and mortality rates among the highest in the world. In order to reduce the health burden of RTCs, effective public health measures should be put in place.A strategy to achieve this goal could be explored using risk prediction modelling. DNA methylation and microRNAs have rapidly emerged as potential biomarkers for assessing the risk of early development and therapeutic stratification of various types of cancer. The integration of biomarkers in the development of risk prediction algorith...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Multidisciplinary approach of head and neck cancer in the elderly: an update.
Squamous-cell carcinoma of the head and neck (SCCHN) represents the sixth most common malignancy and accounts for approximately 6% of new cancer cases annually worldwide. Although the majority of cases occur between the fifth and sixth decades of life, their onset in patients older than 60 years is not rare and up to one fourth of SCCHN cases are diagnosed in patients older that 70 years. As the elderly population with SCCHN is constantly growing and as elderly cancer patients are severely under-represented in clinical trials, there is a clear need to address the particular aspects of this specific patient group, especiall...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Head and neck robotic surgery: Pros and Cons.
Robotic surgery was introduced to the head and neck area in 2005, following urological, gynaecological and cardiothoracic robotic procedures. It has subsequently become very widely used. We review the pros and cons of robotic surgery, along with the development history focusing on head and neck procedures. While continued refinements to robotic surgery will likely overcome its present limitations, patients need to be apprised of the current limitations as well as the evidence regarding its technical and oncological safety. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
A phase II study of hydroxyurea combined with gemcitabine in patients with head and neck squamous carcinoma and gene expression profiles correlated to poor response.
Conclusions
The combination of HU and gemcitabine may be useful in HNSCC control with reasonable tolerance and toxicity. Based on gene expression profiles, a subset of patients may be potentially identified to gain increased treatment benefits. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
