Management of oral carcinoma in a patient with severe trimus using a novel approach.
Trismus is often present in patients diagnosed with oral malignancy. Trismus is a debilitating condition and is treated adequately with release of fibrosis and interposition of vascularised tissue to provide long term improvement in mouth opening. Treatment of an oral cancer in a patient with trismus becomes challenging because of difficult access and further deterioration of mouth opening following treatment of the malignancy. Herein we describe the planning of access and management of oral carcinoma with severe trismus using nasolabial flaps. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Bilateral dentigerous cyst in non-syndromic patient: Case report and review of literature.
The objective of this work is to report a case of bilateral dentigerous cyst in the anterior region of the maxilla in a 43 years-old woman referred to the oral and maxillofacial surgery department, Dentistry Faculty of Bauru, University of São Paulo with absence of the upper canine teeth. Radiographic examination showed the teeth impacted maxillary cuspids and two unilocular radiolucent independent. Incisional biopsy was performed and the diagnosis of lesions was of dentigerous cyst. The proposed treatment was surgical enucleation of the cyst and the removal of impacted teeth under general anesthesia. Th...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Assessment of voice related quality of life and its correlation with socioeconomic status after total laryngectomy.
Conclusion- VHI and V-RQOL scores in our series were superior to other studies due to major population with lower socioeconomic status and better social support which exists in our society. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
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(Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Human papilloma virus in head and neck carcinoma: Experience from a regional cancer center in Gujarat.
Conclusion: The SCC of Head and Neck had 20% of HPV types. Different HPV types were HPV16, 33, 39, 45,52 and 58. Though the biopsies were from carcinomas, our study did not show that there is 100% co-relation of HPV as a sole etiological agent in the genesis of the squamous cell carcinoma. Oral cancers occurred typically in > 50yrs of age and, old heavy drinkers and heavy smokers. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Adenomatoid odontogenic tumour: hamartoma or neoplasm? A contribution to debate.
This study aimed at understanding the biological and cellular mechanisms in this tumour. Eight formalin fixed paraffin embedded blocks of AOT were studied by immunohistochemical staining for proteins p63 and Ki-67 using the System EnVision System™ (Dako Cytomation, Glostrup, Denmark). The analysis was performed considering the distribution of immunoreactivity, and using scores: - (0 to 5% of positive cells); +1 (6-25% positive cells) +2 (26-50% positive cells); 3 + (> 50% positive cells). All the 8 cases examined were positive for proteins p63 and Ki-67. Expression of p63 protein was intensive and involved all cel...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Prognostic factors and survival in patients with squamous cell carcinoma lymph nodes metastases from an unknown primary to the head and neck.
Conclusions. N classification and recurrence were independent prognostic factor that influenced the treatment outcome. Our data indicate that combined surgery and postoperative radiotherapy for CUP offers the best chance for long-term survival. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Expression of hypoxia inducible factor-1 alpha (HIF-1α) in oral squamous cell carcinoma and its correlation with neoangiogenesis and 3-year survival from the disease.
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. OSCC falls into a larger category known as head and neck squamous cell carcinomas (HNSCCs). This collection constitutes all squamous cell carcinomas of the oral cavity, larynx, pharynx and oesophagus of which OSCC is the most common. Cancer cells involve morphological cellular transformation, dysregulation of apoptosis, uncontrolled cellular proliferation, invasion, angiogenesis, and metastasis. Also, one of the hallmarks of cancer is the elevated uptake of glucose even under normal oxygen conditions, known as aerobic glycolysis or the “Wa...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Volumetric variations and the effects of these differences on dosimetry during the course of volumetric modulated arc therapy for head and neck cancer.
CONCLUSION:Significant changes were observed in the volume of target and parotid glands despite it not reflected much in dosimetry. A new CT scan can be recommended to evaluate for an adaptive plan in 5th week in the absence of clinically usable online correction methods. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Evidence-based analysis: The rise and fall of Head and Neck Oncology I: the audit and subsequent investigations.
Head and Neck Oncology, an open access journal with a closed peer-review system, achieved its first official impact factor on the 2nd of July, 2012. As a result, it achieved the prestigious status of boasting the highest impact factor of any journal in the head and neck discipline in the world.
On the 4th of July, 2012 BioMed Central (the former publisher of the journal) reported serious editorial misconduct following an unannounced internal audit.
On the 6th of July, 2012 BioMed Central asked all four Editors-in-chief to stand down or face serious consequences. BioMed Central also stated that they were looking for r...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Canalicular adenoma of parotid: A cytology diagnosis and review of literature.
We describe an unusual case of canalicular adenoma of parotid gland in a women aged 24 years who presented with slightly painful, firm parotid swelling since 6 years duration. Fine needle aspiration cytology of nodule revealed a benign neoplasm and cytological diagnosis of canalicular adenoma was made. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Radical management of solid ameloblastoma of the mandible: Report of a case with 5-year follow-up.
Conclusion:Correct surgical planning is the key for successful management of solid ameloblastoma with multilocular features, which is best treated using radical resection with immediate reconstruction, which ensures complete tumor excision, prevents recurrence, and enables fast and safe dental rehabilitation. Biomedical prototypes should be used since they provide acceptable precision and are useful for surgical planning. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
The dilemma of microinvasion.
Microinvasive oral squamous cell carcinoma is an early stage malignant tumor showing invasion of the epithelial cells confined to the superficial lamina propria without invasion of the deeper structures and are diagnosed mainly based on certain pre-defined histopathological criteria. Such lesions are generally a matter of debate in respect to the clinical presentation, metastatic ability, therapeutic intervention and prognosis. This short communication attempts to compile the available information regarding microinvasive oral squamous cell carcinoma and highlight the importance of efficient communication to the clinician r...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Malignant peripheral nerve sheath tumour of the tongue: A rare presentation with an unusual pattern of recurrence.
We present a rare case of MPNST of the tongue in a gentleman who presented with features of hypoglossal nerve palsy. Excisional biopsy showed a malignant spindle cell tumor in the sub-epithelial connective tissue. The tumour cells were immunopositive for S-100 and Vimentin while immunonegative for pan-cytokeratin, smooth muscle actin (SMA) and desmin. He underwent surgery followed by adjuvant chemo-radiation. Later the disease recurred in the form of isolated pelvic bone metastasis. Palliative chemotherapy was offered to him. With this case report we intend to refer to such unusual presentation and pattern of recurre...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
Unusual peritoneal relapses in human papilloma virus related oropharyngeal squamous cell carcinoma.
Conclusions:HPV associated oropharyngeal cancer appears to be associated with unusual patterns of relapse, including peritoneal metastases. Thus, patients presenting with abdominal pain or bowel obstruction with a previous history of HPV associated oropharyngeal cancer should be investigated for possible metastatic involvement. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research
