ERIGO: a possible strategy to treat orthostatic hypotension in progressive supranuclear palsy? A feasibility study.
Authors: Sorbera C, Portaro S, Cimino V, Leo A, Accorinti M, Silvestri G, Bramanti P, Naro A, Calabrò RS Abstract Progressive supranuclear palsy (PSP) is a neurodegenerative disease of the central nervous system, presenting with different clinical phenotypes, all involving the extrapyramidal system. Orthostatic hypotension (OH) is a common symptom of cardiovascular autonomic dysfunction. OH is defined as a fall in systolic blood pressure of at least 20 mmHg and/or a fall in diastolic blood pressure of at least 10 mmHg on standing or head-up tilt. In this pilot study, we tested the feasibility and efficacy...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Influence of neurorehabilitation on stroke-induced modifications of the quadriceps muscle in elderly subacute stroke patients with paresis.
Authors: Ciancarelli I, Mariangeli F, Tonin P, Ciofani E, Garo ML, Ciancarelli MGT Abstract The influence of intensive multifunctional neurorehabilitation on post-stroke changes at the level of the paretic leg quadriceps muscle was examined in elderly subacute stroke patients. We assessed paretic leg muscle mass thickness and muscle fatty infiltration thickness, as well as clinical outcome measures (National Institutes of Health Stroke Scale, modified Ranking Scale, and Barthel Index) both before and after neurorehabilitation. Improved outcome measures (p ≤ 0.01) and increased muscle mass thickness (p = ...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Motor cortex function in fibromyalgia: a pilot study involving near-infrared spectroscopy and co-recording of laser-evoked potentials.
Authors: Gentile E, Ricci K, Delussi M, de Tommaso M Abstract Interaction between the motor and nociceptive systems seems to play an important role in chronic pain. In this pilot study we used a combination of functional near-infrared spectroscopy (FNIRS) and laserevoked potentials (LEPs) during concurrent finger tapping task and noxious laser stimulation in fibromyalgia (FM) patients and controls. The study included 9 healthy subjects and 15 FM patients. During concurrent FNIRS and LEP recording, participants were required either to remain in resting relaxed condition or to execute a finger tapping task w...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Low back pain related to a sacral insufficiency fracture: role of paravertebral oxygen-ozone therapy in a paradigmatic case of nociplastic pain.
We describe the case of a 68-year-old woman with an acute episode of severe low back pain (LBP) resistant to opioids, who had experienced a sacral insufficiency fracture (SIF) two years earlier. At clinical examination, patient reported constant, dull, non-localizable pain at lumbar and sacral level, exacerbated by paravertebral palpation, particularly at L4-L5 and the sacroiliac joint, with a concomitant and remittent neuropathic component, difficult to localize at lumbar and sacral level. The latest magnetic resonance imaging study revealed disc herniations at L3-L4, L4-L5, and L5-S1 levels. The patient was treated with ...
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Rehabilitation assisted by robotic and electromechanical devices for persons with neurological disabilities: an Italian consensus conference.
Authors: Boldrini P, Bonaiuti D, Mazzoleni S, Posteraro F PMID: 31556393 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - September 28, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Robots for stroke rehabilitation: not all that glitters is gold.
Authors: Morone G PMID: 31172933 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Visual-spatial training in patients with sub-acute stroke without neglect: a randomized, single-blind controlled trial.
Authors: Tramontano M, Dell'Uomo D, Cinnera AM, Luciani C, Di Lorenzo C, Marcotulli M, Vona F, Mercuro A, Abbruzzese S Abstract Many people who have suffered a stroke will experience sensorimotor impairments that disrupt their performance of motor skills, including balance and gait. Furthermore, stroke-induced brain damage can Result in visual disorders that may significantly impact performance of normal daily activities. The primary aim of this study was to investigate the effects, on balance, of visual-spatial training as an add-on intervention to conventional neurorehabilitation in patients with subacut...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Hearing and cognitive impairment: a functional evaluation of associative brain areas in patients affected by Alzheimer's disease.
We examined 131 diagnosed AD patients and a control group (CG) of 36 normal subjects. After a complete clinical investigation, focused on hearing function, all subjects underwent a brain FDG PET/CT. AD subjects vs CG showed reduced glucose consumption in BA 6,7,8,39, whereas we did not find differences in the primary auditory cortex. In AD, connectivity analyses showed a positive correlation of the primary auditory cortex with BA 6,8,21,31,39,40,42 and a negative correlation with BA 19, cerebellum and basal ganglia. Our findings suggest that neurological evaluation of patients with hearing loss might allow earlier (preclin...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

The role of Personal KinetiGraph ™ fluctuator score in quantifying the progression of motor fluctuations in Parkinson's disease.
In conclusion, PKG FS can distinguish EF from TF, as well as dyskinetic from non-dyskinetic patients, but cannot discriminate subtler MF. PKG may provide objective MF measures for routine PD management and clinical trials. PMID: 31172936 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Evaluation of the psychometric properties of the Barthel Index in an Italian ischemic stroke population in the acute phase: a cross-sectional study.
This study demonstrates the psychometric properties of the IcaBI in an Italian stroke population, and therefore shows that the scale can be considered a valid and reliable assessment tool for measuring functional disability in Italian acute ischemic stroke survivors. PMID: 31172937 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Augmentative and alternative communication improves quality of life in the early stages of amyotrophic lateral sclerosis.
In conclusion, in this study we highlighted how early AAC-T in patients with ALS may be a valuable tool to demonstrate how specific strategies and low-technology aids can improve QoL of these patients and their caregivers, also decreasing stress and depression. PMID: 31172938 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Effectiveness of intensive neurorehabilitation in obese subacute stroke patients.
Authors: Ciancarelli I, Tonin P, Garo ML, Tozzi Ciancarelli MG Abstract The relationship between abdominal subcutaneous adipose tissue thickness (aSAT), body fat percentage (BFP), waist-to-hip ratio (WHR) and body mass index (BMI) and outcome measures of neurological deficit and functional recovery was evaluated in obese subacute stroke patients before and after neurorehabilitation. Decreased National Institutes of Health Stroke Scale (p = 0.0001) and modified Rankin Scale (mRS) (p= 0.002) scores, as well as increased Barthel Index (p= 0.0001) scores were detected after neurorehabilitation. Decreased BMI, ...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

A novel neurocognitive rehabilitation tool in the recovery of hemiplegic hand grip after stroke: a case report.
Authors: Paolucci T, Capobianco SV, Vinciguerra SM, Cilli M, Villani C, Saraceni VM Abstract Stroke has significant physical, psychological and social consequences. Recent rehabilitation approaches suggest that cognitive exercises with dual-task (sensory-motor) exercises positively influence the recovery and function of the hemiplegic hand grip. The purpose of this study was to describe a rehabilitation protocol involving the use of a new neurocognitive tool called "UOVO" for hand grip recovery after stroke. A 58-year-old right-handed male patient in the chronic stage of stroke, presenting with left-sided ...
Source: Functional Neurology - June 9, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Music and neurorehabilitation: Yes, we can!
Authors: Raglio A Abstract PMID: 30663962 [PubMed - in process] (Source: Functional Neurology)
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research

Clinical and neuroimaging spectrum of hyperglycemia-associated chorea-ballism: systematic review and exploratory analysis of case reports.
Authors: Gómez-Ochoa SA, Espín-Chico BB, Pinilla-Monsalve GD, Kaas BM, Téllez-Mosquera LE Abstract Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome occurring predominantly in elderly females and in the setting of non-ketotic hyperglycemia (NKH). A systematic review was conducted in accordance with the PRISMA statement. Studies published between 1980 and 2018 that reported demographic, clinical, laboratory and imaging features from patients with HCB were screened. 136 studies describing 286 patients were included in the analysis. The patients included had a median age ...
Source: Functional Neurology - January 23, 2019 Category: Neurology Tags: Funct Neurol Source Type: research