Editorial Board
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 11, 2018 Category: Environmental Health Source Type: research

Titanium dioxide nanoparticles induce mouse hippocampal neuron apoptosis via oxidative stress- and calcium imbalance-mediated endoplasmic reticulum stress
Publication date: Available online 10 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Qiong He, Xuejiao Zhou, Yang Liu, Wenfeng Gou, Jiahui Cui, Zengqiang Li, Yingliang Wu, Daiying ZuoAbstractThe purpose of this study was to explore the potential neurotoxicity and the underlying mechanism of titanium dioxide nanoparticles (TiO2-NPs) to mouse hippocampal neuron HT22 cells. We found that TiO2-NPs had concentration-dependent and time-dependent cytotoxicities to HT22 cells by the MTT assay. Propidium iodide (PI) staining with FACScan flow cytometry proved that TiO2-NPs dose-dependently increased the apop...
Source: Environmental Toxicology and Pharmacology - August 10, 2018 Category: Environmental Health Source Type: research

Cytotoxic and genotoxic effects of antihypertensives distributed in brazil by social programs: are they safe?
Publication date: Available online 9 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, E. Michel Mansur MachadoAbstractHypertension, a chronic non-transmissible multifactorial condition, it is highly frequent in Brazil, affecting about 32.5% of the population over 25 years of age. It is characterized by the sustained increase in systolic and diastolic blood pressure levels above 140 mmHg and 90 mmHg, respectively. I...
Source: Environmental Toxicology and Pharmacology - August 10, 2018 Category: Environmental Health Source Type: research

MicroRNA-375 inhibits the proliferation, migration and invasion of kidney cancer cells by triggering apoptosis and modulation of PDK1 expression
In this study we investigated the potential of miR-375 as the therapeutic target for the treatment of Kidney cancer. The results revealed that miR-375 is significantly downregulated in the Kidney cancer cells. To investigate the role therapeutic potential of miR-375, one kidney cancer cell line (A-498) was selected for further experimentation. It was observed that overexpression of miR-375 inhibits A-498 kidney cancer proliferation by induction of apoptosis. In addition, overexpression of miR-375 causes suppression of migration and invasion of the A-498 kidney cancers cells. Bioinformatic analysis revealed PDK1 to be putat...
Source: Environmental Toxicology and Pharmacology - August 8, 2018 Category: Environmental Health Source Type: research

Effects and mechanisms of sub-chronic exposure to Copper nanoparticles on renal cytochrome P450 enzymes in rats
In this study, we investigated the effects of Cu NPs on renal oxidative stress, cytokines and histopathology of rats. We found that Cu NPs (200 mg/kg) significantly disordered the function and structure of the kidney and caused a dose-dependent increase in oxidative stress and cytokines, which significantly decreased the levels of mRNA, protein, and activity of CYP450 s. Micro-coppers (Cu MPs) and Cu ions have similar effects, but their effects on CYP450 s were weaker than Cu NPs. The expression of nuclear receptors were inhibited and the expression of Akt, STAT3/5, CREB, p70S6K, NF-κB, P38 and E...
Source: Environmental Toxicology and Pharmacology - August 8, 2018 Category: Environmental Health Source Type: research

4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals
Publication date: Available online 3 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Shaoping Huang, Senyang Cao, Tao Zhou, Lu Kong, Geyu LiangABSTRACT4-tert-octylphenol (4t-OP) is a well-known xenoestrogen. Our objective was to explore the effects and molecular mechanisms of 4t-OP on human sperm. Sperm samples were exposed to 0, 0.1, or 0.3 mM 4t-OP for two hours. Results showed that both sperm viability and motility were significantly injured by 0.3 mM 4t-OP. We applied comparative proteomics to explore the molecular targets affected by 4t-OP. 81 differentially expressed (DE) proteins...
Source: Environmental Toxicology and Pharmacology - August 4, 2018 Category: Environmental Health Source Type: research

MicroRNA -375 inhibits the proliferation, migration and invasion of kidney cancer cells by triggering apoptosis and modulation of PDK1 expression
In this study we investigated the potential of miR-375 as the therapeutic target for the treatment of Kidney cancer. The results revealed that miR-375 is significantly downregulated in the Kidney cancer cells. To investigate the role therapeutic potential of miR-375, one kidney cancer cell line (A-498) was selected for further experimentation. It was observed that overexpression of miR-375 inhibits A-498 kidney cancer proliferation by induction of apoptosis. In addition, overexpression of miR-375 causes suppression of migration and invasion of the A-498 kidney cancers cells. Bioinformatic analysis revealed PDK1 to be putat...
Source: Environmental Toxicology and Pharmacology - August 3, 2018 Category: Environmental Health Source Type: research

The effects of 1st and 2nd generation biodiesel exhaust exposure on hematological and biochemical blood indices of Fisher344 male rats – the FuelHealth project
In conclusion, exposure to DEE from B7, which was associated with higher exposure to polycyclic aromatic hydrocarbons, resulted in decreased number of T and NK lymphocytes, while DEE from SHB20 induced a higher level of DNA single-strand breaks, oxidative stress and increased red blood cells parameters. Additionally, DPF technology generated increased number of smaller PM and made the DEE more reactive and more harmful, manifested as deregulation of redox balance. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 3, 2018 Category: Environmental Health Source Type: research

Evidence that the radioprotector effect of ascorbic acid depends on the radiation dose rate
Publication date: Available online 1 August 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Elena González, Martha P. Cruces, Emilio Pimentel, Petra SánchezAbstractMany studies have revealed that ascorbic acid (Aa) acts as a powerful inhibitor of genetic damage. The objetive of the present study was to evaluate the radioprotector effect of Aa at two diferent radiation dose rates. The somatic mutation and recombination test in Drosophila melanogaster was used. 48 h larvae were treated for 24 h with 25, 50 and 100 mM of Aa. After pretreatment, larvae were irradiated with 20&...
Source: Environmental Toxicology and Pharmacology - August 2, 2018 Category: Environmental Health Source Type: research

Altered Formation of the Iron Oxide Nanoparticle-Biocorona due to Individual Variability and Exercise
Publication date: Available online 29 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Lisa M. Kobos, Sherleen Xue-Fu Adamson, Sheelagh Evans, Timothy Gavin, Jonathan H. ShannahanAbstractNanoparticles (NPs), introduced into a biological environment, accumulate a coating of biomolecules or biocorona (BC). Although the BC has toxicological and pharmacological consequences, the effects of inter-individual variability and exercise on NP-BC formation are unknown. We hypothesized that NPs incubated in plasma form distinct BCs between individuals, and exercise causes additional intra-individual alterations. 20...
Source: Environmental Toxicology and Pharmacology - July 29, 2018 Category: Environmental Health Source Type: research

CYP1A1 activity in rainbow trout is inhibited by the environmental pollutant p-cresol
In this study, three piscine CYP isoforms were investigated for their abilities to interact with p-cresol. Therefore, the activity of 7-ethoxyresorufin-O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD), and p-nitrophenol hydroxylase (PNPH) were evaluated in the hepatic microsomes of juvenile rainbow trout. Results showed that EROD activity was inhibited in a competitive manner, BFCOD activity was inhibited in presence the highest tested p-cresol concentration and PNPH activity was not affected. These results indicate that p-cresol might affect the ability of fish to metabolize numerous aromat...
Source: Environmental Toxicology and Pharmacology - July 27, 2018 Category: Environmental Health Source Type: research

Ecotoxicological effect of fipronil and its metabolites on Folsomia candida in tropical soils
Publication date: Available online 26 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Talyta Zortéa, Tamires Rodrigues dos Reis, Suélen Serafini, José Paulo de Sousa, Aleksandro Schafer da Silva, Dilmar BarettaAbstractThe aim of this study is to evaluate the toxicity of the fipronil and its metabolites, fipronil sulfone and fipronil desulfinyl on Folsomia candida. Three types of soils were used to perform the ecotoxicological tests, two natural soils (Oxisol and Entisol), and an artificial substrate (Tropical Artificial Soil). The treatments consisted of increasing doses of a veter...
Source: Environmental Toxicology and Pharmacology - July 27, 2018 Category: Environmental Health Source Type: research

Postnatal low-concentration arsenic exposure induces autism-like behavior and affects frontal cortex neurogenesis in rats
This study aimed to explore the effects of postnatal low-concentration arsenic exposure on learning, social skills and frontal cortex neurogenesis in rats. Water-based arsenic exposure rat models were established on postnatal days 4-10 (P4-P10). The experimental animals were divided into four groups: the control group, a 15 µg/L As2O3 water group, a 30 µg/L As2O3 water group, and a 45 µg/L As2O3 water group. Cognitive function was examined with the Morris water maze, anxiety-like behavior with the open field test and light-dark box test, and social skills with a social interaction test. The frontal ...
Source: Environmental Toxicology and Pharmacology - July 25, 2018 Category: Environmental Health Source Type: research

Serum biomarker levels alter following nanoparticle (Al2O3, CuO, TiO2) exposures in freshwater fish (Oreochromis niloticus)
This study emphasized that NPs are not innocent compounds and can have hazardous effects when taken in substantial levels, suggesting there must be some criteria and limits in their usage and discharge to the environment. Nevertheless, more studies are needed to understand better their toxicities in different classes of animals. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 20, 2018 Category: Environmental Health Source Type: research

Immunotoxicity and genotoxicity of single-walled carbon nanotubes co-exposed with cadmium in the freshwater mussel, Elliptio complanata
Publication date: Available online 18 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Messika Revel, Michel Fournier, Pierre Yves RobidouxAbstractPotential immunotoxicity and genotoxicity of as-produced and purified single walled carbon nanotubes (SWCNT, 500 µg Lˉ¹) with or without cadmium (20 µg Lˉ¹) was investigated in hemocytes of the freshwater mussel, Elliptio complanata. Our results showed a decrease in hemocyte viability after 3, and 8 days of exposure and an increase of hemocyte phagocytic efficiency for organisms exposed to Cd. No modification of the cyclo...
Source: Environmental Toxicology and Pharmacology - July 19, 2018 Category: Environmental Health Source Type: research

KT2 and RT2 modified antimicrobial peptides derived from Crocodylus siamensis Leucrocin I show activity against human colon cancer HCT-116 cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Surachai Maijaroen, Nisachon Jangpromma, Jureerut Daduang, Sompong KlaynongsruangAbstractConventional colon cancer treatments have been associated with side effects. Consequently, the discovery of novel effective and safe therapies is urgently needed. Hence, cationic antimicrobial peptides KT2 and RT2 were evaluated towards human colon cancer HCT-116 cells. The MTT assay indicated that both KT2 and RT2 exhibited anticancer activity with good therapeutic indices, and were found to be non-toxic to non-cancerous Vero cells. ...
Source: Environmental Toxicology and Pharmacology - July 19, 2018 Category: Environmental Health Source Type: research

Electron shuttles enhance the degradation of sulfamethoxazole coupled with Fe(III) reduction by Shewanella oneidensis MR-1
This study indicates that the biochemical mechanisms play a vital role in SMX transformation and Fe(II) generation in this system.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 19, 2018 Category: Environmental Health Source Type: research

Anxiety-associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis MurgasAbstractThe effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into eigh...
Source: Environmental Toxicology and Pharmacology - July 13, 2018 Category: Environmental Health Source Type: research

Effects of diesel exhaust particles on the expression of tau and autophagy proteins in human neuroblastoma cells
The objective of the present study was to evaluate the neurotoxic effects caused by diesel exhaust particles (DEPs). We determined the ability of DEPs and carbon black (CB) to induce neurotoxicity, oxidative stress and inflammation, and to disrupt the expression of tau and autophagy proteins in human neuroblastoma IMR-32 cells. Spherical CB (dominated by C, N, and S) and DEPs (dominated by C, N, and O) in aggregates were observed using a field emission-scanning electron microscope (FE-SEM) equipped with energy-dispersive x-ray (EDX) microanalysis. Cell viability was significantly decreased by CB and DEPs in IMR-32 cells, b...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Corrigendum to “Effect of probiotic supplement on aflatoxicosis and gene expression in the liver of broiler chicken” [Environ. Toxicol. Pharmacol. 60 (2018) 118–127]
Publication date: Available online 29 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ramadan Salem, Nagwan El-Habashi, Sabreen E. Fadl, Osama A. Sakr, Zizy I. Elbialy (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Anxiety- associated behavior and genotoxicity found in adult Danio rerio exposed to tebuconazole-based commercial product
Publication date: Available online 30 June 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Tássia Flávia Dias Castro, José Gilmar da Silva Souza, Aline Ferreira Souza de Carvalho, Isadora de Lima Assis, Marcel José Palmieri, Larissa Fonseca Andrade Vieira, Silvana Marcussi, Monica Rodrigues Ferreira Machado, Luis David Solis MurgasAbstractThe effects of different concentrations of commercial product based on tebuconazole, on adults of Danio rerio, were evaluated through novel tank diving test and micronucleus and comet assay tests. A total of 320 adult D. rerio were divided into ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Corrigendum to “The research of genetic toxicity of β-phellandrene” [Environ. Toxicol. Pharmacol. 54 (2017) 28–33]
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Zhiyuan Cheng, Jianjun Jiang, Xiaohua Yang, Hongqian Chu, Ming Jin, Yuan Li, Tao Xi, Siqi Wang, Yao Huang, Lanqin Shang, Shuang Wu, Weidong Hao, Yueying Qian, Xuetao Wei (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Editorial Board
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Diabetes escalates knee osteoarthritis in rats: Evidence of adaptive mechanism
In conclusion, diabetic-osteoarthritic state is characterised by more altered biochemical profile, relative to what is probable in either disease condition. Nevertheless, this situation remains subject to the influence of endogenous homeostatic mechanisms. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Inter-individual and inter-organ variability in the bioactivation of paracetamol by human liver and kidney tissues
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Ege Arzuk, Burak Turna, Murat Sözbilen, Hilmi OrhanAbstractParacetamol (PAR) overdose is associated with massive hepatic injury; it may induce kidney toxicity as well. It is essential to measure organ-specific activities of related CYPs for evaluating the overdose cases. Available HPLC-based methods require high amounts of tissue samples. In order to develop liquid chromatography mass spectrometry (LC–MS)-based methods to process small amounts of human tissues, liver and kidney samples were obtained. Individual micr...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Assessment of the inhibitory activity of the pyrethroid pesticide deltamethrin against human placental glutathione transferase P1-1: A combined kinetic and docking study
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Victor Markus, Kerem Teralı, Ozlem Dalmizrak, Nazmi OzerAbstractDeltamethrin (DEL), which is a synthetic pyrethroid insecticide, has been used successfully all over the world to treat mosquito nets for the control of malaria. Glutathione S-transferases (GSTs; EC 2.5.1.18) catalyze the conjugation of reduced glutathione (GSH) to a variety of xenobiotics and are normally recognized as detoxification enzymes. Here, we used a colorimetric assay based on the human placental GSTP1-1 (hpGSTP1-1)-catalyzed reaction between GSH and th...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Prenatal alcohol exposure reduces 5-HT concentration in mouse intestinal muscle and mucosa
In conclusion, prenatal alcohol exposure causes a decrease in conversion of tryptophan to 5-HT in both muscle and mucosa although the effect is more pronounced in females. The observed sex difference may be related to changes associated with the estrous cycle. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Expression of cyp1a induced by benzo(A)pyrene and related biochemical and genotoxic biomarkers in the neotropical freshwater fish Prochilodus lineatus
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Caroline Santos, Marcelo Tempesta de Oliveira, Ilce Mara de Syllos Cólus, Silvia Helena Sofia, Claudia Bueno dos Reis MartinezAbstractThe goal of this work was to design specific cyp1a primers for the fish Prochilodus lineatus to study the expression of this gene and its relation to the activity of biotransformation phase I enzyme (ethoxyresorufin O-deethylase - EROD) and genotoxic damage after 6 and 24 h of benzo(a)pyrene (B(a)P) intraperitoneal injection. In comparison to fish injected only with canola oil (vehicle)...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Clinical and radiographic periodontal status and whole salivary cotinine, IL-1β and IL-6 levels in cigarette- and waterpipe-smokers and E-cig users
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Sameer A. Mokeem, Mohammed N. Alasqah, Dimitrios Michelogiannakis, Abdulaziz A. Al-Kheraif, Georgios E. Romanos, Fawad JavedAbstractThe aim was to compare the clinical (plaque index [PI], bleeding on probing [BOP], probing pocket depth [PPD] and clinical attachment loss [CAL]) and radiographic (marginal bone loss [MBL]) periodontal parameters and whole salivary cotinine, interleukin (IL)-1β and IL-6 levels among cigarette-smokers, waterpipe-smokers, E-cig users and never-smokers. In total, 154 male individuals (39 cigaret...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Deciphering the toxic effects of iprodione, a fungicide and malathion, an insecticide on thiol protease inhibitor isolated from yellow Indian mustard seeds
This study was carried out to see the effect of commercially used pesticides on a specific plant protein viz. phytocystatin isolated from yellow mustard seeds (YMP). Phytocystatin is a thiol proteinase inhibitor, which regulates endogenous and exogenous cysteine proteinases and plays a vital physiological role in plants. Different classes of pesticides like fungicide (iprodione) of dicarboximide class and an insecticide (malathion) of class organophosphate are retorted for our study. In the presence of these pesticides, biophysical and biochemical changes were observed in phytocystatin. These changes were evaluated making ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Risk assessment of exposure to aflatoxin B1 and ochratoxin A through consumption of different Pistachio (Pistacia vera L.) cultivars collected from four geographical regions of Iran
In this study, aflatoxin B1 (AFB1) and ochratoxin A (OTA) levels in five pistachio cultivars collected from four sites of Iran, were measured by HPLC. Based on the results, risk assessment for AFB1 and OTA residues was done. The highest mean concentrations of AFB1 and OTA were found in Ahmad-aghaei (4.33 and 2.19 ng/g, respectively) and Akbari (4.08 and 1.943 ng/g, respectively) cultivars from Rafsanjan, Iran. Even the highest concentrations of AFB1 and OTA in analyzed samples were lower than the corresponding maximum limits set by EU authorities. The hazard index (HI) value for consumers of Iranian pistachio is below ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Adapting and applying common methods used in pharmacovigilance to the environment: A possible starting point for the implementation  of eco-pharmacovigilance
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Jun Wang, Mengya Zhang, Shulan Li, Bingshu HeAbstractNow, the occurrence of pharmaceuticals in natural environment has been frequently reported around the world. As a kind of biologically active compounds specially designed to be effective even at very low concentration levels, pharmaceuticals in the environment could have adverse impacts to the health of human beings or other non-targeted organisms due to long-term exposures. To minimize the pharmaceutical pollution from the perspective of drug administration, a new concept c...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Dietary supplementation of Spirulina ameliorates iron-induced oxidative stress in Indian knife fish Notopterus Notopterus
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Deepali Mohanty, Luna SamantaAbstractIron though an essential cofactor for many proteins including haemoglobin and cytochromes, when in excess (>1 ppm in water and 100 ppm in fish tissue) elicits toxicity via Fenton reaction inducing oxidative stress. The present study aimed to evaluate the efficacy of dietary Spirulina (Arthrospira platensis) supplementation on waterborne-iron induced oxidative stress in the tissues of Notopterus notopterus. Juvenile fishes were divided randomly into 4 groups, namely, Group-I: control ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Lithium entrapped chitosan nanoparticles to reduce toxicity and increase cellular uptake of lithium
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Geeva, Shoba NarayanAbstractLithium carbonate is an effective drug against bipolar disorders. Direct use of lithium carbonate has been reported to result in lithium toxication and pulmonary complications. With chitosan micro and nanoparticles gaining attention for their protein absorption, drug targeting and improved dissolution rate of sparingly water-soluble drugs, this work has focused on chitosan loaded Li as a possible alternative to Li alone for cellular uptake. Well standardized ionic gelation technique employed in this...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Hepatoprotective effect of lawsone on rifampicin-isoniazid induced hepatotoxicity in in vitro and in vivo models
This study documented the hepatoprotective efficacy of lawsone, the major bioactive naphthoquinone present in Lawsonia inermis L. (Lythraceae) using in vitro and in vivo models. Lawsone was isolated from the leaves of L. inermis and its structure was confirmed using spectroscopic data. In-vitro antioxidant effect of lawsone was evaluated using ABTS assay. Hepatoprotective effect of lawsone was determined with RIF-INH treated HepG2 cells and Wistar rats. Administration of RIF-INH reduced the viability of the HepG2 cells and the treatment with lawsone significantly restored the viability of the cells even at lower concentrat...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Phenol and chlorinated phenols exhibit different apoptotic potential in human red blood cells (in vitro study)
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Jaromir Michałowicz, Anna Włuka, Monika Cyrkler, Aneta Maćczak, Paulina Sicińska, Katarzyna MokraAbstractPhenol and chlorinated phenols are widely spread in the environment and human surrounding, which leads to a common environmental and occupational exposure of humans to these substances. The aim of this study was to assess eryptotic changes in human red blood cells treated with phenol, 2,4-dichlorophenol (2,4-DCP), 2,4,6-trichlorophenol (2,4,6-TCP) and pentachlorophenol (PCP). The erythrocytes were incubated with phenols...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis
In this study, the biological effects of one of the most abundant OPFRs, tris (1-chloro-2-propyl) phosphate (TCPP), on the immunity in mussel Mytilus galloprovincialis were characterized by testing the reactive oxygen species, apoptosis, antioxidant system and immunity related gene expressions. Results indicated that both TCPP exposures (10 and 100 nmol L−1) significantly (p
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

In vivo investigation on the chronic hepatotoxicity induced by sertraline
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Mansour I. Almansour, Yazun B. Jarrar, Bashir M. JarrarAbstractAlthough sertraline is widely prescribed as relatively safe antidepressant drug, hepatic toxicity was reported in some patients with sertraline treatment. The present study was conducted to investigate the morphometric, hepatotoxicity, and change in gene expression of drug metabolizing enzymes. Male healthy adult rabbits (Oryctolagus cuniculus) ranging from 1050 to 1100 g were exposed to oral daily doses of sertraline (0, 1, 2, 4, 8 mg/kg) for 9 weeks. The anim...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

CLZ-8, a potent small-molecular compound, protects radiation-induced damages both in vitro and in vivo
Publication date: July 2018Source: Environmental Toxicology and Pharmacology, Volume 61Author(s): Tian Feng, Jiyuan Liu, Nan Zhou, Libin Wang, Xueying Liu, Shengyong Zhang, Siwang Wang, Hui ChenAbstractPUMA (p53 up-regulated mediator of apoptosis) is particularly important in initiating radiation-induced damage and apoptosis. It has been shown that inhibition of PUMA can provide a profound benefit for the long-term survival of the mice, without an increased risk of malignancies after irradiation. It becomes to be a potential target for developing an effective treatment aimed to protect cells from lethal radiation. CLZ-8, a...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

The use of liver slices from the Cape vulture (Gyps coprotheres) to better understand the role of liver toxicity of Non-steroidal anti-inflammatory drugs (NSAIDs) in vultures
Publication date: Available online 4 July 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Emmanuel Oluwasegun Adawaren, Lilian Mukandiwa, Emmanuel Mfotie Njoya, Lizette Bekker, Neil Duncan, Vinny NaidooAbstractDiclofenac, a non-steroidal anti-inflammatory drug (NSAID) was responsible for the death of millions of vultures on the Asian subcontinent, following the consumption of diclofenac contaminated carcasses. The aim of this research was to establish if liver slices could serve as an alternate means of predicting the toxicity of NSAIDs in Gyps vultures. The Cape vulture liver slices was prepared and incuba...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Reversal of behavioral decline and neuropathology by a complex vitamin supplement involves modulation of key neurochemical stressors
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Olayemi Joseph Olajide, John Oluwasegun Fatoye, Oluwakunmi Folashade Idowu, Damilola Ilekoya, Ismail Temitayo Gbadamosi, Monsurat Titi Gbadamosi, Nnaemeka Tobechukwu AsogwaAbstractMetal ions are crucial for normal neurochemical signaling and perturbations in their homeostasis have been associated with neurodegenerative processes. Hypothesizing that in vivo modulation of key neurochemical processes including metal ion regulation (by transferrin receptor-1: TfR-1) in cells can improve disease outcome, we investigated the ef...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Toxicity of environmentally-relevant concentrations of arsenic on developing T lymphocyte
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Huan Xu, Xiaolei Wang, Scott W. BurchielAbstractArsenic is a ubiquitous environmental contaminant that exists in many inorganic and organic forms. In particular, arsenite is known to induce immunotoxicity in humans and animals. There are still major gaps in our understanding of the mechanism(s) of the immunotoxicity induced by arsenic at environmentally-relevant concentrations. T cells are an essential part of the immune system required for host resistance to infections and protection from cancer. Developing T cells in th...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Neochlorogenic acid inhibits against LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and involving AMPK pathway
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Sun Young Park, Mei Ling Jin, Eun Hye Yi, Yoon Kim, Geuntae ParkAbstractAcute and chronic inflammatory diseases are associated with excessive inflammation due to the accumulation of pro-inflammatory mediators and cytokines produced by macrophages. In the present study, we investigated the anti-inflammatory properties of neochlorogenic acid (nCGA) from Lonicera japonica on lipopolysaccharide (LPS)-activated inflammation in macrophages and participation of the AMPK/Nrf2 pathway. nCGA pretreatment significantly reduced the p...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

The in vitro toxicity analysis of titanium dioxide (TiO2) nanoparticles on kinematics and biochemical quality of rainbow trout sperm cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Mustafa Erkan Özgür, Sevgi Balcıoğlu, Ahmet Ulu, İmren Özcan, Fatih Okumuş, Süleyman Köytepe, Burhan AteşAbstractIn recent years, titanium dioxide (TiO2) nanoparticles (NPs) as metal oxide nanoparticles are widely used in industry, agriculture, personal care products, cosmetics, sun protection and toothpaste, electronics, foodstuffs and food packaging. This use of nano-TiO2 has been associated with environmental toxicity concerns. Therefore, the aim of this study was to evaluate the in vitro ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Physiological and anthocyanin biosynthesis genes response induced by vanadium stress in mustard genotypes with distinct photosynthetic activity
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Muhammad Imtiaz, Muhammad Adnan Mushtaq, Muhammad Amjad Nawaz, Muhammad Ashraf, Muhammad Shahid Rizwan, Sajid Mehmood, Omar Aziz, Muhammad Rizwan, Muhammad Safiullah Virk, Qaiser Shakeel, Raina Ijaz, Vasilis P. Androutsopoulos, Aristides M. Tsatsakis, Michael D. ColemanAbstractThe present study aimed to elucidate the photosynthetic performance, antioxidant enzyme activities, anthocyanin contents, anthocyanin biosynthetic gene expression, and vanadium uptake in mustard genotypes (purple and green) that differ in photosynth...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Unraveling CYP2E1 haplotypes in alcoholics from Central Brazil: A comparative study with 1000 genomes population
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Jheneffer Sonara Aguiar Ramos, Leandro Prado Felício, Alessandro Arruda Alves, Mariana Paiva Lopes, Thannya Nascimento Soares, Daniela de Melo e SilvaAbstractWe evaluated genetic variability of single nucleotide polymorphisms (SNPs) situated in the CYP2E1 gene promoter in alcoholics. We also compared 1000 Genomes Project of CYP2E1 polymorphisms with frequencies of genotypes and haplotypes. Eight variation points were exclusively found in Brazilians. The allelic distributions of the rs3813867, rs2031920 and rs203192...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Blood-brain barrier breakdown, memory impairment and neurotoxicity caused in mice submitted to orally treatment with thymol
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Matheus D. Baldissera, Carine F. Souza, Antônio Francisco Igor M. De Matos, Pedro Henrique Doleski, Bernardo Baldisserotto, Aleksandro S. Da Silva, Silvia G. MonteiroAbstractSeveral evidences have related the biochemical and pharmacological properties of thymol, but the possible neurotoxic effects of this compound remain unknown and not evaluated. Thus, the purpose of this study was to evaluate whether intake of thymol in different doses (10, 20 and 40 mg/kg) induce neurotoxicity and behavioral alterations using m...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Responses of antioxidant and biotransformation enzymes in Carassius carassius exposed to hexabromocyclododecane
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Huike Dong, Guanghua Lu, Zhenhua Yan, Jianchao Liu, Matthew Nkoom, Haohan YangAbstractThe ubiquitous existence of hexabromocyclododecane (HBCD) in environmental matrices has made it attractive to both field investigators as well as laboratory researchers. However, literature on the biological effects caused by HBCD on aquatic vertebrates seldom exist. This has inevitably increased the difficulty of toxicological assessment in the aquatic environment. Juvenile crucian carp (Carassius carassius) were exposed (flow-through) ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Joint toxicity on hepatic detoxication enzymes in goldfish (Carassius auratus) exposed to binary mixtures of lead and paraquat
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Xiaoming Xu, Zhaojie Cui, Shanshan WangAbstractCompared to single exposure, chemical mixtures might induce joint toxicity including additive, synergistic and antagonistic effects on both organisms and environment. Owing to the specific toxicity of oxidative stress and binding to proteins, lead (Pb) is generally recognized a non-essential and threatening heavy metal to animals and human. Paraquat (PQ) is a widely used herbicide in agriculture and can trigger oxidative stress as well as Pb. Little information was available ...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research

Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells
Publication date: September 2018Source: Environmental Toxicology and Pharmacology, Volume 62Author(s): Eric A. Rodriguez, Brigitte C. Vanle, Jonathan A. Doorn, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. DuffelAbstractAlthough neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity of OH-PCBs and PCB sulfates derived from PCBs 3, 8, 11, and 52 in two neural cell lin...
Source: Environmental Toxicology and Pharmacology - July 11, 2018 Category: Environmental Health Source Type: research