Nanoecotoxicology study of the response of magnetic O-Carboxymethylchitosan loaded silver nanoparticles on Artemia salina
This study investigating survival and enzyme activity of magnetic O-carboxymethylchitosan loaded silver nanoparticle on Artemia salina. The results showed that mortality increased with increasing concentrations of MNPAg. O-Carboxymethylchitosan loaded silver nanoparticles were found to be more toxic, with a LC50 of 902.1 mg/L for γ-Fe2O3/Ag without reducing agent. Accumulation of silver on Artemia salina depends on the type of nanoparticle. Accumulation of nanoparticle containing polymers (carboxymethylchitosan/γ-Fe2O3/Ag without reducing agent, carboxymethylchitosan/γ-Fe2O3/Ag reduced with sucrose...
Source: Environmental Toxicology and Pharmacology - November 17, 2019 Category: Environmental Health Source Type: research

Comparative effects of Mancozeb and Disulfiram-induced striated muscle myopathies in Long-Evans rats
Publication date: Available online 16 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Olivia J. Stephenson, Louis D. TrombettaAbstractDithiocarbamates (DTCs) like mancozeb (MZ) and disulfiram (DS) are used throughout agriculture and medicine and have been implicated in neurotoxicity. Little research has been studied on the reported myopathies caused by these compounds. Their pathogenesis and mechanism of muscle toxicity has not been fully studied. The aim of this study is to investigate if DTCs alter striated muscle tissues in vivo. Long-Evans rats were treated with either MZ or DS followed by anal...
Source: Environmental Toxicology and Pharmacology - November 17, 2019 Category: Environmental Health Source Type: research

Individual and cellular responses of earthworms (Eisenia fetida) to endosulfan at environmentally related concentrations
Publication date: Available online 12 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Yajing Shi, Yajuan Shi, Lisha ZhengAbstractThe presence of endosulfan at high levels in soils poses a potential risk for terrestrial ecosystems and human health via the food chain. Therefore, the effects of endosulfan at environmentally related doses on the terrestrial biota are of great concern. The present study measured the mortality, growth inhibition and ultrastructure of the stomach and skin of earthworms exposed to endosulfan at environmentally related concentrations to identify the individual and cellular ...
Source: Environmental Toxicology and Pharmacology - November 13, 2019 Category: Environmental Health Source Type: research

Comparative Cr, As and CCA induced Cytostaticity in mice kidney: A contribution to assess CCA toxicity
In this study, mouse kidney samples were used to evaluate the effects of CCA, chromium trioxide (CrO3) and arsenic pentoxide (As2O5) on cell pathophysiology by flow cytometry. Samples were collected after 14, 24, 48 and 96 h of animal exposure. While Cr had no statistically significant cytostatic effects, As2O5 induced a S-phase delay in animals exposed for 24 h, and over time a G0/G1 phase blockage. The effects of CCA in S-phase were similar, but more severe than those of As2O5. Since environmental and public health hazards due to the long durability of CCA-treated wood products, these data confirm that CCA has profou...
Source: Environmental Toxicology and Pharmacology - November 13, 2019 Category: Environmental Health Source Type: research

Multi-parametric analysis of ciprofloxacin toxicity at ecologically relevant levels: short- and long-term effects on Daphnia magna
Publication date: Available online 9 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ricardo Dionísio, David Daniel, Gilberto Dias de Alkimin, Bruno NunesAbstractThe increased presence of emergent compounds, such as pharmaceuticals drugs, in the aquatic compartment has been acknowledged as an evolving environmental issue whose consequences are not yet fully characterized. Specific classes of pharmaceutical drugs, such as fluoroquinolone antibiotics, can exert toxic effects to non-target species with ecological significance, since these compounds are environmentally stable and persistent, and...
Source: Environmental Toxicology and Pharmacology - November 10, 2019 Category: Environmental Health Source Type: research

Rat liver and kidney post-mitochondrial dysfunction by addition of chronic mixed metal intoxication and hepatorenal wellness mediated by phenolic components from Croton zambiscus leaves
Publication date: Available online 9 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): J.K Akintunde, S.A Ayeni, M.A Adeoye, A.O ShittuAbstractChronic exposure of mixed-metal intoxication has been associated with prolonged oxidative stress and severe hepatorenal damage. This present study demonstrates the hepatoprotective and renoprotective activity of Croton zambesicus (C-ZAMB) leaves, naturally occurring phenolic compounds against chronic mixed-metal (EOMABRSL) induced toxicity. 0.5 ml of EOMABRSL via oral route induced chronic hepatoxicity and nephrotoxicity on exposure for 98 days (non-wit...
Source: Environmental Toxicology and Pharmacology - November 10, 2019 Category: Environmental Health Source Type: research

Exposure to first line anti-tuberculosis drugs in prepubertal age reduces the quality and functional competence of spermatozoa and oocytes in Swiss albino mice
In conclusion, the rResult of this study indicates that ATD's had varied degree of toxicity, all the ATDs have considerable adverse effect on the functional competence of male and female gametes, however, with varied degree of toxicity functional potential.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 7, 2019 Category: Environmental Health Source Type: research

Comparative Cr, As and CCA induced cytotostaticity in mice kidney: a contribution to assess CCA toxicity
In this study, mouse kidney samples were used to evaluate the effects of CCA, chromium trioxide (CrO3) and arsenic pentoxide (As2O5) on cell pathophysiology by flow cytometry. Samples were collected after 14, 24, 48 and 96 hours of animal exposure. While Cr had no statistically significant cytostatic effects, As2O5 induced a S-phase delay in animals exposed for 24 h, and over time a G0/G1 phase blockage. The effects of CCA in S-phase were similar, but more severe than those of As2O5. Since environmental and public health hazards due to the long durability of CCA-treated wood products, these data confirm that ...
Source: Environmental Toxicology and Pharmacology - November 7, 2019 Category: Environmental Health Source Type: research

Neurobehavioural and biochemical responses associated with exposure to binary waterborne mixtures of zinc and nickel in rats
Publication date: Available online 6 November 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Isaac A. Adedara, Adedayo N. Adegbosin, Michael A. Abiola, Ajibola A. Odunewu, Olatunde Owoeye, Solomon E. Owumi, Ebenezer O. FarombiAbstractEnvironmental and occupational exposure to metal mixtures due to various geogenic and anthropogenic activities poses a health threat to exposed organisms. The outcome of systemic interactions of metals is a topical area of research because it may cause either synergistic or antagonistic effect. The present study investigated the impact of co-exposure to environmentally relevan...
Source: Environmental Toxicology and Pharmacology - November 7, 2019 Category: Environmental Health Source Type: research

Integrating In Vitro Testing and Physiologically-Based Pharmacokinetic (PBPK) Modelling for Chemical Liver Toxicity Assessment – a Case Study of Troglitazone
In conclusion, although with many uncertainties, integrating in vitro assays and PBPK modeling is promising in informing liver toxicity-inducing TGZ doses. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 6, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: November 2019Source: Environmental Toxicology and Pharmacology, Volume 72Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 23, 2019 Category: Environmental Health Source Type: research

Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via nox-2-mir21 axis
Publication date: Available online 20 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sutapa Sarkar, Firas Alhasson, Diana Kimono, Muayad Albadrani, Ratanesh K. Seth, Shuo Xiao, Dwayne E. Porter, Geoff I. Scott, Bryan Brooks, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh ChatterjeeAbstractNAFLD often results in cardiovascular, intestinal and renal complications. Previous reports from our laboratory highlighted NAFLD induced ectopic inflammatory manifestations in the kidney that gave rise to glomerular inflammation. Extending our studies, we hypothesized that existing inflammatory conditions in NAFLD...
Source: Environmental Toxicology and Pharmacology - October 21, 2019 Category: Environmental Health Source Type: research

Effects of common pharmaceutical drugs (paracetamol and acetylsalicylic acid) short term exposure on biomarkers of the mussel Mytilus spp
In this study, the ecotoxicity of common pharmaceutical drugs (namely paracetamol and acetylsalicylic acid) was assessed, by studying the susceptibility of the mussel species Mytilus spp to oxidative stress after being exposed for 96 h to increasing but ecologically relevant concentrations of the two mentioned pharmaceuticals (paracetamol: 0, 0.5, 5, 50, and 500 µg/L; acetylsalicylic acid: 0, 0.1, 1, 10, and 100 µg/L). The oxidative status in exposed organisms was analyzed by measuring oxidative stress biomarkers, namely catalase (CAT), glutathione-S-transferases (GSTs), and lipoperoxidatio...
Source: Environmental Toxicology and Pharmacology - October 20, 2019 Category: Environmental Health Source Type: research

Evaluation of endocrine disruption and gestational disorders in women residing in areas with intensive pesticide application: an exploratory study
This study reinforces the importance of preventing potential cases of cumulative toxicity during the perinatal period through monitoring and epidemiological studies.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 18, 2019 Category: Environmental Health Source Type: research

Organochlorine pollutants’ levels in hair, amniotic fluid and serum samples of pregnant women in Greece. A cohort study
Publication date: Available online 16 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Michail Barmpas, Elena Vakonaki, Manolis Tzatzarakis, Stauros Sifakis, Athanasios Alegakis, Themos Grigoriadis, Danielle Bittencourt Sodré, Georgios Daskalakis, Aristidis Antsaklis, Aristidis TsatsakisAbstractPersistent organic pollutants are synthetic chemicals highly resistant to degradation with strong tendency to bioaccumulation. Assessment of human exposure to these compounds is crucial for public health protection, especially during vulnerable periods.The aim of the present cohort study was to evaluate...
Source: Environmental Toxicology and Pharmacology - October 18, 2019 Category: Environmental Health Source Type: research

Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification
Publication date: Available online 17 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ying Gao, Fangzhong Gui, Demin Li, Ruixue Zhang, Qinyuan Sun, Xiaoying GuoAbstractSkeletal fluorosis causes growth plate impairment and growth retardation during bone development. Longitudinal bone development is accomplished by endochondral ossification in growth plate. However, the mechanism of fluoride impairs growth plate is unclear. To explore the effect of fluoride on various glycosaminoglycans (GAGs) and related signaling pathways in growth plate during endochondral ossification, SD rats and ATDC5 cells were...
Source: Environmental Toxicology and Pharmacology - October 18, 2019 Category: Environmental Health Source Type: research

Effect of formalin in early stages of the freshwater neotropical catfish, Lophiosilurus alexandri
The objective of this study was to evaluate the acute toxicity of formalin and its level of therapeutic safety in early stages of Lophiosilurus alexandri. Experiment 1, larvae 7 days after hatching (DAH) were exposed to 43.2, 86.4, 172.8, 345.6, 691.2, 1404.0 mg/L of formalin. Experiment 2, juveniles with 22 DAH exposed to 54, 108, 216, 432, 648 mg/L. Experiment 3, 45 DAH exposed to 86.4, 172.8, 345.6, 691.2, 1036.8 mg/L. The experiments had a control without addition of formalin and all were carried out in duplicate. The LC50-12 h were: Experiment 1 = 108.86 mg/L; 2: 152.74...
Source: Environmental Toxicology and Pharmacology - October 18, 2019 Category: Environmental Health Source Type: research

Eprinomectin antiparasitic affects survival, reproduction and behavior of Folsomia candida biomarker, and its toxicity depends on the type of soil
The objective of this study was to evaluate the toxicity of the antiparasitic agent eprinomectin in two subtropical soils, using ecotoxicological lethality, reproduction and avoidance behavior tests with springtails (Folsomia candida). Eprinomectin concentrations were 0 (control), 0.5, 1, 2, 4, 8, 12, 16 and 20 mg kg−1 of dry soil combined with either Entisol or Oxisol soils. Statistically significant toxic effects of eprinomectin on springtails were observed in both soils. Eprinomectin was lethal starting at 8 mg kg-1 of dry soil in Entisol, and 20 mg kg−1 of dry soil in Oxisol, with effects less t...
Source: Environmental Toxicology and Pharmacology - October 18, 2019 Category: Environmental Health Source Type: research

Bioconcentration and depuration of cadmium in the selected tissues of rare minnow (Gobiocypris rarus) and the effect of dietary mulberry leaf supplementation on depuration
Publication date: Available online 15 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Xiaoqin Xiong, Haiying Li, Ning Qiu, Liangxia Su, Zhenli Huang, Lirong Song, Jianwei WangAbstractA 56-day trial was conducted to elucidate the bioconcentration and depuration of Cd in the liver and muscle of rare minnows (Gobiocypris rarus) and determine the effect of dietary mulberry leaf supplementation on depuration. Juvenile rare minnows were exposed to environmentally relevant doses of Cd (1 and 10 µg/L) for 28 days of uptake and then allowed 28 days of depuration. The bioaccumulation factors of t...
Source: Environmental Toxicology and Pharmacology - October 16, 2019 Category: Environmental Health Source Type: research

Plastic Pollution in the Environment
Publication date: Available online 11 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 12, 2019 Category: Environmental Health Source Type: research

Diesel exhaust particle and dust mite induced airway inflammation is modified by cerium dioxide nanoparticles
Publication date: Available online 11 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Kirsty Meldrum, Sarah Robertson, Isabella Römer, Tim Marczylo, Timothy W. Gant, Rachel Smith, Teresa D. Tetley, Martin O. LeonardAbstractCerium dioxide nanoparticles (CeO2NPs) have been used as diesel fuel-borne catalysts for improved efficiency and pollutant emissions. Concerns that such material may influence diesel exhaust particle (DEP) effects within the lung we examined responses in mice with and without exposure to house dust mite (HDM). Repeated intranasal instillation of combined HDM and DEP increased...
Source: Environmental Toxicology and Pharmacology - October 12, 2019 Category: Environmental Health Source Type: research

Biochemical responses revealed in an amphibian species after exposure to a forgotten contaminant: An integrated biomarker assessment
Publication date: Available online 10 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): S. Dahms-Verster, A. Nel, J.H.J. van Vuren, R. GreenfieldAbstractVanadium is a metal whose toxicity towards terrestrial and aquatic species has been under-reported to date.. The biochemical responses of vanadium in amphibian species have not been determined. To establish the effects of vanadium (V) on exposed adult Xenopus laevis, acute and chronic exposures were conducted, and biomarker analyses were performed on liver and muscle tissues from exposed frogs. Biomarkers of exposure, such as acetylcholinesterase (ACh...
Source: Environmental Toxicology and Pharmacology - October 11, 2019 Category: Environmental Health Source Type: research

Tributyltin Reduces Bone Mineral Density by Reprograming Bone Marrow Mesenchymal Stem Cells in Rat
Publication date: Available online 7 October 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Wenhuan Yao, Xinglong Wei, Hao Guo, Dong Cheng, Hui Li, Limin Sun, Shu’e Wang, Dongmei Guo, Yanli Yang, Jiliang SiAbstractTributyltin (TBT), a proven endocrine disrupter, was widely used in industry and agriculture. Previous research showed that TBT could alter the balance between osteogenesis and adipogenesis, which may have significant consequences for bone health. Herein, we exposed male rats to TBT chloride (TBTCl) to evaluate the deleterious effects of TBT on bone. Exposure to 50 μg kg-1 ...
Source: Environmental Toxicology and Pharmacology - October 10, 2019 Category: Environmental Health Source Type: research

Increased surface area of halloysite nanotubes due to surface modification predicts lung inflammation and acute phase response after pulmonary exposure in mice
In conclusion, functionalization by etching increased BET surface area of the studied NN and enhanced pulmonary inflammatory toxicity in mice. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 2, 2019 Category: Environmental Health Source Type: research

Toxic effects of ornamental stone processing waste effluents on Geophagus brasiliensis (Teleostei: Cichlidae)
Publication date: November 2019Source: Environmental Toxicology and Pharmacology, Volume 72Author(s): Graciele Petarli Venturoti, Johara Boldrini-França, Walace Pandolpho Kiffer, Aline Priscila Francisco, Aline Silva Gomes, Levy Carvalho GomesAbstractThe ornamental stone industry generates considerable amounts of waste (OSPW), which may eventually reach natural environments and impact the local ecosystem. The aim of this study was to compare the toxic effects of two OSPW effluents in Geophagus brasiliensis: i) leachate effluent from a lagoon in an OSPW landfill (LE) and ii) decanted effluent from an ornamental stone...
Source: Environmental Toxicology and Pharmacology - October 1, 2019 Category: Environmental Health Source Type: research

Eprinomectin affects survival, reproduction and behavior of Folsomia candida, and its toxicity depends on the type of soil
The objective of this study was to evaluate the toxicity of the antiparasitic agent eprinomectin in two subtropical soils, using ecotoxicological lethality, reproduction and avoidance behavior tests with springtails (Folsomia candida). Eprinomectin concentrations were 0 (control), 0.5, 1, 2, 4, 8, 12, 16 and 20 mg kg-1 of dry soil combined with either Entisol or Oxisol soils. Statistically significant toxic effects of eprinomectin on springtails were observed in both soils. Eprinomectin was lethal starting at 8 mg kg-1 of dry soil in Entisol, and 20 mg kg-1 of dry soil in Oxisol, w...
Source: Environmental Toxicology and Pharmacology - September 30, 2019 Category: Environmental Health Source Type: research

Common differentially expressed proteins were found in mouse cleft palate models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid
In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and retinoic acid (RA), using proteomics technology isobaric tags for relative and absolute quantitation (iTRAQ) to investigate the key proteins in the formation of CP. Pregnant mice were given a gavage of TCDD 28μg/kg or retinoic acid 80mg/kg of body weight or equivalent corn oil at gestational day 10.5(GD10.5) and sacrificed at GD 17.5. Foetal mice were recorded and collected for further detection. Western blot was performed to verify the iTRAQ results. Eventually, we obtained 18 common differentially expressed proteins...
Source: Environmental Toxicology and Pharmacology - September 28, 2019 Category: Environmental Health Source Type: research

Sulphated polysaccharide from Sargassum myriocystum confers protection against gentamicin-induced nephrotoxicity in adult zebrafish
Publication date: Available online 23 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Durairaj Vaishnu Devi, Pragasam ViswanathanAbstractThe beneficial effect of purified fraction of sulphated polysaccharide extracted from Sargassum myriocystum (SMP) was examined on the gentamicin-induced nephrotoxicity in adult zebrafish. The major purified fractions (SMP1, SMP2 and SMP3) were obtained by anion-exchange and size-exclusion chromatography and characterized by FTIR, GC-MS and NMR. The in vitro antioxidant activities of all purified SMP fractions were analysed. The SMP2 showed maximum carbohydrate, s...
Source: Environmental Toxicology and Pharmacology - September 24, 2019 Category: Environmental Health Source Type: research

Toxic effects of ornamental stone processing waste effluents on Geophagus brasiliensis
Publication date: Available online 23 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Graciele Petarli Venturoti, Johara Boldrini-França, Walace Pandolpho Kiffer, Aline Priscila Francisco, Aline Silva Gomes, Levy Carvalho GomesAbstractThe ornamental stone industry generates considerable amounts of waste (OSPW), which may eventually reach natural environments and impact the local ecosystem. The aim of this study was to compare the toxic effects of two OSPW effluents in Geophagus brasiliensis: i) leachate effluent from a lagoon in an OSPW landfill (LE) and ii) decanted effluent from an orname...
Source: Environmental Toxicology and Pharmacology - September 24, 2019 Category: Environmental Health Source Type: research

Role of biomarkers in the evaluation of cadmium and ethoprophos combination in male mice
Publication date: Available online 22 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Kawther El-Gendy, Khaled Osman, Eslam Ezz EL-Din, Ayman EL-SeedyAbstractThis work aimed to study the risk assessment procedures of a combination of single and repeated dose of the widely used pesticide, ethoprophos (Etho) and heavy metal cadmium (Cd), on the hematological, biochemical, reproduction and cytogenetic parameters in male mice. The results revealed that the sub-lethal dose (1/50 LD50) of the tested toxic substances (Etho and/or Cd) reduced the body and organ weights, the most hematological profile and ...
Source: Environmental Toxicology and Pharmacology - September 24, 2019 Category: Environmental Health Source Type: research

Cadmium-resistant rhizobacterium Bacillus cereus M4 promotes the growth and reduces cadmium accumulation in rice (Oryza sativa L.)
Publication date: Available online 19 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Changrong Wang, Zhongqi Liu, Yongchun Huang, Yeni Zhang, Xiaohan Wang, Zhouyue HuAbstractRice farmland cadmium pollution is an increasing problem for food safety. Cd-resistant bacterial strain was isolated from rice rhizosphere soil and identified as Bacillus cereus M4. Treatment with M4 fermentation broth increased rice seedlings growth in vermiculite, while reduced Cd accumulation in grains of rice grown in Cd-contaminated potted soil from 0.309 to 0.186 mg/kg. Indoleacetic acid (IAA) was detected in M4 ...
Source: Environmental Toxicology and Pharmacology - September 21, 2019 Category: Environmental Health Source Type: research

Assessing the toxicant effect of spontaneously volatilized 4-vinylcyclohexane exposure in nymphs of the lobster cockroach Nauphoeta cinerea
Publication date: Available online 16 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Emily Pansera Waczuk, Roger Wagner, Bruna Klein, João Batista Teixeira da Rocha, Daniel M.P. Ardisson-Araújo, Nilda Vargas BarbosaAbstractVinylcyclohexene (VCH) is an environmental contaminant well known for its ovotoxicant effects in several organisms. However, the mechanisms underlying the toxicity of VCH as well as its harmful effects toward other organs are until unclear. In this work, we assess some endpoint signals of toxicity induced by volatilized VCH exposure using nymphs of the lobster coc...
Source: Environmental Toxicology and Pharmacology - September 17, 2019 Category: Environmental Health Source Type: research

The Organochlorine Pesticides Pentachlorophenol and Dichlorodiphenyltrichloroethane Increase Secretion and Production of Interleukin 6 by Human Immune Cells
Publication date: Available online 12 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Tamara J. Martin, Sahra Gabure, JaQuel Maise, Sequena Snipes, Margarita Peete, Margaret M. WhalenABSTRACTThe environmental contaminants pentachlorophenol (PCP) and 4, 4′-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 µM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulated stimulates inflammatory diseases and tumor progression. Immune cells exp...
Source: Environmental Toxicology and Pharmacology - September 13, 2019 Category: Environmental Health Source Type: research

Editorial Board
Publication date: October 2019Source: Environmental Toxicology and Pharmacology, Volume 71Author(s): (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 8, 2019 Category: Environmental Health Source Type: research

Impairments of bone marrow hematopoietic cells followed by the sever erythrocyte damage and necrotic liver as the outcome of chronic in vivo exposure to cadmium: Novel insights from quails
Publication date: Available online 4 September 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Damir Suljevic, Anida Corbic, Erna Islamagic, Muhamed Focak, Filip Filipic, Andi AlijagicAbstractCadmium is a heavy metal classified as an environmental hazard, and its toxicity is subject to extensive research. Japanese quails were exposed to cadmium chloride (CdCl2) ad libitum for 20 days. Bone marrow, peripheral blood and liver were analyzed following the exposure. Moreover, we have provided the very first explanation of hematopoietic lines in Japanese quail. Following CdCl2 exposure, changes in the number, siz...
Source: Environmental Toxicology and Pharmacology - September 5, 2019 Category: Environmental Health Source Type: research

Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats
Publication date: Available online 31 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Kimino Minagawa, Shin-ichi Yamada, Ayano Suzuki, Saeko Ta, Toshio Kumai, Fernand Lambein, Kuniko Kusama-EguchiAbstractNeurolathyrism is a motor neuron disease that is caused by the overconsumption of grass peas (Lathyrus sativus L.) under stressful conditions. The neuro-excitatory β-N-oxalyl-L-α,β-diaminopropionic acid present in grass peas was proposed the causative agent of spastic paraparesis of the legs. Historical reports of neurolathyrism epidemics, studies of neurolathyrism animal models, and ...
Source: Environmental Toxicology and Pharmacology - September 1, 2019 Category: Environmental Health Source Type: research

Characterization of the PM2.5 concentration in surgical smoke in different tissues during hemihepatectomy and protective measures
Publication date: Available online 29 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Wenjun Tan, Haoyang Zhu, Nana Zhang, Dinghui Dong, Shanpei Wang, Fenggang Ren, Junxi Xiang, Rongqian Wu, Yi LvAbstractThe characteristics of the PM2.5 concentration in surgical smoke produced by operating on different human tissues during hemihepatectomy were explored to provide a reference for protective measures. Our results showed that the highest concentration of PM2.5 produced by the electrosurgical knife was the liver tissue, followed by muscle, adipose, and vascular tissue. When the single-layer disposable me...
Source: Environmental Toxicology and Pharmacology - August 30, 2019 Category: Environmental Health Source Type: research

Effects of the organochlorine p,p’-DDT on MCF-7 cells: investigating metabolic and immune modulatory transcriptomic changes
The objectives of this study were to investigate DDT-induced transcriptomic alterations in enzymes and transporters involved in xenobiotic metabolism, immune responses, oxidative stress markers, and cell growth in a human breast cancer cell line. MCF-7 cells were exposed to both environmentally-relevant and previously-tested concentrations of p,p’-DDT in a short-term experiment. Significant up-regulation of metabolizing enzymes and transporters (ACHE, GSTO1, NQO1 and ABCC2) and oxidative stress markers (CXCL8, HMOX-1, NFE2L2 and TNF) was clearly observed. Conversely, UGT1A6, AHR and cell growth genes (FGF2 and VEGFA)...
Source: Environmental Toxicology and Pharmacology - August 30, 2019 Category: Environmental Health Source Type: research

Dose-specific Biochemical and Erythrocytic Alterations of Anthracene Exposure on Blood of Anabas testudineus (Bloch)
Publication date: Available online 25 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Sukhendu Dey, Apurba Ratan GhoshAbstractThe present work is designed to compare the chronic toxicity of anthracene [one of the major constituents of polycyclic aromatic hydrocarbons (PAHs)] on Anabas testudineus (Bloch), in an air-breathing carnivorous fish, in laboratory condition under the exposure of two doses of LC50 value, i.e., 0.0075 mg/l (T1), i.e., 25% and 0.015 mg/l (T2) i.e., 50% for 21 days. A comprehensive comparison was recorded based on biochemical parameters and evaluated the erythrocyt...
Source: Environmental Toxicology and Pharmacology - August 26, 2019 Category: Environmental Health Source Type: research

Protective effect of Vitamin D3 against lead induced hepatotoxicity, oxidative stress, immunosuppressive and calcium homeostasis disorders in rat
Publication date: Available online 23 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Hussain Almasmoum, Bassem Refaat, Mazen M. Ghaith, Riyad A. Almaimani, Shakir Idris, Jawwad Ahmad, Abdelghany H. Abdelghany, Mohammad A. BaSalamah, Mohamed El-BoshyAbstractLead (Pb) is an extremely poisonous, non-essential trace element and toxicity develops in humans following frequent exposure to the heavy metal in polluted environmental and occupational settings. Pb induces hepatic damage through the depletion of the antioxidant system, enhancing cellular oxidative stress and stimulation of proinflammatory cytoki...
Source: Environmental Toxicology and Pharmacology - August 24, 2019 Category: Environmental Health Source Type: research

Soil copper uptake by land snails: a semi-field experiment with juvenile Cantareus aspersus snails
Publication date: Available online 16 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): George Andrei Drăghici, Cristina Dehelean, Iulia Pinzaru, Despina Maria Bordean, Aurica Borozan, Aristides Michael Tsatsakis, Leda Kovatsi, Dragos NicaAbstractThere is currently limited scientific evidence linking soil copper and land snails, although these invertebrates are important players in terrestrial ecosystems. In the present study, Cantareus aspersus juveniles, were exposed in two successive phases of 30 days each, to soil spiked with increasing concentrations of copper sulfate. Copper concentrated prefere...
Source: Environmental Toxicology and Pharmacology - August 17, 2019 Category: Environmental Health Source Type: research

Inhibition Effects of Some Antidepressant Drugs on Pentose Phosphate Pathway Enzymes
Publication date: Available online 16 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Muhammet Serhat Özaslan, Neslihan Balcı, Yeliz Demir, Mahmut Gürbüz, Ömer İrfan KüfrevioğluAbstractThe glucose metabolism in the pentose cycle is essential to the source of NADPH. Deficiency of these enzymes have been linked to depression and psychotic disorders. Depression is an increasingly prevalent mental disorder which may cause loss of labor. Antidepressant drugs are commonly employed in treatments of mood disorders and anxiety treatment. The purpose of this study is to investigate ...
Source: Environmental Toxicology and Pharmacology - August 17, 2019 Category: Environmental Health Source Type: research

Toxicity of cadmium in musculoskeletal diseases
The objective of this review is to summarize the molecular mechanisms of inflammation and oxidative stress activated by Cd at the bone level, particularly in osteoporosis, RA, and OA. Cadmium can increase bone resorption, affect the activity of osteoclasts and calcium (Ca) absorption, and impair kidney function, which favors the development of osteoporosis. In the case of RA, Cd interferes with the activity of antioxidant proteins, like superoxide dismutase (SOD) and catalase (CAT). It also promotes an inflammatory state, inducing the process of citrullination, which affects the proteins of immune response. On the other ha...
Source: Environmental Toxicology and Pharmacology - August 17, 2019 Category: Environmental Health Source Type: research

Evaluation of physiological changes induced by the fluoroquinolone antibiotic ciprofloxacin in the freshwater macrophyte species Lemna minor and Lemna gibba
In this study we selected two species of aquatic macrophytes, Lemna minor and Lemna gibba, which are standard plant species inscribed in ecotoxicological testing guidelines. In this work we characterized the toxic effects of the quinolone antibiotic ciprofloxacin (in levels of 0.005, 0.013, 0.031, 0.078, and 0.195 mg/L), focusing on its potential toxicity towards photosynthetic mechanisms, and pro-oxidant effects. These objectives were attained by measuring the concentrations of chlorophyll a and b, and carotenoids levels. The determination of the quantum yield allowed assessing the effects of ciprofloxacin on the p...
Source: Environmental Toxicology and Pharmacology - August 15, 2019 Category: Environmental Health Source Type: research

Targeting p53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats
In conclusion; Adiponectin can be proposed as a promising therapy for HCC. Adiponectin's tumoricidal activity can be partially mediated by blocking HCC-induced reduction in p53 expression as well as reactivation of TRAIL signaling and induction of apoptotic pathway providing more protection for the body against the tumor.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 15, 2019 Category: Environmental Health Source Type: research

DNA damage and adverse neurological outcomes among garlic farmers exposed to organophosphate pesticides
Publication date: Available online 12 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ratana Sapbamrer, Surat Hongsibsong, Nalin Sittitoon, Patchareeya AmputAbstractGarlic farmers used organophosphate pesticides to control insects, resulting in an increased risk for adverse health outcomes. Thus, we investigated exposure to organophosphate pesticides, DNA damage, nerve conduction, and neurological symptoms among 134 garlic farmers. They were interviewed, measured nerve conduction, and collected blood and urine for determining DNA damage and dialkylphosphate metabolites. Total dialkylphosphate levels ...
Source: Environmental Toxicology and Pharmacology - August 13, 2019 Category: Environmental Health Source Type: research

Impacts of plastic products used in daily life on the environment and human health: what is known?
Publication date: Available online 7 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): M.O. Rodrigues, N. Abrantes, F.J.M. Gonçalves, H. Nogueira, J.C. Marques, A.M.M. GonçalvesAbstractPlastics are indispensable and persistent materials used in daily life that can be fragmented into micro- or nanoplastics. They are long polymer chains mixed with additives that can be toxic when in contact with distinct species. The toxicity can result from polymer matrix, additives, degradation products and adsorbed contaminants. Notwithstanding, there is still an immense gap of information concerning the...
Source: Environmental Toxicology and Pharmacology - August 8, 2019 Category: Environmental Health Source Type: research

Targetingp53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats
In conclusion; Adiponectin can be proposed as a promising therapy for HCC. Adiponectin's tumoricidal activity can be partially mediated by blocking HCC-induced reduction in p53 expression as well as reactivation of TRAIL signaling and induction of apoptotic pathway providing more protection for the body against the tumor.Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 8, 2019 Category: Environmental Health Source Type: research

The role of ANXA5 in DBP-induced oxidative stress through ERK/Nrf2 pathway
Publication date: Available online 1 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Lei Zhang, Zhiqiang Qin, Ran Li, Shangqian Wang, Wei Wang, Min Tang, Wei ZhangAbstractDi-N-butylphthalate (DBP) have given rise to more and more attention due to its unique endocrine toxicity to male reproductive system. Our previous studies have demonstrated antioxidative Nrf2 (nuclear factor erythroid related factor 2) pathway play a vital role in DBP induced oxidative stress injury. ANXA5 (annexin A5), which is highly expressed in testicular Leydig and Sertoli cells, was found upregulated after DBP stimulation. Mo...
Source: Environmental Toxicology and Pharmacology - August 3, 2019 Category: Environmental Health Source Type: research

Association of blood chromium and rare earth elements with the risk of DNA damage in chromate exposed population
Publication date: Available online 1 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Yi Bai, Changmao Long, Guiping Hu, Di Zhou, Xiaoying Gao, Zhangjian Chen, Tiancheng Wang, Shanfa Yu, Youli Han, Lailai YanAbstractPollution of heavy metals often occurs in combination with multiple metal ions. Whether the genetic damage among chromate exposed population correlated with rare earth elements (REEs) was still not well elucidated. A total of 291 participants from a chromate production plant were recruited in the present study. The DNA oxidative damage was evaluated by urinary 8-hydroxydeoxyguanosine (8-OH...
Source: Environmental Toxicology and Pharmacology - August 3, 2019 Category: Environmental Health Source Type: research