Environmental Toxicology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Total antioxidant status reduction conditioned by a serum selenium concentration decrease as a mechanism of the ultrasonographically measured brachial artery dilatation impairment in patients with arterial hypertension
The objective of the study was to determine the relationship between serum concentrations of selenium (SeS) and zinc (ZnS), total antioxidant status (TAS) and endothelial function assessed by ultrasonographic method of dilatation of the brachial artery in 141 hypertensive patients.Patients with SeS < median were characterized by a statistically significantly lower flow-mediated dilation (FMD) than patients with SeS ≥ median. Patients with TAS < median were characterized by a significantly lower FMD than patients with TAS ≥ median. Older age, higher BMI, male gender, higher blood total cholestero...
Source: Environmental Toxicology and Pharmacology - January 25, 2020 Category: Environmental Health Source Type: research

The dose-time effects of fluoride on the expression and DNA methylation level of the promoter region of BMP-2 and BMP-7 in rats
This study investigated the dose-time effects of fluoride on BMP-2 and BMP-7 levels and DNA methylation status of the promoter regions of these two genes in peripheral blood of rats. Eighty Wistar male rats were randomly divided into four groups and treated for 1 month and 3 months with distilled water (control), 25 mg/L, 50 mg/L or 100 mg/L of sodium fluoride (NaF). Rats exposed to fluoride had higher protein expression of BMP-2 and BMP-7 in plasma at 1 month and 3 months. An increase in BMP-2 expression was also observed with an increase of fluoride exposure time. Significant hypomethylation was observed in 2 CpG s...
Source: Environmental Toxicology and Pharmacology - January 24, 2020 Category: Environmental Health Source Type: research

hOGG1 promoter methylation, hOGG1 genetic variants and their interactions for risk of coal-borne arsenicosis: a case-control study
Publication date: Available online 21 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Lu Ma, Bing Liang, Yuan Yang, Liyuan Chen, Qizhan Liu, Aihua ZhangAbstractTo identify the effect of hOGG1 methylation, Ser326Cys polymorphism and their interactions on the risk of coal-borne arsenicosis, 113 coal-borne arsenicosis subjects and 55 reference subjects were recruited. Urinary arsenic contents were analyzed with ICP-MS. hOGG1 methylation and Ser326Cys polymorphism was measured by mehtylation-specific PCR and restriction fragment length polymorphism PCR in PBLCs, respectively. The results showed that the...
Source: Environmental Toxicology and Pharmacology - January 22, 2020 Category: Environmental Health Source Type: research

Up and down-regulation of mRNA in the cytotoxicity and genotoxicity of Plumbagin in HepG2/C3A
Publication date: Available online 10 January 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Giovanna Vaz Crippa, Thalita Alves Zanetti, Bruna Isabela Biazi, Adrivânio Baranoski, Lilian Areal Marques, Giuliana Castello Coatti, Sandra Regina Lepri, Mário Sérgio MantovaniAbstractStudies that evaluated the mechanisms of action of Plumbagin (PLB) and its toxicity may contribute to future therapeutic applications of this compound. We investigate biomarker important in the mechanisms of action correlate the expression of mRNA with the cytotoxic and genotoxic effects of PLB on HepG2/C3A. In the analysis of cyt...
Source: Environmental Toxicology and Pharmacology - January 11, 2020 Category: Environmental Health Source Type: research

Analgesic and anti-inflammatory effects and mechanism of action of borneol on photodynamic therapy of acne
This study aims to explore the analgesic and anti-inflammatory effects of borneol, a traditional Chinese medicine, on photodynamic treatment of acne. Here, we found that borneol significantly decreased the auricular swelling rate and pain threshold of rats. We also showed that borneol noticeably reduced macrophage and lymphocyte infiltration. The number of Th cells was significantly higher in the control PDT group than in the PDT plus borneol treatment group (P < 0.05). The expression of IL-6, TNF-α, and IL-8 mRNA and proteins were noticeably lower in the treatment group in comparison to those of the PDT control g...
Source: Environmental Toxicology and Pharmacology - January 9, 2020 Category: Environmental Health Source Type: research