Evaluation of different smoking habits during music festivals through wastewater analysis
Publication date: Available online 2 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Tomáš Mackuľak, Roman Grabic, Marián Gál, Miroslav Gál, Lucia Birošová, Igor Bodík Wastewater analysis is a powerful method that can provide useful information about the abuse of legal and illicit drugs. The aim of our study was to determine nicotine consumption during four different music festivals and to find a connection between smoking and preferences for specific music styles using wastewater analysis. The amount of the nicotine metabolite cotin...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Ethylene bisdithiocarbamate pesticides Maneb and Mancozeb cause metal overload in human colon cells
Publication date: Available online 7 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Lisa Hoffman, Louis Trombetta, Diane Hardej Previous studies in our laboratory have shown that ethylene bisdithiocarbamate (EBDC) fungicides Maneb and Mancozeb are equipotent gastrointestinal toxicants that produce cell loss and metal accumulation within HT-29 and Caco2 colon cells. Nabam, MnCl2, CuCl2 and ZnCl2 exposure produced no loss of viability up to 200μM and increases in metal levels were noted but not to the same extent as Maneb and Mancozeb. EBDC exposure caused increases in copper levels (20-200...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Time-dependent hormesis of chemical mixtures: A case study on sulfa antibiotics and a quorum-sensing inhibitor of Vibrio fischeri
This study investigated the time-dependent hormesis of single and binary mixtures of QSI and SAs of Vibrio fischeri (V.fischeri) for 0-24h. Although the low-dose SAs stimulated the expression of LuxR protein, the high-dose SAs could inhibit bacteria growth by competitively binding to dihydropteroate synthase. Moreover, AinR protein was bound to Benzofuran-3(2H)-one (B3O) with low concentration, thus the N-octanoyl homoserine lactone signal molecules (C8) has chance to bind to LuxR protein to promote light emission. The hormesis effect induced by the mixtures could be deduced that SAs promoted the expression of LuxR protein...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Toxicological evaluation of Yulangsan polysaccharide in Wistar rats: A 26-week oral gavage study
Publication date: Available online 10 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Chunxia Chen, Zhihuan Nong, Mingyu Meng, Qingwei Wen, Xing Lin, Feizhang Qin, Jianchun Huang, Renbin Huang Although numerous studies have proven the medicinal values of Yulangsan polysaccharide (YLSP), the toxicity of this active ingredient is unknown. In the acute toxicity study, a single oral administration of 24g/kg YLSP caused neither toxicological symptoms nor mortality, and the LD50 was estimated>24g/kg. In the chronic toxicity study, we administered doses of 0, 0.6, 1.2 and 2.4g/kg YLSP in...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

A pilot study of low-moderate drinking water arsenic contamination and chronic diseases among reproductive age women in Timiş County, Romania
Publication date: Available online 10 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Celeste D. Butts, Michael S. Bloom, Iulia A. Neamtiu, Simona Surdu, Cristian Pop, Doru Anastasiu, Edward F. Fitzgerald, Eugen S. Gurzau We conducted a pilot study of associations between drinking water contaminated by inorganic arsenic (iAs), mostly<10μg/L, and self-reported chronic diseases in 297 pregnant women. Adjusted for confounding variables, we identified a positive association between iAs and heart disease (OR=1.63, 95%CI 0.81-3.04, p=0.094), which was stronger for women living at the...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways
Publication date: Available online 10 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Yingzhuan Zhan, Rui Liu, Wenjie Wang, Jing Li, Xiaoyan Ou Yang, Yanmin Zhang Both PI3K/AKT/mTOR and mitogen activated protein kinase (MAPK) signaling cascades played an important role in tumorigenesis, a more complete understanding of these signaling pathways allowed the development of new therapeutic strategies. Total saponins isolated from Radix et Rhizoma Leonticis (RLTS) was recognized with anticancer properties. In a murine hepatocellular carcinoma H22 cell-bearing mouse model, RLTS exhibited signifi...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2
Publication date: Available online 10 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Stępnik Maciej, Spryszyńska Sylwia, Smok-Pieniążek Anna, Ferlińska Magdalena, Roszak Joanna, Nocuń Marek The effect of inhibitors of phosphatidylinositol-3-kinase-related kinases (PIKK): ataxia-telangiectasia mutated (ATM), ATM- and Rad3-related (ATR) and DNA-dependent protein kinase (DNA-PK) on response of HepG2 human liver cancer cells to benzo[a]pyrene (BaP) was investigated. PIKK inhibitors: KU55933 (5μM), NU7026 (10μM) or caffeine (1 and 2mM) when used as single agents or in combinations ...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Magnesium lithospermate B acts against dextran sodiumsulfate-induced ulcerative colitis by inhibiting activation of the NRLP3/ASC/Caspase-1 pathway
This study aimed to observe the therapeutic effects of magnesium lithospermate B on acute and chronic colitis induced by dextran sodiumsulfate (DSS) and the role of inflammasome complex (NOD-like receptor protein, NLRP; apoptosis-associated speck-like protein containing, ASC; caspase-1). Establishment of acute and chronic colitis models were by using 5% DSS oral administration in BALB/C male mice. Magnesium lithospermate B (240mg/kg body weight) was given by subcutaneous injection. Samples were collected for biomarker assay, histological examination, immunohistochemical evaluation and western blot. There was obvious increa...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Effect of active fraction of Eriocaulon sieboldianum on human leukemia K562 cells via proliferation inhibition, cell cycle arrest and apoptosis induction
This study could improve the development of E. sieboldianum and raise its application value in cancer adjuvant therapy. Considering it is both a dietary supplement and a traditional Chinese herbal medicine which exhibits anticancer activities, it can be developed into functional food. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Transcriptome profiling and pathway analysis of hepatotoxicity induced by tris (2-Ethylhexyl) trimellitate (TOTM) in mice
In this study, we investigated toxicity effects of TOTM on hepatic differential gene expression analyzed by using high-throughput sequencing analysis for over-represented functions and phenotypically anchored to complementary histopathologic, and biochemical data in the liver of mice. Among 1668 candidate genes, 694 genes were up-regulated and 974 genes were down-regulated after TOTM exposure. Using Gene Ontology analysis, TOTM affected three processes: the cell cycle, metabolic process and oxidative activity. Furthermore, eleven key genes involved in the above processes were validated by real time PCR. Kyoto Encyclopedia ...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Inhalation exposure or body burden? Better way of estimating risk - an application of PBPK model
Publication date: Available online 12 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Dipanjali Majumdar, Chirasree Dutta, Subha Sen We aim to establish a new way for estimating the risk from internal dose or body burden due to exposure of benzene in human subject utilizing physiologically based pharmacokinetic (PBPK) model. We also intend to verify its applicability on human subjects exposed to different levels of benzene. We estimated personal inhalation exposure of benzene for two occupational groups namely petrol pump workers and car drivers with respect to a control group, only environme...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity
Publication date: Available online 12 November 2015 Source:Environmental Toxicology and Pharmacology Author(s): Feng Zhang, Li Chen, Huanhuan Jin, Jiangjuan Shao, Li Wu, Yin Lu, Shizhong Zheng Drug-induced liver injury can lead to acute liver failure. Saikosaponin D (SSD) is a major component isolated from the medicinal herb Bupleurum falactum, which has been linked to hepatotoxicity. We previously reported that SSD disrupted PDGF-βR pathway leading to mitochondrial apoptosis in human LO2 hepatocytes. The present study was aimed at further exploring the underlying mechanisms in vitro and in vivo. We initially...
Source: Environmental Toxicology and Pharmacology - November 13, 2015 Category: Environmental Health Source Type: research

Propolis aqueous extract preserves functional integrity of murine intestinal mucosa after exposure to ionizing radiation
Publication date: Available online 9 October 2015 Source:Environmental Toxicology and Pharmacology Author(s): Mohamed T. Khayyal, Rania M. El-Hazek, Mona A. El-Ghazaly The ability of a specially prepared water propolis extract (PWE) to preserve the functional activity of the intestinal mucosa after radiation exposure was studied. PWE was given orally (650mg/kg) to rats five days prior to irradiation by 6Gy and continued for further two days. Rats were sacrificed 24h later, intestinal segments were examined histologically and homogenates were used to assess relevant biochemical parameters reflecting intestinal injury. ...
Source: Environmental Toxicology and Pharmacology - October 10, 2015 Category: Environmental Health Source Type: research

Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells
Publication date: Available online 3 October 2015 Source:Environmental Toxicology and Pharmacology Author(s): Francesca Felicia Caputi, Donatella Carretta, Francesca Lattanzio, Martina Palmisano, Sanzio Candeletti, Patrizia Romualdi Paraquat (PQ) and maneb (MB) are able to induce neurotoxic effects by promoting α-synuclein (α-syn) aggregates and altering tyrosine-hydroxylase (TH), thus increasing the risk of Parkinson's disease (PD). These pesticides promote neurotoxic effects also by affecting proteasome function that normally regulate protein turnover. We investigated the effects of the two pesticides...
Source: Environmental Toxicology and Pharmacology - October 4, 2015 Category: Environmental Health Source Type: research

Effects of Nanocrystalline PbSe on Hematopoietic System and bone marrow micronucleus rate of Rats
Conclusions Nano PbSe can lead to changes in blood routine index and bone marrow micronucleus rate, and its toxicity was positively related to the dosage. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 2, 2015 Category: Environmental Health Source Type: research

The in vitro effect of Lambda-cyhalothrin on quality and antioxidant responses of Rainbow trout Oncorhynchus mykiss spermatozoa
In conclusion, the oxidant and antioxidant status and, sperm quality were affected by increasing concentrations of LCT. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 2, 2015 Category: Environmental Health Source Type: research

Arsenic and human health effects: A Review
Publication date: Available online 30 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Khaja Shameem Mohammed Abdul, Sudheera Sammanthi Jayasinghe, Ediriweera P.S. Chandana, Channa Jayasumana, P. Mangala C.S. De Silva Arsenic (As) is ubiquitous in nature and humans being exposed to arsenic via atmospheric air, ground water and food sources are certain. Major sources of arsenic contamination could be either through geological or via anthropogenic activities. In physiological individuals, organ system is described as group of organs that transact collectively and associate with other systems ...
Source: Environmental Toxicology and Pharmacology - October 2, 2015 Category: Environmental Health Source Type: research

Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK
In conclusion, our results indicated that ampelopsin mainly elicited apoptosis through extrinsic and intrinsic pathway and that ERK1/2 and P38 had opponent effects on the apoptosis. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - October 2, 2015 Category: Environmental Health Source Type: research

Blocking TGF-β expression inhibits silica particle-induced epithelial-mesenchymal transition in human lung epithelial cells
In this study, we determined the expression of TGF-β-Smad2/3, EMT- and ECM- related markers in lung epithelial cells treated with silica particle by RT-PCR, western-blot and ELISA. In order to explore the role of TGF-β, we used TGF-β inhibitor in the cell model. We found that the cells lost the expression of epithelial phenotypic markers and acquired increased expression of mesenchymal cells markers with ECM deposition after treatment with silica particle. Moreover, the changes of EMT-related event was restricted in response to TGF-β inhibitor. These findings suggest that EMT is essentially involved in ...
Source: Environmental Toxicology and Pharmacology - September 29, 2015 Category: Environmental Health Source Type: research

Chemopreventive activity of grape juice concentrate (G8000TM) on rat colon carcinogenesis induced by azoxymethane
Publication date: Available online 28 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Roseane Mendes Silva, Vanessa Maria de Lima Pazine Campanholo, Ana Paula Ribeiro Paiotti, Ricardo Artigiani Neto, Celina Tizuko Fujiyama Oshima, Daniel Araki Ribeiro, Nora Manoukian Forones Colorectal cancer is the third most common cancer worldwide in both sexes, with similar geographic patterns between genders. This neoplasm has good prognosis if the disease is diagnosed at early stages The aim of this study was to evaluate the effect of red grape juice on the expression of COX-2 and Ki-67 expression ...
Source: Environmental Toxicology and Pharmacology - September 29, 2015 Category: Environmental Health Source Type: research

Individual and combined effects of deoxynivalenol and α-zearalenol on cell proliferation and steroidogenesis of granulosa cells in cattle
This study was conducted to evaluate the impact of deoxynivalenol (DON) and zearalenone (ZEA) metabolite, α-zearalenol (α-Zol), on cell proliferation and steroidogenesis of bovine large (LG) follicle granulosa cells (GC). LGGC were obtained from bovine ovarian follicles (8–22mm) and were cultured for 2 days in medium containing 10% fetal bovine serum followed by 1 or 2 days in serum-free medium without (control) or with treatments. Three different experiments were performed using different dosages of DON and α-Zol and in different combinations and a fourth experiment evaluated estradiol effects on g...
Source: Environmental Toxicology and Pharmacology - September 29, 2015 Category: Environmental Health Source Type: research

Corrigendum to “Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish” [Environ. Toxicol. Pharmacol. 40 (2015) 581–586]
Publication date: Available online 26 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Tao Xu, Qiangwei Wang, Qipeng Shi, Qi Fang, Yongyong Guo, Bingsheng Zhou (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 27, 2015 Category: Environmental Health Source Type: research

p-Methoxycinnamic acid, an active phenylpropanoid induces mitochondrial mediated apoptosis in HCT-116 human colon adenocarcinoma cell line
Publication date: Available online 26 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Sivagami Gunasekaran, KarthikKumar Venkatachalam, Nalini Namasivayam Among the eight phytochemicals (dihydrocarveol, sinapic acid, vanillic acid, ethylgallate, myrtenol, transcarveol, p-methoxycinnamic acid, isoferulic acid) we tested, p-methoxycinnamic acid (p-MCA)[10μM] showed the most potent in vitro growth inhibition on human colon adenocarcinoma(HCT-116 cells). Antiproliferative activity of p-MCA at 24h was associated with DNA damage, morphological changes and the results were comparable with doxoru...
Source: Environmental Toxicology and Pharmacology - September 26, 2015 Category: Environmental Health Source Type: research

Changes in exposure temperature lead to changes in pesticide toxicity to earthworms: A preliminary study
Publication date: Available online 18 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Mirna Velki, Sandra Ečimović The occurring climate changes will have direct consequences to all ecosystems, including the soil ecosystems. The effects of climate change include, among other, the changes in temperature and greater frequency and intensity of extreme weather conditions. Temperature is an important factor in ecotoxicological investigations since it can act as a stressor and influence the physiological status of organisms, as well as affect the fate and transport of pollutants present in the en...
Source: Environmental Toxicology and Pharmacology - September 20, 2015 Category: Environmental Health Source Type: research

Ameliorative effects of thymoquinone against eye lens changes in streptozotocin diabetic rats
Publication date: Available online 16 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Amr A. Fouad, Fahad Alwadani The possible protective effect of thymoquinone against eye lens changes in diabetic rats was investigated. Following diabetes induction by a single injection of streptozotocin (45mg/kg, i.p.), thymoquinone was administered in three different doses (20, 40, and 80mg/kg/day, p.o.) for 12 weeks. Thymoquinone significantly and dose-dependently attenuated the hypoinsulinemia and hyperglycemia in diabetic rats. Also, thymoquinone (particularly 40 and 80mg/kg) significantly decreased th...
Source: Environmental Toxicology and Pharmacology - September 17, 2015 Category: Environmental Health Source Type: research

Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation
Publication date: Available online 16 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Meng Mei, Futian Tang, Meili Lu, Xin He, Hongxin Wang, Xuwei Hou, Jin Hu, Chonghua Xu, Ronghui Han Calpain-1 activation and oxidative stress are two critical factors contributing to apoptosis of hypertrophic cardiomyocyte. Astragaloside IV (ASIV) exhibits protective effect against various heart diseases. The present study was designed to investigate whether the inhibitory effect of ASIV on isoproterenol (ISO)-induced apoptosis of hypertrophic cardiomyocyte was associated with the anti-oxidation and ca...
Source: Environmental Toxicology and Pharmacology - September 17, 2015 Category: Environmental Health Source Type: research

Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells
In this study, the genotoxic potential of OLA was investigated in the human embryonic kidney cell line 293 (HEK293). Results showed that OLA caused significant increases of DNA migration. Lysosomal membrane permeability and mitochondrial membrane potential were reduced after treatment with OLA. OLA was shown to induce ROS production and GSH depletion. The expression of p53 protein is increased in cells incubated with OLA. The activation of p53 and ATM gene was assessed by exposure to OLA. Furthermore, NAC reduced DNA migration, ROS formation, GSH depletion and the expression of the p53 protein and gene. And desipramine sig...
Source: Environmental Toxicology and Pharmacology - September 17, 2015 Category: Environmental Health Source Type: research

Epigenetic Modulation of Chlorella (Chlorella vulgaris) on Exposure to Polycyclic Aromatic Hydrocarbons
Publication date: Available online 12 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Mihi Yang, Je-In Youn, Seung Joon Kim, Jong Y. Park DNA methylation in promoter region can be a new chemopreventive marker against polycyclic aromatic hydrocarbons (PAHs). We performed a randomized, double blind and cross-over trial (N= 12 healthy females) to evaluate chlorella (Chlorella vulgaris)-induced epigenetic modulation on exposure to PAHs. The subjects consumed 4 tablets of placebo or chlorella supplement (total chlorophyll ≈ 8.3mg/tablet) three times a day before meals for 2 weeks. When the...
Source: Environmental Toxicology and Pharmacology - September 13, 2015 Category: Environmental Health Source Type: research

Cytotoxic effect of nanosilver particles on testicular tissue: Evidence for biochemical stress and Hsp70-2 protein expression
In conclusion, the NS particles exert their pathological impact via affecting testicular antioxidant and endocrine statuses, which in turn lead to diminished expression of Hsp70-2. Ultimately, by this mechanism NS particles adversely impact the cellular RNA, DNA and protein contents. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 11, 2015 Category: Environmental Health Source Type: research

Prevention of cyclophosphamide-induced hepatotoxicity and genotoxicity: effect of an L-cysteine based oxovanadium(IV) complex on oxidative stress and DNA damage
This study was aimed to investigate the protective role of an organovanadium complex, viz., oxovanadium(IV)-L-cysteine methyl ester (VC-IV) against cyclophosphamide (CP)-induced hepatotoxicity and genotoxicity in mice. Oral administration of VC-IV quite effectively ameliorated CP-induced histopathological lesions and reduced levels of alanine transaminase, aspartate transaminase and alkaline phosphatase. In addition, VC-IV significantly attenuated CP-induced oxidative stress in the liver as evident from levels of reactive oxygen species, nitric oxide and lipid peroxidation. Restoration of glutathione level and activities o...
Source: Environmental Toxicology and Pharmacology - September 11, 2015 Category: Environmental Health Source Type: research

Quantitative Structure-Activity/EcoToxicity Relationships(QSAR/QEcoSAR) of a Series of Phosphonates
Publication date: Available online 10 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Alina-Maria Petrescu, Mihai V. Putz, Gheorghe Ilia In this paper the structure-toxicity relationship studies were performed for a series of 60 phosphonates. The toxicity of the compounds was determined by two ways: by quantifying the measured toxicity values, Mlog(1/MRIC50) collected by literature, for rodents species; second by using EcoSAR software version 1.11, for calculating the toxicity for fish species, considered as dependent variables and they were related to structural features obtained by molecul...
Source: Environmental Toxicology and Pharmacology - September 11, 2015 Category: Environmental Health Source Type: research

In utero exposure of neonatal buffalo calves to pesticide residues and the alterations within their reproductive tract
In conclusion, in utero exposure of neonatal buffalo calves to pesticide residues may be associated with damaging alterations in their reproductive tract. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 11, 2015 Category: Environmental Health Source Type: research

Toxicological effects of Silver Nanoparticles
Publication date: Available online 11 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Jacob Joe Antony, Periyasamy Sivalingam, Baoan Chen Nanotechnology offers numerous biomedical applications and in so doing exerts toxic effects. AgNPs, one of the metallic nanoparticles is known for its antibacterial applications and hence exposed to human through various healthcare products. Analysis of its toxic effects is necessary before its appliance into the biomedical field. Hence, this mini-review focuses on toxic effects of AgNPs related to human and his environment in vitro and in vivo. (Source: E...
Source: Environmental Toxicology and Pharmacology - September 11, 2015 Category: Environmental Health Source Type: research

Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish
Publication date: September 2015 Source:Environmental Toxicology and Pharmacology, Volume 40, Issue 2 Author(s): Tao Xu, Qiangwei Wang, Qipeng Shi, Qi Fang, Yongyong Guo, Bingsheng Zhou Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate widely used as a flame retardant, and has frequently been detected in the environment and biota. The present study investigates the bioconcentration and metabolism of TDCPP in fish. Zebrafish embryos (from 2h post-fertilization) were exposed to TDCPP (0, 4, 20 and 100μg/L) for six months. Exposure to TDCPP significantly induced phase I metabolic enzymes 7-ethoxyr...
Source: Environmental Toxicology and Pharmacology - September 8, 2015 Category: Environmental Health Source Type: research

Effects of Waterborne Fluoxetine on Stress Response and Osmoregulation in Zebrafish
Publication date: Available online 8 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Murilo S. Abreu, Ana Cristina V. Giacomini, Gessi Koakoski, Thiago A. Oliveira, Darlan Gusso, Bernardo Baldisserotto, Leonardo J.G. Barcellos The presence of fluoxetine in aquatic environments has been reported for decades. Here, we investigate the effects of exposure to fluoxetine on the stress response and osmoregulation in zebrafish. We show that stress response alters osmoregulation and that fluoxetine inhibits these stress-related changes in osmoregulation. The results suggest that the presence of f...
Source: Environmental Toxicology and Pharmacology - September 8, 2015 Category: Environmental Health Source Type: research

Estrogen Receptor (ER)-α, β and Progesterone Receptor (PR) Mediates Changes in Relaxin Receptor (RXFP1 and RXFP2) Expression and Passive Range of Motion of Rats’ Knee
Conclusion Progesterone and high doses of estrogen treatment resulted in the highest range of knee laxity correlated to both relaxin receptor isoforms expression in knee tissues. Our findings thus suggest that female subjects are more vulnerable towards non-traumatic knee injury with estrogen and progesterone fluctuation as compared to male subjects. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 8, 2015 Category: Environmental Health Source Type: research

The lack of protective effects of tea supplementation on liver and jejunal epithelium in adult rats exposed to cadmium and lead
Publication date: Available online 8 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Ewa Tomaszewska, Anna Winiarska-Mieczan, Piotr Dobrowolski Adult rats at the age of 12 weeks were divided into the control group and groups supplemented with green (GT), black (BT), red (RT), or white (WT) tea extracts. The diet (except that for the controls) was mixed with 7mg Cd/kg and 50mg Pb/kg. The experiment lasted 12 weeks. Basal hematology and plasma biochemical parameters as well as the histomorphometrical parameters of jejunal epithelium and liver were determined. The lowest body mass was found in ...
Source: Environmental Toxicology and Pharmacology - September 8, 2015 Category: Environmental Health Source Type: research

Trace elements in scalp hair from potentially exposed individuals in the vicinity of the Bayan Obo mine in Baotou, China
Publication date: Available online 2 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Yuxue Pan, Haitao Li Mining activities including mineral excavation and ore transportation produce and release large amounts of pollutants to the surrounding environment, raising concerns regarding the effects of environmental exposure to pollutants on human health. The concentration of elements in hair can be used as a biomarker of exposure to chemical elements. In the present study, hair samples from 89 relatively healthy volunteers aged 11-77 years old (57 living near Bayan Obo giant REE-Nb-Fe ore deposit ...
Source: Environmental Toxicology and Pharmacology - September 4, 2015 Category: Environmental Health Source Type: research

Diaryl sulfide analogs of combretastatin A-4: toxicogenetic, immunomodulatory and apoptotic evaluations and prospects for use as a new chemotherapeutic drug
Publication date: Available online 2 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Pamela Castilho de Carvalho, Edson dos Anjos dos Santos, Beatriz Ursinos Catelán Shneider, Renata Matuo, João Renato Pesarini, Andréa Luiza Cunha-Laura, Antônio Carlos Duenhas Monreal, Dênis Pires de Lima, Andréia Conceição Milan Brochado Antoniolli, Rodrigo Juliano Oliveira Combretastatin A-4 exhibits efficient anti-cancer potential in human tumors, including multidrug-resistant tumors. We evaluated the mutagenic, apoptotic and immunomodulatory po...
Source: Environmental Toxicology and Pharmacology - September 4, 2015 Category: Environmental Health Source Type: research

Individual and combined effects of deoxynivalenol and zearalenone on mouse kidney
This study was performed to investigate the individual and combined toxic effects of deoxynivalenol (DON) and zearalenone (ZEA) on mouse kidney. A total of 360 female mice were divided into nine groups. Each group received intraperitoneal injection of solvent (control), DON, ZEA, or DON+ZEA four times for 12 d. Results showed that ZEA and/or DON increased the apoptosis rate in the kidney, as well as the levels of serum creatinine and blood urea nitrogen. DON and/or ZEA also induced renal oxidative stress as indicated by increased malondialdehyde concentration and nitric oxide level and reduced superoxide dismutase enzyme a...
Source: Environmental Toxicology and Pharmacology - September 4, 2015 Category: Environmental Health Source Type: research

Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups
The objective of this study was to define the distribution of SNPs of three SLCO genes, SLCO1B1, SLCO1B3, and SLCO2B1, in a Korean population and other ethnic groups. The study was screened using the Illumina GoldenGate assay for genomic DNA from 450 interethnic subjects, including 11 pharmacogenetic core variants and 76 HapMap tagging SNPs. The genotype distribution of the Korean population was similar to East Asian populations, but significantly different from African American and European American cohorts. These interethnic differences will be useful information for prospective studies, including genetic association and...
Source: Environmental Toxicology and Pharmacology - September 4, 2015 Category: Environmental Health Source Type: research

Arsenic Cardiotoxicity: An Overview
Publication date: Available online 3 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Nafiseh Sadat Alamolhodaei, Kobra Shirani, Gholamreza Karimi Arsenic exposures, prevalent through dietary and non-dietary, imposes a serious hazard to global health. Human exposure to arsenic is associated with various cardiopathologic effects, including ischemia, arrhythmia, heart failure and sudden death. Possible mechanisms of arsenic cardiotoxicity include oxidative stress, DNA fragmentation, apoptosis and functional changes of ion channels. Several evidences have shown that mitochondrial disruption, cas...
Source: Environmental Toxicology and Pharmacology - September 4, 2015 Category: Environmental Health Source Type: research

A new index to assess chemicals increasing the greenhouse effect based on their toxicity to algae
Publication date: Available online 4 September 2015 Source:Environmental Toxicology and Pharmacology Author(s): Ting Wang, Xiaoxian Zhang, Dayong Tian, Ya Gao, Zhifen Lin, Ying Liu CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing number of artificial chemicals. Thus, seven types of chemicals and Selenastrum capricornutum (algae) were examined in thi...
Source: Environmental Toxicology and Pharmacology - September 4, 2015 Category: Environmental Health Source Type: research

Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride
Publication date: September 2015 Source:Environmental Toxicology and Pharmacology, Volume 40, Issue 2 Author(s): Ruiyan Niu, Jianming Wang, Zilong Sun, Xingchen Xue, Xiaoyan Yan, Jinming Wang, Jianhai Zhang, Jundong Wang (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - September 1, 2015 Category: Environmental Health Source Type: research

Inhibitory effect of arsenic trioxide on neuronal migration in vitro and its potential molecular mechanism
Publication date: Available online 29 August 2015 Source:Environmental Toxicology and Pharmacology Author(s): Hao Zhou, Ye Liu, Xin-Jie Tan, Yu-Chuan Wang, Kai-Yu Liu, Yu-Xia Cui Primary neuron cultures were established from the brains of neonatal rats and the effects of arsenic trioxide (As2O3) on the migration of neurons and the potential mechanism of As2O3 were investigated. Boyden chamber assay was used to detect the effect of AS2O3 on neuronal migration. Matrix metalloproteinase-2 (MMP-2) and MMP-9 RNA expression and doublecortin (DCX) protein expression were measured. Neuronal migration ability was significan...
Source: Environmental Toxicology and Pharmacology - August 29, 2015 Category: Environmental Health Source Type: research

Impact of aflatoxin B1 on the pharmacokinetic disposition of enrofloxacin in broiler chickens
Publication date: Available online 28 August 2015 Source:Environmental Toxicology and Pharmacology Author(s): Starling Kalpana, G. Srinivasa. Rao, Jitendra K. Malik The potential impact of subchronic exposure of aflatoxin B1 was investigated on the pharmacokinetic disposition of enrofloxacin in broiler chickens. Broiler chickens given either normal or aflatoxin B1 (750μg/kg diet) supplemented diet for 6 weeks received a single oral dose of enrofloxacin (10mg/kg body wt). Blood samples were drawn from the brachial vein at predetermined time intervals after drug administration. Enrofloxacin plasma concentrations anal...
Source: Environmental Toxicology and Pharmacology - August 28, 2015 Category: Environmental Health Source Type: research

Cytotoxic Effect of Nanosilver Particles on Testicular Tissue; Evidence for biochemical Stress and Hsp70-2 Protein Expression
In conclusion, the NS particles exert their pathological impact via affecting testicular antioxidant and endocrine statuses, which in turn lead to diminished expression of Hsp70-2. Ultimately, by this mechanism NS particles adversely impact the cellular RNA, DNA and protein contents. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 28, 2015 Category: Environmental Health Source Type: research

Acute, Mutagenicity, Teratogenicity and Subchronic Oral Toxicity Studies of Diaveridine in Rodents
Publication date: Available online 23 August 2015 Source:Environmental Toxicology and Pharmacology Author(s): Jianzhong Wang, Feifei Sun, Shusheng Tang, Suxia Zhang, Xingyuan Cao Diaveridine (DVD) is a member of the 2, 4-pyrimidinediamine class of dihydrofolate reductase inhibitors. It is used in combination with sulfaquinoxaline as an antiprotozoal agent in animals for the prophylaxis and treatment of coccidiosis and leucocytozoonosis. Herein, we report a complete toxicological safety assessment of DVD for clinical use. The study of toxicity, genetic toxicity (mammalian erythrocyte micronucleus assay, mice sperm ab...
Source: Environmental Toxicology and Pharmacology - August 24, 2015 Category: Environmental Health Source Type: research

Effects of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) on the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism, and differences in the action of parent BDE-47 and its hydroxylated metabolites, 5-OH-BDE-47 and 6-OH-BDE47, on steroid secretion by luteal cells
Conclusions The inhibitory effect of BDE-47 on CYP2B1/2 suggests the possibility of BDE-47 accumulation in the corpus luteum; by affecting steroid secretion and steroidogenesis enzymes, BDE-47 and its metabolites can be responsible for shortening luteal phase. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 23, 2015 Category: Environmental Health Source Type: research

Effect of enrofloxacin and chlorpyrifos on the levels of vitamins A and E in Wistar rats
This study investigates the effects of enrofloxacin and chlorpyrifos, and their combination on vitamin A and E concentrations in the liver of rats. Results of this study indicated a reduction in the contents of vitamins A and E in the liver, which persisted for the entire period of the experiment. Vitamins A and E concentrations were slightly decreased (2-7%) in enrofloxacin-treated rats. In the group of rats intoxicated with chlorpyrifos, a significant decrease in the level of vitamin A was observed up to the 24th hour, and for vitamin E up to the 3rd day from the discontinuation of intoxication with the compounds under s...
Source: Environmental Toxicology and Pharmacology - August 22, 2015 Category: Environmental Health Source Type: research