Study on the interaction between typical phthalic acid esters (PAEs) and human hemoglobin (hHb) by molecular docking
Publication date: Available online 20 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): Songwen Tan, Donglin Wang, Zhenxing Chi, Weiguo Li, Ye Shan This work has evaluated the binding force between hHb and typcial PAEs (DMP, DEP, DPRP, DBP, DIBP, DHP and DPHP) using molecule docking technique. The DPHP with 3 aromatic rings has the strongest binding (-ΔGbinding: 6.0kcalmol−1) than other PAEs (-ΔGbinding: 2.91∼4.48kcalmol−1). The DMP with the lowest molecular weight has a high binding force (-ΔGbinding: 4.48kcalmol−1), while the DHP with the highest molecular weig...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Immune response mechanism of mouse monocytes/macrophages treated with κ-carrageenan polysaccharide
This study investigated the function of κ-carrageenan polysaccharide in immune regulation. The immune response of RAW 264.7 cells treated with κ-carrageenan polysaccharide was explored by MTT assay, general morphological observation, neutral red phagocytosis assay, Griess method, fluorescence method, and enzyme-linked immunosorbent assay. In addition, TLR4 blocking experiment and double-fluorescence immunostaining were performed on cells to demonstrate their immune response mechanism. Results show that κ-carrageenan polysaccharide not only promotes cell proliferation but also activates RAW 264.7 cells, th...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Connexin 43 mediates changes in protein phosphorylation in HK-2 cells during chronic cadmium exposure
In this study, human renal proximal tubule (HK-2) cells were exposed to Cd (1μM, 10 days). Of the 584 protein residues detected using a Phospho Explorer antibody microarray (PEX100), more than half changed their levels of phosphorylation after chronic Cd exposure. Cx43 siRNA attenuated Cd-induced apoptosis and inhibited proliferation, while also attenuating changes in the levels of phosphorylation of many protein residues. According to DAVID Bioinformatics Resources analysis and KEGG PATHWAY database, AKT signal pathway may be the important one. Focusing on the AKT pathway confirmed that Cx43 mediated increased levels o...
Source: Environmental Toxicology and Pharmacology - June 21, 2017 Category: Environmental Health Source Type: research

Computational analysis of the ToxCast estrogen receptor agonist assays to predict vitellogenin induction by chemicals in male fish
Publication date: Available online 13 June 2017 Source:Environmental Toxicology and Pharmacology Author(s): David A. Dreier, Nancy D. Denslow, Christopher J. Martyniuk Endocrine disruptors, especially estrogen receptor (ER) agonists, have received considerable research attention. While there are several mechanistic endpoints for ER agonism in the Endocrine Disruptor Screening Program, there have been growing efforts to develop high-throughput screening assays and computational models to reduce testing cost, time, and animal use. For example, there are 16 ER agonist assays and an integrated computational model in ToxCast. ...
Source: Environmental Toxicology and Pharmacology - June 14, 2017 Category: Environmental Health Source Type: research

Histological alterations in gills and liver of rainbow trout (Oncorhynchus mykiss) after exposure to the antibiotic oxytetracycline
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): S. Rodrigues, S.C. Antunes, B. Nunes, A.T. Correia The aim of this study was to investigate the histopathological effects of oxytetracycline (OTC) on the gill and liver tissues of rainbow trouts (Oncorhynchus mykiss) following acute (96h: 0.005–50mg/L) and chronic (28days: 0.3125–5μg/L) exposures. Results suggest the existence of a cause-and-effect relationship between the exposure to OTC and tissue damage. Most predominant disorders observed in gills were progressive (e.g. hypertrophy of mucous cells and hype...
Source: Environmental Toxicology and Pharmacology - June 8, 2017 Category: Environmental Health Source Type: research

QSAR models for predicting acute toxicity of pesticides in rainbow trout using the CORAL software and EFSA ’s OpenFoodTox database
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Andrey A. Toropov, Alla P. Toropova, Marco Marzo, Jean Lou Dorne, Nikolaos Georgiadis, Emilio Benfenati Optimal (flexible) descriptors were used to establish quantitative structure – activity relationships (QSAR) for toxicity of pesticides (n=116) towards rainbow trout. A heterogeneous set of hundreds of pesticides has been used, taken from the EFSA’s chemical Hazards Database: OpenFoodTox. Optimal descriptors are preparing from simplified molecular input-line entry system (SMILES). So-called, correlation weights...
Source: Environmental Toxicology and Pharmacology - June 7, 2017 Category: Environmental Health Source Type: research

Cadmium, arsenic, selenium and iron – Implications for tumor progression in breast cancer
This study support the role of Cd in breast cancer risk and progression. The possible link between As exposure and breast cancer is still not clear. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - June 4, 2017 Category: Environmental Health Source Type: research

Role of PI3K/AKT/mTOR signaling pathway in DBP-induced apoptosis of testicular sertoli cells in vitro
This study was to investigate the injury effect induced by DBP on rat testicular Sertoli cells in vitro. MTT results showed that DBP can significantly reduce the survival rate of Sertoli cells; Hoechst staining results showed that the Sertoli cells treated with DBP emerged with typical morphological characteristics of apoptosis, nuclear condensation and chromatin condensation; flow cytometry results showed that DBP significantly increased the apoptotic rate of Sertoli cells, and dose-dependent; Western blotting showed that the expression of PTEN protein in Sertoli cells was significantly higher than that in the control gro...
Source: Environmental Toxicology and Pharmacology - June 2, 2017 Category: Environmental Health Source Type: research

Application of novel metal organic framework, MIL-53(Fe) and its magnetic hybrid: For removal of pharmaceutical pollutant, doxycycline from aqueous solutions
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Shakiba Naeimi, Hossein Faghihian As a pharmaceutical pollutant, doxycycline causes contamination when enters into the environment. In this research MIL-53(Fe), and its magnetic hybrid MIL-53(Fe)/Fe3O4 were synthesized and employed for removal of doxycycline from aqueous solutions. The adsorbents were characterized by XRD, SEM, BET, FTIR, EDAX, VSM and TG-DTG technique. The effect of different variables such as DOC concentration, pH, contacting time, and adsorbent dose on the removal efficiency was studied and under optimize...
Source: Environmental Toxicology and Pharmacology - May 23, 2017 Category: Environmental Health Source Type: research

Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay
Publication date: Available online 12 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Radosław Czernych, Milena Chraniuk, Paweł Zagożdżon, Lidia Wolska The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of co...
Source: Environmental Toxicology and Pharmacology - May 13, 2017 Category: Environmental Health Source Type: research

Corrigendum to “The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice” [Environ. Toxicol. Pharmacol. 51 (2017) 16–22]
Publication date: Available online 12 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiao-Yu Qu, Li-Na Tao, Si-Xi Zhang, Jing-Meng Sun, Jun-Qi Niu, Yan-Hua Ding, Yan-Qing Song (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 13, 2017 Category: Environmental Health Source Type: research

The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water
Publication date: Available online 12 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Binggan Wei, Jiangping Yu, Jing Wang, Linsheng Yang, Hairong Li, Chang Kong, Yajuan Xia, Kegong Wu The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and %MMA, and lower SMI (secondary arsenic methylation index) comp...
Source: Environmental Toxicology and Pharmacology - May 13, 2017 Category: Environmental Health Source Type: research

Application of novel metal organic framework, MIL-53(Fe) and its magnetic hybrid; for removal of pharmaceutical pollutant, doxycycline from aqueous solutions
Publication date: Available online 11 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shakiba Naeimi, Hossein Faghihian As a pharmaceutical pollutant, doxycycline causes contamination when enters into the environment. In this research MIL-53(Fe), and its magnetic hybrid MIL-53(Fe)/Fe3O4 were synthesized and employed for removal of doxycycline from aqueous solutions. The adsorbents were characterized by XRD, SEM, BET, FTIR, EDAX, VSM and TG-DTG technique. The effect of different variables such as DOC concentration, pH, contacting time, and adsorbent dose on the removal efficiency was studied and under ...
Source: Environmental Toxicology and Pharmacology - May 12, 2017 Category: Environmental Health Source Type: research

Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural stem/progenitor cells
Publication date: Available online 11 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mayu Nishikawa, Hideki Mori, Masayuki Hara Zinc plays important roles for brain development. Zrt-, Irt-related protein (ZIP) is a major transporter family to regulate the intracellular zinc levels. Neural stem/progenitor cells (NSPCs) are more sensitive than their differentiated progeny (neural/glial cells) to zinc in vitro (Nishikawa et al., 2015). We analyzed relative gene expression of 14 different ZIPs in murine NSPCs and differentiated cells by real-time polymerase chain reaction technique. Expression of Zip4 an...
Source: Environmental Toxicology and Pharmacology - May 12, 2017 Category: Environmental Health Source Type: research

Silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation using gold nanoparticles
We present a nanoparticle (NP)-mediated delivery vehicle that effectively carries and protects siRNA in pediatric ependymoma (EP) and medulloblastoma (MB) cells. The delivery vehicle consists of gold NPs coated with a polymeric shell comprising polyethylene glycol (PG), chitosan and polyethyleneimine (Au-CP-PEI). NPs loaded with siRNA knocked down Ape1 expression by over 75% in both MB and EP cells. Further, this reduction in Ape1 expression is associated with an increase in DNA damage after irradiation. The results indicate that NP-associated delivery of siApe1 is a feasible approach to circumventing pediatric brain tumor...
Source: Environmental Toxicology and Pharmacology - May 11, 2017 Category: Environmental Health Source Type: research

Green synthesis of Au –Cu2−xSe heterodimer nanoparticles and their in-vitro cytotoxicity, photothermal assay
Publication date: July 2017 Source:Environmental Toxicology and Pharmacology, Volume 53 Author(s): Sireesh Babu Maddinedi We demonstrate a new route for the synthesis of heterogeneous nanoparticles (NPs) composed of a gold domain (Au) and a heavily doped semiconductor domain (Cu2−xSe) which exhibit a broad localized surface plasmon resonance (LSPR) arising from interactions between two nanocrystal domains. We also demonstrate the in-vitro cytotoxicity and photo thermal efficiency of as prepared Au–Cu2−xSe heterodimer nanoparticles. This work establishes a new way of tuning LSPR by engineering the density...
Source: Environmental Toxicology and Pharmacology - May 11, 2017 Category: Environmental Health Source Type: research

3 β-Hydroxy-urs-12-en-28-oic acid confers protection against ZnONPs induced adversity in Caenorhabditis elegans
Publication date: Available online 8 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.7...
Source: Environmental Toxicology and Pharmacology - May 9, 2017 Category: Environmental Health Source Type: research

Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure
This study aimed to evaluate the effects of the paracetamol on reproductive, biochemical, genetic, morphological and hematogical biomarkers by waterborne exposure. Male fish of Rhamdia quelen were exposed to environmental concentrations of paracetamol (0, 0.25, 2.5μg/L) in a semi-static bioassay for 21 days. Hemoglobin and hematocrit were reduced upon exposure to 0.25μg/L of paracetamol. Leukocytes and thrombocytes increased after paracetamol exposure. Paracetamol reduced testosterone levels in all exposed groups and increased estradiol levels at higher concentration. Serotonin and dopamine levels increased at exposu...
Source: Environmental Toxicology and Pharmacology - May 9, 2017 Category: Environmental Health Source Type: research

Green synthesis of Au −Cu2−xSe heterodimer nanoparticles and their in-vitro cytotoxicity, photothermal assay
Publication date: Available online 5 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Sireesh Babu Maddinedi We demonstrate a new route for the synthesis of heterogeneous nanoparticles (NPs) composed of a gold domain (Au) and a heavily doped semiconductor domain (Cu2−xSe) which exhibit a broad localized surface plasmon resonance (LSPR) arising from interactions between two nanocrystal domains. We also demonstrate the in-vitro cytotoxicity and photo thermal efficiency of as prepared Au−Cu2−xSe heterodimer nanoparticles. This work establishes a new way of tuning LSPR by engineering the ...
Source: Environmental Toxicology and Pharmacology - May 7, 2017 Category: Environmental Health Source Type: research

Cellular uptake mechanism and clearance kinetics of fluorescence-labeled glycyrrhetinic acid and glycyrrhetinic acid –modified liposome in hepatocellular carcinoma cells
Publication date: Available online 5 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yuqi Sun, Jinghua Lu, Dongxue Yan, Liping Shen, Haiyang Hu, Dawei Chen Glycyrrhetinic acid (GA) is a natural pentacyclic triterpene derivative that exerts significant effects in the suppression of liver cancer. The receptors of GA on liver cells and hepatocellular carcinoma (HCC) cells have drawn broad attention. The effects of GA might depend on its transport into and out of cells. However, the question has not been previously addressed despite its obvious and fundamental importance. In this paper, GA and GA-modified...
Source: Environmental Toxicology and Pharmacology - May 7, 2017 Category: Environmental Health Source Type: research

Associations between the levels of thyroid hormones and lipid/lipoprotein levels: Data from National Health and Nutrition Examination Survey 2007-2012
Publication date: Available online 4 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Ram B. Jain Data from National Health and Nutrition Examination Survey for the years 2007-2012 were used to investigate associations between thyroid hormones and lipid/lipoprotein levels for a representative sample of general US population aged >=20 years. There were no statistically significant differences for adjusted high density lipoprotein levels among thyroid function groups, namely, subclinical hyperthyroid (SCHPR), clinical hyperthyroid (CHPR), euthyroid (EU), clinical hypothyroid (CHYP), and subclinica...
Source: Environmental Toxicology and Pharmacology - May 5, 2017 Category: Environmental Health Source Type: research

The protective study about alleviation of simvastatin on the damages of PEG-BNs in mice
This study provides some basic data and useful information for the treatment of damages caused by the nanoparticles in mice in the future. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - May 2, 2017 Category: Environmental Health Source Type: research

Model-based optimization of parameters for degradation reaction of an organophosphorus pesticide, Paraoxon, using CeO2 nanoparticles in water media
Publication date: Available online 1 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Alicia Salerno, Isabelle Pitault, Thierry Devers, Jocelyne Pelletier, Stéphanie Briançon Degradation and body surface decontamination is vital to prevent the skin penetration of paraoxon (POX), an organophosphorus pesticide, and victims poisoning. CeO2 demonstrated a good efficacy for the degradation of POX. The aim of the study was to develop a model which includes the impact of weight of CeO2, POX and diluent volumes on the degradation kinetics. The modelling was realized with rapid and simple experime...
Source: Environmental Toxicology and Pharmacology - May 2, 2017 Category: Environmental Health Source Type: research

Combination of the Electro/Fe3+/peroxydisulfate (PDS) process with activated sludge culture for the degradation of sulfamethazine
Publication date: Available online 1 May 2017 Source:Environmental Toxicology and Pharmacology Author(s): Amina Ledjeri, Idris Yahiaoui, Hakima Kadji, Farida Aissani-Benissad, Abdeltif Amrane, Florence Fourcade In this paper, the major factors affecting the degradation and the mineralization of sulfamethazine by Electro/Fe3+/peroxydisulfate (PDS) process (e.g. current density, PDS concentration, Fe3+ ions concentration and initial sulfamethazine (SMT) concentration) were evaluated. The relevance of this process as a pretreatment prior to activated sludge culture was also examined. Regarding the impact on SMT degradation a...
Source: Environmental Toxicology and Pharmacology - May 2, 2017 Category: Environmental Health Source Type: research

The effect of passive and active exposure to tobacco smoke on lipid profile parameters and the activity of certain membrane enzymes in the blood of women in the first trimester of pregnancy
Publication date: Available online 27 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Anna Bizoń, Halina Milnerowicz The effect of tobacco smoke on lipid peroxidation, the lipid profile and membrane-bound enzymatic activity in the first trimester of pregnancy was investigated. In the plasma of women with active exposure to tobacco smoke, we have found increased lipid peroxidation and higher total concentrations of cholesterol, triglycerides and low-density lipoproteins in the blood, as well as a decreased concentration of high-density lipoproteins. A higher concentration of low-density lipoproteins...
Source: Environmental Toxicology and Pharmacology - April 28, 2017 Category: Environmental Health Source Type: research

Uranium (238U) bioaccumulation and its persuaded alterations on hematological, serological and histological parameters in freshwater fish Pangasius sutchi
This study can be useful indicators of 238U toxicity to assess fish health in Uranium (238U) biomonitoring programs. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 28, 2017 Category: Environmental Health Source Type: research

Silencing of DNA repair sensitizes pediatric brain tumor cells to ɣ-irradiation using gold nanoparticles
We present a nanoparticle (NP)-mediated delivery vehicle that effectively carries and protects siRNA in pediatric ependymoma (EP) and medulloblastoma (MB) cells. The delivery vehicle consists of gold NPs coated with a polymeric shell comprising polyethylene glycol (PG), chitosan and polyethyleneimine (Au-CP-PEI). NPs loaded with siRNA knocked down Ape1 expression by over 75% in both MB and EP cells. Further, this reduction in Ape1 expression is associated with an increase in DNA damage after irradiation. The results indicate that NP-associated delivery of siApe1 is a feasible approach to circumventing pediatric brain tumor...
Source: Environmental Toxicology and Pharmacology - April 28, 2017 Category: Environmental Health Source Type: research

Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells
Publication date: Available online 26 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Akiko Honda, Pratiti Home Chowdhury, Sho Ito, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Kayo Ueda, Hirohisa Takano We investigated the synergic effects of components of particulate matter with aerodynamic diameters ≤2.5μm (PM2.5) on airway inflammation. Co-exposure to cadmium (Cd) and 9,10-phenanthrenequinone (9,10-PQ) additively/synergistically increased pro-inflammatory responses in airway epithelial cells, whereas co-exposure to Cd and phenanthrene resulted in no acceleration. These results suggest ...
Source: Environmental Toxicology and Pharmacology - April 27, 2017 Category: Environmental Health Source Type: research

Experimental Study of Sucralfate Intervention for Paraquat Poisoning in Rats
Conclusion The results showed that early gastrointestinal lavage with sucralfate effectively reduced the inflammatory response and lung and kidney injuries and improved the survival of the SD rats. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 26, 2017 Category: Environmental Health Source Type: research

Nanoagroparticles emerging trends and future prospect in modern agriculture system
Publication date: Available online 23 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Syed Baker, Tatiana Volova, Svetlana V. Prudnikova, S. Satish, Nagendra Prasad Increment of technical knowledge has remarkably uplifted logical thinking among scientific communities to shape the theoretical concepts into near product-oriented research. The concept of nanotechnology has overwhelmed almost all forms of lives and has traded its applications in myriad fields. Despite rapid expansion of nanotechnology, sustainable competitions still do exist in the field of agriculture. In current scenario, agriculture ...
Source: Environmental Toxicology and Pharmacology - April 23, 2017 Category: Environmental Health Source Type: research

Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices
Publication date: Available online 22 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Haifa Othman, Mohamed Ammari, Kaïs Rtibi, Noura Bensaid, Mohsen Sakly, Hafedh Abdelmelek The present work investigated the effects of prenatal exposure to radiofrequency waves of conventional WiFi devices on postnatal development and behavior of rat offspring. Ten Wistar albino pregnant rats were randomly assigned to two groups (n=5). The experimental group was exposed to a 2.45GHz WiFi signal for 2hours a day throughout gestation period. Control females were subjected to the same conditions as treated group w...
Source: Environmental Toxicology and Pharmacology - April 22, 2017 Category: Environmental Health Source Type: research

Assessment of pulmonary toxicity of gold nanorods following intra-tracheal instillation in rats
Publication date: Available online 22 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Harikiran Lingabathula, Narsimhareddy Yellu The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase leakage, alkaline phosphatase, lipid peroxidation and total microprotein levels in BAL fluids after 1day, 1 week and 1 month post exposure periods. All the pa...
Source: Environmental Toxicology and Pharmacology - April 22, 2017 Category: Environmental Health Source Type: research

Apoptosis of leukemia K562 and Molt-4 cells induced by emamectin benzoate involving mitochondrial membrane potential loss and intracellular Ca2+ modulation
Publication date: Available online 19 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xinming Yun, Wenbing Rao, Ciying Xiao, Qingchun Huang Leukemia threatens millions of people's health and lives, and the pesticide-induced leukemia has been increasingly concerned because of the etiologic exposure. In this paper, cytotoxic effect of emamectin benzoate (EMB), an excellent natural-product insecticide, was evaluated through monitoring cell viability, cell apoptosis, mitochondrial membrane potential and intracellular Ca2+ concentration ([Ca2+]i) in leukemia K562 and Molt-4 cells. Following the exposure ...
Source: Environmental Toxicology and Pharmacology - April 20, 2017 Category: Environmental Health Source Type: research

Arsenic absorption and excretion in chronically exposed developing toad Rhinella arenarum
Publication date: Available online 19 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Mariana Mardirosian, Flavia Bieczynski, Carlos Luquet, Carlos A. Pérez, Guillermina Bongiovanni, Cecilia Lascano, Andrés Venturino We assessed the toxicodynamics of As in developing Rhinella arenarum toad embryos and larvae exposed from fertilization to 0.01–10mgAsL−1. We determined As content in toad embryos and larvae by X-ray fluorescence spectrometry. Toad embryos and larvae actively bioaccumulated As, reaching tissue concentrations more than one-thousand higher than control levels aft...
Source: Environmental Toxicology and Pharmacology - April 19, 2017 Category: Environmental Health Source Type: research

The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: a comparative study
Publication date: Available online 17 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Michaela Mináriková, Veronika Fojtikova, Eliška Vyskočilová, Jan Sedláček, Milan Šikut, Lucie Borek-Dohalska, Marie Stiborová, Marketa Martinkova The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenoba...
Source: Environmental Toxicology and Pharmacology - April 18, 2017 Category: Environmental Health Source Type: research

Crocin attenuates hemorrhagic shock-induced oxidative stress and organ injuries in rats
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Long Yang, Xiujuan Dong We aimed to evaluate the effect of natural antioxidant crocin in alleviating hemorrhagic shock (HS)-induced organ damages. HS rats were treated with crocin during resuscitation. Mortality at 12h and 24h post resuscitation was documented. HS and resuscitation induced organ injuries, as characterized by elevated wet/dry ratio, quantitative assessment ratio, blood urea nitrogen, creatinine, aspartate aminotransferase and alanine aminotransferase, whereas rats received crocin treatment demonstra...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Polymorphism of CYP1A1 gene variants rs4646903 and rs1048943 relation to the incidence of cervical cancer in Chhattisgarh
This study was aimed to look association of CYP1A1 m1 (T>C) and m2 (A>G) gene polymorphisms in Chhattisgarh population. In this case-control study, we analyzed leukocyte DNA from a total of 200 subjects form Chhattisgarh (100 cases and 100 controls). All subjects were genotyped for CYP1A1 m1 (T>C) and m2 (A>G) using PCR-RFLP with statistical analysis by using SPSS version 16.0 and VassarStats (online). Among the two gene variants rs4646903 (T>C) and rs1048943 (A>G), individuals with AG and GG genotypes of CYP1A1 m2 polymorphism have significantly higher and increased risk of cervic...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Protective effect of artemisinin on chronic alcohol induced-liver damage in mice
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Xiaoyan Zhao, Liqing Wang, Hao Zhang, Duoduo Zhang, Zhihao Zhang, Jie Zhang The liver disease related to chronic alcohol consumption is one of the leading causes of death for alcoholics. The efficient drug to ameliorate the alcoholic liver injury was needed urgently. The present study was performed to investigate whether artemisinin possessed the protective effect against chronic alcohol consumption. 50 male Kunming mice were divided into 5 groups: control group (C): 10ml/kg saline+10ml/kg saline, alcohol group (A)...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Silver nanoparticle induced toxicity to human sperm by increasing ROS(reactive oxygen species) production and DNA damage
In this study, we exposed human sperm to different doses of AgNPs (0, 50μgml−1, 100μgml−1, 200μgml−1 or 400μgml−1) for various times (15min, 30min, or 60min), followed by analyses of the sperm viability, motility and the ratio of abnormal to normal sperm.Then, transmission electron microscopy(TEM) was used to explore the sperm ultrastructural characteristics. Reactive oxygen species production and DNA fragmentation were tested using standard kits and the sperm chromatin dispersion method, respectively. The results showed a dose- and time-dependent decline in sperm viability and motility ...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Human Neuronal Cell Based Assay: A New In Vitro Model For Toxicity Evaluation Of Ciguatoxin
Publication date: Available online 14 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Teresa Coccini, Francesca Caloni, Uliana De Simone Ciguatoxins (CTXs) are emerging marine neurotoxins representing the main cause of ciguatera fish poisoning, an intoxication syndrome which configures a health emergency and constitutes an evolving issue constantly changing due to new vectors and derivatives of CTXs, as well as their presence in new non-endemic areas. The study applied the neuroblastoma cell model of human origin (SH-SY5Y) to evaluate species-specific mechanistic information on CTX toxicity. Metabol...
Source: Environmental Toxicology and Pharmacology - April 14, 2017 Category: Environmental Health Source Type: research

Toxicological effects of phenol on four marine microalgae
Publication date: Available online 13 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Weiyan Duan, Fanping Meng, Yufei Lin, Guoshan Wang The toxic effects of phenol on four marine microalgae (Dunaliella salina, Platymonas subcordiformis, Phaeodactylum tricornutum Bohlin, and Skeletonema costatum) were evaluated. The 96h EC50 values were 72.29, 92.97, 27.32, and 27.32mgL−1, respectively, which were lower than those values of freshwater microalgae reported in the literature. During a 96-h exposure to a sub-lethal concentration of phenol (1/2 96h EC50) with green alga (D. salina) and diatom (S. c...
Source: Environmental Toxicology and Pharmacology - April 13, 2017 Category: Environmental Health Source Type: research

Chronic Early Childhood Exposure to Arsenic is Associated with a TNF-mediated Proteomic Signaling Response
This study represents the first serum proteomics assessment in children exposed to iAs. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 10, 2017 Category: Environmental Health Source Type: research

Proinflammatory effects of diesel exhaust particles from moderate blend concentrations of 1st and 2nd generation biodiesel in BEAS-2B bronchial epithelial cells − The FuelHealth project
Publication date: Available online 5 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Tonje S. Skuland, Magne Refsnes, Pål Magnusson, Michał Oczkowski, Joanna Gromadzka-Ostrowska, Marcin Kruszewski, Remigiusz Mruk, Oddvar Myhre, Anna Lankoff, Johan Øvrevik Biodiesel fuel fuels are introduced at an increasing extent as a more carbon-neutral alternative to reduce CO2-emissions, compared to conventional diesel fuel. In the present study we have investigated the impact of increasing the use of 1st generation fatty acid methyl ester (FAME) biodiesel from current 7% blend (B7) to 20% blend (B...
Source: Environmental Toxicology and Pharmacology - April 5, 2017 Category: Environmental Health Source Type: research

Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri
Publication date: Available online 4 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Shifeng Wang, Yuxin Zhang, Qiao Zhang, Sha Peng, Chen Shen, Yangyang Yu, Minyu Zhang, Wei Yang, Qinghua Wu, Yanling Zhang, Shiyou Li, Yanjiang Qiao Improper usage of unprocessed Radix bupleuri (chaihu) may cause fetal toxicity. Baking herb with vinegar is believed to attenuate the toxicity. However, the chemical and molecular basis remained unclear. To this end, we investigated the in vitro toxicity of saikosaponin a, c, d, and their hydrolysates saikosaponin b1, b2. Results showed that SSa and SSd possessed higher ...
Source: Environmental Toxicology and Pharmacology - April 4, 2017 Category: Environmental Health Source Type: research

Silica nanoparticles and lead acetate co-exposure triggered synergistic cytotoxicity in A549 cells through potentiation of mitochondria-dependent apoptosis induction
Publication date: Available online 3 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Chun-Feng Lu, Li-Zhong Li, Wei Zhou, Jun Zhao, Yi-Mei Wang, Shuang-Qing Peng The adverse effects of PM2.5 are the results of combined toxicities of finer particles and their adsorbed toxic pollutants. Nevertheless, the combined toxicity of finer particles and air pollutants still remains unclear. The present study was therefore undertaken to investigate the combined cytotoxicity of silica nanoparticles (nano-SiO2, a typical atmospheric ultrafine particle) and lead acetate (Pb, a representative air pollutant) in A549...
Source: Environmental Toxicology and Pharmacology - April 3, 2017 Category: Environmental Health Source Type: research

Coenzyme Q10 Protects Against Statin-Induced Myotoxicity in Zebrafish Larvae (Danio rerio)
Publication date: Available online 1 April 2017 Source:Environmental Toxicology and Pharmacology Author(s): Rand Pasha, Thomas W. Moon 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme of the mevalonic acid pathway and is required for cholesterol biosynthesis and the synthesis of Coenzyme Q10 (CoQ10). Statins inhibit HMGCR, thus inhibiting the downstream products of this pathway including the biosynthesis of decaprenyl-pyrophosphate that is critical for the synthesis of Coenzyme Q10 (CoQ10). We show that zebrafish (Danio rerio) larvae treated in tank water with Atorvastatin (ATV; Lipitor) exhibi...
Source: Environmental Toxicology and Pharmacology - April 1, 2017 Category: Environmental Health Source Type: research

Molecular cloning, characterization and expression analysis of metallothionein in the liver of the teleost Acrossocheilus fasciatus exposed to cadmium chloride
Publication date: Available online 29 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Guo-Di Liu, Zhang Sheng, Cong-Cong Hou, Jie Ni, Ying-Li Han, You-Fa Wang, Yang Zhou, Su-Yan Fu, Jun-Quan Zhu Metallothionein (MT) has a characteristic molecular structure with a cysteine-rich content. This unique structure provides metal-binding and redox capabilities and promoting metal homeostasis and detoxification in living animals. In order to evaluate the effects of cadmium (Cd) on hepatic MT expression in the liver of Acrossocheilus fasciatus, we obtained the complete cDNA of the A. fasciatus liver MT for th...
Source: Environmental Toxicology and Pharmacology - March 29, 2017 Category: Environmental Health Source Type: research

Dexmedetomidine attenuates propofol-induce neuroapoptosis partly via the activation of the PI3k/Akt/GSK3 β pathway in the hippocampus of neonatal rats
Publication date: Available online 28 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jing Lv, Yi Wei, Yehua Chen, Xu Zhang, Zheng Gong, Yage Jiang, Qin Gong, Lifang Zhou, Hao Wang, Yubo Xie Recent studies have demonstrated that propofol causes neurodegeneration in developing brains. Evidence has shown that dexmedetomidine has neuroprotective effects. However, whether dexmedetomidine can reduce propofol-induced neuroapoptosis and by what mechanisms it acts remain unclear. We investigated whether dexmedetomidine can attenuate propofol-induced neuroapoptosis by disturbing the PI3K/Akt/GSK3β pathw...
Source: Environmental Toxicology and Pharmacology - March 28, 2017 Category: Environmental Health Source Type: research

Pharmacokinetics of sulfamethoxazole and trimethoprim in Pacific white shrimp, Litopenaeus vannamei, after oral administration of single-dose and multiple-dose
Publication date: Available online 28 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Rongrong Ma, Yuan Wang, Xiong Zou, Kun Hu, Beibei Sun, Wenhong Fang, Guihong Fu, Xianle Yang The tissue distribution and depletion of sulfamethoxazole (SMZ) and trimethoprim (TMP) were studied in Pacific white shrimp, Litopenaeus vannamei, after single-dose and multiple-dose oral administration of SMZ-TMP (5:1) via medicated feed. In single-dose oral administration, shrimps were fed once at a dose of 100 mg/kg (drug weight/body weight). In multiple-dose oral administration, shrimps were fed three times a day...
Source: Environmental Toxicology and Pharmacology - March 28, 2017 Category: Environmental Health Source Type: research

Occurrence and risk assessment of estrogenic compounds in the East Lake, China
Publication date: Available online 27 March 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jun Wang, Yindi Zhu Forty two surface water samples were collected in May and June of 2013 in five lakelets of the East Lake, China. Four steroid hormones (17β-estradiol (βE2), estrone (E1), 17α-estradiol (αE2) and 17α-ethinylestradiol (αEE2)) were analyzed in these samples. Determination of four estrogenic compounds was performed on high performance liquid chromatography/mass spectrometry (HPLC/MS). βE2 was detected with the highest detection frequency of 62% and its concentr...
Source: Environmental Toxicology and Pharmacology - March 27, 2017 Category: Environmental Health Source Type: research