The Insect repellents: A silent environmental chemical toxicant to the health
Publication date: Available online 29 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Dijendra Nath Roy, Ritobrata Goswami, Ayantika Pal In recent years, a large number of insect repellents have been developed with the idea of consumer benefits. In addition to already known advantageous application of insect repellents, there is increasing concern about the potential toxicity in environment leading to health caused by random use of these compounds. An increasing number of evidence suggests that insect repellents may trigger undesirable hazardous interactions with biological systems with a potentia...
Source: Environmental Toxicology and Pharmacology - January 30, 2017 Category: Environmental Health Source Type: research

Silica nanoparticles induced intrinsic apoptosis in neuroblastoma SH-SY5Y cells via CytC/Apaf-1 pathway
Publication date: Available online 30 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yanyan Yang, Yongbo Yu, Jiahui Wang, Yanbo Li, Yang Li, Jia Wei, Tong Zheng, Minghua Jin, Zhiwei Sun The present study was to investigate effects of Silica nanoparticles (SiNPs) on nervous system and explore potential mechanisms in human neuroblastoma cells (SH-SY5Y). Cytotoxicity was detected by cell viability and Lactate dehydrogenase (LDH) release. Flow cytometry analysis was applied to assess mitochondrial membrane potential (MMP) loss, intracellular Ca2+ and apoptosis. To clarify the mechanism of SiNPs-induc...
Source: Environmental Toxicology and Pharmacology - January 30, 2017 Category: Environmental Health Source Type: research

The endoplasmic reticulum stress inducer thapsigargin enhances the toxicity of ZnO nanoparticles to macrophages and macrophage-endothelial co-culture
In this study, the effects of ER stress inducer thapsigargin (TG) on the toxicity of ZnO NPs to THP-1 macrophages were investigated. The results showed that TG enhanced ZnO NP induced cytotoxicity as revealed by water soluble tetrazolium-1 (WST-1) and neutral red uptake assays, but not lactate dehydrogenase (LDH) assay. ZnO NPs dose-dependently enhanced the accumulation of intracellular Zn ions without the induction of reactive oxygen species (ROS), and the presence of TG did not significantly affect these effects. In the co-culture, exposure of THP-1 macrophages in the upper chamber to ZnO NPs and TG significantly reduced...
Source: Environmental Toxicology and Pharmacology - January 30, 2017 Category: Environmental Health Source Type: research

Effects of TiO2 nanoparticles at predicted environmental relevant concentration on the marine scallop Chlamys farreri: An integrated biomarker approach
In this study, we investigated the oxidative stress, neurotoxicity and histopathological effects of TiO2 NPs at predicted environmental relevant concentration (1mg/L) to marine scallop Chlamys farreri. The results showed that TiO2 NPs caused obviously oxidative damage on the scallops as evidenced by the significantly elevated superoxide dismutase (SOD), catalase (CAT) activities and malondialdehyde (MDA) contents. The increased acetylcholine esterase (AChE) activities reflected neurotoxicity of TiO2 NPs. The histopathological analysis revealed alterations in the gill and digestive gland, such as dysplastic and necrosis. Ad...
Source: Environmental Toxicology and Pharmacology - January 28, 2017 Category: Environmental Health Source Type: research

Ocular promoting activity of grape polyphenols —A review
Publication date: March 2017 Source:Environmental Toxicology and Pharmacology, Volume 50 Author(s): Sithranga Boopathy Natarajan, Jin-Woo Hwang, Yon-Suk Kim, Eun-Kyung Kim, Pyo-Jam Park The eye is a sensitive organ with complex optical system involves in the perception of light. Although it has several protective mechanisms by itself, various physiological and metabolic disorders are detrimental to the proper functioning of the visual system. Grape juice has long been used worldwide for its potent medicinal values including ocular promotion. Bioactivities of grape products are highly attributed to the presence of health p...
Source: Environmental Toxicology and Pharmacology - January 28, 2017 Category: Environmental Health Source Type: research

Oral application of carbon nanofibers in rats increases blood concentration of IL6 and IL10 and decreases locomotor activity
In conclusion, our results revealed that oral intake of 500mg/kg CNF induced some adverse effects, which, however, can be still partially compensated by the organism. Graphical abstract (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 25, 2017 Category: Environmental Health Source Type: research

Baicalin and chrysin mixture imparts cyto-protection against methylglyoxal induced cytotoxicity and diabetic tubular injury by modulating RAGE, oxidative stress and inflammation
Publication date: Available online 23 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jyotsna Singh, Bhushan P. Choudhari, Poonam Kakkar Protective effect of mixture of flavonoids baicalin and chrysin (BCH) was studied against methylglyoxal (MG, a precursor of AGEs) induced cytotoxicity in NRK 52E kidney epithelial cells. Flow cytometry and microscopic analysis showed increased ROS generation, compromised antioxidant status, depolarization of mitochondria and apoptosis in MG stressed cells which was significantly transformed (p ≤0.01) during BCH co-treatment. In vivo studies in streptozotocin i...
Source: Environmental Toxicology and Pharmacology - January 24, 2017 Category: Environmental Health Source Type: research

Computation of adsorption parameters for the removal of dye from wastewater by microwave assisted sawdust: Theoretical and experimental analysis
Publication date: Available online 23 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Suganya S., Senthil Kumar P., Saravanan A., Sundar Rajan P., Ravikumar C. In this research, the microwave assistance has been employed for the preparation of novel material from agro/natural bio-waste i.e. sawdust, for the effective removal of methylene blue (MB) dye from aqueous solution. The characterization of the newly prepared microwave assisted sawdust (MASD) material was performed by using FTIR, SEM and XRD analyses. In order to obtain the maximum removal of MB dye from wastewater, the adsorption experimen...
Source: Environmental Toxicology and Pharmacology - January 24, 2017 Category: Environmental Health Source Type: research

Concentrations and human health implications of heavy metals in market foods from a Chinese coal-mining city
Publication date: Available online 21 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Jiali Cheng, Xianhui Zhang, Zhenwu Tang, Yufei Yang, Zhiqiang Nie, Qifei Huang Concentrations of heavy metals (As, Cd, Co, Cr, Cu, Hg, Pb and Sb) in vegetables, meat and fish purchased from traditional agri-product markets in Huainan, China, were measured. Concentrations of the eight metals in most of the measured samples were lower than their respective maximum allowable concentrations (MACs), except for Pb, Cd, Cr and Cu in some of the samples exceeded safe limits. Based on local food consumption, the intake of...
Source: Environmental Toxicology and Pharmacology - January 22, 2017 Category: Environmental Health Source Type: research

Folic Acid Improve Developmental Toxicity Induced by Aluminum Sulphates
Conclusion: Aluminum sulphate can produce hazardous effects on bone of the fetuses, which may affect the life style of these fetuses later on. Folic acid might give a protective role and so should be given to females who tried to conceive. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 19, 2017 Category: Environmental Health Source Type: research

Concentrations of fluoride in water and plasma for US children and adolescents: Data from NHANES 2013 –2014
This study was undertaken to investigate how fluoride concentrations vary in water and plasma with age, gender, race/ethnicity, housing ownership, use of prescription fluoride drops and/or tablets, exposure to environmental tobacco smoke, and recent use of tobacco products (among adolescents). Fluoride concentrations in water were found to be lower among those aged 3-5 years than those aged 6-11 years (p=0.02), lower for non-Hispanic Asians than Hispanics (p=0.04) among 3-5 years old, lower for non-Hispanic Asians than non-Hispanic blacks (p=0.04) among 6-11 years old, and lower for those who used prescription fluoride dro...
Source: Environmental Toxicology and Pharmacology - January 18, 2017 Category: Environmental Health Source Type: research

Adsorption of quinolone, tetracycline, and penicillin antibiotics from aqueous solution using activated carbons: Review
Publication date: March 2017 Source:Environmental Toxicology and Pharmacology, Volume 50 Author(s): Muthanna J. Ahmed Antibiotics, an important type of pharmaceutical pollutant, have attracted many researchers to the study of their removal from aqueous solutions. Activated carbon (AC) has been widely used as highly effective adsorbent for antibiotics because of its large specific surface area, high porosity, and favorable pore size distribution. In this article, the adsorption performance of AC towards three major types of antibiotics such as tetracyclines, quinolones, and penicillins were reviewed. According to collected...
Source: Environmental Toxicology and Pharmacology - January 17, 2017 Category: Environmental Health Source Type: research

In vitro toxicity evaluation of melamine on mouse TM4 Sertoli cells
Publication date: Available online 15 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Lingling Chang, Jingyuan Wang, Ruiping She, Longhuan Ma, Qiaoxing Wu The male reproductive toxicity of melamine (MA) has been recognized in recent years excepted for its renal toxicity. Our previous in vivo studies revealed that the damages of Sertoli cell barrier played a critical role in MA-induced testicular toxicity in mice. Herein, we performed an in vitro study to comprehensively evaluate the toxicity of MA on Sertoli cell by examining the influences of MA on the viability, morphology, mortality and interce...
Source: Environmental Toxicology and Pharmacology - January 16, 2017 Category: Environmental Health Source Type: research

Identification of Potential Antioxidant Indices by Biogenic Gold Nanoparticles in Hyperglycemic Wistar Rats
Publication date: Available online 15 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Manimegalai Sengani, Devi Rajeswari V Oxidative stress is a crucial factor in diabetes, where the abnormal metabolic ambience leads to hyperglycemia resulting in the onset of several vascular complications. Under homeostasis, innate antioxidants efficiently inhibit the oxidative stress, thereby restrain further progression of diabetes. In the present study, a potential antioxidant marker was identified from hepatic tissue of diabetic Wistar rats after oral administration of biogenic gold nanoparticles (GNPs). Dia...
Source: Environmental Toxicology and Pharmacology - January 16, 2017 Category: Environmental Health Source Type: research

Distribution of PAHs in different compartment of creek ecosystem: ecotoxicological concern and human health risk
We report levels of polycyclic aromatic hydrocarbons in sediment, seawater, fish and crab samples from Thane creek, India. Concentrations of sixteen USEPA PAH in sediments varies from 874 to 1925ngg−1, dry weight (dw) in winter, between 219 to 495ngg−1 in summer. In seawater Σ16 PAHs concentration during winter was recorded 706±193ngL−1, and during summer 337±79ngL−1. Total concentrations of PAHs in consumable portion of lizard fish, bombay duck and crab were found 156.8±18 and 122±24.5ngg−1, 117.4±17.65ngg−1 and 95.8 ±16.2ngg−1, 348&...
Source: Environmental Toxicology and Pharmacology - January 16, 2017 Category: Environmental Health Source Type: research

Endoplasmic reticulum stress and apoptosis via PERK-eIF2 α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury
This study found that the protein level of GRP78 is higher in M10 group than in control group. PERK signaling and the relevant apoptosis factors were also activated. Morphological measurements showed that protein BAX and CHOP accumulated in the alveolar epithelium and the alveolar walls with epithelium were damaged and that the number of pulmonary alveoli decreased. The findings showed that ERS and PERK pathway are activated and eventually lead to apoptosis. Severe ERS mediated the apoptosis of alveolar epithelium cells as well as decreasing numbers of pulmonary alveoli. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - January 4, 2017 Category: Environmental Health Source Type: research

The effect of Platycodin D on the expression of cytoadherence proteins P1 and P30 in Mycoplasma pneumoniae models
Publication date: Available online 3 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Yan-li Meng, Wei-ming Wang, Dan-dan Lv, Qiu-xia An, Wei-hong Lu, Xin Wang, Guixin Tang Platycodin D is one of the most important monomers of the Qinbaiqingfei pellet (Qinbai), which has already been approved as the first effective new Traditional Chinese Medicine used to fight against Mycoplasma pneumoniae (M. pneumoniae) in clinic in China. In previous studies, pharmacodynamics experiment has proved that Platycodin D has anti-M. pneumoniae effect and the minimum inhibitory concentration (MIC) is 16mμg/ml. This...
Source: Environmental Toxicology and Pharmacology - January 4, 2017 Category: Environmental Health Source Type: research

Effects of phosphate binders on the gastrointestinal absorption of arsenate and of an SGLT2 inhibitor drug on the urinary excretion of arsenite in mice
Publication date: Available online 3 January 2017 Source:Environmental Toxicology and Pharmacology Author(s): Miklós Poór, Balázs Németi, Zoltán Gregus Arsenate (AsV) and arsenite (AsIII) are typical sources of acute and chronic arsenic poisoning. Therefore, reducing inner exposure to these arsenicals is a rational objective. Because AsV mimics phosphate, phosphate binder drugs may decrease the intestinal AsV absorption. Indeed, lanthanum and aluminium salts and sevelamer removed AsV from solution in vitro, especially at acidic pH. In mice gavaged with AsV, lanthanum chloride, lanthanum ...
Source: Environmental Toxicology and Pharmacology - January 3, 2017 Category: Environmental Health Source Type: research

Involvement of Water Channel Aquaporin 5 in H2S-Induced Pulmonary Edema
This study aims to investigate the effects of H2S on the expression of water channel aquaporin 5 (AQP5) and to elucidate the signaling pathways involved in AQP5 regulation. In an in vivo study, C57BL6 mice were exposed to sub-lethal concentrations of inhaled H2S, and histological injury of the lungs and ultrastructure injury of the epithelial cells were evaluated. With real-time PCR and western blot assays, we found that H2S exposure contributed to a significant decrease in AQP5 expression both in murine lung tissue and the A549 cell line, and the ERK1/2 and p38 MAPK signaling pathways were demonstrated to be implicated in...
Source: Environmental Toxicology and Pharmacology - December 31, 2016 Category: Environmental Health Source Type: research

Impact of Probable Interaction of Low Temperature and Ambient Fine particulate matter on the Function of Rats Alveolar Macrophages
Publication date: Available online 28 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Bin Luo, Jiangtao Liu, Gaoqiang Fei, Ting Han, Kai Zhang, Lina Wang, Hongxia Shi, Li zhang, Ye Ruan, Jingping Niu The present study aimed to explore the probable interaction of low temperature and ambient fine particulate matter (PM2.5) on rat alveolar macrophages (AMs). AMs were separated from rat BALF and exposed to PM2.5 (0, 25, 50, 100μg/ml) under different temperature (18, 24, 30, 37°C) for 8h. Results indicated that viability and phagocytosis function of AMs decreased with the decline of temperature...
Source: Environmental Toxicology and Pharmacology - December 29, 2016 Category: Environmental Health Source Type: research

Dietary overload lithium decreases the adipogenesis in abdominal adipose tissue of broiler chickens
In conclusion, dietary overload lithium decreased the adipogenesis in abdominal adipose tissue of chicken, which was accompanied by depressing transcriptional expression of adipogenesis-associated factors. Hypothalamic NPY had a potential role in the adipogenesis in abdominal adipose tissue of broilers with a short-term overload lithium treatment. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 27, 2016 Category: Environmental Health Source Type: research

The effect of glyphosate-based herbicide Roundup and its co-formulant, POEA, on the motoric activity of rat intestine – In vitro study
Publication date: Available online 26 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Magdalena Chłopecka, Marta Mendel, Natalia Dziekan, Wojciech Karlik The study was aimed at evaluating the effect of Roundup, polyoxyethylene tallow amine (POEA) and mixture of glyphosate and POEA in different levels on the motoric activity of jejunum strips. The incubation in the Roundup solutions caused a significant, mostly miorelaxant, reversible reaction of smooth muscle; only in the highest tested dose which is equivalent to the agricultural concentration (1% corresponding to 1.7g glyphosate/L) there was a...
Source: Environmental Toxicology and Pharmacology - December 27, 2016 Category: Environmental Health Source Type: research

BDE-47 and BDE-209 inhibit proliferation of Neuro-2a cells via inducing G1-phase arrest
Publication date: Available online 21 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Hongmei Chen, Xuexi Tang, Bin Zhou, Ningning Xu, Zhongyuan Zhou, Kuan Fang, You Wang Cell proliferation is closely related to cell cycle which is strictly regulated by genes and regulatory proteins. In the present study, we comparatively analyzed the toxic effects of BDE-47 and BDE-209 on cell proliferation of Neuro-2a cells, and the possible mechanism was discussed. The results indicated that BDE-47 significantly inhibited the cell proliferation and the cell cycle were arrest at G1 phase, while BDE-209 had litt...
Source: Environmental Toxicology and Pharmacology - December 25, 2016 Category: Environmental Health Source Type: research

Agmatine modulates melanogenesis via MITF signaling pathway
Publication date: Available online 13 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Eun-Jeong Kwon, Moon-Moo Kim Agmatine contained in soybean is also found in Manaca, an anti-aging plant, inhabited in Amazon and induces vasodilation by the promotion of NO synthesis in blood vessel. However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. It was determined whether agmatine regulates melanin synthesis at cellular level in addition ...
Source: Environmental Toxicology and Pharmacology - December 14, 2016 Category: Environmental Health Source Type: research

The effect of ethephon on immune system in male offspring of mice
Publication date: Available online 12 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Siqi Wang, Haifeng Jin, Qiuqiong Tang, Jun Fu, Zeming Ren, Cike Peng, Lanqin Shang, Weidong Hao, Xuetao Wei Ethephon can liberate ethylene which could interfere the plant growth process. The aim of the present study was to determine the effect of ethephon on developing immune system of male offspring. Ethephon could enhance NK cell activity in male mice. For 4-week-old male mice, lymphocytes of peripheral blood increased while the hemolytic plaque number decreased. Delayed type hypersensitivity(DTH) was inhibite...
Source: Environmental Toxicology and Pharmacology - December 13, 2016 Category: Environmental Health Source Type: research

Oxidative stress, endocrine disruption, and malformation of Bufo gargarizans embryo exposed to sub-lethal cadmium concentrations
Publication date: Available online 12 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Chao Wu, Yuhui Zhang, Lihong Chai, Hongyuan Wang Thyroid hormone (TH) is critical for vertebrate postembryonic development as well as embryonic development. Chinese toad (Bufo gargarizans) embryos were exposed to different concentrations of cadmium (5, 50, 100, 200 and 500μg Cd L−1) for 7 days. Malformations were monitored daily, and growth and development of embryos were measured at day 4 and 7, and type 2 and 3 iodothyronine deiodinase (Dio2 and Dio3), thyroid hormone receptors (TRα and TRβ...
Source: Environmental Toxicology and Pharmacology - December 13, 2016 Category: Environmental Health Source Type: research

Oral administration of nano-titanium dioxide particle disrupts hepatic metabolic functions in a mouse model
This study provided useful information for risk analysis and regulation of TiO2 NPs by administration agencies. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 12, 2016 Category: Environmental Health Source Type: research

Concurrent administration of diethylhexyl phthalate reduces the threshold dose at which bisphenol A disrupts blastocyst implantation and cadherins in mice
Publication date: Available online 9 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Evan D. Borman, Warren G. Foster, Denys deCatanzaro Many people are repeatedly exposed to both bisphenol A (BPA) and diethylhexyl phthalate (DEHP), but there has been little research concerning their effects in combination. Both can disrupt blastocyst implantation in inseminated females, albeit at high doses. We exposed mice on gestation days (GD) 1–4 to combinations of BPA and DEHP in doses below the threshold necessary to disrupt implantation on their own. On GD 6, there were fewer normally-developed impl...
Source: Environmental Toxicology and Pharmacology - December 10, 2016 Category: Environmental Health Source Type: research

Ocular promoting activity of grape polyphenols -A review
Publication date: Available online 9 December 2016 Source:Environmental Toxicology and Pharmacology Author(s): Sithranga Boopathy Natarajan, Jin-Woo Hwang, Yon-Suk Kim, Eun-Kyung Kim, Pyo-Jam Park The eye is a sensitive organ with complex optical system involves in the perception of light. Although it has several protective mechanisms by itself, various physiological and metabolic disorders are detrimental to the proper functioning of the visual system. Grape juice has long been used worldwide for its potent medicinal values including ocular promotion. Bioactivities of grape products are highly attributed to the presence ...
Source: Environmental Toxicology and Pharmacology - December 10, 2016 Category: Environmental Health Source Type: research

Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells
This study will investigate the apoptotic molecular mechanisms which result from tebufenozide-induced DNA damage in HeLa cells. Our results demonstrate that tebufenozide could trigger arrest in G1/S phase related to a downregulation of cyclin E and cyclin-dependent kinase (CDK) 2 protein. In addition, Western blotting showed apoptosis was associated with the upregulation of p53, Bax and cleaved-PARP, as well as downregulation of Bcl-2 and PARP. Tebufenozide also regulated changes in mitochondrial permeability and reduced mitochondrial number and intracellular ATP production. Briefly, these results suggest that tebufenozide...
Source: Environmental Toxicology and Pharmacology - December 9, 2016 Category: Environmental Health Source Type: research

The contribution of keratinocytes in capecitabine-stimulated Hand-Foot-Syndrome
In conclusion, these results suggested that HFS of capecitabine may be developed from reduction of corneous layer through stimulation of intracellular mitochondrial dysfunction following activation of caspase-dependent apoptosis pathway. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - December 5, 2016 Category: Environmental Health Source Type: research

Environment friendly approach for size controllable synthesis of biocompatible Silver nanoparticles using diastase
Publication date: Available online 30 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Sireesh Babu Maddinedi, Badal Kumar Mandal, Kiran Kumar Anna A green, facile method for the size selective synthesis of silver nanoparticles (AgNPs) using diastase as green reducing and stabilizing agent is reported. The thiol groups present in the diastase are mainly responsible for the rapid reaction rate of silver nanoparticles synthesis. The variation in the size and morphology of AgNPs were studied by changing the pH of diastase. The prepared silver nanoparticles were characterized by using UV-Vis, XRD, FTI...
Source: Environmental Toxicology and Pharmacology - December 1, 2016 Category: Environmental Health Source Type: research

Bendiocarb induced histopathological and biochemical alterations in rat liver and Preventive role of vitamins C and E
In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8mg/kg of body weight (bw), 100mg/kg-bw and 100mg/kg-bw for 28 days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde leve...
Source: Environmental Toxicology and Pharmacology - November 28, 2016 Category: Environmental Health Source Type: research

Cellular stress and histopathological tools used as biomarkers in Oreochromis mossambicus for assessing metal contamination
This study suggests that, the importance of antioxidative enzymes, cellular biomarkers, AChE, and histopathology used as biomarkers in aquatic ecosystem biomonitoring. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 25, 2016 Category: Environmental Health Source Type: research

In vitro assessment of deferoxamine on mesenchymal stromal cells from tumor and bone marrow
In this study, we first isolated tumor-associated MSCs (TAMSCs) from EG-7 tumors, which were positive for CD29, CD44, CD73, CD90 and CD105. Ex vivo cultured stem cells derived from tumor and bone marrow compartment were exposed to DFO. We demonstrated that DFO had growth-arresting and apoptosis-inducing effect on TAMSCs and bone marrow MSCs (BMMSCs). DFO also influenced the expression pattern of adhesion molecule VCAM-1 on both TAMSCs and BMMSCs. Notwithstanding its widespread use, our results here warrants caution in the application of DFO, and also highlights the need for careful evaluation of the bone marrow compartment...
Source: Environmental Toxicology and Pharmacology - November 24, 2016 Category: Environmental Health Source Type: research

Emerging Biopharmaceuticals from Marine Actinobacteria
Publication date: Available online 22 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Syed Shams ul Hassan, Komal Anjum, Syed Qamar Abbas, Najeeb Akhter, Bibi Ibtesam Shagufta, Sayed Asmat Ali Shah, Umber Tasneem Actinobacteria are quotidian microorganisms in the marine world, playing a crucial ecological role in the recycling of refractory biomaterials and producing novel secondary metabolites with pharmaceutical applications. Actinobacteria have been isolated from the huge area of marine organisms including sponges, tunicates, corals, mollusks, crabs, mangroves and seaweeds. Natural products in...
Source: Environmental Toxicology and Pharmacology - November 23, 2016 Category: Environmental Health Source Type: research

Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells
In this study, the influences of triclosan, an anti-bacterial agent recently known for an endocrine disrupting chemical (EDC), and kaempferol on breast cancer progression were examined by measuring their effects on epithelial-mesenchymal transition (EMT) and metastatic-related behaviors of MCF-7 breast cancer cells. Morphological changes of MCF-7 cells were observed, and a wound-healing assay was performed after the treatment of triclosan and kaempferol. The effects of triclosan and kaempferol on protein expression of EMT-related markers such as E-cadherin, N-cadherin, Snail, and Slug and metastasis-related markers such as...
Source: Environmental Toxicology and Pharmacology - November 23, 2016 Category: Environmental Health Source Type: research

The injury of Fine Particulate Matter from Cooking Oil Fumes on Umbilical Cord Blood Vessels in vitro
In conclusion, our data suggested that exposure to COFs-derived PM2.5 resulted in increasing of oxidative stress and inflammation, as well as dysfunction of UCs. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - November 22, 2016 Category: Environmental Health Source Type: research

Genetic variability in the system of natriuretic B peptide and principal toxicological parameters in workers exposed to lead
Publication date: Available online 21 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Marta Jurdziak, Paweł Gać, Rafał Poręba, Marzena Gonerska, Anna Jonkisz, Małgorzata Gromek, Małgorzata Poręba, Anna Szymańska-Chabowska, Grzegorz Mazur, Małgorzata Sobieszczańska The study was aimed at evaluating the influence of selected polymorphisms of natriuretic peptide B precursor (NPPB) and natriuretic peptide receptor C (NPR3) genes on blood lead concentration (Pb-B) and blood zinc protoporphyrin concentration (ZnPP) in persons occupationally exposed to lead. Investigations were conducted on 36...
Source: Environmental Toxicology and Pharmacology - November 22, 2016 Category: Environmental Health Source Type: research

Heavy metal burdens of public primary school children related to playground soils and classroom dusts in Ibadan North-West local government area, Nigeria
Publication date: Available online 19 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): F. Akinwunmi, T.F. Akinhanmi, Z.A. Atobatele, O. Adewole, K. Odekunle, L.A. Arogundade, O.O. Odukoya, O.M. Olayiwola, O. Ademuyiwa Information about heavy metal burden of children in Nigeria related to playground soils and classroom dusts is lacking. Playground soil, classroom dust, blood and spot urine samples (n=253) were collected from 6 urban and 2 semi-rural public schools in Ibadan North-West, Nigeria. Samples were analyzed for Pb, Cu, Zn, Fe and Mn. Mean blood Pb levels in urban area (male, 41.66±8...
Source: Environmental Toxicology and Pharmacology - November 20, 2016 Category: Environmental Health Source Type: research

A Ca2+ chelator ameliorates chromium (VI)-induced hepatocyte L-02 injury via down-regulation of Voltage-Dependent Anion Channel 1 (VDAC1) expression
This study aimed to explore the mechanism of cell injury induced by Cr(VI) and tentatively offer clues to repairing this cell damage using [Ca2+]i and VDAC1. L-02 hepatocytes were treated with Cr(VI)/BAPTA, and the levels of [Ca2+]i and cell injury associated with Cr(VI) were determined in addition to the effect of BAPTA. The expression of VDAC1 in Cr(VI)-induced cells was evaluated. The results showed a dose-dependent elevation of the level of VDAC1 and the mRNA level of the VDAC1 biogenesis-related gene Sam50. BAPTA could ameliorate less severe damage induced by 4μM Cr(VI) via reducing VDAC1 and Sam50. Additionally, c...
Source: Environmental Toxicology and Pharmacology - November 19, 2016 Category: Environmental Health Source Type: research

Atorvastatin protected from Paraquat-induced cytotoxicity in Alveolar macrophages via down-regulation of TLR-4
Publication date: Available online 18 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Nazli Alizadeh-Tabrizi, Hassan Malekinejad, Soheil Varasteh, Hadi Cheraghi The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat in the presence and absence of atorvastatin for 24h. Cell viability, myeloperoxidase activity; nitric oxide generation and total antioxidant capacity were assessed. Expressio...
Source: Environmental Toxicology and Pharmacology - November 19, 2016 Category: Environmental Health Source Type: research

NSCA-1 —a novel N-substituted coumalamide derivative—increases Adriamycin sensitivity in HepG2/adriamycin cells through modulating Akt/GSK-3β signaling and p53-dependant apoptotic pathway
In this study, we report the synthesis and biological evaluation of a novel N-substituted coumalamide derivative (NSCA-1). The results indicated that NSCA-1 exerts synergistic cytotoxicity with Adriamycin in HepG2/ADR (HepG2/adriamycin) cells. Furthermore, both of the Akt kinase activity and phosphorylated Akt (Ser473) were found to be inhibited by NSCA-1 and subsequently resulting in decreased phosphorylation of GSK-3β. The intracellular accumulation of Adriamycin was also boosted by NSCA-1 via reducing the expression of p-gp. In addition, we found that combined treatment with NSCA-1 enhance cell apoptosis induced by...
Source: Environmental Toxicology and Pharmacology - November 18, 2016 Category: Environmental Health Source Type: research

Role of DNA methylation in bisphenol A exposed mouse spermatocyte
Publication date: December 2016 Source:Environmental Toxicology and Pharmacology, Volume 48 Author(s): Li Yin, Yanlin Dai, Xiao Jiang, Yong Liu, Hongqiang Chen, Fei Han, Jia Cao, Jinyi Liu As a widespread environmental contaminant, bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) has been implicated in male reproductive function injury. Previous studies have investigated the mechanisms of DNA damage and oxidative stress caused by BPA; however, little is known regarding its impact on DNA methylation. In this paper, we assessed the adverse effects of BPA on mouse spermatocytes and investigated a potential role of DNA meth...
Source: Environmental Toxicology and Pharmacology - November 15, 2016 Category: Environmental Health Source Type: research

Evaluation of 8-hydroxy-2-deoxyguanosine and NFkB activation, oxidative stress response, acetylcholinesterase activity, and histopathological changes in rainbow trout brain exposed to linuron
Publication date: Available online 13 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Ahmet Topal, Gonca Alak, Serdar Altun, Hüseyin Serkan Erol, Muhammed Atamanalp Linuron is a widely used herbicide to control grasses and annual broad leaf weeds. It is known that linuron has toxic effects on different organisms. However, the toxic effects of linuron on aquatic organisms, especially fish, is completely unknown. Thus, we aimed to investigate changes in 8-hydroxy-2-deoxyguanosine (8-OHdG) and nuclear factor kappa B (NFkB) activity, histopathological changes, antioxidant responses and acetylcho...
Source: Environmental Toxicology and Pharmacology - November 14, 2016 Category: Environmental Health Source Type: research

Study on the relationship of genotoxic and oxidative potential of a new mixed chelate copper antitumoral drug, Casiopeina II-gly (Cas II-gly) in Drosophila melanogaster
Publication date: Available online 13 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Vega E. Jiménez, Pimentel Emilio, Martha P. Cruces, A. Amaya-Chávez, L. Ruiz-Azuara The present study evaluates the superoxide dismutase (SOD) and catalase (CAT) activities in a wild strain of Drosophila melanogaster and the genotoxic potential induced by Cas II-gly (a new antineoplastic drug) using the somatic mutation and recombination test. Larvae 48h old were treated with Cas II-gly in a range of 0 to 1.5mM and aliquot were taken every 24h to have individuals treated for 24, 48, 72h and adultho...
Source: Environmental Toxicology and Pharmacology - November 14, 2016 Category: Environmental Health Source Type: research

Improved building up a model of toxicity towards Pimephales promelas by the Monte Carlo method
Publication date: Available online 11 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Alla P. Toropova, Andrey A. Toropov, Maria Raskova, Ivan Raska By optimization of so-called correlation weights of attributes of simplified molecular input-line entry system (SMILES) quantitative structure − activity relationships (QSAR) for toxicity towards Pimephales promelas are established. A new SMILES attribute has been utilized in this work. This attribute is a molecular descriptor, which reflects (i) presence of different kinds of bonds (double, triple, and stereo chemical bonds); (ii) presence of ...
Source: Environmental Toxicology and Pharmacology - November 12, 2016 Category: Environmental Health Source Type: research

Dietary exposure to polybrominated diphenyl ether 47 (BDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles
Publication date: December 2016 Source:Environmental Toxicology and Pharmacology, Volume 48 Author(s): Alexandra T. Yost, Leah M. Thornton, Barney J. Venables, Marlo K. Sellin Jeffries Few studies have investigated the thyroid-disrupting effects of polybrominated diphenyl ethers (PBDEs) across multiple levels of biological organization in anurans, despite their suitability for the screening of thyroid disruptors. Therefore, the present study evaluated the effects of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) on development, thyroid histology and thyroid hormone-related gene expression in Xenopus laevis expose...
Source: Environmental Toxicology and Pharmacology - November 11, 2016 Category: Environmental Health Source Type: research

Development of an in vitro test battery for the screening of the receptor-mediated mechanism and the spindle-poison mode of action of estrogenic compounds
In this study, a battery of tests, suitable for reproductive toxicology testing, was developed with the objective of detecting the mechanism of action of estrogenic and xenoestrogenic compounds. With this aim, two compounds known for their estrogenic activity, diethylstilbestrol and 17β-estradiol, were used to set up four different in vitro tests: 1) bovine oocyte in vitro maturation assay, 2) bovine preimplantation embryo in vitro culture assay and 3) MCF-7 and 4) BALB/3T3 cell lines proliferation and cytotoxicity assay, respectively. The results show that this battery of tests allows to identify and to distinguish b...
Source: Environmental Toxicology and Pharmacology - November 10, 2016 Category: Environmental Health Source Type: research

Role of DNA methylation in bisphenol Aexposed mouse spermatocyte
Publication date: Available online 9 November 2016 Source:Environmental Toxicology and Pharmacology Author(s): Li Yin, Yanlin Dai, Jiang Xiao, Yong Liu, Hongqiang Chen, Fei Han, Jia Cao, Jinyi Liu As a widespread environmental contaminant, bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) has been implicated in male reproductive function injury. Previous studies have investigated the mechanisms of DNA damage and oxidative stress caused by BPA; however, little is known regarding its impact on DNA methylation. In this paper, we assessed the adverse effects of BPA on mouse spermatocytes and investigated a potential role of ...
Source: Environmental Toxicology and Pharmacology - November 10, 2016 Category: Environmental Health Source Type: research