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Inhalation exposure to low levels of ethyl tertiary butyl ether: Its genetic effects were significantly modified by ALDH2 activity
This study was aimed to verify the genotoxic effects in three genetic types,Aldh2 KO, heterogeneous (HT), and wild type (WT), of mice exposed to lower concentrations of ETBE (50 –500 ppm) by inhalation. Histopathology assessments in the livers, measurements of genotoxic biomarkers in blood and livers, and urinary 8‐hydroxydeoxyguanosion (8‐OH‐dG) for the oxidative DNA damage of whole body were performed. Significant histopathological changes and DNA strand breaks bo th in hepatocytes and leukocytes were found in HT and KO male mice exposed to ≥200 ppm ETBE, but not in 50 ppm ETBE. 8‐OH‐dG levels either in liv...
Source: Environmental and Molecular Mutagenesis - November 25, 2018 Category: Molecular Biology Authors: Zuquan Weng, Yuhong Shi, Megumi Suda, Yukie Yanagiba, Toshihiro Kawamoto, Tamie Nakajima, Rui ‐Sheng Wang Tags: Research Article Source Type: research

Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells
This article is protected by copyright. All rights reserved. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 24, 2018 Category: Molecular Biology Authors: Anne Fernandez ‐Vidal, Liana C. Arnaud, Manon Maumus, Marianne Chevalier, Gladys Mirey, Bernard Salles, Julien Vignard, Elisa Boutet‐Robinet Tags: Research Article Source Type: research

The SOS System: A complex and tightly regulated response to DNA damage
This article is protected by copyright. All rights reserved. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 16, 2018 Category: Molecular Biology Authors: Katarzyna H. Maslowska, Karolina Makiela ‐Dzbenska, Iwona J. Fijalkowska Tags: Review Source Type: research

Issue Information
Environmental and Molecular Mutagenesis, Volume 59, Issue 9, Page 769-771, December 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 11, 2018 Category: Molecular Biology Tags: Issue Information Source Type: research

Cytome Micronucleus Assays with a Metabolically Competent Human Derived Liver Cell Line (Huh6): A Promising Approach for Routine Testing of Chemicals?
One of the main problems ofin vitro genotoxicity tests is the inadequate representation of drug metabolizing enzymes in most indicator cell lines which are currently used. We identified recently a human derived liver cell line (Huh6) which detected induction of DNA damage by representatives of different groups of promutagens without enzyme mix and showed that these cells are more suitable in terms of reproducibility and sensitivity as other currently used liver derived lines. We developed a protocol for micronucleus (MN) cytome assays with these cells and validated the procedure in experiments with representatives of diffe...
Source: Environmental and Molecular Mutagenesis - November 8, 2018 Category: Molecular Biology Authors: Miroslav Mi šík, Armen Nersesyan, Claudia Bolognesi, Michael Kundi, Franziska Ferk, Siegfried Knasmueller Tags: Research Article Source Type: research

Geraniin Differentially Modulates Chromosome Stability of Colon Cancer and Noncancerous Cells by Oppositely Regulating Their Spindle Assembly Checkpoint
This article is protected by copyright. All rights reserved. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 7, 2018 Category: Molecular Biology Authors: Xihan Guo, Xueqin Dai, Juan Ni, Xiaoling Ma, Jinglun Xue, Xu Wang Tags: Research Article Source Type: research

Bioflavonoids promote stable translocations between MLL ‐AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 2, 2018 Category: Molecular Biology Authors: Bhawana Bariar, C. Greer Vestal, Bradley Deem, Donna Goodenow, Mimi Ughetta, R. Warren Engledove, Mark Sahyouni, Christine Richardson Source Type: research

Mutagenic activity of N ‐nitrosodiethylamine in cell lines expressing human CYP2E1 – adequacy of dimethylsulfoxide as solvent
Environmental and Molecular Mutagenesis,Volume 0, Issue ja, -Not available-. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - November 2, 2018 Category: Molecular Biology Authors: Guifang Jin, Lu Cai, Keqi Hu, Yuyi Luo, Yuting Chen, Hansruedi Glatt, Yungang Liu Source Type: research

In vitro exposure to CPF affects bovine sperm epigenetic gene methylation pattern and the ability of sperm to support fertilization and embryo development
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 26, 2018 Category: Molecular Biology Authors: Maria Michela Pallotta, Vincenza Barbato, Alain Pinton, Herv è Acloque, Roberto Gualtieri, Riccardo Talevi, Hèléne Jammes, Teresa Capriglione Source Type: research

Evaluation of U. S. National Toxicology Program (NTP) mouse lymphoma assay data using International Workshop on Genotoxicity Tests (IWGT) and the Organization for Economic Co ‐Operation and Development (OECD) criteria
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 25, 2018 Category: Molecular Biology Authors: M. R. Schisler, B. B. Gollapudi, M. M. Moore Source Type: research

Toxic and genotoxic effects of silver nanoparticles in Drosophila
Environmental and Molecular Mutagenesis,Volume 0, Issue ja, -Not available-. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 24, 2018 Category: Molecular Biology Authors: Mohamed Alaraby, Sara Romero, Alba Hern ández, Ricard Marcos Source Type: research

In Utero Exposure to Benzo[a]pyrene Induces Ovarian Mutations at Doses that Deplete Ovarian Follicles in Mice
Environmental and Molecular Mutagenesis,Volume 0, Issue ja, -Not available-. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 24, 2018 Category: Molecular Biology Authors: Ulrike Luderer, Matthew J. Meier, Gregory W. Lawson, Marc A. Beal, Carole L. Yauk, Francesco Marchetti Source Type: research

Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig ‐a assay
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 19, 2018 Category: Molecular Biology Authors: Zhiying Ji, Raja S. Settivari, Matthew J. LeBaron Source Type: research

Using a gene expression biomarker to identify DNA damage ‐inducing agents in microarray profiles
Environmental and Molecular Mutagenesis, EarlyView. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 17, 2018 Category: Molecular Biology Authors: J. Christopher Corton, Andrew Williams, Carole L. Yauk Source Type: research

Issue Information
Environmental and Molecular Mutagenesis,Volume 59, Issue 8, Page 669-671, October 2018. (Source: Environmental and Molecular Mutagenesis)
Source: Environmental and Molecular Mutagenesis - October 15, 2018 Category: Molecular Biology Source Type: research