Urban Dust Microbiome: Impact on Later Atopy and Wheezing
Conclusion: Higher early exposure to fungal diversity might help to prevent from developing sensitization to aero-allergens in early childhood, but the reasons for attenuated effects in later childhood require further prospective studies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be ...
Source: EHP Research - May 27, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Use of Cooking Fuels and Cataract in a Population-Based Study: The India Eye Disease Study
Conclusions: Our results provide robust evidence for the association of biomass fuels with cataract in women but not in men. Our finding for kerosene and cataract in women is novel and requires confirmation in other studies. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access...
Source: EHP Research - May 25, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Particulate Air Pollution and Fasting Blood Glucose in Non-Diabetic Individuals: Associations and Epigenetic Mediation in the Normative Aging Study, 2000-2011
Conclusions: In non-diabetics, short/medium-term PM2.5 was associated with higher FBG. Mediation analysis indicated that part of this association was mediated by ICAM-1 promoter methylation. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publ...
Source: EHP Research - May 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment
Conclusion: The present results suggest that background exposures to POPs can alter maternal thyroid homeostasis. This research contributes to the understanding of multipollutant exposures using multivariate statistical approaches and highlights the complexity of investigating environmental concentrations and mixtures in regards to maternal and infant thyroid function. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be repla...
Source: EHP Research - May 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

A Systematic Comparison of Linear Regression-Based Statistical Methods to Assess Exposome-Health Associations
Conclusions: Correlation between exposures is a challenge for exposome research, and the statistical methods investigated in this study are limited in their ability to efficiently differentiate true predictors from correlated covariates in a realistic exposome context. While GUESS and DSA provided a marginally better balance between sensitivity and FDP, they did not outperform the other multivariate methods across all scenarios and properties examined, and computational complexity and flexibility should also be considered when choosing between these methods. This EHP Advance Publica...
Source: EHP Research - May 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children’s Health Study
Conclusions: Genetic and epigenetic variation in DNA methylation reprogramming genes and in LINE1 retrotransposons may play important roles in downstream cardiovascular consequences of prenatal air pollution exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this d...
Source: EHP Research - May 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Early Exposure to Traffic-Related Air Pollution, Respiratory Symptoms at 4 Years of Age, and Potential Effect Modification by Parental Allergy, Stressful Family Events, and Gender: A Prospective Follow-up Study of the PARIS Birth Cohort
We examined data of 2,015 children from the PARIS birth cohort followed up with repeated questionnaires completed by parents until age 4 years. TRAP exposure in each child’s first year of life was estimated by nitrogen oxides (NOx) air dispersion modeling, taking into account both home and day care locations. Association between TRAP exposure and patterns of wheezing, dry night cough and rhinitis symptoms was studied using multinomial logistic regression models adjusted for potential confounders. Effect modification by parental history of allergy, ‘stressful’ family events, and gender wa...
Source: EHP Research - May 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study
We examined the relationship between prenatal exposure to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) and cord blood levels of glucocorticoid and androgenic hormones. Methods: We conducted a hospital-based birth cohort study between July 2002 and October 2005 in Sapporo, Japan (n=514). In total, 185 mother-infant pairs were included in the present study. Prenatal PFOS and PFOA levels in maternal serum samples were measured using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Cord blood levels of glucocorticoid (cortisol and cortisone) and androgenic hormones (dehydroe...
Source: EHP Research - May 24, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Total Effective Xenoestrogen Burden in Serum Samples and Risk for Breast Cancer in a Population-Based Multicase-Control Study in Spain
Conclusions: This is the first study to show a strong positive association between serum total xenoestrogen burden and breast cancer risk, thus highlighting the importance of evaluating xenoestrogen mixtures, rather than single compounds, when studying hormone-related cancers. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI ...
Source: EHP Research - May 20, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Reducing Emergency Department Visits for Acute Gastrointestinal Illnesses in North Carolina (USA) by Extending Community Water Service
Conclusions: This research provides new evidence that extending regulated community water service to populations currently relying on private wells may decrease the population burden of acute gastrointestinal illness. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this d...
Source: EHP Research - May 20, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Gender-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions
Conclusions: Diazinon exposure perturbed the gut microbiome community structure, functional metagenome, and associated metabolic profiles in a gender-specific manner. These findings may provide novel insights regarding perturbations of the gut microbiome and its functions as a potential new mechanism contributing to diazinon neurotoxicity and, in particular, its sex-selective effects. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This docume...
Source: EHP Research - May 20, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

A Difference-in-Differences Approach to Assess the Effect of a Heat Action Plan on Heat-Related Mortality, and Differences in Effectiveness According to Gender, Age, and Socioeconomic Status (Montreal, Quebec)
Author Affiliations open 1Institute for Health and Social Policy, McGill University Montreal, QC, Canada; 2Direction de santé publique de l’Agence de la santé et des services sociaux de Montréal, QC, Canada; 3Institut National de Santé Publique du Québec, Montréal, QC, Canada; 4Biomedical Ethics Unit, McGill University. QC, Canada; 5Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, QC, Canada PDF Version (448 KB) Abstract About This Article Background: The impact of heat waves on mortality and health inequalities is well documen...
Source: EHP Research - May 20, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Estimating Causal Effects of Local Air Pollution on Daily Deaths: Effect of Low Levels
Conclusions: We conclude that there is a causal association of local air pollution with daily deaths at concentrations below EPA standards. The estimated attributable risk in Boston exceeded 1,800 deaths during the study period, indicating important public health benefits can follow from further control efforts. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon ...
Source: EHP Research - May 20, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with Pubertal Timing among Russian Boys
Conclusions: Our results suggest that TEQs may delay, while nondioxin-like-PCBs advance, the timing of male puberty. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citation: Burns JS, Lee MM, Williams PL, Korrick SA, Serg...
Source: EHP Research - May 17, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Nano-Scale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain
Author Affiliations open 1Davis School of Gerontology, 2Viterbi School of Engineering, 3USC Dornsife College, University of Southern California, Los Angeles, California, USA PDF Version (5.7 MB) Abstract About This Article Supplemental Material Background: Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported. Objective: We evaluated the olfactory neuroepithelium (OE) and brain regional responses to a nano-sized subfraction of urban traffic...
Source: EHP Research - May 17, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Bisphenol A and Adiposity in an Inner-City Birth Cohort
Conclusions: Analyses of the CCCEH longitudinal birth cohort found associations between prenatal urinary BPA concentrations and FMI, %BF and WC. Our results suggest that prenatal BPA exposure may contribute to developmental origins of adiposity. These findings are consistent with several prior studies, raising concern about the pervasiveness of BPA. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the cop...
Source: EHP Research - May 17, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

The Impact of Individual Anthropogenic Emissions Sectors on the Global Burden of Human Mortality due to Ambient Air Pollution
Conclusions: The contributions of emissions sectors to ambient air pollution-related mortality differ among regions, suggesting region-specific air pollution control strategies. Global sector-specific actions targeting Land Transportation (ozone) and Residential & Commercial (PM2.5) would particularly benefit human health. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted v...
Source: EHP Research - May 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Urinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia
Conclusions: Urinary concentrations of BPA and several phthalate metabolites were significantly associated with increased risk of preeclampsia. If validated, these results indicate an environmental contribution of endocrine disrupting chemicals to preeclampsia and poise a modifiable means to reduce the mortality and morbidity associated with this condition. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with...
Source: EHP Research - May 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Children's Health Source Type: research

Long-Term Exposure to Particulate Matter and Self-Reported Hypertension: A Prospective Analysis in the Nurses’ Health Study
We examined the association of hypertension incidence with long-term residential exposures to ambient particulate matter and residential distance to roadway. Methods: We estimated 24-month and cumulative average exposures to PM10, PM2.5, and PM2.5-10 and residential distance to road for women in the prospective nationwide Nurses’ Health Study. Hazard ratios and 95% confidence intervals were calculated for incident hypertension 1988-2008 in Cox proportional hazards models, adjusted for potential confounders. We considered effect modification by age, diet, diabetes, obesity, region, and latitude....
Source: EHP Research - May 13, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database
Conclusions: Curation and integration of exposure data within CTD provides researchers with new opportunities to correlate exposures with human health outcomes, identify underlying potential molecular mechanisms, and improve understanding about the exposome. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citati...
Source: EHP Research - May 12, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Depression, Mental Distress and Domestic Conflict among Louisiana Women Exposed to the Deepwater Horizon Oil Spill in the WaTCH Study
Conclusions: This large population-based study of women in southern coastal Louisiana, a particularly disaster-prone area of the country, revealed high rates of poor mental health outcomes. Reported exposure to the DHOS was a significant predictor of these outcomes, suggesting avenues for future disaster mitigation through the provision of mental health services. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced ...
Source: EHP Research - May 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

Assessing the Association between Thermotolerant Coliforms in Drinking Water and Diarrhea: An Analysis of Individual Level Data from Multiple Studies
Author Affiliations open 1Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; 2Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA; 3Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; 4School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; 5Aquaya Institute, Nairobi, Kenya PDF Version (454 KB) Abstract About This Article Supplemental Material Background: Fecally-contaminated drinking water is believed ...
Source: EHP Research - May 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Temporal Trends of Secondhand Smoke Exposure: Nonsmoking Workers in the United States (NHANES 2001–2010)
Conclusions: During the period from 2001 to 2010, the overall SHS exposure in nonsmoking workers has declined with substantial decline in food preparation/service and blue-collar workers. Although disparities persist in SHS exposure, the gap among occupations has narrowed. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI numb...
Source: EHP Research - May 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides
Conclusions: This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used by risk assessors as well as researchers to systematize, inform and increase efficiency in selecting and prioritizing agents for hazard identification, risk assessment, regulation or further investigation. This approach could be extended to an array of outcomes and agents, including occupational carcinogens, drugs, and foods. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are comple...
Source: EHP Research - May 10, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Ten-Year Monitored Natural Recovery of Lead-Contaminated Mine Tailing in Klity Creek, Kanchanaburi Province, Thailand
Conclusion: The MNR method is not suitable to use as the sole remedial approach for Klity Creek (KC2 to KC7). Although MNR is applicable at KC8, it may require up to 377±76 years to restore the sediment to the background Pb concentration. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will ...
Source: EHP Research - May 8, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Evaluation of OASIS QSAR Models Using ToxCast in Vitro Estrogen and Androgen Receptor Binding Data and Application in an Integrated Endocrine Screening Approach
Author Affiliations open Toxicology Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan, USA PDF Version (421 KB) Abstract About This Article Supplemental Material Background: Integrative testing strategies (ITS) for potential endocrine activity can use tiered in silico and in vitro models. Each component of an ITS should be thoroughly assessed. Objectives: We used the data from three in vitro ToxCast binding assays to assess OASIS, a quantitative structure-activity relationship (QSAR) platform covering both estrogen (ER) and androgen receptor (AR) binding. For stronger ...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Size-Dependent Deposition, Translocation, and Microglial Activation of Inhaled Silver Nanoparticles in the Rodent Nose and Brain
Conclusions: This study demonstrates that after a six-hour inhalation exposure in rats to 20 and 110 nm AgNP at a single point in time, Ag deposition in the nose, the rate of translocation to the brain, and subsequent microglial activation in the OB, differed depending on AgNP size and time since exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it ...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Assessing Temporal and Spatial Patterns of Observed and Predicted Ozone in Multiple Urban Areas
Conclusions: These changes have implications for how O3 exposure may change due to NOx reductions and are informative in the design of future epidemiology studies and risk assessments. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publicatio...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Urbanization Level and Vulnerability to Heat-Related Mortality in Jiangsu Province, China
Author Affiliations open 1State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China; 2Department of Environmental Health Sciences, Program in Climate and Health, Mailman School of Public Health, Columbia University, New York, New York, USA; 3Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, China; 4Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA PDF Version (1.6 MB) Abstract About This Article Supplemental Material Background: While adverse effects of high temper...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy
Conclusions: These results support previous reports showing the potential for environmental phthalate exposure to alter circulating levels of thyroid hormones in pregnant women. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

The Legal Implications of Report-Back in Household Exposure Studies
Conclusions: Researchers should still report back results to participants who want them, but should disclose these risks as part of the informed consent process. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process. Citati...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Review Source Type: research

Lactational Exposure to Polybrominated Diphenyl Ethers and Its Relation to Early Childhood Anthropometric Measurements
Conclusions: We observed little evidence of associations between early-life PBDE exposures via breast milk and anthropometric measurements overall; however, our results prompt the need for sex-specific investigations in larger cohorts. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be abl...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Exposures to Particulate Matter from the Eruptions of the Puyehue Volcano and Birth Outcomes in Montevideo, Uruguay
This study explores the effect of particulate matter with diameter of 10 micrometers or less (PM10) on perinatal outcomes in Uruguay, a middle-income country in South America with levels of PM10 that in general do not exceed the recommended thresholds. The analyzed outcomes are preterm birth, term birth weight, and term low birth weight. Methods: We take advantage of the sharp variation in PM10 concentrations due to the Puyehue eruptions to estimate the associations between mother’s exposure to PM10 in each trimester of pregnancy and perinatal outcomes. We use birth registries for 2010-2013 ...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China
Conclusions: Both prenatal and postnatal OP exposure may adversely affect the neurodevelopment of infants living in the agricultural area. The present study added to the accumulating evidence on associations of prenatal and postnatal OP exposure with infant neurodevelopment. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number u...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis
Author Affiliations open 1ISGlobal, Center for Research in Environmental Epidemiology, Barcelona, Spain; 2Consorcio de Investigación Biomédica de Epidemiología y Salud Pública, Spain; 3Universitat Pompeu Fabra, Barcelona, Spain; 4Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain; 5Center for Research in Occupational Health, Barcelona, Spain; 6Norwegian Institute of Public Health, Oslo, Norway; 7Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal; 8Institute of Environmental Med...
Source: EHP Research - May 6, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Particulate Air Pollution, Exceptional Aging, and Rates of Centenarians: A Nationwide Analysis of the United States, 1980–2010
Author Affiliations open 1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 2Department of Economics, 142 Faculty Office Building, Brigham Young University, Provo, Utah, USA; 3Environmental Health Directorate, Health Canada, Ottawa, Ontario, Canada; 4Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California, USA PDF Version (612 KB) Abstract About This Article Supplemental Material Background: Exceptional aging, defined as reaching age 85 years, shows geographic inequalities that may dep...
Source: EHP Research - May 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline
Conclusions: There are many similarities between the effect of occupational endotoxin exposure and tobacco smoke exposure on lung parenchyma and airway remodeling. The effects of occupational endotoxin exposure appear to persist even after exposure cessation. LAAI-950 may not be a reliable indicator of emphysema in subjects without spirometric impairment. Lung mass is a CT-based biomarker of accelerated lung function decline. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI n...
Source: EHP Research - May 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease
Conclusions: Women with lower neighborhood SES may be more susceptible to air pollution-related health effects. The association between air pollution and cardiovascular disease was not explained by confounding from individual or neighborhood SES. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will...
Source: EHP Research - May 3, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research’”
Research and Toxicology Department, Humane Society International, London, United Kingdom About This Article open Citation: Langley G. 2016. Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.’” Environ Health Perspect 124:A85; http://dx.doi.org/10.1289/ehp.1611305 Address correspondence to G. Langley, 8 Crow Furlong, Hitchin, Hertfordshire, SG5 2HW, United Kingdom. E-mail: sciencesources@btinternet.com The author works for Humane Society International, one of whose goals is the phasing out of animal use in testing and research. Fina...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence May 2016 Source Type: research

Comment on “Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research”
Americans for Medical Advancement, Goleta, California, USA About This Article open Citation: Greek R. 2016. Comment on “Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.” Environ Health Perspect 124:A84; http://dx.doi.org/10.1289/ehp.1511148 Address correspondence to R. Greek, Americans for Medical Advancement, 2251 Refugio Rd, Goleta, CA 93117 USA. E-mail: drraygreek@gmail.com The author is the president of Americans for Medical Advancement (AFMA), a nonprofit organization that advocates for science-based medical research. AFMA does not oppose the use of animals in scien...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence May 2016 Source Type: research

Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic
Conclusions In conclusion, since there are now numerous animal and epidemiological studies indicating that environmental pollutants could contribute to the global obesity epidemic, there is an urgent need to reduce the burden of environmental contaminants so that obesity does not become the normal outlook in the future. The workshop attendees concluded that public health efforts should focus on the importance of early obesity prevention by means of reducing chemical exposures, rather than only treating the established disease. Just as a bad start can last a lifetime and beyond, a good start can last a lifetime as well. Re...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication May 2016 Source Type: research

In Memoriam: Carol Stroebel
About This Article open Citation: Witherspoon NO. 2016. In memoriam: Carol Stroebel. Environ Health Perspect 124:A80; http://dx.doi.org/10.1289/EHP284 Final Publication: 1 May 2016 PDF Version (207 KB) Carol Stroebel, 1956–2016 It is with very heavy hearts that the board and staff of the Children’s Environmental Health Network (CEHN) announce the loss of our long-time colleague, champion, and friend Carol Stroebel. Carol, of Winchester, Virginia, passed away surrounded by loved ones on 16 January 2016. Carol was diagnosed with cholangiocarcinoma (bile duct cancer) in the fall of 2014. Despite this in...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: In Memoriam May 2016 Source Type: research

Cleaning Up Muddy Waters: The Fight to Revive Senegal’s Hann Bay
Once a sparkling jewel with white sand beaches, Senegal’s Hann Bay is now severely polluted with untreated sewage, industrial waste, and more. Researchers are studying what’s in the water, how it’s affecting life around the bay, and how it can be cleaned up. Here, student Cheikh Tidiane Dione takes samples of wastewater from one of the canals feeding into the bay.© Jori Lewis   Dark streaks appear in the waters of Hann Bay, which curves around the inside hook of the Cap-Vert Peninsula. Dakar’s population has roughly quintupled since 1960 as migrants from the interior of...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News May 2016 Source Type: research

Pipe Dreams: Tapping into the Health Information in Our Sewers
The emerging field of sewage chemical-information mining is taking advantage of a readily available yet underappreciated resource: the untreated waste flowing under our feet and the biosolids remaining after treatment. It turns out that sewage and sewage sludge hold a wealth of data on chemical consumption and exposure, and potentially even the health status of whole communities.EHP Freezers at the National Sewage Sludge Repository hold hundreds of samples of raw sewage and sludge collected from more than 200 sites around the United States.© Arjunkrishna Venkatesan   Most c...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News May 2016 Source Type: research

Prenatal Air Pollution and Reduced Birth Weight: Decline in Placental Mitochondria as a Potential Mechanism
Julia R. Barrett, MS, ELS, a Madison, WI–based science writer and editor, is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences. About This Article open Citation: Barrett JR. 2016. Prenatal air pollution and reduced birth weight: decline in placental mitochondria as a potential mechanism. Environ Health Perspect 124:A98; http://dx.doi.org/10.1289/ehp.124-A98 Published: 1 May 2016 PDF Version (175 KB) Related EHP Article Prenatal Ambient Air Pollution, Placental Mitochondrial Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohort...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection May 2016 Source Type: research

Crumbling Infrastructure and Learning Impairment: A Call for Responsibility
Duke University, Durham, North Carolina, USA About This Article open Citation: Levin ED. 2016. Crumbling infrastructure and learning impairment: a call for responsibility. Environ Health Perspect 124:A79; http://dx.doi.org/10.1289/EHP69 E-mail: edlevin@duke.edu The author declares he has no actual or potential competing financial interest. Final Publication: 1 May 2016 PDF Version (126 KB) We have known for many decades that lead exposure in children causes long-lasting cognitive dysfunction (Byers and Lord 1943; McKhann 1932). A great number of basic and human health studies have shown in great detail t...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Editorial Featured May 2016 Source Type: research

E-Waste and Harm to Vulnerable Populations: A Growing Global Problem
Conclusion: Global, national, and local levels efforts must aim to create safe recycling operations that consider broad security issues for people who rely on e-waste processing for survival. Paramount to these efforts is reducing pregnant women and children’s e-waste exposures to mitigate harmful health effects. With human environmental health in mind, novel dismantling methods and remediation technologies and intervention practices are needed to protect communities. Citation: Heacock M, Kelly CB, Asante KA, Birnbaum LS, Bergman AL, Bruné MN, Buka I, Carpenter DO, Chen A, Huo X, Kamel M, Landrigan PJ, Magal...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Sam Duvall Tags: Commentary May 2016 Source Type: research

Effects of Noise Exposure on Systemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistance in Male Mice
Conclusions: Noise exposure at 95 dB SPL caused insulin resistance in male ICR mice, which was prolonged with longer noise exposure and was likely related to the blunted insulin signaling in skeletal muscle. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Long-Term Fine Particulate Matter Exposure and Major Depressive Disorder in a Community-Based Urban Cohort
Conclusion: Long-term PM2.5 exposure increased the risk of MDD among the general population. Individuals with underlying chronic diseases are more vulnerable to long-term PM2.5 exposure. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the pu...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Effects of Tributyltin Chloride on Cybrids with or without an ATP Synthase Pathologic Mutation
Conclusions: In addition to the known genetic causes, our findings suggest that environmental exposure to TBTC might contribute to the etiology of striatal necrosis syndromes. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication p...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research