Model organisms at the heart of regeneration [REVIEW]
ABSTRACT
Heart failure is a major cause of death worldwide owing to the inability of the adult human heart to regenerate after a heart attack. However, many vertebrate species are capable of complete cardiac regeneration following injury. In this Review, we discuss the various model organisms of cardiac regeneration, and outline what they have taught us thus far about the cellular and molecular responses essential for optimal cardiac repair. We compare across different species, highlighting evolutionarily conserved mechanisms of regeneration and demonstrating the importance of developmental gene expression programmes, plas...
Source: DMM Disease Models and Mechanisms - September 26, 2019 Category: Biomedical Science Authors: Price, E. L., Vieira, J. M., Riley, P. R. Tags: REVIEW Source Type: research
The latest from the preLights community - September 2019 [PREPRINT HIGHLIGHTS]
(Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - September 26, 2019 Category: Biomedical Science Tags: PREPRINT HIGHLIGHTS Source Type: research
First person - Karishma Chhabria [FIRST PERSON]
ABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms (DMM), helping early-career researchers promote themselves alongside their papers. Karishma Chhabria is first author on ‘Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish’, published in DMM. Karishma conducted the research described in this article while a PhD student in Tim Chico and Clare Howarth's lab at University of Sheffield, UK. She is now a postdoc in the lab of David Kleinfeld at UCSD, USA, invest...
Source: DMM Disease Models and Mechanisms - September 24, 2019 Category: Biomedical Science Tags: FIRST PERSON Source Type: research
Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish [RESEARCH ARTICLE]
This article has an associated First Person interview with the first author of the paper. (Source: DMM Disease Models and Mechanisms)
Source: DMM Disease Models and Mechanisms - September 24, 2019 Category: Biomedical Science Authors: Chhabria, K., Vouros, A., Gray, C., MacDonald, R. B., Jiang, Z., Wilkinson, R. N., Plant, K., Vasilaki, E., Howarth, C., Chico, T. J. A. Tags: Metabolic Disorders, Zebrafish as a Disease Model RESEARCH ARTICLE Source Type: research
First person - Eleftheria Pervolaraki [FIRST PERSON]
ABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms (DMM), helping early-career researchers promote themselves alongside their papers. Eleftheria Pervolaraki is first author on ‘Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours’, published in DMM. Eleftheria conducted the research described in this article while a Research Fellow at the School of Biomedical Sciences, University of Leeds, UK. She is now M...
Source: DMM Disease Models and Mechanisms - September 23, 2019 Category: Biomedical Science Tags: FIRST PERSON Source Type: research
