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Is Metformin Poised for a Second Career as an Antimicrobial?
Abstract BackgroundMetformin, a widely used anti‐hyperglycemic, has a good safety profile, reasonably manageable side‐effects, is inexpensive and causes a desirable amount of weight loss. In four studies of patients with tuberculosis (one prospective and three retrospective), metformin administration resulted in better outcomes. In mice with several models of endotoxemia, metformin diminished levels of pro‐inflammatory cytokines and improved survival. Laboratory studies showed effectiveness of the drug on multiple pathogens, including Trichinella spiralis, Staphylococcus aureus, Pseudomonas aeruginosa, Hepatitis B vi...
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Faiza Malik, Syed Faizan Mehdi, Haroon Ali, Priya Patel, Anam Basharat, Amrat Kumar, Fnu Ashok, Joanna Stein, Wunnie Brima, Prashant Malhotra, Jesse Roth Tags: REVIEW ARTICLE Source Type: research

The association of low muscle mass with soluble receptor for advanced glycation end products (sRAGE): The Korean Sarcopenic Obesity Study (KSOS)
ConclusionsThe present study shows that a low circulating level of sRAGE may be an independent risk factor for the presence of low muscle mass. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Tae Nyun Kim, Man Sik Park, Eun Joo Lee, Hye Soo Chung, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Sei Hyun Baik, Kyung Mook Choi Tags: RESEARCH ARTICLE Source Type: research

Evaluation of olfaction and taste function in type 2 diabetic patients with and without peripheral neuropathy
ConclusionIn conclusion, this study demonstrates that T2DM is associated with olfactory and gustatory dysfunction. The fact that there was no difference between the diabetic patients with and without DPN elicits the idea of central neuropathy. This novel finding might facilitate the addition of olfactory and gustatory tests to the methodological spectrum of afferent pathway investigations. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Semih Yazla, S üay Özmen, Sinem Kıyıcı, Demet Yıldız, Mehmet Haksever, Sündüz Gencay Tags: RESEARCH ARTICLE Source Type: research

Improved Insulin Sensitivity Appears to Remain for a Mean of Four Years Following Islet Cell Transplant for Type 1 Diabetes
ConclusionsIS measured by SIis was improved several years following transplant, while IS measured by HOMA‐IR did not worsen. Higher exenatide dose, more islets transplanted, and diet and exercise (lowering leptin and RANKL) may improve IS, which may enhance glycemic control and lower metabolic demand on transplanted islets. Long‐term clamp studies are needed to confirm these results. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Brett Rydzon, Rebecca S. Monson, Jose Oberholzer, Krista A. Varady, Melena D. Bellin, Kirstie K. Danielson Tags: RESEARCH ARTICLE Source Type: research

The effects of probiotic administration on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double ‐blind, placebo‐controlled trial
ConclusionsOverall, probiotic supplementation for 12 weeks among subjects with DFU had beneficial effects on ulcer size, glycemic control, total cholesterol, hs‐CRP, plasma NO, TAC and MDA levels. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Sima Mohseni, Masomeh Bayani, Fereshteh Bahmani, Maryam Tajabadi ‐Ebrahimi, Mohammad Ali Bayani, Parvaneh Jafari, Zatollah Asemi Tags: RESEARCH ARTICLE Source Type: research

Vitamin D ratio and glycemic control in individuals with type 2 diabetes mellitus: a systematic review
ConclusionTherefore, despite the association of vitamin D with glucose metabolism, there is insufficient evidence of the beneficial effects of its supplementation on the metabolic control of type 2 diabetes mellitus. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Ramara Kadija Fonseca Santos, Paula Nascimento Brand ão‐Lima, Raissa Maria Dumas Delatore Tete, Analícia Rocha Santos Freire, Liliane Viana Pires Tags: REVIEW ARTICLE Source Type: research

A Case ‐control Study: The Association of Serum Paraoxonase 1 Activity and Concentration with the Development of Type 2 Diabetes Mellitus
ConclusionsLower PON1 activity and concentration were associated with an increased risk of developing T2D when adjusted for many of the common risk markers for T2D previously identified. Thus, PON1 may have merit as a biomarker for the development of T2D. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: J. Allen Crow, Edward C. Meek, Robert W. Wills, Janice E. Chambers Tags: RESEARCH ARTICLE Source Type: research

Neck circumference, a valuable anthropometric measurement to detect metabolic syndrome among different age groups in China
ConclusionsNC contributed to determining metabolic syndrome risk beyond the classical anthropometric indices among different age groups in China. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Ting Cui, Ban ‐huao Yan, Zhan Liu, Hui Yang, Michael Gyan, Yu‐xia Ma Tags: RESEARCH ARTICLE Source Type: research

Effects of Alcohol on Plasma Glucose and Prevention of Alcohol ‐induced Hypoglycemia in Type 1 Diabetes – A Systematic Review with GRADE
ConclusionsThe majority of included studies showed that ethanol intake increased the risk of hypoglycemia in patients with T1D. However, the evidence for how to prevent ethanol‐induced hypoglycemia is sparse, and further investigations are needed to establish evidence‐based recommendations. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: R. Tetzschner, K. N ørgaard, A. Ranjan Tags: REVIEW ARTICLE Source Type: research

Distribution and related factors of cardiometabolic disease stage based on body mass index level in Chinese adults – The National Diabetes and Metabolic Disorders Survey
ConclusionsOf Chinese men and women with normal weight, over one third had mild‐to‐moderate CMD, and less than one third had severe CMD, while of these with overweight or obesity, nearly one third had mild‐to‐moderate CMD, and nearly two thirds had severe CMD. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Xuhong Hou, Peizhu Chen, Gang Hu, Yue Chen, Siyu Chen, Jingzhu Wu, Xiaojing Ma, Lei Chen, Zhaojun Yang, Wenying Yang, Weiping Jia, Tags: RESEARCH ARTICLE Source Type: research

Low triglyceride as a marker for increased risk of cardiovascular diseases in patients with long ‐term type 2 diabetes: a cross sectional survey in China
ConclusionsAlthough high triglyceride was associated with increased risk of CVD in short‐term T2DM, low triglyceride was associated with increased CVD risk in long‐term T2DM. Low triglyceride may be a marker of CVD risk in Chinese patients with long‐term T2DM. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - November 1, 2017 Category: Endocrinology Authors: Yanfeng Ren, Qian Ren, Juming Lu, Xiaohui Guo, Xiaoxu Huo, Linong Ji, Xilin Yang Tags: RESEARCH ARTICLE Source Type: research

Association of change in waist circumference and dyslipidaemia risk: The rural Chinese cohort study
ConclusionsDynamic change in waist circumference was closely related to the incidence of dyslipidaemia in a rural Chinese population. Waist circumference reduction could decrease dyslipidaemia risk, whereas WC increase may increase the risk. Interventions to control or reduce WC to within the normal range are important for early prevention of dyslipidaemia. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 19, 2017 Category: Endocrinology Authors: Junmei Zhou, Yongcheng Ren, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yang Zhao, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Xinping Luo, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu, Ming Zhang Tags: RESEARCH ARTICLE Source Type: research

Association between insulin ‐induced weight change and CVD mortality: Evidence from a historic cohort study of 18,814 patients in UK primary care
ConclusionInsulin‐induced weight gain did not translate to adverse cardiovascular outcomes and mortality in patients with T2D. These data provide reassurance on the cardiovascular safety of insulin patients with T2D. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 19, 2017 Category: Endocrinology Authors: Uchenna Anyanwagu, Jil Mamza, Richard Donnelly, Iskandar Idris Tags: RESEARCH ARTICLE Source Type: research

Coronary artery bypass grafting versus percutaneous coronary intervention in patients with noninsulin treated type 2 diabetes mellitus: A meta ‐analysis of randomized controlled trials
ConclusionsIn NITDM patients, our study suggests that CABG surgery is associated with reduced risk of mortality and morbidity, although with increased incidence of stroke compared with percutaneous coronary intervention. The decision if to have percutaneous coronary intervention or CABG surgery should factor the risk for stroke of the patients when considering CABG over percutaneous coronary intervention. Adequately powered RCTs are needed to confirm the results of this meta‐analysis. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 19, 2017 Category: Endocrinology Authors: Yushu Wang, Meiqin Wen, Junteng Zhou, Yucheng Chen, Qing Zhang Tags: RESEARCH ARTICLE Source Type: research

[HDL ‐C/apoA‐I]: A multivessel cardiometabolic risk marker in women with T2DM
Conclusion[HDL‐C/apoA‐I] can stratify T2DM women according to metabolic phenotype, macrovascular and coronary damage, β‐cell function, microangiopathic risk, and retinopathy. This ratio is a versatile and readily available marker of cardiometabolic status and vascular complications in T2DM women. (Source: Diabetes/Metabolism Research and Reviews)
Source: Diabetes/Metabolism Research and Reviews - October 16, 2017 Category: Endocrinology Authors: Michel P. Hermans, Paul Valensi, Sylvie A. Ahn, Michel F. Rousseau Tags: RESEARCH ARTICLE Source Type: research