Relationship between family meal frequency and individual dietary intake among diabetic patients.
CONCLUSIONS: A strong relationship between family meal frequency and individual dietary intake among diabetic patients was recorded. The present study is one of the few studies that have examined family cohesion as a mediator of the relationship and to our best knowledge is the first work to demonstrate a trend towards complete mediation. Results obtained can be used by health professionals to devise strategies for increasing knowledge and awareness of both diabetic patients and their respective families to curd down this public health burden.
PMID: 26258111 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - August 12, 2015 Category: Endocrinology Authors: Ruhee D, Mahomoodally F Tags: J Diabetes Metab Disord Source Type: research
Insulin administered by needle-free jet injection corrects marked hyperglycaemia faster in overweight or obese patients with diabetes.
CONCLUSIONS: Administration of rapid-acting insulin by jet injection results in faster correction of marked hyperglycaemia in overweight or obese patients with insulin-requiring diabetes.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01947556.
PMID: 26259978 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 11, 2015 Category: Endocrinology Authors: de Wit HM, Engwerda EE, Tack CJ, de Galan BE Tags: Diabetes Obes Metab Source Type: research
Bioavailability of insulin detemir and human insulin at the level of peripheral interstitial fluid in humans assessed by open flow microperfusion.
CONCLUSIONS: OFM proved useful for target tissue measurements of human insulin and the analogue insulin detemir. Our tissue data confirm a highly effective retention of insulin detemir in the vascular compartment. The higher insulin detemir relative to human insulin tissue concentrations at comparable pharmacodynamics, however, indicate that the lower potency of insulin detemir in humans is due to a reduced effect in peripheral insulin sensitive tissues and is in line with the reduced in-vitro receptor affinity.
PMID: 26260082 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 11, 2015 Category: Endocrinology Authors: Bodenlenz M, Ellmerer M, Schaupp L, Jacobsen LV, Plank J, Brunner GA, Wutte A, Aigner B, Mautner SI, Pieber TR Tags: Diabetes Obes Metab Source Type: research
Diagnosis of Primary Hypophysitis in Germany.
CONCLUSION: In contrast to the literature, hypogonadism was found to be the most frequent endocrine failure in PrHy. Weight gain was identified as a clinical sign of PrHy. In the majority of patients, PrHy can be reliably identified by characteristic clinical signs and symptoms, obviating histological confirmation. The diagnostic approach should be standardized in PrHy.
PMID: 26262437 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 11, 2015 Category: Endocrinology Authors: Honegger J, Schlaffer S, Menzel C, Droste M, Werner S, Elbelt U, Strasburger C, Störmann S, Küppers A, der Werf CS, Deutschbein T, Stieg M, Rotermund R, Milian M, Petersenn S, Pituitary Working Group of the German Society of Endocrinology Tags: J Clin Endocrinol Metab Source Type: research
Anti-atherosclerotic effects of sitagliptin in patients with type 2 diabetes mellitus.
CONCLUSION: Sitagliptin shows an adiponectin-dependent anti-atherothrombotic effect, which may be beneficial for primary prevention of atherothrombosis, in patients with type 2 diabetes.
PMID: 26251624 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - August 10, 2015 Category: Endocrinology Authors: Omoto S, Taniura T, Nishizawa T, Tamaki T, Shouzu A, Nomura S Tags: Diabetes Metab Syndr Obes Source Type: research
Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis.
In conclusion, Zinc supplementation has favourable effects on plasma lipid parameters. Zinc supplementation significantly reduced total cholesterol, LDL cholesterol and triglycerides. Therefore it may have the potential to reduce the incidence of atherosclerosis related morbidity and mortality.
PMID: 26244049 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - August 8, 2015 Category: Endocrinology Authors: Ranasinghe P, Wathurapatha WS, Ishara MH, Jayawardana R, Galappatthy P, Katulanda P, Constantine GR Tags: Nutr Metab (Lond) Source Type: research
Effect of the different assays of HbA1c on diabetic patients monitoring.
CONCLUSIONS: Results show that some HbA1c assays capability to classify diabetic patients according to HbA1c level is still unacceptable.
PMID: 26244134 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - August 8, 2015 Category: Endocrinology Authors: Razi F, Nasli Esfahani E, Rahnamaye Farzami M, Tootee A, Qorbani M, Ebrahimi SA, Nahid M, Pasalar P Tags: J Diabetes Metab Disord Source Type: research
The Role of Bone Marrow Fat in Skeletal Health: Usefulness and perspectives for clinicians.
CONCLUSIONS: We conclude that most human data demonstrate an inverse relationship between BMF and BMD, but data on the relationship with fractures is inconsistent and needs further study. In daily practice, the usefulness for clinicians of assessing BMF using MRI is still limited. However, the perspectives are exciting, particularly in terms of improving the diagnosis and management of osteoporosis.
PMID: 26244490 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 5, 2015 Category: Endocrinology Authors: Paccou J, Hardouin P, Cotten A, Penel G, Cortet B Tags: J Clin Endocrinol Metab Source Type: research
Effect of 6-months' vitamin D supplementation on residual beta cell function in children with type 1 diabetes: a case control interventional study.
CONCLUSIONS: There was a trend towards lesser decline of RBCF with short term cholecalciferol supplementation in children with T1D. Further larger studies are urgently needed to explore the beneficial effects of the relatively inexpensive vitamin D supplementation on RBCF.
PMID: 26244673 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 5, 2015 Category: Endocrinology Authors: Mishra A, Dayal D, Sachdeva N, Attri SV Tags: J Pediatr Endocrinol Metab Source Type: research
An unusual case of hereditary nephrogenic diabetes insipidus (HNDI) affecting mother and daughter.
We report a mother and daughter in the same family with HNDI due to a heterozygous deletion in exon 1 of the AVPR2 gene, not previously described in the literature. A 5-year-old girl was referred for investigation of polyuria and polydipsia. The patient had a water deprivation test elsewhere at the age of 3 that was inconclusive. A degree of water restriction was imposed leading to headaches. The thyroid, cortisol, renal, and calcium profiles were normal. Her mother showed similar symptoms that had not been previously investigated. AQP2 (Aquaporin) and initial AVPR2 gene sequencing had not identified a mutation, but subseq...
Source: Diabetes Metab - August 5, 2015 Category: Endocrinology Authors: Giri D, Hart R, Jones C, Ellis I, Ramakrishnan R Tags: J Pediatr Endocrinol Metab Source Type: research
Elevated Serum Fibroblast Growth Factor 21 Levels in Patients with Hyperthyroidism.
CONCLUSION: Serum FGF21 levels were elevated in patients with hyperthyroidism and declined after thionamides treatment. And serum FGF21 levels was independently associated with hyperthyroidism.
PMID: 26241324 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 4, 2015 Category: Endocrinology Authors: Xiao F, Lin M, Huang P, Zeng J, Zeng X, Zhang H, Li X, Yang S, Li Z, Li X Tags: J Clin Endocrinol Metab Source Type: research
Development of a Weighted Cardiometabolic Disease Staging (CMDS) System for the Prediction of Future Diabetes.
CONCLUSIONS: The weighted CMDS score has high model discrimination power for diabetes, and can be used clinically to identify patients for weight loss therapy based on differential risk for future diabetes.
PMID: 26241327 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 4, 2015 Category: Endocrinology Authors: Guo F, Garvey WT Tags: J Clin Endocrinol Metab Source Type: research
Type 2 diabetes mellitus development programs in the new regulatory environment with cardiovascular safety requirements.
Abstract
For type 2 diabetes mellitus treatment and clinical development, proper evaluation of cardiovascular risk has been required by regulatory agencies (eg, the US Food and Drug Administration) since cardiovascular safety is very important in this patient population. The US Food and Drug Administration issued general guidelines for cardiovascular safety evaluation that outlined the requirements considered adequate for cardiovascular safety evaluation. However, there are multiple options to obtain the data and fulfill these requirements. In this paper, we outline the potential pathways and challenges in...
Source: Diabetes Metab - August 2, 2015 Category: Endocrinology Authors: Yang F, Stewart M, Ye J, DeMets D Tags: Diabetes Metab Syndr Obes Source Type: research
The humanistic and economic burden associated with increasing body mass index in the EU5.
CONCLUSION: Increased BMI was associated with worse HRQoL, greater comorbidities, higher direct and indirect costs, and worse health utilities. Weight management may improve patient outcomes.
PMID: 26229497 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - August 2, 2015 Category: Endocrinology Authors: Gupta S, Richard L, Forsythe A Tags: Diabetes Metab Syndr Obes Source Type: research
Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats.
CONCLUSION: The results of the present study suggest that H2S treatment showed significant improvement in behavioral and biochemical abnormalities induced by STZ administration. Thus H2S represents a target of treatment to prevent the progression of complications by DN.
PMID: 26221579 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - July 31, 2015 Category: Endocrinology Authors: Kaur M, Sachdeva S, Bedi O, Kaur T, Kumar P Tags: J Diabetes Metab Disord Source Type: research
